SI9200260A - Lipophilic oligosaccharide antibiotic salt compostition - Google Patents

Lipophilic oligosaccharide antibiotic salt compostition Download PDF

Info

Publication number
SI9200260A
SI9200260A SI19929200260A SI9200260A SI9200260A SI 9200260 A SI9200260 A SI 9200260A SI 19929200260 A SI19929200260 A SI 19929200260A SI 9200260 A SI9200260 A SI 9200260A SI 9200260 A SI9200260 A SI 9200260A
Authority
SI
Slovenia
Prior art keywords
formula
antibiotic
pharmaceutically acceptable
cyclodextrin
hydroxypropyl
Prior art date
Application number
SI19929200260A
Other languages
English (en)
Slovenian (sl)
Inventor
Mahesh Patel
Vincent P. Gullo
Roberta Hare
David Loebenberg
James B. Morton
George H. Miller
Reewon Y. Kwon
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of SI9200260A publication Critical patent/SI9200260A/sl

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04Cyclic acetals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
SI19929200260A 1991-10-16 1992-10-16 Lipophilic oligosaccharide antibiotic salt compostition SI9200260A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77786491A 1991-10-16 1991-10-16

Publications (1)

Publication Number Publication Date
SI9200260A true SI9200260A (en) 1993-06-30

Family

ID=25111545

Family Applications (1)

Application Number Title Priority Date Filing Date
SI19929200260A SI9200260A (en) 1991-10-16 1992-10-16 Lipophilic oligosaccharide antibiotic salt compostition

Country Status (27)

Country Link
US (1) US5624914A (ko)
EP (2) EP0538011B1 (ko)
JP (1) JP2614407B2 (ko)
KR (1) KR100249584B1 (ko)
CN (1) CN1035923C (ko)
AT (1) ATE156019T1 (ko)
AU (1) AU678344B2 (ko)
CA (1) CA2121345C (ko)
DE (1) DE69221252T2 (ko)
DK (1) DK0538011T3 (ko)
ES (1) ES2104845T3 (ko)
FI (1) FI941723A0 (ko)
GR (1) GR3024800T3 (ko)
HK (1) HK1001085A1 (ko)
HR (1) HRP921069B1 (ko)
HU (1) HUT75157A (ko)
IL (1) IL103446A (ko)
MX (1) MX9205922A (ko)
NO (1) NO307326B1 (ko)
NZ (1) NZ244735A (ko)
PH (1) PH31675A (ko)
PL (1) PL170591B1 (ko)
SI (1) SI9200260A (ko)
TW (1) TW221378B (ko)
WO (1) WO1993007904A1 (ko)
YU (1) YU48722B (ko)
ZA (1) ZA927923B (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380172B1 (en) 1991-10-16 2002-04-30 Schering Corporation Monomeric lipophilic oligosaccharide antibiotic compositions
US5948688A (en) * 1991-10-16 1999-09-07 Schering Corporation Method of determining monomeric drug content
US5652226A (en) * 1995-12-22 1997-07-29 Schering Corporation Water soluble antibiotics
US5776912A (en) * 1996-12-20 1998-07-07 Schering Corporation Lipophilic oligosaccharide antibiotic compositions
US5763600A (en) * 1997-04-18 1998-06-09 Schering Corporation Oligosaccharide antibiotics and process for preparation thereof
AU9597198A (en) * 1997-10-03 1999-04-27 Galenica Pharmaceuticals, Inc. Imine-forming polysaccharides, preparation thereof and the use thereof as adjuvants and immunostimulants
US6162910A (en) * 1998-11-30 2000-12-19 Schering Corporation Process for preparing lipophilic oligosaccharide antibiotics
CO5231233A1 (es) * 1998-12-18 2002-12-27 Cherinf Corp Proceso para recuperar antibioticos oligosacaridos lipofilic lipofilicos
US6320044B1 (en) 1998-12-18 2001-11-20 Schering Corporation Process for recovering lipophilic oligosaccharide antibiotics
WO2001039573A2 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Verwendung von lungensurfactant zur behandlung von legionärskrankheit
US6861513B2 (en) 2000-01-12 2005-03-01 Schering Corporation Everninomicin biosynthetic genes
ATE416791T1 (de) * 2000-05-02 2008-12-15 Theravance Inc Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält
US6699505B2 (en) * 2000-10-17 2004-03-02 Massachusetts Institute Of Technology Method of increasing the efficacy of antibiotics by compexing with cyclodextrins
DE10109166A1 (de) * 2001-02-25 2002-09-12 Combinature Biopharm Ag Avilamycin-Derivate
BRPI0508854A (pt) * 2004-03-17 2007-08-28 Panacos Pharmaceuticals Inc sais farmacêuticos de ácido-3-o-(3',3'-dimetilsuccinil) betulìnico
EP1987935A3 (en) * 2004-12-01 2008-11-19 Nitto Denko Corporation Foam Filling Member
BRPI0610668A2 (pt) * 2005-04-12 2010-07-13 Panacos Pharmaceuticals Inc polimorfas de di-n-metil-d-glucamina do ácido 3-o-(3',3'-dimetilsuccinil) betulìnico
RU2550271C2 (ru) * 2007-09-14 2015-05-10 Санофи Пастер Байолоджикс Ко. Иммуногенная композиция для лечения или профилактики clostridium difficile, способ ее получения и способ индукции иммунного ответа к c. difficile
JP2010095454A (ja) * 2008-10-14 2010-04-30 Cyclochem:Kk 抗菌組成物
WO2012097223A2 (en) * 2011-01-14 2012-07-19 Emory University Oligosaccharide conjugates for targeting bacteria and uses related thereto
US20160361345A1 (en) 2015-06-10 2016-12-15 Vtesse, Inc. Hydroxypropyl Beta-Cyclodextrin Compositions and Methods
CN106317143B (zh) * 2016-08-23 2020-10-30 河北圣雪大成制药有限责任公司 一种提取阿维拉霉素的方法
US11958917B2 (en) 2022-02-18 2024-04-16 Beren Therapeutics P.B.C. Compositions of hydroxypropyl-beta-cyclodextrin and methods of purifying the same
CN117024611B (zh) * 2023-03-01 2024-05-17 中国科学院南海海洋研究所 寡糖类抗生素everninomicin高产菌株的构建及活性的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR128F (ko) * 1962-04-02
US3915956A (en) * 1973-07-09 1975-10-28 Schering Corp Reduction products of everninomicins and methods for their manufacture
US3920629A (en) * 1973-09-19 1975-11-18 Schering Corp Desevernitrose everninomicins and method for their manufacture
US4006225A (en) * 1973-10-31 1977-02-01 Schering Corporation Method of using reduction products of everninomicins as antibacterial agents and pharmaceutical compositions useful therefor
US4027016A (en) * 1976-01-19 1977-05-31 Schering Corporation Everninomicin antibacterial derivatives, electrochemical method for their manufacture, method for their use as antibacterial agents, and pharmaceutical compositions useful therefor
US3998708A (en) * 1976-01-19 1976-12-21 Schering Corporation Electrochemical process for preparing hydroxylaminoeverninomicins
US4129720A (en) * 1977-02-14 1978-12-12 Schering Corporation Aminoeverninomicin and derivatives thereof
US4597968A (en) * 1982-08-06 1986-07-01 Schering Corporation Antibiotic 13-384 complex from Micromonospora carbonacea var africana
DE3346123A1 (de) * 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
US4596795A (en) * 1984-04-25 1986-06-24 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4735903A (en) * 1984-06-21 1988-04-05 Schering Corporation Micromonospora carbonacea var africana
US4870060A (en) * 1985-03-15 1989-09-26 Janssen Pharmaceutica Derivatives of γ-cylodextrin
US4767748A (en) * 1985-10-15 1988-07-30 Schering Corporation Substituted oligosaccharide antibodies
US4622314A (en) * 1985-10-15 1986-11-11 Schering Corporation Substituted oligosaccharide antibiotics
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5017566A (en) * 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도

Also Published As

Publication number Publication date
DK0538011T3 (da) 1997-09-08
YU48722B (sh) 1999-07-28
US5624914A (en) 1997-04-29
NO307326B1 (no) 2000-03-20
MX9205922A (es) 1994-08-31
AU2780692A (en) 1993-05-21
GR3024800T3 (en) 1998-01-30
PL170591B1 (pl) 1997-01-31
IL103446A0 (en) 1993-03-15
DE69221252T2 (de) 1998-01-22
FI941723A (fi) 1994-04-14
DE69221252D1 (de) 1997-09-04
TW221378B (ko) 1994-03-01
JP2614407B2 (ja) 1997-05-28
NO941276L (no) 1994-04-08
HRP921069B1 (en) 1999-12-31
ES2104845T3 (es) 1997-10-16
ZA927923B (en) 1993-04-26
AU678344B2 (en) 1997-05-29
WO1993007904A1 (en) 1993-04-29
EP0610295A1 (en) 1994-08-17
FI941723A0 (fi) 1994-04-14
PH31675A (en) 1999-01-18
NO941276D0 (no) 1994-04-08
HUT75157A (en) 1997-04-28
IL103446A (en) 1997-02-18
HRP921069A2 (en) 1994-12-31
HK1001085A1 (en) 1998-05-22
CN1035923C (zh) 1997-09-24
KR100249584B1 (ko) 2000-04-01
EP0538011A1 (en) 1993-04-21
CA2121345A1 (en) 1993-04-29
HU9401104D0 (en) 1994-07-28
YU92192A (sr) 1996-01-09
NZ244735A (en) 1995-12-21
CN1073359A (zh) 1993-06-23
JPH06510546A (ja) 1994-11-24
CA2121345C (en) 1998-08-25
ATE156019T1 (de) 1997-08-15
EP0538011B1 (en) 1997-07-30

Similar Documents

Publication Publication Date Title
SI9200260A (en) Lipophilic oligosaccharide antibiotic salt compostition
UA75083C2 (uk) Похідні глікопептидфосфонатів
JP6063123B2 (ja) 抗菌性組成物
US5776912A (en) Lipophilic oligosaccharide antibiotic compositions
JP2022506069A (ja) Bcl-2阻害剤のシクロデキストリンに基づく製剤
CN113413389A (zh) 一种组蛋白去乙酰化酶抑制剂的制剂及其制备方法和用途
JP3597239B2 (ja) 安定な点眼剤
EP0399716A1 (en) Hypoallergenic steroidal anesthetic/hypnotic compositions
EP0165123A2 (fr) Dérivés lipophiles de muramylpeptides ayant des propriétés d'activation des macrophages, compositions les contenant et procédé pour les obtenir
US7795207B2 (en) Lipopeptide compositions
WO1996041646A2 (en) Pharmaceutical compositions containing lornoxicam and cyclodextrin
CA2371942A1 (en) Pseudomycin antifungal compositions and methods for their use
WO2007057005A1 (de) Lipopeptid zusammensetzungen
AU2015276911A2 (en) Methods for treating infections
EP1994938A1 (en) New lipoglycodepsipeptide compositions
JPH05271237A (ja) ランカシジン群抗生物質包接体
JPH02218611A (ja) ニユーモシステイス・カリニイの抑制方法
JPH02172913A (ja) ポリプレニル系化合物含有注射剤