SI9010635B - Postopek za izdelavo transdermalnega terapevtskega sistema s povečanim tokom dejavne snovi - Google Patents
Postopek za izdelavo transdermalnega terapevtskega sistema s povečanim tokom dejavne snovi Download PDFInfo
- Publication number
- SI9010635B SI9010635B SI9010635A SI9010635A SI9010635B SI 9010635 B SI9010635 B SI 9010635B SI 9010635 A SI9010635 A SI 9010635A SI 9010635 A SI9010635 A SI 9010635A SI 9010635 B SI9010635 B SI 9010635B
- Authority
- SI
- Slovenia
- Prior art keywords
- therapeutic system
- transdermal therapeutic
- manufacturing
- layer
- islands
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title claims abstract 20
- 238000000034 method Methods 0.000 title claims abstract 18
- 239000013543 active substance Substances 0.000 title claims abstract 12
- 238000004519 manufacturing process Methods 0.000 claims abstract 19
- 239000000463 material Substances 0.000 claims abstract 13
- 239000011159 matrix material Substances 0.000 claims abstract 11
- 239000007788 liquid Substances 0.000 claims abstract 2
- 239000010410 layer Substances 0.000 claims 15
- 239000002904 solvent Substances 0.000 claims 6
- 239000000243 solution Substances 0.000 claims 4
- 229920002367 Polyisobutene Polymers 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- -1 opioids Substances 0.000 claims 2
- 239000004584 polyacrylic acid Substances 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 229920005573 silicon-containing polymer Polymers 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 229940123907 Disease modifying antirheumatic drug Drugs 0.000 claims 1
- 239000013032 Hydrocarbon resin Substances 0.000 claims 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 229920006271 aliphatic hydrocarbon resin Polymers 0.000 claims 1
- 230000003356 anti-rheumatic effect Effects 0.000 claims 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000003435 antirheumatic agent Substances 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- 239000008240 homogeneous mixture Substances 0.000 claims 1
- 229920006270 hydrocarbon resin Polymers 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
- 239000011241 protective layer Substances 0.000 claims 1
- 239000006104 solid solution Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 239000003270 steroid hormone Substances 0.000 claims 1
- 229920003048 styrene butadiene rubber Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
Classifications
- 
        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
 
- 
        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
 
- 
        - A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
 
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Decoration By Transfer Pictures (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title | 
|---|---|---|---|
| DE3910543A DE3910543A1 (de) | 1989-04-01 | 1989-04-01 | Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung | 
| YU63590A YU48321B (sh) | 1989-04-01 | 1990-03-30 | Postupak za izradu transdermalnog terapijskog sistema sa povišenim protokom aktivne materije | 
Publications (2)
| Publication Number | Publication Date | 
|---|---|
| SI9010635A SI9010635A (sl) | 1998-06-30 | 
| SI9010635B true SI9010635B (sl) | 1998-12-31 | 
Family
ID=6377599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date | 
|---|---|---|---|
| SI9010635A SI9010635B (sl) | 1989-04-01 | 1990-03-30 | Postopek za izdelavo transdermalnega terapevtskega sistema s povečanim tokom dejavne snovi | 
Country Status (25)
| Country | Link | 
|---|---|
| US (2) | US5230898A (OSRAM) | 
| EP (1) | EP0391172B1 (OSRAM) | 
| JP (1) | JP2552191B2 (OSRAM) | 
| KR (1) | KR960007517B1 (OSRAM) | 
| AT (1) | ATE88911T1 (OSRAM) | 
| AU (1) | AU627283B2 (OSRAM) | 
| CA (1) | CA2013050C (OSRAM) | 
| CZ (1) | CZ284287B6 (OSRAM) | 
| DD (1) | DD293266A5 (OSRAM) | 
| DE (2) | DE3910543A1 (OSRAM) | 
| DK (1) | DK0391172T3 (OSRAM) | 
| ES (1) | ES2055201T3 (OSRAM) | 
| FI (1) | FI103478B1 (OSRAM) | 
| HR (1) | HRP930590B1 (OSRAM) | 
| HU (1) | HU205254B (OSRAM) | 
| IE (1) | IE65520B1 (OSRAM) | 
| IL (1) | IL93956A (OSRAM) | 
| NO (1) | NO180671C (OSRAM) | 
| NZ (1) | NZ233152A (OSRAM) | 
| PL (1) | PL163297B1 (OSRAM) | 
| PT (1) | PT93621B (OSRAM) | 
| SI (1) | SI9010635B (OSRAM) | 
| SK (1) | SK280782B6 (OSRAM) | 
| YU (1) | YU48321B (OSRAM) | 
| ZA (1) | ZA902465B (OSRAM) | 
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration | 
| US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration | 
| DE4110027C2 (de) * | 1991-03-27 | 1996-08-29 | Lohmann Therapie Syst Lts | Verfahren zur Konfektionierung transdermaler therapeutischer Pflaster | 
| DK170792B1 (da) * | 1992-08-27 | 1996-01-22 | Coloplast As | Hudpladeprodukt til dosering af et eller flere medikamenter | 
| US5989586A (en) * | 1992-10-05 | 1999-11-23 | Cygnus, Inc. | Two-phase matrix for sustained release drug delivery device | 
| AU667161B2 (en) * | 1993-04-28 | 1996-03-07 | Daiichi Pharmaceutical Co., Ltd. | Butyrophenone transdermal compositions | 
| US5919478A (en) * | 1993-06-25 | 1999-07-06 | Alza Corporation | Incorporating poly-N-vinyl amide in a transdermal system | 
| US5466465A (en) * | 1993-12-30 | 1995-11-14 | Harrogate Holdings, Limited | Transdermal drug delivery system | 
| DE59509232D1 (de) * | 1994-02-18 | 2001-06-13 | Drossapharm Ag Basel | Transdermales therapeutisches System | 
| JPH11506744A (ja) * | 1995-06-07 | 1999-06-15 | ノウブン ファーマシューティカルズ インク. | 室温で液体である低分子量薬を含む経皮組成物 | 
| US6316022B1 (en) | 1995-06-07 | 2001-11-13 | Noven Pharmaceuticals, Inc. | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures | 
| US5906830A (en) * | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same | 
| US5869089A (en) * | 1996-03-21 | 1999-02-09 | China-America Technology Corp. (Ctc) | Manufacturing method of programmable transdermal therapeutic system | 
| US7150881B2 (en) * | 1997-06-26 | 2006-12-19 | Mylan Technologies, Inc. | Adhesive mixture for transdermal delivery of highly plasticizing drugs | 
| DE19814087A1 (de) | 1998-03-30 | 1999-10-14 | Lohmann Therapie Syst Lts | Feuchtigkeitsaktivierbares therapeutisches System | 
| NZ525878A (en) * | 1998-12-07 | 2004-12-24 | Elan Pharma Int Ltd | A method of treating nicotine dependance with mecamylamine | 
| DE19906152B4 (de) * | 1999-02-10 | 2005-02-10 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige Laminate für Transdermalsysteme | 
| US6183770B1 (en) | 1999-04-15 | 2001-02-06 | Acutek International | Carrier patch for the delivery of agents to the skin | 
| DE19918105C1 (de) | 1999-04-22 | 2000-09-21 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit einem stark wirksamen Neuroleptikum | 
| US6974588B1 (en) | 1999-12-07 | 2005-12-13 | Elan Pharma International Limited | Transdermal patch for delivering volatile liquid drugs | 
| DE50102470D1 (de) * | 2000-03-10 | 2004-07-08 | Basf Ag | Verwendung von quervernetztem polyvinylpyrrolidon als sprengmittel in kompakten, teilchenförmigen wasch- und reinigungsmitteln | 
| DE10012908B4 (de) * | 2000-03-16 | 2005-03-17 | Lts Lohmann Therapie-Systeme Ag | Stabilisierte übersättigte transdermale therapeutische Matrixsysteme und Verfahren zu ihrer Herstellung | 
| DE10027258C1 (de) * | 2000-05-31 | 2001-10-31 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit okklusiver wirkstoffhaltiger Schicht und nicht-okklusiver Rückschicht | 
| USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties | 
| DE10102817B4 (de) * | 2001-01-23 | 2006-01-12 | Lts Lohmann Therapie-Systeme Ag | Vorrichtung und Verfahren zur Hitzepulsgestützten transdermalen Applikation von Wirkstoffen | 
| EP1390085B1 (en) | 2001-05-01 | 2009-08-05 | A.V. Topchiev Institute of Petrochemical Synthesis | Hydrogel compositions | 
| US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening | 
| US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media | 
| US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member | 
| US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use | 
| US20050113510A1 (en) * | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components | 
| DE10141651B4 (de) * | 2001-08-24 | 2007-02-15 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung | 
| DE10136784A1 (de) * | 2001-07-27 | 2003-02-20 | Lohmann Therapie Syst Lts | Darreichungsformen mit wirkstoffhaltigen Partikeln, zur Anwendung auf der Haut oder Schleimhaut | 
| DE10159745A1 (de) | 2001-12-05 | 2003-07-03 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit verbessertem Langzeittragekomfort | 
| US20030147972A1 (en) * | 2002-02-05 | 2003-08-07 | Christopher W. Denver | Method and composition for diminishing loss of color in flavors and fragrances | 
| AR033748A1 (es) * | 2002-05-15 | 2004-01-07 | Thalas Group Inc | Un dispositivo para la administracion transdermica de sustancias farmacologicamente activas que comprende dos capas adhesivas superpuestas y un procedimiento para prepararlo | 
| US20040086551A1 (en) | 2002-10-30 | 2004-05-06 | Miller Kenneth J. | Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl | 
| IL152574A (en) | 2002-10-31 | 2009-09-22 | Transpharma Medical Ltd | A system for passing through the skin of dry items or dried medicines | 
| US7383084B2 (en) | 2002-10-31 | 2008-06-03 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized medications | 
| IL152575A (en) * | 2002-10-31 | 2008-12-29 | Transpharma Medical Ltd | A skin-to-skin transmission system of water-insoluble drugs | 
| US8133505B2 (en) | 2002-10-31 | 2012-03-13 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized medications | 
| US7662404B2 (en) * | 2002-10-31 | 2010-02-16 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides | 
| IL152573A (en) * | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | A system for the transmission through the skin of a medical preparation against vomiting and nausea | 
| DE10251963A1 (de) * | 2002-11-08 | 2004-05-19 | Lts Lohmann Therapie-Systeme Ag | Transmucosale pharmazeutische Darreichungsform | 
| JP2005155749A (ja) | 2003-11-25 | 2005-06-16 | Nifco Inc | パイプクランプ | 
| US8658201B2 (en) * | 2004-01-30 | 2014-02-25 | Corium International, Inc. | Rapidly dissolving film for delivery of an active agent | 
| US20050202073A1 (en) | 2004-03-09 | 2005-09-15 | Mylan Technologies, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery | 
| US9205062B2 (en) * | 2004-03-09 | 2015-12-08 | Mylan Pharmaceuticals, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery | 
| CA2576158C (en) * | 2004-08-05 | 2020-10-27 | Corium International, Inc. | Adhesive composition | 
| ITMI20041697A1 (it) * | 2004-09-03 | 2004-12-03 | Bouty S P A | Sistema terapeutico a rilascio controllato per uso topico in forma di cerotto multistrato | 
| DE102004059674B4 (de) * | 2004-12-10 | 2010-05-06 | Acino Ag | Transdermales System zur Abgabe von Scopolamin | 
| JP2008543359A (ja) * | 2005-06-10 | 2008-12-04 | トランスファーマ メディカル,リミティド | 経皮投薬用のパッチ | 
| TWI419717B (zh) * | 2005-06-17 | 2013-12-21 | Altea Therapeutics Corp | 滲透傳送系統及其使用方法 | 
| US7888422B2 (en) | 2005-11-09 | 2011-02-15 | Mylan Technologies Inc. | Long-wearing removable pressure sensitive adhesive | 
| US7955677B2 (en) * | 2005-12-07 | 2011-06-07 | Mylan Technologies, Inc. | Two-sided non-stick release film | 
| NL1031708C2 (nl) * | 2006-04-27 | 2007-11-05 | Advanced Chem Tech | Beschermende bekleding voor op metaalhydride gebaseerde inrichtingen. | 
| DE102006026578B4 (de) * | 2006-06-08 | 2009-01-08 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung | 
| US20080057090A1 (en) * | 2006-09-01 | 2008-03-06 | Mcentire Edward Enns | Wrinkle masking film composition for skin | 
| US7879942B2 (en) | 2006-10-05 | 2011-02-01 | Eastman Chemical Company | Switchable adhesive article for attachment to skin and method of using the same | 
| US9017301B2 (en) * | 2007-09-04 | 2015-04-28 | Mylan Technologies, Inc. | Transdermal drug delivery systems comprising a coated release liner | 
| US8281675B2 (en) * | 2007-10-17 | 2012-10-09 | Syneron Medical Ltd | Dissolution rate verification | 
| EP2211918B1 (en) | 2007-10-29 | 2017-10-18 | Syneron Medical Ltd. | Vertical patch drying | 
| FR2924349B1 (fr) | 2007-12-03 | 2010-01-01 | Dbv Tech | Methode de desensibilitation aux allergenes | 
| CA3138128C (en) * | 2008-03-31 | 2024-02-13 | Passport Technologies, Inc. | Permeant delivery system and methods for use thereof | 
| JP5552255B2 (ja) * | 2008-04-16 | 2014-07-16 | 日東電工株式会社 | 薬物経皮投与デバイス | 
| US8784879B2 (en) | 2009-01-14 | 2014-07-22 | Corium International, Inc. | Transdermal administration of tamsulosin | 
| DE102009056746A1 (de) * | 2009-12-04 | 2011-06-09 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System für die Verabreichung von Peptiden | 
| DE102010024105A1 (de) * | 2010-06-17 | 2011-12-22 | Grünenthal GmbH | Transdermale Verabreichung von Memantin | 
| EP2710085B1 (en) | 2011-05-16 | 2018-09-26 | Avery Dennison Corporation | Adhesive containing microparticles | 
| DE102011090178A1 (de) * | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation | 
| CN105073934B (zh) | 2013-02-07 | 2021-12-28 | 艾利丹尼森公司 | 具有改进性质的抗微生物粘合剂 | 
| EP2968014B1 (en) | 2013-03-15 | 2019-04-24 | Avery Dennison Corporation | Transparent cover dressing application system and inclusion of label strip | 
| WO2015188031A2 (en) | 2014-06-05 | 2015-12-10 | Avery Dennison Corporation | Articles with active agent concentrated at the substrate contacting surface and related methods | 
| KR101892270B1 (ko) * | 2017-04-07 | 2018-08-27 | 주식회사 삼양사 | 피부자극을 최소화 할 수 있는 경피 흡수용 패취 시스템 | 
| WO2020110100A1 (en) * | 2018-11-29 | 2020-06-04 | Cannabidose Medical Ltd | Devices for topical delivery of active agents to a target site | 
| CN111610871A (zh) * | 2019-02-25 | 2020-09-01 | 英属维尔京群岛商天材创新材料科技股份有限公司 | 电极结构及其触控面板 | 
| WO2022178120A1 (en) * | 2021-02-18 | 2022-08-25 | Agonex Biopharmaceuticals, Inc. | Systems, devices, and formulations for time-phased histamine delivery | 
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| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| GB1361289A (en) * | 1971-06-14 | 1974-07-24 | Alza Corp | Bandage for administering drugs | 
| US3996934A (en) * | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage | 
| US3921636A (en) * | 1973-01-15 | 1975-11-25 | Alza Corp | Novel drug delivery device | 
| US3993072A (en) * | 1974-08-28 | 1976-11-23 | Alza Corporation | Microporous drug delivery device | 
| US3996939A (en) * | 1975-07-22 | 1976-12-14 | National Catheter Corporation | Intubation stylets | 
| ATE12731T1 (de) * | 1979-01-11 | 1985-05-15 | Key Pharma | Polymere diffusionsmatrix und verfahren zu deren herstellung. | 
| US4438139A (en) * | 1979-08-14 | 1984-03-20 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing estrogens | 
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| DE3333240A1 (de) * | 1983-09-12 | 1985-03-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mittel zur transdermalen applikation von arzneimittelwirkstoffen | 
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| US4749574A (en) * | 1986-04-14 | 1988-06-07 | Fujisawa Pharmaceutical Co., Ltd. | Sustained-release transdermal delivery preparations | 
| US4946870A (en) * | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives | 
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| DK154806C (da) * | 1986-12-19 | 1989-06-26 | Coloplast As | Saarplejemiddel indeholdende et aktivt stof til fremme af saarbehandlingen og fremgangsmaade til fremstilling deraf | 
| US4837027A (en) * | 1987-11-09 | 1989-06-06 | Alza Corporation | Transdermal drug delivery device | 
| US4781924A (en) * | 1987-11-09 | 1988-11-01 | Alza Corporation | Transdermal drug delivery device | 
| US4942037A (en) * | 1988-06-02 | 1990-07-17 | Merck & Co., Inc. | Transdermal delivery systems | 
| SE8904296D0 (sv) * | 1989-12-21 | 1989-12-21 | Pharmacia Ab | Transdermal system | 
- 
        1989
        - 1989-04-01 DE DE3910543A patent/DE3910543A1/de active Granted
 
- 
        1990
        - 1990-03-15 AU AU51314/90A patent/AU627283B2/en not_active Ceased
- 1990-03-23 DE DE9090105527T patent/DE59001338D1/de not_active Expired - Fee Related
- 1990-03-23 ES ES90105527T patent/ES2055201T3/es not_active Expired - Lifetime
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