SI2940030T1 - Postopek za izdelavo P1, P4-di(uridin 5'-)tetrafosfata - Google Patents
Postopek za izdelavo P1, P4-di(uridin 5'-)tetrafosfataInfo
- Publication number
- SI2940030T1 SI2940030T1 SI201330744T SI201330744T SI2940030T1 SI 2940030 T1 SI2940030 T1 SI 2940030T1 SI 201330744 T SI201330744 T SI 201330744T SI 201330744 T SI201330744 T SI 201330744T SI 2940030 T1 SI2940030 T1 SI 2940030T1
- Authority
- SI
- Slovenia
- Prior art keywords
- tetraphosphate
- uridine
- producing
- Prior art date
Links
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 title 2
- YDHWWBZFRZWVHO-UHFFFAOYSA-H [oxido-[oxido(phosphonatooxy)phosphoryl]oxyphosphoryl] phosphate Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O YDHWWBZFRZWVHO-UHFFFAOYSA-H 0.000 title 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 title 1
- 229940045145 uridine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012287578 | 2012-12-28 | ||
| PCT/JP2013/083100 WO2014103704A1 (ja) | 2012-12-28 | 2013-12-10 | Ｐ１，ｐ４－ジ（ウリジン５'－）テトラホスフェートの製造法 |
| EP13869663.8A EP2940030B1 (en) | 2012-12-28 | 2013-12-10 | Method for producing p1,p4-di(uridine 5'-)tetraphosphate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2940030T1 true SI2940030T1 (sl) | 2017-09-29 |
Family
ID=51020794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201330744T SI2940030T1 (sl) | 2012-12-28 | 2013-12-10 | Postopek za izdelavo P1, P4-di(uridin 5'-)tetrafosfata |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10179799B2 (sl) |
| EP (1) | EP2940030B1 (sl) |
| JP (1) | JP6049760B2 (sl) |
| KR (1) | KR102024700B1 (sl) |
| CN (1) | CN105026414B (sl) |
| CA (1) | CA2896455C (sl) |
| CY (1) | CY1119372T1 (sl) |
| DK (1) | DK2940030T3 (sl) |
| ES (1) | ES2629743T3 (sl) |
| HR (1) | HRP20171333T1 (sl) |
| HU (1) | HUE035675T2 (sl) |
| LT (1) | LT2940030T (sl) |
| PL (1) | PL2940030T3 (sl) |
| PT (1) | PT2940030T (sl) |
| RS (1) | RS56227B1 (sl) |
| SI (1) | SI2940030T1 (sl) |
| WO (1) | WO2014103704A1 (sl) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018079503A1 (ja) | 2016-10-25 | 2018-05-03 | ヤマサ醤油株式会社 | Ｐ１，ｐ４－ジ（ウリジン５'－）テトラホスフェートの精製方法 |
| CN107056859A (zh) * | 2017-04-28 | 2017-08-18 | 广东众生药业股份有限公司 | 一种高纯度p1，p4‑二（尿苷‑5’‑四磷酸）盐的制备方法 |
| CN108164577A (zh) * | 2017-04-28 | 2018-06-15 | 广东众生药业股份有限公司 | 一种p1，p4-二（尿苷-5’-四磷酸）钠盐的工业化制备方法 |
| KR102504764B1 (ko) * | 2017-06-21 | 2023-03-02 | 주식회사 종근당 | 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법 |
| CN110218233B (zh) * | 2018-03-01 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | 一种p1,p4-二（尿苷5`-）四磷酸盐的制备方法 |
| CN109021049B (zh) * | 2018-06-14 | 2020-12-08 | 扬子江药业集团北京海燕药业有限公司 | 一种尿苷5′-二磷酸-苯并咪唑二钠的合成方法 |
| CN110655545B (zh) * | 2018-06-28 | 2022-09-09 | 上海致根医药科技有限公司 | P1，p4-二(尿苷5’-)四磷酸酯的制备方法 |
| KR20200106738A (ko) | 2019-03-05 | 2020-09-15 | 주식회사 파마코스텍 | P1,p4-디(우리딘 5'-)테트라포스페이트, 이의 염 또는 이의 수화물의 신규한 제조방법 |
| CN110590887B (zh) * | 2019-09-04 | 2020-12-15 | 江苏金殳医药科技有限公司 | 一种磷酸酯的制备方法 |
| CN111040245B (zh) * | 2019-12-18 | 2022-05-31 | 江苏集萃先进高分子材料研究所有限公司 | 一种焦聚磷酸咪唑阻燃剂及其制备方法 |
| KR20210077946A (ko) * | 2019-12-18 | 2021-06-28 | 주식회사 종근당 | 우리딘 5’-디인산(udp), 이의 염 또는 이의 수화물의 제조방법 |
| CN111662350B (zh) * | 2020-07-07 | 2022-06-07 | 南京宸翔医药研究有限责任公司 | 一种绿色化智能化高纯度地夸磷索四钠的制备方法 |
| WO2022212442A1 (en) | 2021-03-31 | 2022-10-06 | Modernatx, Inc. | Synthesis of trinucleotide and tetranucleotide caps for mrna production |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008024169A1 (en) * | 2006-07-21 | 2008-02-28 | Glsynthesis, Inc. | Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use |
| JP5051422B2 (ja) | 2006-07-21 | 2012-10-17 | アイシン精機株式会社 | タイヤ空気圧監視システム |
| CA2659595C (en) * | 2006-07-26 | 2016-01-19 | Yamasa Corporation | Process for producing di(pyrimidine nucleoside 5'-)polyphosphate |
-
2013
- 2013-12-10 PL PL13869663T patent/PL2940030T3/pl unknown
- 2013-12-10 CN CN201380074088.5A patent/CN105026414B/zh active Active
- 2013-12-10 RS RS20170824A patent/RS56227B1/sr unknown
- 2013-12-10 CA CA2896455A patent/CA2896455C/en active Active
- 2013-12-10 PT PT138696638T patent/PT2940030T/pt unknown
- 2013-12-10 JP JP2014554298A patent/JP6049760B2/ja active Active
- 2013-12-10 SI SI201330744T patent/SI2940030T1/sl unknown
- 2013-12-10 LT LTEP13869663.8T patent/LT2940030T/lt unknown
- 2013-12-10 DK DK13869663.8T patent/DK2940030T3/en active
- 2013-12-10 EP EP13869663.8A patent/EP2940030B1/en active Active
- 2013-12-10 WO PCT/JP2013/083100 patent/WO2014103704A1/ja active Application Filing
- 2013-12-10 ES ES13869663.8T patent/ES2629743T3/es active Active
- 2013-12-10 KR KR1020157017372A patent/KR102024700B1/ko active IP Right Grant
- 2013-12-10 US US14/758,102 patent/US10179799B2/en active Active
- 2013-12-10 HU HUE13869663A patent/HUE035675T2/hu unknown
-
2017
- 2017-09-05 HR HRP20171333TT patent/HRP20171333T1/hr unknown
- 2017-09-07 CY CY20171100946T patent/CY1119372T1/el unknown
-
2018
- 2018-11-30 US US16/206,380 patent/US11208428B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DK2940030T3 (en) | 2017-07-24 |
| EP2940030A1 (en) | 2015-11-04 |
| EP2940030A4 (en) | 2016-09-14 |
| JP6049760B2 (ja) | 2016-12-21 |
| CN105026414B (zh) | 2017-06-23 |
| RS56227B1 (sr) | 2017-11-30 |
| PL2940030T3 (pl) | 2017-11-30 |
| CY1119372T1 (el) | 2018-02-14 |
| CA2896455C (en) | 2021-04-20 |
| US10179799B2 (en) | 2019-01-15 |
| PT2940030T (pt) | 2017-09-11 |
| JPWO2014103704A1 (ja) | 2017-01-12 |
| US20190092803A1 (en) | 2019-03-28 |
| WO2014103704A1 (ja) | 2014-07-03 |
| HUE035675T2 (hu) | 2018-05-28 |
| KR102024700B1 (ko) | 2019-09-24 |
| CA2896455A1 (en) | 2014-07-03 |
| LT2940030T (lt) | 2017-07-10 |
| HRP20171333T1 (hr) | 2017-11-03 |
| KR20150100708A (ko) | 2015-09-02 |
| ES2629743T3 (es) | 2017-08-14 |
| EP2940030B1 (en) | 2017-06-14 |
| US11208428B2 (en) | 2021-12-28 |
| US20160194347A1 (en) | 2016-07-07 |
| CN105026414A (zh) | 2015-11-04 |
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