SI9620043A - Variante humane DNaze I - Google Patents

Variante humane DNaze I Download PDF

Info

Publication number
SI9620043A
SI9620043A SI9620043A SI9620043A SI9620043A SI 9620043 A SI9620043 A SI 9620043A SI 9620043 A SI9620043 A SI 9620043A SI 9620043 A SI9620043 A SI 9620043A SI 9620043 A SI9620043 A SI 9620043A
Authority
SI
Slovenia
Prior art keywords
ala
leu
val
asp
amino acid
Prior art date
Application number
SI9620043A
Other languages
English (en)
Slovenian (sl)
Inventor
Robert A. Lazarus
Steven Shak
Jana S. Ulmer
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1995/002366 external-priority patent/WO1996026278A1/fr
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of SI9620043A publication Critical patent/SI9620043A/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases RNAses, DNAses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI9620043A 1995-02-24 1996-02-21 Variante humane DNaze I SI9620043A (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1995/002366 WO1996026278A1 (fr) 1995-02-24 1995-02-24 VARIANTES DE LA DNAse I HUMAINE
US54052795A 1995-10-10 1995-10-10
PCT/US1996/002421 WO1996026279A1 (fr) 1995-02-24 1996-02-21 Variantes de dnase i humaine

Publications (1)

Publication Number Publication Date
SI9620043A true SI9620043A (sl) 1998-06-30

Family

ID=26789529

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9620043A SI9620043A (sl) 1995-02-24 1996-02-21 Variante humane DNaze I

Country Status (20)

Country Link
EP (2) EP1980618A2 (fr)
JP (1) JP4549439B2 (fr)
AR (1) AR003926A1 (fr)
AT (1) ATE397073T1 (fr)
AU (1) AU695863B2 (fr)
BR (1) BR9607328A (fr)
CA (1) CA2211413C (fr)
DE (1) DE69637548D1 (fr)
DK (1) DK0854927T3 (fr)
ES (1) ES2308775T3 (fr)
HU (1) HU222665B1 (fr)
IL (1) IL117218A (fr)
NO (1) NO326616B1 (fr)
NZ (1) NZ334762A (fr)
PL (1) PL184951B1 (fr)
RO (1) RO118886B1 (fr)
SI (1) SI9620043A (fr)
SK (1) SK284191B6 (fr)
TR (1) TR199700842T1 (fr)
WO (1) WO1996026279A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391607B1 (en) 1996-06-14 2002-05-21 Genentech, Inc. Human DNase I hyperactive variants
WO2013114373A1 (fr) * 2012-02-01 2013-08-08 Protalix Ltd. Formulations liquides inhalables d'adnase i
DK3063275T3 (da) * 2013-10-31 2019-11-25 Resolve Therapeutics Llc Terapeutiske nuklease-albumin-fusioner og fremgangsmåder
CN104131093B (zh) * 2014-07-23 2015-12-09 哈尔滨工程大学 DNA蛋白结合位点的DNase高通测序检测信号处理方法
NZ733912A (en) 2015-01-04 2023-04-28 Protalix Ltd Modified dnase and uses thereof
KR20230104160A (ko) 2020-10-07 2023-07-07 프로탈릭스 리미티드 장기-작용성 데옥시리보뉴클레아제(dnase)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
AU597574B2 (en) 1986-03-07 1990-06-07 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
AU630658B2 (en) * 1988-12-23 1992-11-05 Genentech Inc. Human dnase
US5464817A (en) * 1990-04-11 1995-11-07 Brigham And Women's Hospital Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I
US5279823A (en) 1992-06-08 1994-01-18 Genentech, Inc. Purified forms of DNASE
DK0666985T3 (da) 1992-11-02 1997-12-29 Genentech Inc Kompakteringsanalysemetode til vurdering af behandling af respiratoriske sygdomme
UA66749C2 (en) * 1995-02-24 2004-06-15 Genentech Inc Actin-resistant variants of human dnase i, isolated nucleic acid, a method for treatment of patients suffering from pulmonary diseases

Also Published As

Publication number Publication date
NZ334762A (en) 2000-10-27
SK284191B6 (sk) 2004-10-05
NO973877D0 (no) 1997-08-22
DK0854927T3 (da) 2008-09-08
EP1980618A2 (fr) 2008-10-15
TR199700842T1 (xx) 1998-01-21
EP0854927A1 (fr) 1998-07-29
JP4549439B2 (ja) 2010-09-22
AR003926A1 (es) 1998-09-30
CA2211413C (fr) 2010-06-22
PL322002A1 (en) 1998-01-05
EP0854927B1 (fr) 2008-05-28
AU695863B2 (en) 1998-08-27
BR9607328A (pt) 1997-12-30
PL184951B1 (pl) 2003-01-31
HUP9702147A2 (hu) 1999-07-28
HUP9702147A3 (en) 1999-09-28
SK114897A3 (en) 1998-03-04
JPH11503004A (ja) 1999-03-23
DE69637548D1 (de) 2008-07-10
NO326616B1 (no) 2009-01-19
ES2308775T3 (es) 2008-12-01
CA2211413A1 (fr) 1996-08-29
HU222665B1 (hu) 2003-09-29
IL117218A0 (en) 1996-06-18
AU5026396A (en) 1996-09-11
RO118886B1 (ro) 2003-12-30
WO1996026279A1 (fr) 1996-08-29
NO973877L (no) 1997-10-24
ATE397073T1 (de) 2008-06-15
IL117218A (en) 2004-06-01

Similar Documents

Publication Publication Date Title
US6348343B2 (en) Human DNase I variants
US7407785B2 (en) Human DNase I hyperactive variants
JP5185914B2 (ja) ヒトdnアーゼii
SI9620043A (sl) Variante humane DNaze I
SI9520153A (sl) Variante humane DNaze I
JP4624380B2 (ja) ヒトdnアーゼ変異体
JP2009060900A (ja) ヒトdnアーゼi変異体
NZ505985A (en) Human DNase I variants with a lower binding affinity for actin that native human dnase

Legal Events

Date Code Title Description
IF Valid on the event date
KO00 Lapse of patent

Effective date: 20060315