HK1040745A1 - 胞質磷脂酶a2的晶體結構以及用其來鑒定激動劑和拮抗劑的方法 - Google Patents

胞質磷脂酶a2的晶體結構以及用其來鑒定激動劑和拮抗劑的方法

Info

Publication number
HK1040745A1
HK1040745A1 HK02102245.7A HK02102245A HK1040745A1 HK 1040745 A1 HK1040745 A1 HK 1040745A1 HK 02102245 A HK02102245 A HK 02102245A HK 1040745 A1 HK1040745 A1 HK 1040745A1
Authority
HK
Hong Kong
Prior art keywords
cpla2
antagonists
methods
same
crystal structure
Prior art date
Application number
HK02102245.7A
Other languages
English (en)
Inventor
Dessen Andrea
S Somers William
L Stahl Mark
S Seehra Jasbir
Original Assignee
遺傳研究所有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 遺傳研究所有限公司 filed Critical 遺傳研究所有限公司
Publication of HK1040745A1 publication Critical patent/HK1040745A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK02102245.7A 1999-02-15 2002-03-25 胞質磷脂酶a2的晶體結構以及用其來鑒定激動劑和拮抗劑的方法 HK1040745A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/250,083 US6801860B1 (en) 1999-02-15 1999-02-15 Crystal structure of cPLA2 and methods of identifying agonists and antagonists using same
PCT/US2000/003745 WO2000047763A1 (en) 1999-02-15 2000-02-14 CRYSTAL STRUCTURE OF cPLA2, AND METHODS OF IDENTIFYING AGONISTS AND ANTAGONISTS USING SAME

Publications (1)

Publication Number Publication Date
HK1040745A1 true HK1040745A1 (zh) 2002-06-21

Family

ID=22946256

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02102245.7A HK1040745A1 (zh) 1999-02-15 2002-03-25 胞質磷脂酶a2的晶體結構以及用其來鑒定激動劑和拮抗劑的方法

Country Status (23)

Country Link
US (1) US6801860B1 (zh)
EP (1) EP1155144A4 (zh)
JP (1) JP2002540766A (zh)
KR (1) KR20010103010A (zh)
CN (1) CN1238520C (zh)
AU (1) AU779488B2 (zh)
BG (1) BG105886A (zh)
BR (1) BR0008231A (zh)
CA (1) CA2362612A1 (zh)
CZ (1) CZ20012933A3 (zh)
EA (1) EA200100899A1 (zh)
EE (1) EE200100426A (zh)
HK (1) HK1040745A1 (zh)
HR (1) HRP20010678A2 (zh)
HU (1) HUP0200554A3 (zh)
IL (1) IL144673A0 (zh)
MX (1) MXPA01008192A (zh)
NO (1) NO20013947L (zh)
NZ (1) NZ514176A (zh)
PL (1) PL351242A1 (zh)
SK (1) SK11782001A3 (zh)
TR (1) TR200102366T2 (zh)
WO (1) WO2000047763A1 (zh)

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AU2001290240A1 (en) * 2000-09-19 2002-04-02 Kyowa Hakko Kogyo Co. Ltd. Polypeptide having phospholipase a2 actiivty
US7625883B1 (en) * 2000-11-07 2009-12-01 I.R.B. Istituto di Ricerche Biotechnologiche S.R.L. Glycerophosphoinositol derivatives as modulators of cytosolic A2 phospholipase
WO2002066655A1 (fr) * 2001-02-22 2002-08-29 Japan Science And Technology Corporation Nouvelles phospholipidases a2 independantes du calcium, genes associes et promoteur de ces phospholipidases
US8168234B2 (en) 2001-06-20 2012-05-01 Metaproteomics, Llc Compositions that treat or inhibit pathological conditions associated with inflammatory response
US7205151B2 (en) * 2001-06-20 2007-04-17 Metaproteomics, Llc Complex mixtures exhibiting selective inhibition of cyclooxygenase-2
US20040115290A1 (en) * 2001-06-20 2004-06-17 Tripp Matthew L. Modulation of inflammation by hops fractions and derivatives
US7815944B2 (en) * 2001-06-20 2010-10-19 Metaproteomics, Llc Anti-inflammatory pharmaceutical compositions for reducing inflammation and the treatment of prevention of gastric toxicity
US7718198B2 (en) * 2001-06-20 2010-05-18 Metaproteomics, Llc Treatment modalities for autoimmune diseases
US7901713B2 (en) * 2001-06-20 2011-03-08 Metaproteomics, Llc Inhibition of COX-2 and/or 5-LOX activity by fractions isolated or derived from hops
US7270835B2 (en) * 2001-06-20 2007-09-18 Metaproteomics, Llc Compositions that treat or inhibit pathological conditions associated with inflammatory response
US7901714B2 (en) * 2001-06-20 2011-03-08 Metaproteomics, Llp Treatment modalities for autoimmune diseases
US8142819B2 (en) * 2002-10-21 2012-03-27 Metaproteomics, Llc Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response
US8206753B2 (en) 2001-06-20 2012-06-26 Metaproteomics, Llc Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes
US8158160B2 (en) 2001-11-13 2012-04-17 Eric Hauser Kuhrts Anti-inflammatory cyclooxygenase inhibitors
EP1558271A4 (en) * 2002-10-21 2006-01-11 Metaproteomics Llc COMPOSITIONS FOR TREATING OR INHIBITING PATHOLOGICAL CONDITIONS IN CONNECTION WITH AN INFLAMMATORY ANSWER
JP2007527407A (ja) * 2003-05-22 2007-09-27 メタプロテオミクス， エルエルシー 炎症を軽減するためおよび胃腸毒性の処置または予防のための抗炎症性薬学的組成物
US20050192356A1 (en) * 2004-02-27 2005-09-01 Babish John G. Synergistic anti-inflammatory pharmaceutical compositions and methods of use
US7914831B2 (en) 2004-02-27 2011-03-29 Metaproteomics, Llc Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines
CN101444139A (zh) * 2004-11-13 2009-05-27 麦特普罗泰欧米克斯有限公司 抑制环氧合酶-2的组合物
CA2597627A1 (en) 2005-02-15 2006-08-24 Dana-Farber Cancer Institute, Inc. Modulation of muc1 activity
US20080248131A1 (en) * 2005-08-09 2008-10-09 Metaproteomics, Llc Protein Kinase Modulation by Hops and Acacia Products
WO2007024940A2 (en) 2005-08-22 2007-03-01 Dana-Farber Cancer Institute, Inc. Mitochondrial localization of muc1
AU2006321727A1 (en) * 2005-12-09 2007-06-14 Metaproteomics, Llc Protein kinase modulation by hops and Acacia products
KR20090023722A (ko) * 2006-06-20 2009-03-05 메타프로테오믹스, 엘엘씨 테트라하이드로이소알파산 기본 단백질 키나제 변조 암 치료방법
WO2008097840A2 (en) 2007-02-02 2008-08-14 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of muc1 by hsf1 and stat3
WO2008097844A2 (en) 2007-02-02 2008-08-14 Dana -Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins
WO2008101121A2 (en) 2007-02-14 2008-08-21 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to promoter regulation by muc1 and klf proteins
MX2009010049A (es) * 2007-03-19 2010-03-04 Metaproteomics Llc Metodos y composiciones para promover la salud de huesos y articulaciones.
KR20100029201A (ko) 2007-05-11 2010-03-16 메타프로테오믹스, 엘엘씨 중금속 해독 방법 및 조성물
MX2010006425A (es) * 2007-12-10 2010-08-31 Metaproteomics Llc Moduladores de proteina cinasa de objetivos multiples 1,3-ciclopentadiona-substituida de cancer, angiogenesis y las trayectorias inflamatorias asociadas con los mismos.
JP2011516492A (ja) * 2008-04-02 2011-05-26 メタプロテオミクス， エルエルシー 内皮炎症及び内皮−単球相互作用の置換１，３−シクロペンタジオンによる減弱
EP2727601B1 (en) 2008-10-17 2018-06-13 Dana-Farber Cancer Institute, Inc. Encapsulated Muc-1 cytoplasmic domain peptides as inhibitors of cancer
FI20105629A0 (fi) * 2010-06-03 2010-06-03 Estaja Oy Menetelmä lipidiaktivoituvien entsyymien peptidi-inhibiittoreiden valmistamiseksi ja menetelmällä valmistettuja peptidejä
DK3524617T5 (da) 2013-03-15 2024-09-02 Gladiator Biosciences Inc Gla-domæner som terapeutiske midler
CA3074291A1 (en) 2017-09-05 2019-03-14 GLAdiator Biosciences, Inc. Delivery of payloads to stem cells
CN117187211A (zh) * 2023-08-04 2023-12-08 华南理工大学 一种磷脂酶c晶体及磷脂酶c突变体的制备方法与应用

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US5622832A (en) 1990-02-28 1997-04-22 Genetics Institute, Inc. Arachidonic acid releasing phospholipase A2 enzyme and methods of use
CA2061738A1 (en) * 1991-03-01 1992-09-02 Ruth M. Kramer Antibodies reactive with human cytosolic phospholipase a2
IL101507A0 (en) 1991-04-17 1992-12-30 Lilly Co Eli Compounds,vectors and methods for expressing human,cytosolic phospholipase a2
US5221410A (en) 1991-10-09 1993-06-22 Schering Corporation Crystal forming device
US5466595A (en) 1994-07-27 1995-11-14 Genetics Institute, Inc. Calcium independent cytosolic phospholipase A2/B enzymes

Also Published As

Publication number Publication date
HUP0200554A2 (en) 2002-06-29
MXPA01008192A (es) 2002-10-23
US6801860B1 (en) 2004-10-05
EP1155144A4 (en) 2002-08-28
BR0008231A (pt) 2001-10-30
IL144673A0 (en) 2002-05-23
EP1155144A1 (en) 2001-11-21
TR200102366T2 (tr) 2002-02-21
SK11782001A3 (sk) 2002-03-05
CA2362612A1 (en) 2000-08-17
NZ514176A (en) 2004-09-24
CZ20012933A3 (cs) 2002-02-13
HRP20010678A2 (en) 2003-08-31
BG105886A (en) 2002-05-31
EE200100426A (et) 2002-12-16
PL351242A1 (en) 2003-04-07
WO2000047763A1 (en) 2000-08-17
JP2002540766A (ja) 2002-12-03
EA200100899A1 (ru) 2002-04-25
NO20013947L (no) 2001-10-10
AU779488B2 (en) 2005-01-27
CN1238520C (zh) 2006-01-25
CN1348502A (zh) 2002-05-08
KR20010103010A (ko) 2001-11-17
AU2993700A (en) 2000-08-29
NO20013947D0 (no) 2001-08-14
HUP0200554A3 (en) 2006-06-28

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