BR112014000290A2 - formulações de combinação de darunavir - Google Patents
formulações de combinação de darunavirInfo
- Publication number
- BR112014000290A2 BR112014000290A2 BR112014000290A BR112014000290A BR112014000290A2 BR 112014000290 A2 BR112014000290 A2 BR 112014000290A2 BR 112014000290 A BR112014000290 A BR 112014000290A BR 112014000290 A BR112014000290 A BR 112014000290A BR 112014000290 A2 BR112014000290 A2 BR 112014000290A2
- Authority
- BR
- Brazil
- Prior art keywords
- darunavir
- combination formulations
- formulations
- solvate
- hiv
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Abstract
resumo patente de invenção: "formulações de combinação de darunavir". esta invenção refere-se a formas de dosagem oral sólidas do inibidor do hiv darunavir e/ou um seu sal ou solvato farmaceuticamente aceitável, e a suas formulações de combinação.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11173067 | 2011-07-07 | ||
EP11173067.7 | 2011-07-07 | ||
PCT/EP2012/063249 WO2013004818A1 (en) | 2011-07-07 | 2012-07-06 | Darunavir combination formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014000290A2 true BR112014000290A2 (pt) | 2017-02-07 |
BR112014000290B1 BR112014000290B1 (pt) | 2022-05-10 |
Family
ID=46551505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014000290-8A BR112014000290B1 (pt) | 2011-07-07 | 2012-07-06 | Forma de dosagem oral de combinação de darunavir, processo para preparação de uma forma de dosagem oral e uso de granulado de darunavir |
Country Status (23)
Country | Link |
---|---|
US (3) | US20140142070A1 (pt) |
EP (1) | EP2729130B1 (pt) |
JP (1) | JP6122427B2 (pt) |
KR (1) | KR102058097B1 (pt) |
CN (1) | CN103826616B (pt) |
AU (1) | AU2012280198B2 (pt) |
BR (1) | BR112014000290B1 (pt) |
CA (1) | CA2838659C (pt) |
CY (1) | CY1121999T1 (pt) |
DK (1) | DK2729130T3 (pt) |
EA (1) | EA026587B1 (pt) |
ES (1) | ES2651212T3 (pt) |
HR (1) | HRP20171889T1 (pt) |
HU (1) | HUE035241T2 (pt) |
IL (1) | IL229933A (pt) |
LT (1) | LT2729130T (pt) |
MX (1) | MX343689B (pt) |
NO (1) | NO2729130T3 (pt) |
PL (1) | PL2729130T3 (pt) |
PT (1) | PT2729130T (pt) |
RS (1) | RS56667B1 (pt) |
SI (1) | SI2729130T1 (pt) |
WO (1) | WO2013004818A1 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE035241T2 (en) | 2011-07-07 | 2018-05-02 | Janssen Sciences Ireland Uc | Darunavir combination products |
WO2013130766A1 (en) * | 2012-03-01 | 2013-09-06 | Gilead Sciences, Inc. | Spray dried formulations |
CA3012242C (en) | 2012-12-21 | 2021-11-02 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
EP3632415A1 (en) | 2015-11-09 | 2020-04-08 | Gilead Sciences, Inc. | Therapeutic compositions for treatment of human immunodeficiency virus |
US20190175509A1 (en) * | 2016-08-08 | 2019-06-13 | Hetero Labs Limited | High Drug Loaded Tablet Composition for Treating HIV |
EP3496719B1 (en) * | 2016-08-08 | 2023-06-14 | Hetero Labs Limited | A multi-class anti-retroviral composition |
WO2018029561A1 (en) | 2016-08-08 | 2018-02-15 | Hetero Labs Limited | Anti-retroviral compositions |
US20180085387A1 (en) * | 2016-09-27 | 2018-03-29 | Gilead Sciences, Inc. | Therapeutic compositions for treatment of human immunodeficiency virus |
US10786518B2 (en) * | 2017-07-20 | 2020-09-29 | Janssen Sciences Ireland Uc | Compositions and methods of treating HIV |
US20200101093A1 (en) | 2018-09-28 | 2020-04-02 | Janssen Sciences Ireland Unlimited Company | Methods of Treating and Preventing Neuropsychiatric and/or Neurocognitive Complications in Patients Infected with HIV |
WO2021180963A1 (en) | 2020-03-13 | 2021-09-16 | Janssen Sciences Ireland Unlimited Company | A protease inhibitor regimen for treating subjects infected with hiv |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
ES2127938T3 (es) | 1993-08-24 | 1999-05-01 | Searle & Co | Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas. |
AU771780B2 (en) | 1998-06-23 | 2004-04-01 | Board Of Trustees Of The University Of Illinois, The | Fitness assay and associated methods |
TWI286476B (en) | 2001-12-12 | 2007-09-11 | Tibotec Pharm Ltd | Combination of cytochrome P450 dependent protease inhibitors |
HUE034389T2 (en) | 2002-05-16 | 2018-02-28 | Janssen Sciences Ireland Uc | Pseudopolymorphic forms of an HIV protease inhibitor |
TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
WO2007143422A2 (en) | 2006-05-30 | 2007-12-13 | Janssen Pharmaceutica N.V. | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor |
US20080039428A1 (en) * | 2006-06-29 | 2008-02-14 | Panacos Pharmaceuticals, Inc. | Antiretroviral combination therapy |
TWI411613B (zh) | 2006-07-07 | 2013-10-11 | Gilead Sciences Inc | 用於改善被細胞色素p450單氧合酶所代謝之治療劑的藥物動力性質之調節劑 |
MX2009004439A (es) * | 2006-10-25 | 2009-05-11 | Mcneil Ppc Inc | Composicion de ibuprofeno. |
MX2009008935A (es) | 2007-02-23 | 2009-11-02 | Gilead Sciences Inc | Moduladores de las propiedades farmacocineticas de productos terapeuticos. |
US20100190809A1 (en) | 2007-06-25 | 2010-07-29 | Jody Firmin Voorspoels | Combination formulations |
AR069539A1 (es) | 2007-07-25 | 2010-02-03 | Tibotec Pharm Ltd | Avances respecto de las formulaciones de comprimidos contra el vih |
NZ584998A (en) | 2007-11-20 | 2012-08-31 | Janssen Pharmaceutica Nv | Cycloalkyloxy-and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor |
GT200800303A (es) * | 2007-12-24 | 2009-09-18 | Combinacion anti-retroviral | |
EA201591353A1 (ru) * | 2008-05-02 | 2016-01-29 | Джилид Сайэнс, Инк. | Применение частиц твердого носителя для улучшения технологических характеристик фармацевтического агента |
PE20110994A1 (es) * | 2009-02-06 | 2012-01-24 | Gilead Sciences Inc | Comprimidos antivirales que comprenden elvitegravir, emtricitabina, disoproxil fumarato de tenofovir y un derivado de tiazol |
CA2776807C (en) * | 2009-09-17 | 2018-10-16 | Mylan Laboratories Limited | An improved process for the preparation of darunavir |
WO2011141921A1 (en) | 2010-05-10 | 2011-11-17 | Hetero Research Foundation | Darunavir compositions |
HUE035241T2 (en) | 2011-07-07 | 2018-05-02 | Janssen Sciences Ireland Uc | Darunavir combination products |
BR112014000195A2 (pt) | 2011-07-07 | 2017-02-21 | Janssen R&D Ireland | formulações de darunavir |
WO2013115916A1 (en) | 2012-02-03 | 2013-08-08 | Gilead Sciences, Inc. | Combination therapy comprising gs-7340 and cobicistat for use in the treatment of viral infections |
JP2018502118A (ja) | 2015-01-03 | 2018-01-25 | マイラン・ラボラトリーズ・リミテッドMylan Laboratories Limited | 非晶質ヘミフマル酸テノホビルアラフェナミドおよびその予備混合物を調製するプロセス |
-
2012
- 2012-07-06 HU HUE12738060A patent/HUE035241T2/en unknown
- 2012-07-06 SI SI201231141T patent/SI2729130T1/en unknown
- 2012-07-06 LT LTEP12738060.8T patent/LT2729130T/lt unknown
- 2012-07-06 NO NO12738060A patent/NO2729130T3/no unknown
- 2012-07-06 WO PCT/EP2012/063249 patent/WO2013004818A1/en active Application Filing
- 2012-07-06 US US14/131,282 patent/US20140142070A1/en not_active Abandoned
- 2012-07-06 ES ES12738060.8T patent/ES2651212T3/es active Active
- 2012-07-06 KR KR1020147000092A patent/KR102058097B1/ko active IP Right Grant
- 2012-07-06 JP JP2014517822A patent/JP6122427B2/ja active Active
- 2012-07-06 EP EP12738060.8A patent/EP2729130B1/en active Active
- 2012-07-06 EA EA201490222A patent/EA026587B1/ru unknown
- 2012-07-06 BR BR112014000290-8A patent/BR112014000290B1/pt active IP Right Grant
- 2012-07-06 DK DK12738060.8T patent/DK2729130T3/en active
- 2012-07-06 AU AU2012280198A patent/AU2012280198B2/en active Active
- 2012-07-06 RS RS20171244A patent/RS56667B1/sr unknown
- 2012-07-06 CA CA2838659A patent/CA2838659C/en active Active
- 2012-07-06 PL PL12738060T patent/PL2729130T3/pl unknown
- 2012-07-06 MX MX2013015199A patent/MX343689B/es active IP Right Grant
- 2012-07-06 CN CN201280033554.0A patent/CN103826616B/zh active Active
- 2012-07-06 PT PT127380608T patent/PT2729130T/pt unknown
-
2013
- 2013-12-17 IL IL229933A patent/IL229933A/en active IP Right Grant
-
2017
- 2017-12-05 HR HRP20171889TT patent/HRP20171889T1/hr unknown
- 2017-12-05 CY CY20171101267T patent/CY1121999T1/el unknown
-
2019
- 2019-11-27 US US16/697,888 patent/US11654150B2/en active Active
-
2023
- 2023-05-05 US US18/313,266 patent/US20230302024A1/en active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: GILEAD SCIENCES, INC. (US) , JANSSEN SCIENCES IREL |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/07/2012, OBSERVADAS AS CONDICOES LEGAIS |