SI9300056B - Antibiotični karbapenemi - Google Patents
Antibiotični karbapenemi Download PDFInfo
- Publication number
- SI9300056B SI9300056B SI9300056A SI9300056A SI9300056B SI 9300056 B SI9300056 B SI 9300056B SI 9300056 A SI9300056 A SI 9300056A SI 9300056 A SI9300056 A SI 9300056A SI 9300056 B SI9300056 B SI 9300056B
- Authority
- SI
- Slovenia
- Prior art keywords
- hydroxyethyl
- ylthio
- carboxy
- carboxylic acid
- methylcarbapenem
- Prior art date
Links
- 229940041011 carbapenems Drugs 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- -1 nitro, hydroxy, carboxy Chemical group 0.000 claims abstract 28
- 150000001875 compounds Chemical class 0.000 claims abstract 22
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 13
- 239000001257 hydrogen Substances 0.000 claims abstract 13
- 125000000217 alkyl group Chemical group 0.000 claims abstract 11
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 claims abstract 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 6
- 150000003839 salts Chemical class 0.000 claims abstract 6
- 150000002148 esters Chemical class 0.000 claims abstract 5
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 4
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract 4
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 4
- 150000002431 hydrogen Chemical class 0.000 claims abstract 4
- 238000001727 in vivo Methods 0.000 claims abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims abstract 3
- 125000004776 1-fluoroethyl group Chemical group [H]C([H])([H])C([H])(F)* 0.000 claims abstract 2
- 125000005236 alkanoylamino group Chemical group 0.000 claims abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 2
- 125000006239 protecting group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- BSHRJMFSUUNQRJ-LOASFGFYSA-N (5R)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Chemical compound CC(O)C1[C@H]2C(C)C=C(N2C1=O)C(O)=O BSHRJMFSUUNQRJ-LOASFGFYSA-N 0.000 claims 1
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims 1
- 125000004750 (C1-C6) alkylaminosulfonyl group Chemical group 0.000 claims 1
- BSIMZHVOQZIAOY-SCSAIBSYSA-N 1-carbapenem-3-carboxylic acid Chemical compound OC(=O)C1=CC[C@@H]2CC(=O)N12 BSIMZHVOQZIAOY-SCSAIBSYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- JUZNIMUFDBIJCM-ANEDZVCMSA-N Invanz Chemical compound O=C([C@H]1NC[C@H](C1)SC=1[C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)NC1=CC=CC(C(O)=O)=C1 JUZNIMUFDBIJCM-ANEDZVCMSA-N 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004986 diarylamino group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 150000003460 sulfonic acids Chemical class 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929202298A GB9202298D0 (en) | 1992-02-04 | 1992-02-04 | Antibiotic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9300056A SI9300056A (en) | 1993-09-30 |
| SI9300056B true SI9300056B (sl) | 2000-02-29 |
Family
ID=10709764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9300056A SI9300056B (sl) | 1992-02-04 | 1993-02-02 | Antibiotični karbapenemi |
Country Status (35)
| Country | Link |
|---|---|
| US (7) | US5478820A (nl) |
| EP (1) | EP0579826B1 (nl) |
| JP (1) | JP2730600B2 (nl) |
| KR (1) | KR100200986B1 (nl) |
| CN (1) | CN1036006C (nl) |
| AP (1) | AP398A (nl) |
| AT (1) | ATE173262T1 (nl) |
| AU (1) | AU668133B2 (nl) |
| CA (1) | CA2106370C (nl) |
| CZ (1) | CZ286878B6 (nl) |
| DE (2) | DE69322007T2 (nl) |
| DK (1) | DK0579826T3 (nl) |
| ES (1) | ES2123654T3 (nl) |
| FI (1) | FI104074B1 (nl) |
| GB (2) | GB9202298D0 (nl) |
| GE (1) | GEP20022694B (nl) |
| HK (1) | HK1013998A1 (nl) |
| HR (1) | HRP930103B1 (nl) |
| HU (3) | HU213675B (nl) |
| IL (1) | IL104588A (nl) |
| LU (1) | LU90970I2 (nl) |
| MY (1) | MY111685A (nl) |
| NL (1) | NL300104I2 (nl) |
| NO (2) | NO304315B1 (nl) |
| NZ (2) | NZ246917A (nl) |
| PL (3) | PL174601B1 (nl) |
| RU (1) | RU2117659C1 (nl) |
| SG (1) | SG48817A1 (nl) |
| SI (1) | SI9300056B (nl) |
| SK (1) | SK280890B6 (nl) |
| TW (1) | TW408124B (nl) |
| UA (1) | UA44885C2 (nl) |
| WO (1) | WO1993015078A1 (nl) |
| YU (1) | YU48998B (nl) |
| ZA (1) | ZA93453B (nl) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| CA2106330A1 (en) * | 1992-10-07 | 1994-04-08 | Patrice J. Siret | Antibiotic compounds |
| US5602118A (en) * | 1993-03-16 | 1997-02-11 | American Cyanamid Company | 2-thiosubstituted carbapenems |
| GB9515975D0 (en) | 1995-08-04 | 1995-10-04 | Zeneca Ltd | Chemical compounds |
| UA62920C2 (en) * | 1996-05-28 | 2004-01-15 | Merck & Co Inc | Carbapeneme antibiotic, a composition and a method for the preparation |
| HRP970281B1 (en) * | 1996-05-28 | 2002-04-30 | Merck & Co Inc | Carbapenem antibiotic, composition and method of preparation |
| AR008255A1 (es) * | 1996-07-12 | 1999-12-29 | Merck & Co Inc | Procedimiento para sintetizar antibioticos de carbapenem |
| EP0923545A1 (en) | 1996-08-17 | 1999-06-23 | Zeneca Limited | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors |
| US5877328A (en) * | 1996-10-10 | 1999-03-02 | Merck & Co., Inc. | Process for synthesizing carbapenem side chain intermediates |
| CA2266701C (en) * | 1996-10-10 | 2002-12-24 | Merck & Co., Inc. | Process for synthesizing carbapenem side chain intermediates |
| WO1998018800A1 (en) * | 1996-10-28 | 1998-05-07 | Merck & Co., Inc. | Stabilized carbapenem antibiotic compositions and method of making |
| US6180783B1 (en) | 1997-06-16 | 2001-01-30 | Merck & Co., Inc. | Stabilized carbapenem intermediates and improved process for carbapenem synthesis |
| NZ500955A (en) * | 1997-06-16 | 2001-06-29 | Merck & Co Inc | Stabilized 1-beta-methyl-carbapenem intermediates and synthetic use |
| CA2294341C (en) * | 1997-07-10 | 2007-09-25 | Merck & Co., Inc. | Crystalline forms of antibiotic side chain intermediates |
| US5965747A (en) * | 1997-07-10 | 1999-10-12 | Merck & Co., Inc. | Crystalline forms of antibiotic side chain intermediates |
| US5872250A (en) * | 1997-07-30 | 1999-02-16 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
| EP1060180B1 (en) * | 1998-03-02 | 2006-03-29 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
| US6504027B1 (en) | 1998-03-02 | 2003-01-07 | Merck & Co., Inc. | Decarboxylation process for synthesizing carbapenem antibiotics |
| JP2002518402A (ja) | 1998-06-17 | 2002-06-25 | メルク エンド カムパニー インコーポレーテッド | カルバペネム中間体の合成方法、及び製造された化合物 |
| US6548492B1 (en) | 1999-10-29 | 2003-04-15 | Merck & Co., Inc. | Process for formulation of carbapenem antibiotic compositions |
| US6486150B2 (en) | 1999-10-29 | 2002-11-26 | Merck & Co., Inc. | Process for formulation of antibiotic compounds |
| GB9930317D0 (en) * | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| GB9930318D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| AR035728A1 (es) * | 2001-01-16 | 2004-07-07 | Merck & Co Inc | Proceso perfeccionado para la sintesis de carbapenem |
| ES2368997T3 (es) | 2001-09-26 | 2011-11-24 | Merck Sharp & Dohme Corp. | Procedimiento de fabricación de compuestos de carbapenem. |
| USRE40794E1 (en) | 2001-09-26 | 2009-06-23 | Merck & Co., Inc. | Crystalline forms of carbapenem antibiotics and methods of preparation |
| CA2465854A1 (en) * | 2001-11-08 | 2003-09-04 | Merck & Co., Inc. | Compounds useful in the treatment of anthrax |
| IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
| PT1511472E (pt) * | 2002-05-29 | 2009-07-24 | Merck & Co Inc | Compostos úteis no tratamento de antrax e inibição do factor letal |
| EP1747550A2 (en) * | 2004-05-07 | 2007-01-31 | Infinium Labs, Inc. | Multi-position multi-level user interface system |
| CN1950354A (zh) * | 2004-05-11 | 2007-04-18 | 默克公司 | N－磺酰化－氨基酸衍生物的制备方法 |
| US20100003276A1 (en) * | 2004-12-07 | 2010-01-07 | Hermes Jeffery D | Methods for treating anthrax and inhibiting lethal factor |
| CN100344613C (zh) * | 2005-10-20 | 2007-10-24 | 上海交通大学 | (2s,4s)－1－(4－硝基苄氧羰基)－2－[(3－烯丙氧羰基)－苯基氨基甲酰基]－吡咯烷－4－基硫醇的制备方法 |
| AU2012233003B2 (en) * | 2005-12-07 | 2014-12-18 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| CA2783572C (en) * | 2005-12-07 | 2016-08-09 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| US8293894B2 (en) * | 2006-11-20 | 2012-10-23 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of carbapenem antibiotic |
| CN101357916B (zh) * | 2007-06-22 | 2010-12-15 | 山东轩竹医药科技有限公司 | 含有二氢咪唑甲酰胺基的培南化合物 |
| CN101367815B (zh) * | 2007-06-28 | 2012-07-04 | 山东轩竹医药科技有限公司 | 六元环甲酰胺取代的巯基吡咯烷碳青霉烯化合物 |
| CN101367807B (zh) * | 2007-06-28 | 2011-01-12 | 山东轩竹医药科技有限公司 | 被巯基吡咯烷甲酰胺基吡啶取代的培南衍生物 |
| CN101362760B (zh) * | 2007-08-07 | 2010-12-15 | 山东轩竹医药科技有限公司 | 1β-甲基碳代青霉烯化合物 |
| CN101362761B (zh) * | 2007-08-12 | 2011-05-18 | 山东轩竹医药科技有限公司 | 含有巯基哌啶的碳代青霉烯抗生素 |
| CN101412720B (zh) * | 2007-08-27 | 2011-05-18 | 山东轩竹医药科技有限公司 | 含有巯基氮杂环乙烯基的碳青霉烯化合物 |
| CN101376641B (zh) * | 2007-08-28 | 2010-12-08 | 上海医药工业研究院 | 碳青霉烯类青霉素厄他培南的中间体及其制备方法和应用 |
| EP2505190A1 (en) | 2008-06-11 | 2012-10-03 | Ranbaxy Laboratories Limited | Polymorphic forms of ertapenem monosodium salt and process for it's preparation |
| CA2732619A1 (en) * | 2008-07-30 | 2010-02-04 | Ranbaxy Laboratories Limited | Process for the preparation of carbapenem compounds |
| RU2521391C2 (ru) * | 2008-09-18 | 2014-06-27 | Ману ЧАУДХАРИ | Новые однократные единичные составы карбапенема и аминогликозида |
| KR101694506B1 (ko) | 2009-04-30 | 2017-01-10 | 씨에스피씨 종콰이 팔마씨우티컬 테크놀로지 (스자좡) 컴퍼니 리미티드 | 에르타페넴의 중간체, 이를 포함하는 조성물 및 이의 제조 방법 |
| WO2011048583A1 (en) | 2009-10-23 | 2011-04-28 | Ranbaxy Laboratories Limited | Process for the preparation of carbapenem compounds |
| US8729260B2 (en) | 2010-05-19 | 2014-05-20 | Savior Lifetec Corporation | Process for the preparation of carbapenem using cabapenem intermediates and recovery of cabapenem |
| CN102558182B (zh) * | 2010-12-31 | 2015-02-11 | 石药集团中奇制药技术（石家庄）有限公司 | 一种厄他培南钠晶型及其制备方法 |
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