SI9011847B - Postopek za izdelavo obliža z dejavno snovjo, vsebujočega estrogen - Google Patents

Postopek za izdelavo obliža z dejavno snovjo, vsebujočega estrogen Download PDF

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Publication number
SI9011847B
SI9011847B SI9011847A SI9011847A SI9011847B SI 9011847 B SI9011847 B SI 9011847B SI 9011847 A SI9011847 A SI 9011847A SI 9011847 A SI9011847 A SI 9011847A SI 9011847 B SI9011847 B SI 9011847B
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SI
Slovenia
Prior art keywords
adhesive
active substance
process according
weight
adhesive film
Prior art date
Application number
SI9011847A
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English (en)
Other versions
SI9011847A (sl
Inventor
Hans-Rainer Hoffmann
Robert Peter Klein
Reinhold Meconi
Guenter Cordes
Hans Michael Wolf
Original Assignee
Lts Lohmann Therapie-Systeme Gmbh & Co.Kg
Schwarz Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6390993&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI9011847(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lts Lohmann Therapie-Systeme Gmbh & Co.Kg, Schwarz Pharma Gmbh filed Critical Lts Lohmann Therapie-Systeme Gmbh & Co.Kg
Publication of SI9011847A publication Critical patent/SI9011847A/sl
Publication of SI9011847B publication Critical patent/SI9011847B/sl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/07—Stiffening bandages
    • A61L15/12—Stiffening bandages containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Adhesive Tapes (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (11)

  1. -1- PATENTNI ZAHTEVKI Postopek za izdelavo obliža z dejavno snovjo, vsebujočega estrogen 1. Postopek za izdelavo obliža z dejavno snovjo za kontrolirano oddajo dejavnih snovi na kožo, ki je sestavljen iz hrbtnega sloja in v vodi neraztopljivega lepilnega filma iz lepila za oprijemanje in je z njim spojen, ki vsebuje v vodi nabrekljive polimere in v katerem je dejavna snov vsaj delno raztopljena ter iz ponovno odstranljivega zaščitnega sloja, ki pokriva lepilni film, označen s tem, da se lepilna masa na osnovi homo- in/ali kopolimerov homogenizira z vsaj enim derivatom akrilne ali metakrilne kisline, pri čemer se kot predhodno ali istočasno dodana dejavna snov uporabljajo estrogeni in njihovi farmacevtsko neoporečni derivati sami ali v kombinaciji z gestageni, da se masa nanese na ponovno odstranljivi zaščitni sloj ali odstranljiv vmesni sloj ter po izhlapenju topila prekrije s hrbtnim slojem, ki je nepropusten za dejavno snov.
  2. 2. Postopek po zahtevku 1, označen s tem, da se lepilna masa, ki vsebuje dejavno snov, nanese na hrbtni sloj, ki je nepropusten za dejavno snov, in po izhlapenju topila prekrije s ponovno odstranljivim zaščitnim slojem ali vmesnim slojem.
  3. 3. Postopek po zahtevkih 1 in 2, označen s tem, da se v lepilu uporablja delno ali popolno raztopljene dejavne snovi v koncentraciji od 0,5 do 10,0 masnih %.
  4. 4. Postopek po zahtevkih 1 do 3, označen s tem, da se uporabi omrežljivo oprijemno lepilo.
  5. 5. Postopek po enem od zahtevkov 1 do 4, označen s tem, da se kot oprijemno lepilo uporabi oprijemno lepilo v raztopini, disperziji ali topilu.
  6. 6. Postopek po enem od zahtevkov 1 do 5, označen s tem, da se kot oprijemno lepilo uporablja lepilo z najmanj eno smolo, ki ga naredi lepljivega, v količini od 0,5 do 50 masnih %, prednostno od 1 do 20 masnih %.
  7. 7. Postopek po enem od zahtevkov 1 do 6, označen s tem, da se v lepljivi film vnesejo snovi, ki upočasnjujejo ali preprečujejo kristalizacijo dejavne snovi v deležu od 0,1 do 20 masnih %, prednostno 0,5 do 10 masnih %.
  8. 8. Postopek po enem od zahtevkov 1 do 7, označen s tem, da se uporabi lepilni film z deležem v -2- vodi nabrekljivih polimerov od 0,01 do 10 masnih %, prvenstveno od 0,1 do 5 masnih %.
  9. 9. Postopek po enem od zahtevkov 1 do 8, označen s tem, da se lepilni film, ki vsebuje dejavno snov uporablja v debelini od 0,01 do 0,3 mm, prvenstveno od 0,04 do 0,20 mm.
  10. 10. Postopek po enem od zahtevkov 1 do 9, označen s tem, da se razdelitev obližev z dejavno snovjo izvede z rezanjem in/ali izsekavanjem oblike.
  11. 11. Postopek po enem od zahtevkov 1 do 10, označen s tem, da se odstranljivi vmesni sloj odstrani v kasnejši delovni fazi in se zamenja s ponovno odstranljivim zaščitnim slojem.
SI9011847A 1989-10-06 1990-10-01 Postopek za izdelavo obliža z dejavno snovjo, vsebujočega estrogen SI9011847B (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3933460A DE3933460A1 (de) 1989-10-06 1989-10-06 Oestrogenhaltiges wirkstoffpflaster
YU184790A YU48102B (sh) 1989-10-06 1990-10-01 Postupak za izradu flastera sa aktivnom materijom koji sadrži estrogen

Publications (2)

Publication Number Publication Date
SI9011847A SI9011847A (sl) 1998-06-30
SI9011847B true SI9011847B (sl) 1999-08-31

Family

ID=6390993

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9011847A SI9011847B (sl) 1989-10-06 1990-10-01 Postopek za izdelavo obliža z dejavno snovjo, vsebujočega estrogen

Country Status (26)

Country Link
US (1) US5393529A (sl)
EP (1) EP0421454B2 (sl)
JP (1) JP2766864B2 (sl)
KR (1) KR960004300B1 (sl)
AT (1) ATE126069T1 (sl)
AU (1) AU637637B2 (sl)
CA (1) CA2027053C (sl)
CZ (1) CZ282363B6 (sl)
DE (2) DE3933460A1 (sl)
DK (1) DK0421454T3 (sl)
ES (1) ES2078929T5 (sl)
FI (1) FI100380B (sl)
GR (2) GR3017851T3 (sl)
HR (1) HRP930676B1 (sl)
HU (1) HU206831B (sl)
IE (1) IE72141B1 (sl)
IL (1) IL95776A (sl)
MY (1) MY106628A (sl)
NO (1) NO303321B1 (sl)
NZ (1) NZ235581A (sl)
PL (1) PL165270B1 (sl)
PT (1) PT95505B (sl)
SI (1) SI9011847B (sl)
SK (1) SK279514B6 (sl)
YU (1) YU48102B (sl)
ZA (1) ZA907969B (sl)

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US5393529A (en) 1995-02-28
CZ282363B6 (cs) 1997-07-16
FI100380B (fi) 1997-11-28
HRP930676A2 (en) 1994-10-31
YU48102B (sh) 1997-03-07
SI9011847A (sl) 1998-06-30
NZ235581A (en) 1993-03-26
DK0421454T3 (da) 1995-08-09
IL95776A (en) 1994-10-07
HU906356D0 (en) 1991-04-29
HU206831B (en) 1993-01-28
NO904338D0 (no) 1990-10-05
KR910007548A (ko) 1991-05-30
GR3033662T3 (en) 2000-10-31
PL165270B1 (pl) 1994-12-30
HRP930676B1 (en) 2000-10-31
ES2078929T3 (es) 1996-01-01
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NO904338L (no) 1991-04-08
YU184790A (sh) 1992-12-21
DE59009495D1 (de) 1995-09-14
HUT56290A (en) 1991-08-28
JP2766864B2 (ja) 1998-06-18
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IE903572A1 (en) 1991-04-10
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EP0421454B2 (de) 2000-04-05
NO303321B1 (no) 1998-06-29
MY106628A (en) 1995-06-30
IE72141B1 (en) 1997-03-26
DE3933460A1 (de) 1991-04-18
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ATE126069T1 (de) 1995-08-15
AU637637B2 (en) 1993-06-03
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PT95505A (pt) 1991-08-14
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CA2027053A1 (en) 1991-04-07
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AU6312890A (en) 1991-04-11
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ZA907969B (en) 1991-08-28

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