SK11782001A3 - Kryštalická štruktúra cPLA2 a spôsoby indentifikácie agonistov a antagonistov s jej použitím - Google Patents

Kryštalická štruktúra cPLA2 a spôsoby indentifikácie agonistov a antagonistov s jej použitím Download PDF

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Publication number
SK11782001A3
SK11782001A3 SK1178-2001A SK11782001A SK11782001A3 SK 11782001 A3 SK11782001 A3 SK 11782001A3 SK 11782001 A SK11782001 A SK 11782001A SK 11782001 A3 SK11782001 A3 SK 11782001A3
Authority
SK
Slovakia
Prior art keywords
cpla
cpla2
atoms
model
activity
Prior art date
Application number
SK1178-2001A
Other languages
English (en)
Slovak (sk)
Inventor
Andrea Dessen
William S. Somers
Mark L. Stahl
Jasbir S. Seehra
Original Assignee
Genetics Institute, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute, Inc. filed Critical Genetics Institute, Inc.
Publication of SK11782001A3 publication Critical patent/SK11782001A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SK1178-2001A 1999-02-15 2000-02-14 Kryštalická štruktúra cPLA2 a spôsoby indentifikácie agonistov a antagonistov s jej použitím SK11782001A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/250,083 US6801860B1 (en) 1999-02-15 1999-02-15 Crystal structure of cPLA2 and methods of identifying agonists and antagonists using same
PCT/US2000/003745 WO2000047763A1 (en) 1999-02-15 2000-02-14 CRYSTAL STRUCTURE OF cPLA2, AND METHODS OF IDENTIFYING AGONISTS AND ANTAGONISTS USING SAME

Publications (1)

Publication Number Publication Date
SK11782001A3 true SK11782001A3 (sk) 2002-03-05

Family

ID=22946256

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1178-2001A SK11782001A3 (sk) 1999-02-15 2000-02-14 Kryštalická štruktúra cPLA2 a spôsoby indentifikácie agonistov a antagonistov s jej použitím

Country Status (23)

Country Link
US (1) US6801860B1 (ru)
EP (1) EP1155144A4 (ru)
JP (1) JP2002540766A (ru)
KR (1) KR20010103010A (ru)
CN (1) CN1238520C (ru)
AU (1) AU779488B2 (ru)
BG (1) BG105886A (ru)
BR (1) BR0008231A (ru)
CA (1) CA2362612A1 (ru)
CZ (1) CZ20012933A3 (ru)
EA (1) EA200100899A1 (ru)
EE (1) EE200100426A (ru)
HK (1) HK1040745A1 (ru)
HR (1) HRP20010678A2 (ru)
HU (1) HUP0200554A3 (ru)
IL (1) IL144673A0 (ru)
MX (1) MXPA01008192A (ru)
NO (1) NO20013947L (ru)
NZ (1) NZ514176A (ru)
PL (1) PL351242A1 (ru)
SK (1) SK11782001A3 (ru)
TR (1) TR200102366T2 (ru)
WO (1) WO2000047763A1 (ru)

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AU2001286931A1 (en) 2000-08-30 2002-03-13 The Salk Institute For Biological Studies Methods and compositions for determining isomerase enzymatic activity
EP1329511A4 (en) * 2000-09-19 2005-01-19 Kyowa Hakko Kogyo Kk POLYPEPTIDE WITH PHOSPHOLIPASE A2 ACTIVITY
CA2427352C (en) * 2000-11-07 2010-10-12 I.R.B. Istituto Di Ricerche Biotecnologiche S.R.L. Glycerophosphoinositol derivatives as modulators of cytosolic phospholipase
CA2439182C (en) * 2001-02-22 2009-04-14 Japan Science And Technology Corporation Novel calcium-independent phospholipases a2, genes thereof and promoter of the same
US7718198B2 (en) * 2001-06-20 2010-05-18 Metaproteomics, Llc Treatment modalities for autoimmune diseases
US8206753B2 (en) 2001-06-20 2012-06-26 Metaproteomics, Llc Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes
US20040115290A1 (en) 2001-06-20 2004-06-17 Tripp Matthew L. Modulation of inflammation by hops fractions and derivatives
US7815944B2 (en) * 2001-06-20 2010-10-19 Metaproteomics, Llc Anti-inflammatory pharmaceutical compositions for reducing inflammation and the treatment of prevention of gastric toxicity
US8142819B2 (en) * 2002-10-21 2012-03-27 Metaproteomics, Llc Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response
US7270835B2 (en) * 2001-06-20 2007-09-18 Metaproteomics, Llc Compositions that treat or inhibit pathological conditions associated with inflammatory response
US7205151B2 (en) * 2001-06-20 2007-04-17 Metaproteomics, Llc Complex mixtures exhibiting selective inhibition of cyclooxygenase-2
US7901714B2 (en) * 2001-06-20 2011-03-08 Metaproteomics, Llp Treatment modalities for autoimmune diseases
US8168234B2 (en) * 2001-06-20 2012-05-01 Metaproteomics, Llc Compositions that treat or inhibit pathological conditions associated with inflammatory response
US7901713B2 (en) * 2001-06-20 2011-03-08 Metaproteomics, Llc Inhibition of COX-2 and/or 5-LOX activity by fractions isolated or derived from hops
US8158160B2 (en) 2001-11-13 2012-04-17 Eric Hauser Kuhrts Anti-inflammatory cyclooxygenase inhibitors
MXPA05004288A (es) * 2002-10-21 2005-08-02 Metaproteomics Llc Composiciones para tratar o inhibir los estados patologicos asociados con la respuesta inflamatoria.
ATE421357T1 (de) * 2003-05-22 2009-02-15 Metaproteomics Llc Entzündungshemmende arzneizubereitungen zur entzündungsverminderung und die therapie oder die prophylaxe von der gastrischen toxizität
US20050192356A1 (en) * 2004-02-27 2005-09-01 Babish John G. Synergistic anti-inflammatory pharmaceutical compositions and methods of use
US7914831B2 (en) * 2004-02-27 2011-03-29 Metaproteomics, Llc Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines
US20090274778A1 (en) * 2004-11-13 2009-11-05 Babish John G Compositions Exhibiting Inhibition Of Cyclooxygenase-2
US7931904B2 (en) 2005-02-15 2011-04-26 Dana Farber Cancer Institute, Inc. Modulation of MUC1 activity
JP2009504657A (ja) * 2005-08-09 2009-02-05 メタプロテオミクス，エルエルシー ホップ及びアカシア産物によるプロテインキナーゼ調節
US8017315B2 (en) 2005-08-22 2011-09-13 Dana Farber Cancer Institute, Inc. Mitochondrial localization of MUC1
WO2007067812A2 (en) * 2005-12-09 2007-06-14 Metaproteomics, Llc Protein kinase modulation by hops and acacia products
CA2654964A1 (en) * 2006-06-20 2007-12-27 Metaproteomics, Llc Reduced isoalpha acid based protein kinase modulation cancer treatment
WO2008097840A2 (en) 2007-02-02 2008-08-14 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of muc1 by hsf1 and stat3
WO2008097844A2 (en) 2007-02-02 2008-08-14 Dana -Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins
WO2008101121A2 (en) 2007-02-14 2008-08-21 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to promoter regulation by muc1 and klf proteins
US8815306B2 (en) * 2007-03-19 2014-08-26 Metaproteomics, Llc Methods and compositions for promoting bone and joint health
JP2010526882A (ja) * 2007-05-11 2010-08-05 メタプロテオミクス， エルエルシー 重金属無害化のための方法と組成物
JP2011506464A (ja) * 2007-12-10 2011-03-03 メタプロテオミクス， エルエルシー 癌、血管新生及びそれらに関連する炎症経路の置換１，３−シクロペンタジオン多重標的プロテインキナーゼ・モジュレーター
WO2009124176A1 (en) * 2008-04-02 2009-10-08 Metaprotemics, Llc Substituted 1,3-cyclopentadione attenuated endothelial inflammation and endothelial-monocyte interactions
NZ592537A (en) 2008-10-17 2012-07-27 Dana Farber Cancer Inst Inc Muc-1 cytoplasmic domain peptides as inhibitors of cancer
FI20105629A0 (fi) * 2010-06-03 2010-06-03 Estaja Oy Menetelmä lipidiaktivoituvien entsyymien peptidi-inhibiittoreiden valmistamiseksi ja menetelmällä valmistettuja peptidejä
PL3524618T3 (pl) 2013-03-15 2023-07-10 GLAdiator Biosciences, Inc. Domeny gla jako środki ukierunkowujące
WO2019051002A1 (en) 2017-09-05 2019-03-14 GLAdiator Biosciences, Inc. PROCESS FOR INTRACELLULAR DELIVERY
CN117187211A (zh) * 2023-08-04 2023-12-08 华南理工大学 一种磷脂酶c晶体及磷脂酶c突变体的制备方法与应用

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US5622832A (en) 1990-02-28 1997-04-22 Genetics Institute, Inc. Arachidonic acid releasing phospholipase A2 enzyme and methods of use
CA2061738A1 (en) * 1991-03-01 1992-09-02 Ruth M. Kramer Antibodies reactive with human cytosolic phospholipase a2
IL101507A0 (en) 1991-04-17 1992-12-30 Lilly Co Eli Compounds,vectors and methods for expressing human,cytosolic phospholipase a2
US5221410A (en) 1991-10-09 1993-06-22 Schering Corporation Crystal forming device
US5466595A (en) 1994-07-27 1995-11-14 Genetics Institute, Inc. Calcium independent cytosolic phospholipase A2/B enzymes

Also Published As

Publication number Publication date
HUP0200554A3 (en) 2006-06-28
EP1155144A4 (en) 2002-08-28
TR200102366T2 (tr) 2002-02-21
NZ514176A (en) 2004-09-24
PL351242A1 (en) 2003-04-07
NO20013947D0 (no) 2001-08-14
AU779488B2 (en) 2005-01-27
CZ20012933A3 (cs) 2002-02-13
JP2002540766A (ja) 2002-12-03
AU2993700A (en) 2000-08-29
EA200100899A1 (ru) 2002-04-25
IL144673A0 (en) 2002-05-23
BR0008231A (pt) 2001-10-30
CN1348502A (zh) 2002-05-08
BG105886A (en) 2002-05-31
MXPA01008192A (es) 2002-10-23
NO20013947L (no) 2001-10-10
KR20010103010A (ko) 2001-11-17
CA2362612A1 (en) 2000-08-17
HK1040745A1 (zh) 2002-06-21
EE200100426A (et) 2002-12-16
HRP20010678A2 (en) 2003-08-31
HUP0200554A2 (en) 2002-06-29
US6801860B1 (en) 2004-10-05
WO2000047763A1 (en) 2000-08-17
CN1238520C (zh) 2006-01-25
EP1155144A1 (en) 2001-11-21

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