RU2648140C2 - Олигонуклеотиды для модулирования экспрессии генов и их применения - Google Patents

Олигонуклеотиды для модулирования экспрессии генов и их применения Download PDF

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RU2648140C2
RU2648140C2 RU2014138198A RU2014138198A RU2648140C2 RU 2648140 C2 RU2648140 C2 RU 2648140C2 RU 2014138198 A RU2014138198 A RU 2014138198A RU 2014138198 A RU2014138198 A RU 2014138198A RU 2648140 C2 RU2648140 C2 RU 2648140C2
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oligonucleotides
seq
oligonucleotide
gene
pna
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RU2014138198A
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RU2014138198A (ru
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Роберто ТОНЕЛЛИ
Леонардо ВЕНТУРЕЛЛИ
Андреа ТОРТОРИ
Лука МОНТЕМУРРО
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Бьодженера С.П.А.
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61K31/47Quinolines; Isoquinolines
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RU2014138198A 2012-02-24 2013-02-21 Олигонуклеотиды для модулирования экспрессии генов и их применения RU2648140C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000275A ITMI20120275A1 (it) 2012-02-24 2012-02-24 Oligonucleotidi per la modulazione dell'espressione genica e loro usi
ITMI2012A000275 2012-02-24
PCT/IB2013/051410 WO2013124807A2 (en) 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and uses thereof

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RU2014138198A RU2014138198A (ru) 2016-04-10
RU2648140C2 true RU2648140C2 (ru) 2018-03-22

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US (2) US10023867B2 (https=)
EP (1) EP2817407B1 (https=)
JP (2) JP6333739B2 (https=)
KR (1) KR101992925B1 (https=)
CN (2) CN115216475A (https=)
AR (1) AR090129A1 (https=)
AU (2) AU2013223694B2 (https=)
BR (1) BR112014020885B1 (https=)
CA (1) CA2864060C (https=)
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ES (1) ES2651147T3 (https=)
HK (1) HK1201878A1 (https=)
HU (1) HUE034846T2 (https=)
IN (1) IN2014MN01493A (https=)
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NO (1) NO2817407T3 (https=)
PL (1) PL2817407T3 (https=)
PT (1) PT2817407T (https=)
RS (1) RS56631B1 (https=)
RU (1) RU2648140C2 (https=)
SG (2) SG11201404852WA (https=)
SI (1) SI2817407T1 (https=)
SM (1) SMT201800042T1 (https=)
TN (1) TN2014000327A1 (https=)
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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20120275A1 (it) * 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi
AU2013262709A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating MECP2 expression
JP2015523854A (ja) 2012-05-16 2015-08-20 ラナ セラピューティクス インコーポレイテッド Smn遺伝子ファミリー発現を調節するための組成物及び方法
BR112014028634A2 (pt) 2012-05-16 2017-06-27 Rana Therapeutics Inc composições e métodos para modulação da expressão de utrn
CA2873766A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating atp2a2 expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
CA2873769A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating hemoglobin gene family expression
US11033571B2 (en) 2016-12-13 2021-06-15 Am Sciences Inc Pharmaceutical composition for preventing or treating hepatitis B
WO2023182812A1 (ko) * 2022-03-22 2023-09-28 주식회사 바이오엔 담즙산염 및 양이온성 펩타이드를 포함하는 단백질 전달용 조성물 및 이의 용도

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092617A1 (en) * 2001-05-17 2002-11-21 Avi Biopharma, Inc. Combined approach to treatment of cancer using a c-myc antisense oligomer
WO2003070917A2 (en) * 2002-02-20 2003-08-28 Sirna Therapeutics, Inc. Rna interference mediated inhibition of myc and myb genes or genes of their respective pathways
RU2007119313A (ru) * 2004-10-25 2008-11-27 Новартис АГ (CH) Полинуклеотиды и полипептиды torc и способы применения
WO2009009739A2 (en) * 2007-07-12 2009-01-15 Theracrine, Inc. Methods and compositions for facilitating cell death of cancer stem cells and for treating cancer
US7981615B2 (en) * 2006-04-11 2011-07-19 The Regents Of The University Of California Compositions and methods for treating diseases associated with T-box and N-Myc

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001514873A (ja) * 1997-08-20 2001-09-18 ソーマジェニックス インコーポレイテッド 結合特性が改善されたアンチセンスおよびアンチジーン治療薬並びにそれらの使用方法
CA2400028A1 (en) 2000-02-14 2001-08-23 Arthur P. Bollon Libraries of optimum subsequence regions of mrna and genomic dna for control of gene expression
JP2004524371A (ja) * 2001-04-13 2004-08-12 ザ・ポピュレイション・カウンシル,インコーポレイテッド 核レセプターを介するペプチド核酸の細胞核内導入
ITMI20030860A1 (it) * 2003-04-29 2004-10-30 Univ Bologna Metodo per l'inibizione selettiva del gene n-myc
WO2005045032A2 (en) * 2003-10-20 2005-05-19 Sima Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF EARLY GROWTH RESPONSE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US7498315B2 (en) * 2004-06-01 2009-03-03 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
GB0415263D0 (en) * 2004-07-07 2004-08-11 Norwegian Radium Hospital Res Method
EP1971371B1 (en) * 2005-12-01 2015-08-05 Pronai Therapeutics, Inc. Cancer therapies and pharmaceutical compositions used therein
US20080038783A1 (en) * 2006-06-29 2008-02-14 Applera Corporation Compositions and Methods Pertaining to Guanylation of PNA Oligomers
EP2268284A2 (en) * 2008-02-05 2011-01-05 Antisoma Research Limited Use of g-rich oligonucleotides for treating neoplastic diseases
CN102361985B (zh) * 2008-12-04 2017-06-20 库尔纳公司 通过抑制肿瘤抑制基因的天然反义转录物治疗肿瘤抑制基因相关性疾病
CN102058535B (zh) * 2010-12-21 2013-05-01 中国人民解放军总医院 叶酸受体靶向的新型脂质体
ITMI20120275A1 (it) * 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092617A1 (en) * 2001-05-17 2002-11-21 Avi Biopharma, Inc. Combined approach to treatment of cancer using a c-myc antisense oligomer
WO2003070917A2 (en) * 2002-02-20 2003-08-28 Sirna Therapeutics, Inc. Rna interference mediated inhibition of myc and myb genes or genes of their respective pathways
RU2007119313A (ru) * 2004-10-25 2008-11-27 Новартис АГ (CH) Полинуклеотиды и полипептиды torc и способы применения
US7981615B2 (en) * 2006-04-11 2011-07-19 The Regents Of The University Of California Compositions and methods for treating diseases associated with T-box and N-Myc
WO2009009739A2 (en) * 2007-07-12 2009-01-15 Theracrine, Inc. Methods and compositions for facilitating cell death of cancer stem cells and for treating cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
WO 2002092617 А1, 21.11.2002, посл.8,11. WO 2009009739 А2, 15.01.09, посл. 455. *
посл. 455. *
посл.8,11. *

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WO2013124807A2 (en) 2013-08-29
AU2013223694B2 (en) 2019-01-03
DK2817407T3 (en) 2017-12-18
AR090129A1 (es) 2014-10-22
SMT201800042T1 (it) 2018-03-08
RS56631B1 (sr) 2018-03-30
ITMI20120275A1 (it) 2013-08-25
SG11201404852WA (en) 2014-10-30
KR101992925B1 (ko) 2019-06-25
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