SK107193A3 - Bis-naphthalimides containing linkers derived into the aminoacids, as anticancerous agents - Google Patents

Bis-naphthalimides containing linkers derived into the aminoacids, as anticancerous agents Download PDF

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Publication number
SK107193A3
SK107193A3 SK1071-93A SK107193A SK107193A3 SK 107193 A3 SK107193 A3 SK 107193A3 SK 107193 A SK107193 A SK 107193A SK 107193 A3 SK107193 A3 SK 107193A3
Authority
SK
Slovakia
Prior art keywords
compound
formula
methyl
nitro
bis
Prior art date
Application number
SK1071-93A
Other languages
English (en)
Slovak (sk)
Inventor
Jung-Hui Sun
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of SK107193A3 publication Critical patent/SK107193A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK1071-93A 1991-03-27 1992-03-25 Bis-naphthalimides containing linkers derived into the aminoacids, as anticancerous agents SK107193A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67606191A 1991-03-27 1991-03-27
US07/805,044 US5206249A (en) 1991-03-27 1991-12-11 Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
PCT/US1992/002134 WO1992017453A1 (fr) 1991-03-27 1992-03-25 Bis-naphthalimides contenant des linkers derives d'acide amine et utilises comme agents anticancereux

Publications (1)

Publication Number Publication Date
SK107193A3 true SK107193A3 (en) 1994-08-10

Family

ID=27101469

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1071-93A SK107193A3 (en) 1991-03-27 1992-03-25 Bis-naphthalimides containing linkers derived into the aminoacids, as anticancerous agents

Country Status (17)

Country Link
US (1) US5206249A (fr)
EP (2) EP0577753A1 (fr)
JP (1) JPH06506229A (fr)
CZ (1) CZ281868B6 (fr)
FI (1) FI934225A (fr)
HU (1) HUT68969A (fr)
IE (1) IE920958A1 (fr)
IL (1) IL101380A (fr)
MA (1) MA22476A1 (fr)
MX (1) MX9201355A (fr)
MY (1) MY108433A (fr)
NO (1) NO180584C (fr)
NZ (1) NZ242126A (fr)
SK (1) SK107193A3 (fr)
TW (1) TW205547B (fr)
WO (1) WO1992017453A1 (fr)
YU (1) YU30092A (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5461176A (en) * 1991-03-27 1995-10-24 The Du Pont Merck Pharmaceutical Company Processes for preparing bis-naphthalimides containing amino-acid derived linkers
US5329048A (en) * 1991-03-27 1994-07-12 The Dupont Merck Pharmaceutical Company Process of preparing tetraamino intermediates
JPH07501822A (ja) * 1991-12-11 1995-02-23 デュポン・ファーマシュウティカルズ・カンパニー 抗癌剤として有用な高度に水溶性のビス−ナフタルイミド
US5235045A (en) * 1992-03-19 1993-08-10 Microbiomed Corporation Non-azo naphthalimide dyes
US5376664A (en) * 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
US5364867A (en) * 1992-11-30 1994-11-15 Sterling Winthrop Inc. 4-phenylpiperdine agents for treating cns disorders
US5359070A (en) * 1993-02-11 1994-10-25 The Du Pont Merck Pharmaceutical Company Unsymmetrical bis-imides as anticancer agents
US5416089A (en) * 1993-06-24 1995-05-16 The Du Pont Merck Pharmaceutical Company Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
US5766600A (en) * 1993-08-09 1998-06-16 Microbiomed Corporation Non-azo naphtalimide dyes and uses for same
IL110460A (en) * 1993-08-18 2001-01-11 Basf Ag Bite-naphthalimides, their preparation and pharmaceutical preparations containing them
US6204243B1 (en) 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
WO1995008539A1 (fr) * 1993-09-24 1995-03-30 The Du Pont Merck Pharmaceutical Company Procedes ameliores de preparation de composes bis-imides
US5604095A (en) * 1994-07-22 1997-02-18 Cancer Therapy & Research Center Unsymmetrically linked bisnaphthalimides as antitumor agents
US5561042A (en) * 1994-07-22 1996-10-01 Cancer Therapy And Research Center Diamine platinum naphthalimide complexes as antitumor agents
US5641782A (en) * 1995-02-16 1997-06-24 The Dupont Merck Pharmaceutical Company 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides
FR2751655B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9723407D0 (en) 1997-11-05 1998-01-07 Ciba Geigy Ag Organic compounds
US6300331B1 (en) 1998-07-03 2001-10-09 Taiho Pharmaceutical Co., Ltd. Naphthalimidobenzamide derivatives
US6395897B1 (en) 1999-03-02 2002-05-28 Boehringer Ingelheim Pharmaceuticals, Inc. Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5
AU3883600A (en) 1999-03-16 2000-10-04 Regents Of The University Of California, The Glycosylated polyamines
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
GB0003111D0 (en) 2000-02-10 2000-03-29 Novartis Ag Organic compounds
US20040082788A1 (en) * 2002-07-08 2004-04-29 Chemgenex Therapeutics, Inc. Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof
CA2554775A1 (fr) * 2004-01-30 2005-08-18 Chemgenex Pharmaceuticals, Inc. Dosage de naphthalimide par genotypage de n-acetyle transferase
US20050288310A1 (en) * 2004-06-04 2005-12-29 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and PARP-1 inhibitors
US7947839B2 (en) * 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
US8420665B2 (en) 2008-01-11 2013-04-16 Northwestern University Anti-cancer compounds
WO2011044472A1 (fr) * 2009-10-08 2011-04-14 Angus Chemical Company Polyamines pauvres en voc
CN109490291B (zh) * 2018-11-20 2021-05-11 上海应用技术大学 基于吸电子基取代的1,8-萘酰亚胺类化合物作为氟离子的显色试剂的用途
WO2020139971A2 (fr) * 2018-12-27 2020-07-02 Alucent Biomedical, Inc. Procédés de fabrication de naphtalimides dimères et formes à l'état solide de ceux-ci

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146720A (en) * 1976-10-27 1979-03-27 Laboratorios Made, S.A. N-aminoethyl-substituted-3-nitronaphthalimides
DE3481120D1 (de) * 1983-04-01 1990-03-01 Warner Lambert Co 3,6-disubstituierte-1,8-naphthalimide, verfahren zu ihrer herstellung und ihre verwendung.
US4665071A (en) * 1984-02-21 1987-05-12 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
DE3535496A1 (de) * 1985-10-04 1987-04-16 Bayer Ag Verfahren zur fluoreszenzloeschung und neue kationische naphthalin-peri-dicarbonsaeureimid-derivate
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents

Also Published As

Publication number Publication date
HUT68969A (en) 1995-08-28
HU9302719D0 (en) 1993-12-28
IE920958A1 (en) 1992-10-07
TW205547B (fr) 1993-05-11
IL101380A (en) 1996-10-31
MX9201355A (es) 1992-10-01
FI934225A0 (fi) 1993-09-27
YU30092A (sr) 1996-01-09
EP0577753A1 (fr) 1994-01-12
NO180584C (no) 1997-05-14
CZ206093A3 (en) 1994-03-16
FI934225A (fi) 1993-10-15
CZ281868B6 (cs) 1997-03-12
MA22476A1 (fr) 1992-10-01
NO933455D0 (no) 1993-09-27
IL101380A0 (en) 1992-11-15
WO1992017453A1 (fr) 1992-10-15
NO933455L (no) 1993-11-26
NO180584B (no) 1997-02-03
AU1767692A (en) 1992-11-02
NZ242126A (en) 1996-09-25
EP0506008A1 (fr) 1992-09-30
AU666847B2 (en) 1996-02-29
JPH06506229A (ja) 1994-07-14
MY108433A (en) 1996-09-30
US5206249A (en) 1993-04-27

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