SI2817407T1 - Oligonucleotides for modulating gene expression and their use - Google Patents

Oligonucleotides for modulating gene expression and their use Download PDF

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Publication number
SI2817407T1
SI2817407T1 SI201330845T SI201330845T SI2817407T1 SI 2817407 T1 SI2817407 T1 SI 2817407T1 SI 201330845 T SI201330845 T SI 201330845T SI 201330845 T SI201330845 T SI 201330845T SI 2817407 T1 SI2817407 T1 SI 2817407T1
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Slovenia
Prior art keywords
oligonucleotide
gene
seq
nucleotide
tumor
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SI201330845T
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English (en)
Slovenian (sl)
Inventor
Roberto Tonelli
Leonardo Venturelli
Andrea Tortori
Luca Montemurro
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Biogenera S.P.A.
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Publication of SI2817407T1 publication Critical patent/SI2817407T1/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/3513—Protein; Peptide
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SI201330845T 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and their use SI2817407T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000275A ITMI20120275A1 (it) 2012-02-24 2012-02-24 Oligonucleotidi per la modulazione dell'espressione genica e loro usi
EP13716415.8A EP2817407B1 (en) 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and uses thereof
PCT/IB2013/051410 WO2013124807A2 (en) 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and uses thereof

Publications (1)

Publication Number Publication Date
SI2817407T1 true SI2817407T1 (en) 2018-01-31

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SI201330845T SI2817407T1 (en) 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and their use

Country Status (28)

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US (2) US10023867B2 (https=)
EP (1) EP2817407B1 (https=)
JP (2) JP6333739B2 (https=)
KR (1) KR101992925B1 (https=)
CN (2) CN115216475A (https=)
AR (1) AR090129A1 (https=)
AU (2) AU2013223694B2 (https=)
BR (1) BR112014020885B1 (https=)
CA (1) CA2864060C (https=)
CY (1) CY1120084T1 (https=)
DK (1) DK2817407T3 (https=)
ES (1) ES2651147T3 (https=)
HK (1) HK1201878A1 (https=)
HU (1) HUE034846T2 (https=)
IN (1) IN2014MN01493A (https=)
IT (1) ITMI20120275A1 (https=)
LT (1) LT2817407T (https=)
MA (1) MA35935B1 (https=)
NO (1) NO2817407T3 (https=)
PL (1) PL2817407T3 (https=)
PT (1) PT2817407T (https=)
RS (1) RS56631B1 (https=)
RU (1) RU2648140C2 (https=)
SG (2) SG11201404852WA (https=)
SI (1) SI2817407T1 (https=)
SM (1) SMT201800042T1 (https=)
TN (1) TN2014000327A1 (https=)
WO (1) WO2013124807A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20120275A1 (it) * 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi
EA201492122A1 (ru) 2012-05-16 2015-10-30 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии utrn
BR112014028631A2 (pt) 2012-05-16 2017-10-17 Rana Therapeutics Inc composições e métodos para modulação da expressão da família de genes da hemoglobina
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
AU2013262699A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating ATP2A2 expression
SG11201407483YA (en) 2012-05-16 2014-12-30 Rana Therapeutics Inc Compositions and methods for modulating smn gene family expression
EA201492116A1 (ru) 2012-05-16 2015-05-29 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии mecp2
MX2019006803A (es) 2016-12-13 2019-11-18 Am Sciences Inc Composicion farmaceutica para prevenir o tratar la hepatitis b.
KR20230141513A (ko) * 2022-03-22 2023-10-10 주식회사 바이오엔 담즙산염 및 양이온성 펩타이드를 포함하는 단백질 전달용 조성물 및 이의 용도

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1019429A4 (en) * 1997-08-20 2001-08-08 Somagenics Inc ANTISENSE THERAPEUTIC PRODUCTS WITH IMPROVED BINDING PROPERTIES AND METHODS OF USE
CA2400028A1 (en) 2000-02-14 2001-08-23 Arthur P. Bollon Libraries of optimum subsequence regions of mrna and genomic dna for control of gene expression
JP2004524371A (ja) * 2001-04-13 2004-08-12 ザ・ポピュレイション・カウンシル，インコーポレイテッド 核レセプターを介するペプチド核酸の細胞核内導入
NZ530101A (en) 2001-05-17 2007-01-26 Avi Biopharma Inc Methods for treating cancer by administering an oligomer antisense to c-myc together with a cancer chemotherapeutic agent
EP1448590A4 (en) * 2002-02-20 2004-12-15 Sirna Therapeutics Inc Inhibition of the myc and myb genes mediated by RNA interference mediated or genes of the corresponding synthetic pathways
ITMI20030860A1 (it) * 2003-04-29 2004-10-30 Univ Bologna Metodo per l'inibizione selettiva del gene n-myc
WO2005045032A2 (en) * 2003-10-20 2005-05-19 Sima Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF EARLY GROWTH RESPONSE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20080152700A1 (en) * 2004-06-01 2008-06-26 Reza Sheikhnejad Methods and compositions for the inhibition of gene expression
GB0415263D0 (en) * 2004-07-07 2004-08-11 Norwegian Radium Hospital Res Method
RU2007119313A (ru) * 2004-10-25 2008-11-27 Новартис АГ (CH) Полинуклеотиды и полипептиды torc и способы применения
ES2548240T3 (es) * 2005-12-01 2015-10-15 Pronai Therapeutics, Inc. Terapias para el cáncer y composiciones farmacéuticas usadas en las mismas
US7625874B2 (en) * 2006-04-11 2009-12-01 The Regents Of The University Of California Compositions and methods for treating diseases associated with T-box and N-Myc
US20080038783A1 (en) * 2006-06-29 2008-02-14 Applera Corporation Compositions and Methods Pertaining to Guanylation of PNA Oligomers
WO2009009739A2 (en) 2007-07-12 2009-01-15 Theracrine, Inc. Methods and compositions for facilitating cell death of cancer stem cells and for treating cancer
JP2011511051A (ja) * 2008-02-05 2011-04-07 アンティソマ リサーチ リミテッド 生物学的物質およびそれらの使用
US20110294870A1 (en) * 2008-12-04 2011-12-01 Opko Curna, Llc Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
CN102058535B (zh) * 2010-12-21 2013-05-01 中国人民解放军总医院 叶酸受体靶向的新型脂质体
ITMI20120275A1 (it) * 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi

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DK2817407T3 (en) 2017-12-18
ITMI20120275A1 (it) 2013-08-25
RU2648140C2 (ru) 2018-03-22
HK1201878A1 (en) 2015-09-11
CN104169421A (zh) 2014-11-26
JP6333739B2 (ja) 2018-05-30
NO2817407T3 (https=) 2018-02-03
LT2817407T (lt) 2018-01-25
EP2817407B1 (en) 2017-09-06
JP2018078893A (ja) 2018-05-24
RU2014138198A (ru) 2016-04-10
PL2817407T3 (pl) 2018-03-30
WO2013124807A3 (en) 2013-12-27
AR090129A1 (es) 2014-10-22
CA2864060C (en) 2020-03-10
WO2013124807A2 (en) 2013-08-29
SG10201606946YA (en) 2016-10-28
US20160040166A1 (en) 2016-02-11
PT2817407T (pt) 2017-12-07
SMT201800042T1 (it) 2018-03-08
RS56631B1 (sr) 2018-03-30
HUE034846T2 (en) 2018-03-28
CA2864060A1 (en) 2013-08-29
IN2014MN01493A (https=) 2015-04-17
AU2013223694A1 (en) 2014-09-25
JP2015513398A (ja) 2015-05-14
CN115216475A (zh) 2022-10-21
US20180282731A1 (en) 2018-10-04
ES2651147T3 (es) 2018-01-24
US10752900B2 (en) 2020-08-25
AU2013223694B2 (en) 2019-01-03
EP2817407A2 (en) 2014-12-31
BR112014020885A2 (pt) 2018-01-09
TN2014000327A1 (en) 2015-12-21
CY1120084T1 (el) 2018-12-12
US10023867B2 (en) 2018-07-17
KR20140130514A (ko) 2014-11-10
MA35935B1 (fr) 2014-12-01
KR101992925B1 (ko) 2019-06-25
BR112014020885B1 (pt) 2020-10-27
SG11201404852WA (en) 2014-10-30
AU2018278972A1 (en) 2019-01-17

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