SI2731973T1 - A bacterial host strain expressing a recombinant DSBC - Google Patents
A bacterial host strain expressing a recombinant DSBC Download PDFInfo
- Publication number
- SI2731973T1 SI2731973T1 SI201231206T SI201231206T SI2731973T1 SI 2731973 T1 SI2731973 T1 SI 2731973T1 SI 201231206 T SI201231206 T SI 201231206T SI 201231206 T SI201231206 T SI 201231206T SI 2731973 T1 SI2731973 T1 SI 2731973T1
- Authority
- SI
- Slovenia
- Prior art keywords
- seq
- bacterial cell
- antibody
- gram
- antigen
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title claims abstract 19
- 102000040430 polynucleotide Human genes 0.000 claims abstract 14
- 108091033319 polynucleotide Proteins 0.000 claims abstract 14
- 239000002157 polynucleotide Substances 0.000 claims abstract 14
- 239000012634 fragment Substances 0.000 claims abstract 12
- 239000000427 antigen Substances 0.000 claims abstract 10
- 102000036639 antigens Human genes 0.000 claims abstract 10
- 108091007433 antigens Proteins 0.000 claims abstract 10
- 239000013604 expression vector Substances 0.000 claims abstract 7
- 210000004027 cell Anatomy 0.000 claims 16
- 238000000034 method Methods 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 210000004602 germ cell Anatomy 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 229920001427 mPEG Polymers 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241001646716 Escherichia coli K-12 Species 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 206010064571 Gene mutation Diseases 0.000 claims 1
- 101150052672 IGS1 gene Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 210000001322 periplasm Anatomy 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11173880 | 2011-07-13 | ||
| PCT/EP2012/002945 WO2013007388A1 (en) | 2011-07-13 | 2012-07-13 | Bacterial host strain expressing recombinant dsbc |
| EP12737492.4A EP2731973B1 (en) | 2011-07-13 | 2012-07-13 | Bacterial host strain expressing recombinant dsbc |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2731973T1 true SI2731973T1 (en) | 2018-04-30 |
Family
ID=46545736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231206T SI2731973T1 (en) | 2011-07-13 | 2012-07-13 | A bacterial host strain expressing a recombinant DSBC |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US9725516B2 (forum.php) |
| EP (2) | EP2731973B1 (forum.php) |
| JP (3) | JP6431370B2 (forum.php) |
| KR (1) | KR102023786B1 (forum.php) |
| CN (1) | CN103649124B (forum.php) |
| AU (1) | AU2012283388B2 (forum.php) |
| BR (1) | BR112013032871B1 (forum.php) |
| CA (1) | CA2841824C (forum.php) |
| CY (1) | CY1119985T1 (forum.php) |
| DK (1) | DK2731973T3 (forum.php) |
| EA (1) | EA031449B1 (forum.php) |
| ES (1) | ES2659155T3 (forum.php) |
| HR (1) | HRP20180226T1 (forum.php) |
| HU (1) | HUE035674T2 (forum.php) |
| IL (1) | IL229947B (forum.php) |
| IN (1) | IN2014DN00202A (forum.php) |
| LT (1) | LT2731973T (forum.php) |
| ME (1) | ME02957B (forum.php) |
| MX (1) | MX348738B (forum.php) |
| NO (1) | NO2731973T3 (forum.php) |
| PL (1) | PL2731973T3 (forum.php) |
| PT (1) | PT2731973T (forum.php) |
| RS (1) | RS56926B1 (forum.php) |
| SG (1) | SG10201807560XA (forum.php) |
| SI (1) | SI2731973T1 (forum.php) |
| SM (1) | SMT201800068T1 (forum.php) |
| WO (1) | WO2013007388A1 (forum.php) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ580245A (en) * | 2007-03-22 | 2012-01-12 | Biogen Idec Inc | Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof |
| EP2993231B1 (en) | 2009-09-24 | 2018-08-01 | UCB Biopharma SPRL | Bacterial strain for recombinant protein expression, having protease deficient degp retaining chaperone activity, and knocked out tsp and ptr genes |
| GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201000591D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
| NO2731973T3 (forum.php) * | 2011-07-13 | 2018-04-14 | ||
| GB201208367D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
| GB201223276D0 (en) * | 2012-12-21 | 2013-02-06 | Ucb Pharma Sa | Antibodies and methods of producing same |
| MX390701B (es) | 2014-12-22 | 2025-03-21 | Ucb Biopharma Sprl | Manufactura de proteína. |
| KR101810778B1 (ko) * | 2015-06-23 | 2017-12-20 | 서울대학교산학협력단 | Cd154 결합 폴리펩타이드 및 그 용도 |
| RU2018128784A (ru) | 2016-01-27 | 2020-02-27 | МЕДИММЬЮН, ЭлЭлСи | Способы получения антител с заданным профилем гликозилирования |
| WO2019193418A1 (en) | 2018-04-05 | 2019-10-10 | Bio-Rad Abd Serotec Gmbh | Display systems for proteins of interest |
| EP3877407A1 (en) * | 2018-11-05 | 2021-09-15 | F. Hoffmann-La Roche AG | Methods of producing two chain proteins in prokaryotic host cells |
| CN109371049A (zh) * | 2018-11-14 | 2019-02-22 | 天津大学 | 分子伴侣在促进单克隆抗体的形成和/或提高单克隆抗体的表达量中的应用 |
| US11674164B2 (en) | 2019-03-18 | 2023-06-13 | Bio-Rad Abd Serotec Gmbh | Periplasmic fusion proteins |
| PL4010500T3 (pl) * | 2019-08-05 | 2025-06-23 | Wacker Chemie Ag | Szczep bakteryjny do uwalniania białka rekombinowanego w sposobie fermentacji |
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| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| GB8907617D0 (en) | 1989-04-05 | 1989-05-17 | Celltech Ltd | Drug delivery system |
| US5508192A (en) | 1990-11-09 | 1996-04-16 | Board Of Regents, The University Of Texas System | Bacterial host strains for producing proteolytically sensitive polypeptides |
| US5264365A (en) | 1990-11-09 | 1993-11-23 | Board Of Regents, The University Of Texas System | Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides |
| GB9112536D0 (en) | 1991-06-11 | 1991-07-31 | Celltech Ltd | Chemical compounds |
| US5474771A (en) | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| JPH08500963A (ja) | 1992-04-28 | 1996-02-06 | ザ・リージェンツ・オブ・ザ・ユニヴァーシティー・オブ・ミシガン | ヒューマンｃｒａｂｐ−▲ｉ▼及びｃｒａｂｐ−▲ｉｉ▼ |
| GB9215540D0 (en) | 1992-07-22 | 1992-09-02 | Celltech Ltd | Protein expression system |
| US5304472A (en) | 1992-11-20 | 1994-04-19 | Genentech, Inc. | Method of controlling polypeptide production in bacterial cells |
| US5639635A (en) | 1994-11-03 | 1997-06-17 | Genentech, Inc. | Process for bacterial production of polypeptides |
| AU2660397A (en) | 1996-04-05 | 1997-10-29 | Board Of Regents, The University Of Texas System | Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells |
| GB9625640D0 (en) | 1996-12-10 | 1997-01-29 | Celltech Therapeutics Ltd | Biological products |
| US6083715A (en) | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
| JP2000083670A (ja) | 1998-09-09 | 2000-03-28 | Hsp Kenkyusho:Kk | ＤｓｂＡ／ＤｓｂＢ／ＤｓｂＣ／ＤｓｂＤ発現プラスミド |
| US6306619B1 (en) | 1999-06-29 | 2001-10-23 | Washington University | DegP periplasmic protease a new anti-infective target and an in vitro assay for DegP protease function |
| GB0006398D0 (en) | 2000-03-16 | 2000-05-03 | Novartis Ag | Organic compounds |
| GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| WO2002018446A2 (en) | 2000-09-01 | 2002-03-07 | Biogen, Inc. | Methods of designing and producing compounds having improved binding affinity for cd154 or other trimeric proteins |
| AU8867501A (en) | 2000-09-01 | 2002-03-13 | Biogen Inc | Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design |
| US7041479B2 (en) | 2000-09-06 | 2006-05-09 | The Board Of Trustess Of The Leland Stanford Junior University | Enhanced in vitro synthesis of active proteins containing disulfide bonds |
| DE60135498D1 (de) * | 2000-12-14 | 2008-10-02 | Genentech Inc | Produktion von ganzen Antikörpern in prokaryontischen Zellen |
| CZ304484B6 (cs) | 2000-12-14 | 2014-05-21 | Genentech, Inc. | Bakteriální hostitelské kmeny a způsob tvorby polypeptidu |
| TWI334439B (en) | 2001-08-01 | 2010-12-11 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
| MXPA04001566A (es) | 2001-08-27 | 2004-05-17 | Genentech Inc | Un sistema para expresion y ensamblado de anticuerpos. |
| GB0124317D0 (en) | 2001-10-10 | 2001-11-28 | Celltech R&D Ltd | Biological products |
| WO2003048306A2 (en) | 2001-11-16 | 2003-06-12 | Idec Pharmaceuticals Corporation | Polycistronic expression of antibodies |
| GB0129105D0 (en) * | 2001-12-05 | 2002-01-23 | Celltech R&D Ltd | Expression control using variable intergenic sequences |
| SI1517921T1 (sl) | 2002-06-28 | 2006-10-31 | Domantis Ltd | Dvojno-specificni ligandi z zvisano serumsko razpolovno dobo |
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| ATE482235T1 (de) | 2003-06-13 | 2010-10-15 | Biogen Idec Inc | Aglycosyl-anti-cd154 (cd40-ligand) antikörper und deren verwendungen |
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| GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| GB0315450D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
| AU2004261198A1 (en) | 2003-07-26 | 2005-02-10 | Biogen Idec Ma Inc. | Altered antibodies having improved antigen-binding affinity |
| JP5102028B2 (ja) | 2004-07-26 | 2012-12-19 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 抗ｃｄ１５４抗体 |
| JP2008511337A (ja) * | 2004-09-02 | 2008-04-17 | ジェネンテック・インコーポレーテッド | ヘテロ多量体分子 |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| GB0425534D0 (en) | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Process for obtaining antibodies |
| GB0520169D0 (en) | 2005-10-04 | 2005-11-09 | Celltech R&D Ltd | Biological products |
| NZ580245A (en) * | 2007-03-22 | 2012-01-12 | Biogen Idec Inc | Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof |
| EP2535349A1 (en) | 2007-09-26 | 2012-12-19 | UCB Pharma S.A. | Dual specificity antibody fusions |
| US7662587B1 (en) | 2009-03-05 | 2010-02-16 | E. I. Du Pont De Nemours And Company | Gene knockout mutations that increase peptide production |
| EP2993231B1 (en) | 2009-09-24 | 2018-08-01 | UCB Biopharma SPRL | Bacterial strain for recombinant protein expression, having protease deficient degp retaining chaperone activity, and knocked out tsp and ptr genes |
| US8470552B2 (en) | 2009-10-12 | 2013-06-25 | Keck Graduate Institute | Strategy to reduce lactic acid production and control PH in animal cell culture |
| CA2780143A1 (en) * | 2009-11-05 | 2011-05-12 | Genentech, Inc. | Methods and composition for secretion of heterologous polypeptides |
| GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201000588D0 (en) * | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201000591D0 (en) * | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201001791D0 (en) | 2010-02-03 | 2010-03-24 | Ucb Pharma Sa | Process for obtaining antibodies |
| GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
| NO2731973T3 (forum.php) | 2011-07-13 | 2018-04-14 | ||
| EP2546267A1 (en) | 2011-07-13 | 2013-01-16 | UCB Pharma S.A. | Bacterial host strain expressing recombinant DsbC |
| GB201208367D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
-
2012
- 2012-07-13 NO NO12737492A patent/NO2731973T3/no unknown
- 2012-07-13 DK DK12737492.4T patent/DK2731973T3/da active
- 2012-07-13 SG SG10201807560XA patent/SG10201807560XA/en unknown
- 2012-07-13 AU AU2012283388A patent/AU2012283388B2/en active Active
- 2012-07-13 IN IN202DEN2014 patent/IN2014DN00202A/en unknown
- 2012-07-13 EP EP12737492.4A patent/EP2731973B1/en active Active
- 2012-07-13 RS RS20180171A patent/RS56926B1/sr unknown
- 2012-07-13 ME MEP-2018-33A patent/ME02957B/me unknown
- 2012-07-13 HU HUE12737492A patent/HUE035674T2/en unknown
- 2012-07-13 CA CA2841824A patent/CA2841824C/en active Active
- 2012-07-13 WO PCT/EP2012/002945 patent/WO2013007388A1/en active Application Filing
- 2012-07-13 JP JP2014519454A patent/JP6431370B2/ja active Active
- 2012-07-13 EP EP17196968.6A patent/EP3339325A1/en not_active Withdrawn
- 2012-07-13 KR KR1020137034718A patent/KR102023786B1/ko active Active
- 2012-07-13 SM SM20180068T patent/SMT201800068T1/it unknown
- 2012-07-13 HR HRP20180226TT patent/HRP20180226T1/hr unknown
- 2012-07-13 LT LTEP12737492.4T patent/LT2731973T/lt unknown
- 2012-07-13 CN CN201280034512.9A patent/CN103649124B/zh active Active
- 2012-07-13 PL PL12737492T patent/PL2731973T3/pl unknown
- 2012-07-13 ES ES12737492.4T patent/ES2659155T3/es active Active
- 2012-07-13 EA EA201490274A patent/EA031449B1/ru not_active IP Right Cessation
- 2012-07-13 SI SI201231206T patent/SI2731973T1/en unknown
- 2012-07-13 PT PT127374924T patent/PT2731973T/pt unknown
- 2012-07-13 BR BR112013032871-1A patent/BR112013032871B1/pt active IP Right Grant
- 2012-07-13 MX MX2014000302A patent/MX348738B/es active IP Right Grant
- 2012-07-13 US US14/131,994 patent/US9725516B2/en active Active
-
2013
- 2013-12-17 IL IL22994713A patent/IL229947B/en active IP Right Grant
-
2017
- 2017-08-03 US US15/667,649 patent/US9957328B2/en active Active
- 2017-10-31 JP JP2017209932A patent/JP2018019719A/ja active Pending
-
2018
- 2018-02-15 CY CY20181100192T patent/CY1119985T1/el unknown
-
2019
- 2019-11-01 JP JP2019200029A patent/JP7062626B2/ja active Active
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