KR101992925B1 - 유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도 - Google Patents

유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도 Download PDF

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KR101992925B1
KR101992925B1 KR1020147026837A KR20147026837A KR101992925B1 KR 101992925 B1 KR101992925 B1 KR 101992925B1 KR 1020147026837 A KR1020147026837 A KR 1020147026837A KR 20147026837 A KR20147026837 A KR 20147026837A KR 101992925 B1 KR101992925 B1 KR 101992925B1
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oligonucleotide
seq
oligonucleotides
gene
pna
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KR20140130514A (ko
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로베르토 토넬리
레오나르도 벤투렐리
안드레아 토르토리
루카 몬테무로
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바이오제네라 에스.피.에이.
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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KR1020147026837A 2012-02-24 2013-02-21 유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도 Active KR101992925B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000275A ITMI20120275A1 (it) 2012-02-24 2012-02-24 Oligonucleotidi per la modulazione dell'espressione genica e loro usi
ITMI2012A000275 2012-02-24
PCT/IB2013/051410 WO2013124807A2 (en) 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and uses thereof

Publications (2)

Publication Number Publication Date
KR20140130514A KR20140130514A (ko) 2014-11-10
KR101992925B1 true KR101992925B1 (ko) 2019-06-25

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KR1020147026837A Active KR101992925B1 (ko) 2012-02-24 2013-02-21 유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도

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US (2) US10023867B2 (https=)
EP (1) EP2817407B1 (https=)
JP (2) JP6333739B2 (https=)
KR (1) KR101992925B1 (https=)
CN (2) CN115216475A (https=)
AR (1) AR090129A1 (https=)
AU (2) AU2013223694B2 (https=)
BR (1) BR112014020885B1 (https=)
CA (1) CA2864060C (https=)
CY (1) CY1120084T1 (https=)
DK (1) DK2817407T3 (https=)
ES (1) ES2651147T3 (https=)
HK (1) HK1201878A1 (https=)
HU (1) HUE034846T2 (https=)
IN (1) IN2014MN01493A (https=)
IT (1) ITMI20120275A1 (https=)
LT (1) LT2817407T (https=)
MA (1) MA35935B1 (https=)
NO (1) NO2817407T3 (https=)
PL (1) PL2817407T3 (https=)
PT (1) PT2817407T (https=)
RS (1) RS56631B1 (https=)
RU (1) RU2648140C2 (https=)
SG (2) SG11201404852WA (https=)
SI (1) SI2817407T1 (https=)
SM (1) SMT201800042T1 (https=)
TN (1) TN2014000327A1 (https=)
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ITMI20120275A1 (it) * 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi
EA201492122A1 (ru) 2012-05-16 2015-10-30 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии utrn
BR112014028631A2 (pt) 2012-05-16 2017-10-17 Rana Therapeutics Inc composições e métodos para modulação da expressão da família de genes da hemoglobina
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
AU2013262699A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating ATP2A2 expression
SG11201407483YA (en) 2012-05-16 2014-12-30 Rana Therapeutics Inc Compositions and methods for modulating smn gene family expression
EA201492116A1 (ru) 2012-05-16 2015-05-29 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии mecp2
MX2019006803A (es) 2016-12-13 2019-11-18 Am Sciences Inc Composicion farmaceutica para prevenir o tratar la hepatitis b.
KR20230141513A (ko) * 2022-03-22 2023-10-10 주식회사 바이오엔 담즙산염 및 양이온성 펩타이드를 포함하는 단백질 전달용 조성물 및 이의 용도

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ITMI20120275A1 (it) * 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi

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DK2817407T3 (en) 2017-12-18
ITMI20120275A1 (it) 2013-08-25
RU2648140C2 (ru) 2018-03-22
HK1201878A1 (en) 2015-09-11
CN104169421A (zh) 2014-11-26
JP6333739B2 (ja) 2018-05-30
NO2817407T3 (https=) 2018-02-03
LT2817407T (lt) 2018-01-25
EP2817407B1 (en) 2017-09-06
JP2018078893A (ja) 2018-05-24
RU2014138198A (ru) 2016-04-10
PL2817407T3 (pl) 2018-03-30
WO2013124807A3 (en) 2013-12-27
AR090129A1 (es) 2014-10-22
CA2864060C (en) 2020-03-10
WO2013124807A2 (en) 2013-08-29
SG10201606946YA (en) 2016-10-28
US20160040166A1 (en) 2016-02-11
PT2817407T (pt) 2017-12-07
SMT201800042T1 (it) 2018-03-08
RS56631B1 (sr) 2018-03-30
HUE034846T2 (en) 2018-03-28
CA2864060A1 (en) 2013-08-29
IN2014MN01493A (https=) 2015-04-17
AU2013223694A1 (en) 2014-09-25
JP2015513398A (ja) 2015-05-14
SI2817407T1 (en) 2018-01-31
CN115216475A (zh) 2022-10-21
US20180282731A1 (en) 2018-10-04
ES2651147T3 (es) 2018-01-24
US10752900B2 (en) 2020-08-25
AU2013223694B2 (en) 2019-01-03
EP2817407A2 (en) 2014-12-31
BR112014020885A2 (pt) 2018-01-09
TN2014000327A1 (en) 2015-12-21
CY1120084T1 (el) 2018-12-12
US10023867B2 (en) 2018-07-17
KR20140130514A (ko) 2014-11-10
MA35935B1 (fr) 2014-12-01
BR112014020885B1 (pt) 2020-10-27
SG11201404852WA (en) 2014-10-30
AU2018278972A1 (en) 2019-01-17

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