KR101992925B1 - 유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도 - Google Patents

유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도 Download PDF

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KR101992925B1
KR101992925B1 KR1020147026837A KR20147026837A KR101992925B1 KR 101992925 B1 KR101992925 B1 KR 101992925B1 KR 1020147026837 A KR1020147026837 A KR 1020147026837A KR 20147026837 A KR20147026837 A KR 20147026837A KR 101992925 B1 KR101992925 B1 KR 101992925B1
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oligonucleotide
seq
oligonucleotides
gene
pna
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KR20140130514A (ko
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로베르토 토넬리
레오나르도 벤투렐리
안드레아 토르토리
루카 몬테무로
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바이오제네라 에스.피.에이.
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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KR1020147026837A 2012-02-24 2013-02-21 유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도 Active KR101992925B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000275A ITMI20120275A1 (it) 2012-02-24 2012-02-24 Oligonucleotidi per la modulazione dell'espressione genica e loro usi
ITMI2012A000275 2012-02-24
PCT/IB2013/051410 WO2013124807A2 (en) 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and uses thereof

Publications (2)

Publication Number Publication Date
KR20140130514A KR20140130514A (ko) 2014-11-10
KR101992925B1 true KR101992925B1 (ko) 2019-06-25

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KR1020147026837A Active KR101992925B1 (ko) 2012-02-24 2013-02-21 유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도

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US (2) US10023867B2 (https=)
EP (1) EP2817407B1 (https=)
JP (2) JP6333739B2 (https=)
KR (1) KR101992925B1 (https=)
CN (2) CN115216475A (https=)
AR (1) AR090129A1 (https=)
AU (2) AU2013223694B2 (https=)
BR (1) BR112014020885B1 (https=)
CA (1) CA2864060C (https=)
CY (1) CY1120084T1 (https=)
DK (1) DK2817407T3 (https=)
ES (1) ES2651147T3 (https=)
HK (1) HK1201878A1 (https=)
HU (1) HUE034846T2 (https=)
IN (1) IN2014MN01493A (https=)
IT (1) ITMI20120275A1 (https=)
LT (1) LT2817407T (https=)
MA (1) MA35935B1 (https=)
NO (1) NO2817407T3 (https=)
PL (1) PL2817407T3 (https=)
PT (1) PT2817407T (https=)
RS (1) RS56631B1 (https=)
RU (1) RU2648140C2 (https=)
SG (2) SG11201404852WA (https=)
SI (1) SI2817407T1 (https=)
SM (1) SMT201800042T1 (https=)
TN (1) TN2014000327A1 (https=)
WO (1) WO2013124807A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20120275A1 (it) * 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi
AU2013262709A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating MECP2 expression
JP2015523854A (ja) 2012-05-16 2015-08-20 ラナ セラピューティクス インコーポレイテッド Ｓｍｎ遺伝子ファミリー発現を調節するための組成物及び方法
BR112014028634A2 (pt) 2012-05-16 2017-06-27 Rana Therapeutics Inc composições e métodos para modulação da expressão de utrn
CA2873766A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating atp2a2 expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
CA2873769A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating hemoglobin gene family expression
US11033571B2 (en) 2016-12-13 2021-06-15 Am Sciences Inc Pharmaceutical composition for preventing or treating hepatitis B
WO2023182812A1 (ko) * 2022-03-22 2023-09-28 주식회사 바이오엔 담즙산염 및 양이온성 펩타이드를 포함하는 단백질 전달용 조성물 및 이의 용도

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001514873A (ja) * 1997-08-20 2001-09-18 ソーマジェニックス インコーポレイテッド 結合特性が改善されたアンチセンスおよびアンチジーン治療薬並びにそれらの使用方法
CA2400028A1 (en) 2000-02-14 2001-08-23 Arthur P. Bollon Libraries of optimum subsequence regions of mrna and genomic dna for control of gene expression
JP2004524371A (ja) * 2001-04-13 2004-08-12 ザ・ポピュレイション・カウンシル，インコーポレイテッド 核レセプターを介するペプチド核酸の細胞核内導入
JP2004537517A (ja) 2001-05-17 2004-12-16 エイブイアイ バイオファーマ， インコーポレイテッド ｃ−ｍｙｃアンチセンスオリゴマーを使用した、癌を処置するための併用アプローチ
AU2003213203A1 (en) * 2002-02-20 2003-09-09 Ribozyme Pharmaceuticals, Incorporated Rna interference mediated inhibition of myc and myb genes or genes of their respective pathways
ITMI20030860A1 (it) * 2003-04-29 2004-10-30 Univ Bologna Metodo per l'inibizione selettiva del gene n-myc
WO2005045032A2 (en) * 2003-10-20 2005-05-19 Sima Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF EARLY GROWTH RESPONSE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US7498315B2 (en) * 2004-06-01 2009-03-03 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
GB0415263D0 (en) * 2004-07-07 2004-08-11 Norwegian Radium Hospital Res Method
RU2007119313A (ru) * 2004-10-25 2008-11-27 Новартис АГ (CH) Полинуклеотиды и полипептиды torc и способы применения
EP1971371B1 (en) * 2005-12-01 2015-08-05 Pronai Therapeutics, Inc. Cancer therapies and pharmaceutical compositions used therein
US7625874B2 (en) * 2006-04-11 2009-12-01 The Regents Of The University Of California Compositions and methods for treating diseases associated with T-box and N-Myc
US20080038783A1 (en) * 2006-06-29 2008-02-14 Applera Corporation Compositions and Methods Pertaining to Guanylation of PNA Oligomers
WO2009009739A2 (en) * 2007-07-12 2009-01-15 Theracrine, Inc. Methods and compositions for facilitating cell death of cancer stem cells and for treating cancer
EP2268284A2 (en) * 2008-02-05 2011-01-05 Antisoma Research Limited Use of g-rich oligonucleotides for treating neoplastic diseases
CN102361985B (zh) * 2008-12-04 2017-06-20 库尔纳公司 通过抑制肿瘤抑制基因的天然反义转录物治疗肿瘤抑制基因相关性疾病
CN102058535B (zh) * 2010-12-21 2013-05-01 中国人民解放军总医院 叶酸受体靶向的新型脂质体
ITMI20120275A1 (it) * 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi

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WO2013124807A2 (en) 2013-08-29
AU2013223694B2 (en) 2019-01-03
DK2817407T3 (en) 2017-12-18
RU2648140C2 (ru) 2018-03-22
AR090129A1 (es) 2014-10-22
SMT201800042T1 (it) 2018-03-08
RS56631B1 (sr) 2018-03-30
ITMI20120275A1 (it) 2013-08-25
SG11201404852WA (en) 2014-10-30
CY1120084T1 (el) 2018-12-12
PT2817407T (pt) 2017-12-07
CA2864060C (en) 2020-03-10
AU2013223694A1 (en) 2014-09-25
HK1201878A1 (en) 2015-09-11
CN104169421A (zh) 2014-11-26
SI2817407T1 (en) 2018-01-31
IN2014MN01493A (https=) 2015-04-17
US20180282731A1 (en) 2018-10-04
RU2014138198A (ru) 2016-04-10
EP2817407A2 (en) 2014-12-31
LT2817407T (lt) 2018-01-25
KR20140130514A (ko) 2014-11-10
EP2817407B1 (en) 2017-09-06
TN2014000327A1 (en) 2015-12-21
PL2817407T3 (pl) 2018-03-30
JP2018078893A (ja) 2018-05-24
NO2817407T3 (https=) 2018-02-03
BR112014020885A2 (pt) 2018-01-09
CN115216475A (zh) 2022-10-21
ES2651147T3 (es) 2018-01-24
US10023867B2 (en) 2018-07-17
US10752900B2 (en) 2020-08-25
MA35935B1 (fr) 2014-12-01
CA2864060A1 (en) 2013-08-29
AU2018278972A1 (en) 2019-01-17
US20160040166A1 (en) 2016-02-11
JP6333739B2 (ja) 2018-05-30
WO2013124807A3 (en) 2013-12-27
HUE034846T2 (en) 2018-03-28
JP2015513398A (ja) 2015-05-14
SG10201606946YA (en) 2016-10-28
BR112014020885B1 (pt) 2020-10-27

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