SI9620099A - Diglikozilirani 1,2-dioli kot mimetiki sialil-Lewis X in sialil-Lewis A - Google Patents
Diglikozilirani 1,2-dioli kot mimetiki sialil-Lewis X in sialil-Lewis A Download PDFInfo
- Publication number
- SI9620099A SI9620099A SI9620099A SI9620099A SI9620099A SI 9620099 A SI9620099 A SI 9620099A SI 9620099 A SI9620099 A SI 9620099A SI 9620099 A SI9620099 A SI 9620099A SI 9620099 A SI9620099 A SI 9620099A
- Authority
- SI
- Slovenia
- Prior art keywords
- alkyl
- aryl
- cycloalkyl
- aralkyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH191495 | 1995-06-29 | ||
| PCT/EP1996/002785 WO1997001569A1 (en) | 1995-06-29 | 1996-06-26 | Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI9620099A true SI9620099A (sl) | 1998-08-31 |
Family
ID=4221546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9620099A SI9620099A (sl) | 1995-06-29 | 1996-06-26 | Diglikozilirani 1,2-dioli kot mimetiki sialil-Lewis X in sialil-Lewis A |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0836610A1 (zh) |
| JP (1) | JPH11508548A (zh) |
| KR (1) | KR19990028543A (zh) |
| CN (1) | CN1196731A (zh) |
| AU (1) | AU707474B2 (zh) |
| BR (1) | BR9609285A (zh) |
| CA (1) | CA2224346A1 (zh) |
| CZ (1) | CZ419797A3 (zh) |
| EA (1) | EA001356B1 (zh) |
| HU (1) | HUP9801805A3 (zh) |
| IL (1) | IL118740A0 (zh) |
| MX (1) | MX9800218A (zh) |
| NO (1) | NO976065L (zh) |
| NZ (1) | NZ311686A (zh) |
| PL (1) | PL324258A1 (zh) |
| SI (1) | SI9620099A (zh) |
| SK (1) | SK177897A3 (zh) |
| TR (1) | TR199701728T1 (zh) |
| WO (1) | WO1997001569A1 (zh) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4564713B2 (ja) | 2000-11-01 | 2010-10-20 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 窒素性複素環式化合物、ならびに窒素性複素環式化合物およびその中間体を作製するための方法 |
| EP1577289A1 (en) * | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
| SI2264043T1 (en) | 2005-09-02 | 2018-01-31 | Glycomimetics, Inc. | HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS |
| EP1764093A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
| EP1764095A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| EP1764096A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
| WO2008060378A2 (en) * | 2006-10-12 | 2008-05-22 | Glycomimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
| EP2457573A1 (en) * | 2007-02-09 | 2012-05-30 | GlycoMimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and N-Acetyl hexosamines |
| US8895510B2 (en) | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| JP2015500887A (ja) | 2011-12-22 | 2015-01-08 | グリコミメティクス， インコーポレイテッド | Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法 |
| HUE038423T2 (hu) | 2012-12-07 | 2018-10-29 | Glycomimetics Inc | E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára |
| PT3227310T (pt) | 2014-12-03 | 2019-11-06 | Glycomimetics Inc | Inibidores heterobifuncionais de e-selectinas e recetores de quimiocina cxcr4 |
| CA3009836A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
| KR102653723B1 (ko) | 2016-10-07 | 2024-04-01 | 글리코미메틱스, 인크. | 매우 강력한 다량체성 e-셀렉틴 길항물질 |
| US11197877B2 (en) | 2017-03-15 | 2021-12-14 | Glycomimetics. Inc. | Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists |
| US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| CA3085356A1 (en) | 2017-12-29 | 2019-07-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
| BR112020018184A2 (pt) | 2018-03-05 | 2021-02-02 | Glycomimetics, Inc. | usos de compostos |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5326752A (en) * | 1991-11-27 | 1994-07-05 | Glycomed Incorporated | Substituted lactose and lactosamine derivatives as cell adhesion inhibitors |
| WO1993023031A1 (en) * | 1992-05-08 | 1993-11-25 | The Biomembrane Institute | Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response |
| CA2100412A1 (en) * | 1992-07-15 | 1994-01-16 | Yutaka Yamada | Glycolipid derivatives |
-
1996
- 1996-06-26 IL IL11874096A patent/IL118740A0/xx unknown
- 1996-06-26 CZ CZ974197A patent/CZ419797A3/cs unknown
- 1996-06-26 CN CN96196452A patent/CN1196731A/zh active Pending
- 1996-06-26 WO PCT/EP1996/002785 patent/WO1997001569A1/en not_active Application Discontinuation
- 1996-06-26 CA CA002224346A patent/CA2224346A1/en not_active Abandoned
- 1996-06-26 HU HU9801805A patent/HUP9801805A3/hu unknown
- 1996-06-26 KR KR1019970709861A patent/KR19990028543A/ko not_active Application Discontinuation
- 1996-06-26 EP EP96922034A patent/EP0836610A1/en not_active Ceased
- 1996-06-26 SI SI9620099A patent/SI9620099A/sl unknown
- 1996-06-26 BR BR9609285A patent/BR9609285A/pt not_active Application Discontinuation
- 1996-06-26 NZ NZ311686A patent/NZ311686A/xx unknown
- 1996-06-26 TR TR97/01728T patent/TR199701728T1/xx unknown
- 1996-06-26 EA EA199800103A patent/EA001356B1/ru not_active IP Right Cessation
- 1996-06-26 PL PL96324258A patent/PL324258A1/xx unknown
- 1996-06-26 SK SK1778-97A patent/SK177897A3/sk unknown
- 1996-06-26 AU AU63053/96A patent/AU707474B2/en not_active Ceased
- 1996-06-26 JP JP9504171A patent/JPH11508548A/ja active Pending
-
1997
- 1997-12-23 NO NO976065A patent/NO976065L/no not_active Application Discontinuation
-
1998
- 1998-01-07 MX MX9800218A patent/MX9800218A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9800218A (es) | 1998-07-31 |
| HUP9801805A2 (hu) | 1998-12-28 |
| CA2224346A1 (en) | 1997-01-16 |
| CN1196731A (zh) | 1998-10-21 |
| NZ311686A (en) | 2000-01-28 |
| SK177897A3 (en) | 1998-08-05 |
| PL324258A1 (en) | 1998-05-11 |
| KR19990028543A (ko) | 1999-04-15 |
| AU6305396A (en) | 1997-01-30 |
| EP0836610A1 (en) | 1998-04-22 |
| CZ419797A3 (cs) | 1998-06-17 |
| TR199701728T1 (xx) | 1998-03-21 |
| HUP9801805A3 (en) | 2002-01-28 |
| NO976065D0 (no) | 1997-12-23 |
| IL118740A0 (en) | 1996-10-16 |
| EA199800103A1 (ru) | 1998-08-27 |
| EA001356B1 (ru) | 2001-02-26 |
| AU707474B2 (en) | 1999-07-08 |
| BR9609285A (pt) | 1999-05-11 |
| WO1997001569A1 (en) | 1997-01-16 |
| JPH11508548A (ja) | 1999-07-27 |
| NO976065L (no) | 1998-02-17 |
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