SI2729130T1 - Combined formulations of darunavir - Google Patents
Combined formulations of darunavir Download PDFInfo
- Publication number
- SI2729130T1 SI2729130T1 SI201231141T SI201231141T SI2729130T1 SI 2729130 T1 SI2729130 T1 SI 2729130T1 SI 201231141 T SI201231141 T SI 201231141T SI 201231141 T SI201231141 T SI 201231141T SI 2729130 T1 SI2729130 T1 SI 2729130T1
- Authority
- SI
- Slovenia
- Prior art keywords
- dosage form
- oral dosage
- darunavir
- form according
- silicon dioxide
- Prior art date
Links
- CJBJHOAVZSMMDJ-HEXNFIEUSA-N darunavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)C1=CC=CC=C1 CJBJHOAVZSMMDJ-HEXNFIEUSA-N 0.000 title claims abstract 8
- 229960005107 darunavir Drugs 0.000 title claims abstract 8
- 239000000203 mixture Substances 0.000 title claims abstract 7
- 238000009472 formulation Methods 0.000 title claims abstract 3
- 239000006186 oral dosage form Substances 0.000 claims abstract 12
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 239000012453 solvate Substances 0.000 claims abstract 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 8
- ZCIGNRJZKPOIKD-CQXVEOKZSA-N cobicistat Chemical compound S1C(C(C)C)=NC(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC=2C=CC=CC=2)NC(=O)OCC=2SC=NC=2)CC=2C=CC=CC=2)=C1 ZCIGNRJZKPOIKD-CQXVEOKZSA-N 0.000 claims 6
- 229960002402 cobicistat Drugs 0.000 claims 6
- 239000000314 lubricant Substances 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- 229960003943 hypromellose Drugs 0.000 claims 3
- 239000000377 silicon dioxide Substances 0.000 claims 3
- 235000012239 silicon dioxide Nutrition 0.000 claims 3
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 2
- 239000007884 disintegrant Substances 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000007580 dry-mixing Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 229920003125 hypromellose 2910 Polymers 0.000 claims 1
- 229940031672 hypromellose 2910 Drugs 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11173067 | 2011-07-07 | ||
| PCT/EP2012/063249 WO2013004818A1 (en) | 2011-07-07 | 2012-07-06 | Darunavir combination formulations |
| EP12738060.8A EP2729130B1 (en) | 2011-07-07 | 2012-07-06 | Darunavir combination formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2729130T1 true SI2729130T1 (en) | 2018-03-30 |
Family
ID=46551505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231141T SI2729130T1 (en) | 2011-07-07 | 2012-07-06 | Combined formulations of darunavir |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20140142070A1 (enExample) |
| EP (1) | EP2729130B1 (enExample) |
| JP (1) | JP6122427B2 (enExample) |
| KR (1) | KR102058097B1 (enExample) |
| CN (1) | CN103826616B (enExample) |
| AU (1) | AU2012280198B2 (enExample) |
| BR (1) | BR112014000290B1 (enExample) |
| CA (1) | CA2838659C (enExample) |
| CY (1) | CY1121999T1 (enExample) |
| DK (1) | DK2729130T3 (enExample) |
| EA (1) | EA026587B1 (enExample) |
| ES (1) | ES2651212T3 (enExample) |
| HR (1) | HRP20171889T1 (enExample) |
| HU (1) | HUE035241T2 (enExample) |
| IL (1) | IL229933A (enExample) |
| LT (1) | LT2729130T (enExample) |
| MX (1) | MX343689B (enExample) |
| NO (1) | NO2729130T3 (enExample) |
| PL (1) | PL2729130T3 (enExample) |
| PT (1) | PT2729130T (enExample) |
| RS (1) | RS56667B1 (enExample) |
| SI (1) | SI2729130T1 (enExample) |
| SM (1) | SMT201700574T1 (enExample) |
| WO (1) | WO2013004818A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140142070A1 (en) | 2011-07-07 | 2014-05-22 | Janssen R&D Ireland | Darunavir combination formulations |
| JP2015508822A (ja) * | 2012-03-01 | 2015-03-23 | ギリアード サイエンシーズ， インコーポレイテッド | 噴霧乾燥製剤 |
| DK3067358T3 (da) | 2012-12-21 | 2019-11-04 | Gilead Sciences Inc | Polycykliske carbamoylpyridon-forbindelser og deres farmaceutiske anvendelse |
| SI3346995T1 (sl) | 2015-11-09 | 2019-11-29 | Gilead Sciences Inc | Terapevtski sestavek za zdravljenje virusa človeške imunske pomanjkljivosti |
| WO2018029566A1 (en) * | 2016-08-08 | 2018-02-15 | Hetero Labs Limited | A high drug loaded tablet composition for treating hiv |
| ES2952878T3 (es) * | 2016-08-08 | 2023-11-06 | Hetero Labs Ltd | Una composición antirretroviral multiclase |
| EP3496718A4 (en) | 2016-08-08 | 2020-01-22 | Hetero Labs Limited | ANTIRETROVIRAL COMPOSITIONS |
| EP3518935A1 (en) * | 2016-09-27 | 2019-08-07 | Gilead Sciences, Inc. | Therapeutic compositions for treatment of human immunodeficiency virus |
| BR112020000842A2 (pt) | 2017-07-20 | 2020-07-21 | Janssen Sciences Ireland Unlimited Company | composições e métodos para tratamento do hiv |
| WO2020064980A1 (en) | 2018-09-28 | 2020-04-02 | Janssen Sciences Ireland Unlimited Company | Methods of treating and preventing neuropsychiatric and/or neurocognitive complications in patients infected with hiv |
| WO2021180963A1 (en) | 2020-03-13 | 2021-09-16 | Janssen Sciences Ireland Unlimited Company | A protease inhibitor regimen for treating subjects infected with hiv |
| CN119700779B (zh) * | 2024-11-28 | 2025-11-04 | 安徽贝克生物制药有限公司 | 一种达芦那韦和考比司他复合片剂及其制备方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| DK0715618T3 (da) | 1993-08-24 | 1999-08-23 | Searle & Co | Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
| PT2336134T (pt) | 1998-06-23 | 2016-10-19 | The Board Of Trustees Of The Univ Of Illionis | Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia |
| AR037797A1 (es) | 2001-12-12 | 2004-12-01 | Tibotec Pharm Ltd | Combinacion de inhibidores de proteasa dependientes del citocromo p450 |
| JP4864320B2 (ja) | 2002-05-16 | 2012-02-01 | テイボテク・フアーマシユーチカルズ・リミテツド | Ｈｉｖプロテアーゼ阻害剤の疑似多形相 |
| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
| JP5285603B2 (ja) | 2006-05-30 | 2013-09-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒスタミンｈ３受容体のモジュレーターとしての置換ピリジルアミド化合物 |
| US20080039428A1 (en) * | 2006-06-29 | 2008-02-14 | Panacos Pharmaceuticals, Inc. | Antiretroviral combination therapy |
| AR061838A1 (es) | 2006-07-07 | 2008-09-24 | Gilead Sciences Inc | Moduladores de propiedades farmacocineticas de terapeuticos |
| US20080113021A1 (en) * | 2006-10-25 | 2008-05-15 | Robert Shen | Ibuprofen composition |
| TWI533868B (zh) | 2007-02-23 | 2016-05-21 | 吉李德科學股份有限公司 | 治療劑藥物動力學性質之調節劑 |
| AU2008267237A1 (en) * | 2007-06-25 | 2008-12-31 | Tibotec Pharmaceuticals | Combination formulations comprising darunavir and etravirine |
| AR069539A1 (es) * | 2007-07-25 | 2010-02-03 | Tibotec Pharm Ltd | Avances respecto de las formulaciones de comprimidos contra el vih |
| MY158253A (en) | 2007-11-20 | 2016-09-30 | Janssen Pharmaceutica Nv | Cycloalkyloxy- and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor |
| PA8809601A1 (es) * | 2007-12-24 | 2009-07-23 | Cipla Ltd | Combinación anti-retroviral |
| SG10201609006WA (en) * | 2008-05-02 | 2016-12-29 | Gilead Sciences Inc | The use of solid carrier particles to improve the processability of a pharmaceutical agent |
| US20100285122A1 (en) * | 2009-02-06 | 2010-11-11 | Gilead Sciences, Inc. | Tablets for combination therapy |
| PL2477992T3 (pl) * | 2009-09-17 | 2017-07-31 | Mylan Laboratories Limited | Proces przygotowania Darunawiru i jego amorficznych postaci |
| ES2699183T3 (es) | 2010-05-10 | 2019-02-07 | Hetero Research Foundation | Composiciones de darunavir |
| DK2729128T3 (en) | 2011-07-07 | 2016-11-21 | Janssen Sciences Ireland Uc | Darunavir-FORMULATIONS |
| US20140142070A1 (en) | 2011-07-07 | 2014-05-22 | Janssen R&D Ireland | Darunavir combination formulations |
| AU2012327170A1 (en) | 2012-02-03 | 2013-08-22 | Gilead Sciences, Inc. | Therapeutic compounds |
| US20170348334A1 (en) | 2015-01-03 | 2017-12-07 | Mylan Laboratories Limited | Processes for the preparation of amorphous tenofovir alafenamide hemifumarate and a premix thereof |
-
2012
- 2012-07-06 US US14/131,282 patent/US20140142070A1/en not_active Abandoned
- 2012-07-06 HU HUE12738060A patent/HUE035241T2/en unknown
- 2012-07-06 ES ES12738060.8T patent/ES2651212T3/es active Active
- 2012-07-06 DK DK12738060.8T patent/DK2729130T3/en active
- 2012-07-06 MX MX2013015199A patent/MX343689B/es active IP Right Grant
- 2012-07-06 RS RS20171244A patent/RS56667B1/sr unknown
- 2012-07-06 SI SI201231141T patent/SI2729130T1/en unknown
- 2012-07-06 NO NO12738060A patent/NO2729130T3/no unknown
- 2012-07-06 CA CA2838659A patent/CA2838659C/en active Active
- 2012-07-06 EA EA201490222A patent/EA026587B1/ru unknown
- 2012-07-06 JP JP2014517822A patent/JP6122427B2/ja active Active
- 2012-07-06 SM SM20170574T patent/SMT201700574T1/it unknown
- 2012-07-06 KR KR1020147000092A patent/KR102058097B1/ko active Active
- 2012-07-06 PL PL12738060T patent/PL2729130T3/pl unknown
- 2012-07-06 PT PT127380608T patent/PT2729130T/pt unknown
- 2012-07-06 HR HRP20171889TT patent/HRP20171889T1/hr unknown
- 2012-07-06 WO PCT/EP2012/063249 patent/WO2013004818A1/en not_active Ceased
- 2012-07-06 AU AU2012280198A patent/AU2012280198B2/en active Active
- 2012-07-06 CN CN201280033554.0A patent/CN103826616B/zh active Active
- 2012-07-06 LT LTEP12738060.8T patent/LT2729130T/lt unknown
- 2012-07-06 BR BR112014000290-8A patent/BR112014000290B1/pt active IP Right Grant
- 2012-07-06 EP EP12738060.8A patent/EP2729130B1/en active Active
-
2013
- 2013-12-17 IL IL229933A patent/IL229933A/en active IP Right Grant
-
2017
- 2017-12-05 CY CY20171101267T patent/CY1121999T1/el unknown
-
2019
- 2019-11-27 US US16/697,888 patent/US11654150B2/en active Active
-
2023
- 2023-05-05 US US18/313,266 patent/US20230302024A1/en active Pending
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