CA2106999A1 - Bis-naphtalimides contenant des lieurs derives aminoacides utilises comme anticancereux - Google Patents

Bis-naphtalimides contenant des lieurs derives aminoacides utilises comme anticancereux

Info

Publication number
CA2106999A1
CA2106999A1 CA002106999A CA2106999A CA2106999A1 CA 2106999 A1 CA2106999 A1 CA 2106999A1 CA 002106999 A CA002106999 A CA 002106999A CA 2106999 A CA2106999 A CA 2106999A CA 2106999 A1 CA2106999 A1 CA 2106999A1
Authority
CA
Canada
Prior art keywords
compound
formula
bis
methyl
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002106999A
Other languages
English (en)
Inventor
Jung-Hui Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/805,044 external-priority patent/US5206249A/en
Application filed by Individual filed Critical Individual
Priority to CA002106999A priority Critical patent/CA2106999A1/fr
Publication of CA2106999A1 publication Critical patent/CA2106999A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002106999A 1991-03-27 1992-03-25 Bis-naphtalimides contenant des lieurs derives aminoacides utilises comme anticancereux Abandoned CA2106999A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002106999A CA2106999A1 (fr) 1991-03-27 1992-03-25 Bis-naphtalimides contenant des lieurs derives aminoacides utilises comme anticancereux

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US67606191A 1991-03-27 1991-03-27
US07/676,061 1991-03-27
US07/805,044 1991-12-11
US07/805,044 US5206249A (en) 1991-03-27 1991-12-11 Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
CA002106999A CA2106999A1 (fr) 1991-03-27 1992-03-25 Bis-naphtalimides contenant des lieurs derives aminoacides utilises comme anticancereux

Publications (1)

Publication Number Publication Date
CA2106999A1 true CA2106999A1 (fr) 1992-09-28

Family

ID=27169611

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002106999A Abandoned CA2106999A1 (fr) 1991-03-27 1992-03-25 Bis-naphtalimides contenant des lieurs derives aminoacides utilises comme anticancereux

Country Status (1)

Country Link
CA (1) CA2106999A1 (fr)

Similar Documents

Publication Publication Date Title
US5206249A (en) Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
US5376664A (en) Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
AU640888B2 (en) Bis-naphthalimides as anticancer agents
US5461176A (en) Processes for preparing bis-naphthalimides containing amino-acid derived linkers
HU219232B (en) Bis-naphthalimide derivatives, process for producing them, and pharmaceutical compositions containing them
US5488110A (en) Highly water soluble bis-naphthalimides useful as anticancer agents
JP2701980B2 (ja) 抗ガン剤としてのアミドおよびチオアミドリンカー含有のビス−ナフタルイミド類
US5329048A (en) Process of preparing tetraamino intermediates
CS200231B2 (en) Process for preparing n-substituted lactames
CA2106999A1 (fr) Bis-naphtalimides contenant des lieurs derives aminoacides utilises comme anticancereux
AU666847C (en) Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
RU2066316C1 (ru) Производные бис-нафталимидов, их энантиомерные или диастереомерные формы, или их смеси, или их фармацевтически приемлемые соли, противоопухолевая композиция и способ лечения
LV10045B (en) Bis-naphthalimides with a bond derived from amino acids, their use as anti-cancer agents
WO1995029895A1 (fr) Derives dihydrodibenzo(de,h)isoquinolines et leur utilisation en tant qu'agents anticancereux
WO1996025400A2 (fr) Bisnaphtalimides substitues 3-aromatiques et 3-heteroaromatiques
US5359070A (en) Unsymmetrical bis-imides as anticancer agents
HU210345A9 (hu) Aminosav eredetű linkereket tartalmazó bisz-naftálimid rákellenes szerek
WO1999024435A1 (fr) Derives d'azachromachalime a action d'hypotenseur

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead