IL101380A - Bite-naphthalimides, their preparation and pharmaceutical preparations containing them - Google Patents

Bite-naphthalimides, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL101380A
IL101380A IL10138092A IL10138092A IL101380A IL 101380 A IL101380 A IL 101380A IL 10138092 A IL10138092 A IL 10138092A IL 10138092 A IL10138092 A IL 10138092A IL 101380 A IL101380 A IL 101380A
Authority
IL
Israel
Prior art keywords
bis
nitro
benz
isoquinoline
dione
Prior art date
Application number
IL10138092A
Other languages
English (en)
Hebrew (he)
Other versions
IL101380A0 (en
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of IL101380A0 publication Critical patent/IL101380A0/xx
Publication of IL101380A publication Critical patent/IL101380A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL10138092A 1991-03-27 1992-03-26 Bite-naphthalimides, their preparation and pharmaceutical preparations containing them IL101380A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67606191A 1991-03-27 1991-03-27
US07/805,044 US5206249A (en) 1991-03-27 1991-12-11 Bis-naphthalimides containing amino-acid derived linkers as anticancer agents

Publications (2)

Publication Number Publication Date
IL101380A0 IL101380A0 (en) 1992-11-15
IL101380A true IL101380A (en) 1996-10-31

Family

ID=27101469

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10138092A IL101380A (en) 1991-03-27 1992-03-26 Bite-naphthalimides, their preparation and pharmaceutical preparations containing them

Country Status (17)

Country Link
US (1) US5206249A (fr)
EP (2) EP0577753A1 (fr)
JP (1) JPH06506229A (fr)
CZ (1) CZ281868B6 (fr)
FI (1) FI934225A (fr)
HU (1) HUT68969A (fr)
IE (1) IE920958A1 (fr)
IL (1) IL101380A (fr)
MA (1) MA22476A1 (fr)
MX (1) MX9201355A (fr)
MY (1) MY108433A (fr)
NO (1) NO180584C (fr)
NZ (1) NZ242126A (fr)
SK (1) SK107193A3 (fr)
TW (1) TW205547B (fr)
WO (1) WO1992017453A1 (fr)
YU (1) YU30092A (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5461176A (en) * 1991-03-27 1995-10-24 The Du Pont Merck Pharmaceutical Company Processes for preparing bis-naphthalimides containing amino-acid derived linkers
US5329048A (en) * 1991-03-27 1994-07-12 The Dupont Merck Pharmaceutical Company Process of preparing tetraamino intermediates
JPH07501822A (ja) * 1991-12-11 1995-02-23 デュポン・ファーマシュウティカルズ・カンパニー 抗癌剤として有用な高度に水溶性のビス−ナフタルイミド
US5235045A (en) * 1992-03-19 1993-08-10 Microbiomed Corporation Non-azo naphthalimide dyes
US5376664A (en) * 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
US5364867A (en) * 1992-11-30 1994-11-15 Sterling Winthrop Inc. 4-phenylpiperdine agents for treating cns disorders
US5359070A (en) * 1993-02-11 1994-10-25 The Du Pont Merck Pharmaceutical Company Unsymmetrical bis-imides as anticancer agents
US5416089A (en) * 1993-06-24 1995-05-16 The Du Pont Merck Pharmaceutical Company Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
US5766600A (en) * 1993-08-09 1998-06-16 Microbiomed Corporation Non-azo naphtalimide dyes and uses for same
IL110460A (en) * 1993-08-18 2001-01-11 Basf Ag Bite-naphthalimides, their preparation and pharmaceutical preparations containing them
US6204243B1 (en) 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
WO1995008539A1 (fr) * 1993-09-24 1995-03-30 The Du Pont Merck Pharmaceutical Company Procedes ameliores de preparation de composes bis-imides
US5604095A (en) * 1994-07-22 1997-02-18 Cancer Therapy & Research Center Unsymmetrically linked bisnaphthalimides as antitumor agents
US5561042A (en) * 1994-07-22 1996-10-01 Cancer Therapy And Research Center Diamine platinum naphthalimide complexes as antitumor agents
US5641782A (en) * 1995-02-16 1997-06-24 The Dupont Merck Pharmaceutical Company 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides
FR2751655B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9723407D0 (en) 1997-11-05 1998-01-07 Ciba Geigy Ag Organic compounds
US6300331B1 (en) 1998-07-03 2001-10-09 Taiho Pharmaceutical Co., Ltd. Naphthalimidobenzamide derivatives
US6395897B1 (en) 1999-03-02 2002-05-28 Boehringer Ingelheim Pharmaceuticals, Inc. Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5
AU3883600A (en) 1999-03-16 2000-10-04 Regents Of The University Of California, The Glycosylated polyamines
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
GB0003111D0 (en) 2000-02-10 2000-03-29 Novartis Ag Organic compounds
US20040082788A1 (en) * 2002-07-08 2004-04-29 Chemgenex Therapeutics, Inc. Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof
CA2554775A1 (fr) * 2004-01-30 2005-08-18 Chemgenex Pharmaceuticals, Inc. Dosage de naphthalimide par genotypage de n-acetyle transferase
US20050288310A1 (en) * 2004-06-04 2005-12-29 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and PARP-1 inhibitors
US7947839B2 (en) * 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
US8420665B2 (en) 2008-01-11 2013-04-16 Northwestern University Anti-cancer compounds
WO2011044472A1 (fr) * 2009-10-08 2011-04-14 Angus Chemical Company Polyamines pauvres en voc
CN109490291B (zh) * 2018-11-20 2021-05-11 上海应用技术大学 基于吸电子基取代的1,8-萘酰亚胺类化合物作为氟离子的显色试剂的用途
WO2020139971A2 (fr) * 2018-12-27 2020-07-02 Alucent Biomedical, Inc. Procédés de fabrication de naphtalimides dimères et formes à l'état solide de ceux-ci

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146720A (en) * 1976-10-27 1979-03-27 Laboratorios Made, S.A. N-aminoethyl-substituted-3-nitronaphthalimides
DE3481120D1 (de) * 1983-04-01 1990-03-01 Warner Lambert Co 3,6-disubstituierte-1,8-naphthalimide, verfahren zu ihrer herstellung und ihre verwendung.
US4665071A (en) * 1984-02-21 1987-05-12 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
DE3535496A1 (de) * 1985-10-04 1987-04-16 Bayer Ag Verfahren zur fluoreszenzloeschung und neue kationische naphthalin-peri-dicarbonsaeureimid-derivate
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents

Also Published As

Publication number Publication date
HUT68969A (en) 1995-08-28
HU9302719D0 (en) 1993-12-28
IE920958A1 (en) 1992-10-07
TW205547B (fr) 1993-05-11
MX9201355A (es) 1992-10-01
FI934225A0 (fi) 1993-09-27
YU30092A (sr) 1996-01-09
EP0577753A1 (fr) 1994-01-12
NO180584C (no) 1997-05-14
CZ206093A3 (en) 1994-03-16
FI934225A (fi) 1993-10-15
CZ281868B6 (cs) 1997-03-12
MA22476A1 (fr) 1992-10-01
NO933455D0 (no) 1993-09-27
IL101380A0 (en) 1992-11-15
WO1992017453A1 (fr) 1992-10-15
NO933455L (no) 1993-11-26
NO180584B (no) 1997-02-03
AU1767692A (en) 1992-11-02
NZ242126A (en) 1996-09-25
EP0506008A1 (fr) 1992-09-30
AU666847B2 (en) 1996-02-29
JPH06506229A (ja) 1994-07-14
MY108433A (en) 1996-09-30
SK107193A3 (en) 1994-08-10
US5206249A (en) 1993-04-27

Similar Documents

Publication Publication Date Title
US5206249A (en) Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
US5376664A (en) Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
AU640888B2 (en) Bis-naphthalimides as anticancer agents
US5461176A (en) Processes for preparing bis-naphthalimides containing amino-acid derived linkers
US5488110A (en) Highly water soluble bis-naphthalimides useful as anticancer agents
US5329048A (en) Process of preparing tetraamino intermediates
WO1992017454A1 (fr) Bis-naphtalimides contenant des linkers amide et thioamide et utilises comme agents anticancereux
AU666847C (en) Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
CA2106999A1 (fr) Bis-naphtalimides contenant des lieurs derives aminoacides utilises comme anticancereux
US5641782A (en) 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides
LV10045B (en) Bis-naphthalimides with a bond derived from amino acids, their use as anti-cancer agents
RU2066316C1 (ru) Производные бис-нафталимидов, их энантиомерные или диастереомерные формы, или их смеси, или их фармацевтически приемлемые соли, противоопухолевая композиция и способ лечения
US5359070A (en) Unsymmetrical bis-imides as anticancer agents
JPH09512539A (ja) ジヒドロジベンゾ（ｄｅ，ｈ）イソキノリン誘導体および抗癌剤としての該誘導体の使用
HU210345A9 (hu) Aminosav eredetű linkereket tartalmazó bisz-naftálimid rákellenes szerek

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH Patent void