SI9500238A - Procedure for the production of lovastatin - Google Patents

Procedure for the production of lovastatin Download PDF

Info

Publication number
SI9500238A
SI9500238A SI9500238A SI9500238A SI9500238A SI 9500238 A SI9500238 A SI 9500238A SI 9500238 A SI9500238 A SI 9500238A SI 9500238 A SI9500238 A SI 9500238A SI 9500238 A SI9500238 A SI 9500238A
Authority
SI
Slovenia
Prior art keywords
lovastatin
medium
aspergillus terreus
diameter
aureus
Prior art date
Application number
SI9500238A
Other languages
English (en)
Slovenian (sl)
Inventor
Ivan Radez
Neda Benicki
Branislav Filipovic
Silvia Zupancic
Miroslav Pokorny
Jaroslav Tihi
Dusan Krasovec
Martina Zupancic
Original Assignee
Krka Tovarna Zdravil
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil filed Critical Krka Tovarna Zdravil
Priority to SI9500238A priority Critical patent/SI9500238A/sl
Priority to EP96922367A priority patent/EP0842290B1/en
Priority to PCT/SI1996/000016 priority patent/WO1997005269A1/en
Priority to AU63263/96A priority patent/AU6326396A/en
Priority to JP50753097A priority patent/JP3689429B2/ja
Priority to HR960357A priority patent/HRP960357B1/xx
Publication of SI9500238A publication Critical patent/SI9500238A/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
SI9500238A 1995-07-27 1995-07-27 Procedure for the production of lovastatin SI9500238A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
SI9500238A SI9500238A (en) 1995-07-27 1995-07-27 Procedure for the production of lovastatin
EP96922367A EP0842290B1 (en) 1995-07-27 1996-07-16 Process for the preparation of lovastatin
PCT/SI1996/000016 WO1997005269A1 (en) 1995-07-27 1996-07-16 Process for the preparation of lovastatin
AU63263/96A AU6326396A (en) 1995-07-27 1996-07-16 Process for the preparation of lovastatin
JP50753097A JP3689429B2 (ja) 1995-07-27 1996-07-16 ロバスタチンの製造方法
HR960357A HRP960357B1 (en) 1995-07-27 1996-07-25 Process for the preparation of lovastatin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9500238A SI9500238A (en) 1995-07-27 1995-07-27 Procedure for the production of lovastatin

Publications (1)

Publication Number Publication Date
SI9500238A true SI9500238A (en) 1997-02-28

Family

ID=20431662

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9500238A SI9500238A (en) 1995-07-27 1995-07-27 Procedure for the production of lovastatin

Country Status (6)

Country Link
EP (1) EP0842290B1 (hr)
JP (1) JP3689429B2 (hr)
AU (1) AU6326396A (hr)
HR (1) HRP960357B1 (hr)
SI (1) SI9500238A (hr)
WO (1) WO1997005269A1 (hr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9807362A (pt) * 1997-02-20 2000-04-18 Dsm Nv Produção fermentativa de compostos úteis em escala industrial usando meios quimicamente definidos
KR100234976B1 (ko) * 1997-08-01 1999-12-15 김충환 세룰레닌 및 엘-메치오닌 유사체에 동시 내성을 갖는 아스퍼질 러스속 미생물 및 그를 이용한 메비놀린산의 제조방법
SK281320B6 (sk) * 1997-10-13 2001-02-12 Biotika, A. S. Kmeň aspergillus terreus a fermentácia lovastatínu týmto produkčným kmeňom
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
IL132822A0 (en) * 1998-03-20 2001-03-19 Biogal Gyogyszergyar Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid
HU226966B1 (en) * 1998-03-20 2010-03-29 Teva Gyogyszergyar Zartkoeruee Fermentation process
CN102621238A (zh) * 2011-02-01 2012-08-01 北京北大维信生物科技有限公司 一种测定HMG-CoA还原酶抑制剂浓度的方法
CN114958625B (zh) * 2022-07-07 2023-12-19 福安药业集团烟台只楚药业有限公司 一种发酵生产洛伐他汀的土曲霉的培养与保存方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342767A (en) * 1980-01-23 1982-08-03 Merck & Co., Inc. Hypocholesteremic fermentation products
US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
HU208997B (en) * 1992-06-17 1994-02-28 Gyogyszerkutato Intezet Microbiological method for producing mevinoline

Also Published As

Publication number Publication date
AU6326396A (en) 1997-02-26
HRP960357A2 (en) 1998-04-30
HRP960357B1 (en) 2004-10-31
EP0842290B1 (en) 2004-01-28
EP0842290A1 (en) 1998-05-20
JP2000500642A (ja) 2000-01-25
WO1997005269A1 (en) 1997-02-13
JP3689429B2 (ja) 2005-08-31

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Legal Events

Date Code Title Description
IF Valid on the prs date
KO00 Lapse of patent

Effective date: 20050831