JP2014070061A5 - - Google Patents
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- JP2014070061A5 JP2014070061A5 JP2012219334A JP2012219334A JP2014070061A5 JP 2014070061 A5 JP2014070061 A5 JP 2014070061A5 JP 2012219334 A JP2012219334 A JP 2012219334A JP 2012219334 A JP2012219334 A JP 2012219334A JP 2014070061 A5 JP2014070061 A5 JP 2014070061A5
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- JP
- Japan
- Prior art keywords
- weight
- total amount
- amount
- formulation
- tablet according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 26
- 238000009472 formulation Methods 0.000 claims 16
- 238000002360 preparation method Methods 0.000 claims 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims 8
- 239000000314 lubricant Substances 0.000 claims 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 6
- 239000011230 binding agent Substances 0.000 claims 5
- 235000019359 magnesium stearate Nutrition 0.000 claims 4
- CVWXJKQAOSCOAB-UHFFFAOYSA-N quizartinib Chemical compound O1C(C(C)(C)C)=CC(NC(=O)NC=2C=CC(=CC=2)C=2N=C3N(C4=CC=C(OCCN5CCOCC5)C=C4S3)C=2)=N1 CVWXJKQAOSCOAB-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000001913 cellulose Substances 0.000 claims 3
- 229920002678 cellulose Polymers 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000004088 foaming agent Substances 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 2
- -1 5-tert-butyl-isoxazol-3-yl Chemical group 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 125000004190 benzothiazol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N=C(*)SC2=C1[H] 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 238000007922 dissolution test Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims 1
- 239000007888 film coating Substances 0.000 claims 1
- 238000009501 film coating Methods 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 claims 1
- 239000011973 solid acid Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012219334A JP6116847B2 (ja) | 2012-10-01 | 2012-10-01 | シクロデキストリンとの混合体を含有する錠剤 |
| PCT/US2013/062577 WO2014055397A1 (en) | 2012-10-01 | 2013-09-30 | Tablet containing composite with cyclodextrin |
| ES13776660.6T ES2665868T3 (es) | 2012-10-01 | 2013-09-30 | Comprimido que contiene material compuesto con ciclodextrina |
| EP13776660.6A EP2903593B1 (en) | 2012-10-01 | 2013-09-30 | Tablet containing composite with cyclodextrin |
| US14/432,387 US9675549B2 (en) | 2012-10-01 | 2013-09-30 | Tablet containing composite with cyclodextrin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012219334A JP6116847B2 (ja) | 2012-10-01 | 2012-10-01 | シクロデキストリンとの混合体を含有する錠剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014070061A JP2014070061A (ja) | 2014-04-21 |
| JP2014070061A5 true JP2014070061A5 (enExample) | 2015-11-19 |
| JP6116847B2 JP6116847B2 (ja) | 2017-04-19 |
Family
ID=49354944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012219334A Active JP6116847B2 (ja) | 2012-10-01 | 2012-10-01 | シクロデキストリンとの混合体を含有する錠剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9675549B2 (enExample) |
| EP (1) | EP2903593B1 (enExample) |
| JP (1) | JP6116847B2 (enExample) |
| ES (1) | ES2665868T3 (enExample) |
| WO (1) | WO2014055397A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202000092T1 (it) * | 2009-05-14 | 2020-05-08 | Ambit Biosciences Corp | Formulazione essiccata a spruzzo o liofilizzata di ac220 |
| CA2976752C (en) | 2015-02-20 | 2019-12-17 | Daiichi Sankyo Company, Limited | Method for treating cancer by combined use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60161925A (ja) * | 1984-02-02 | 1985-08-23 | Sanwa Kagaku Kenkyusho:Kk | 安定なカリジノゲナーゼ打錠製剤の製法 |
| WO2002002083A1 (en) * | 2000-06-30 | 2002-01-10 | Yamanouchi Pharmaceutical Co., Ltd. | Tablet rapidly disintegrating in mouth and process for producing the same |
| JP5027375B2 (ja) * | 2002-02-20 | 2012-09-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 改良製剤 |
| FR2849029B1 (fr) * | 2002-12-20 | 2005-03-18 | Lafon Labor | Procede de preparation et formes cristallines des enantiomeres optiques du modafinil. |
| JP2005314413A (ja) * | 2004-04-02 | 2005-11-10 | Ono Pharmaceut Co Ltd | 経口投与用医薬組成物 |
| TWI409267B (zh) | 2006-03-17 | 2013-09-21 | Ambit Biosciences Corp | 治療疾病用之咪唑并噻唑化合物 |
| KR101572701B1 (ko) | 2007-09-19 | 2015-11-27 | 암비트 바이오사이언시즈 코포레이션 | Ｎ-(5-ｔｅｒｔ-부틸-이속사졸-3-일)-Ｎ'-[4-[7-(2-모르폴린-4-일-에톡시)이미다조[2,1-Ｂ][1,3]벤조티아졸-2-일]페닐]우레아를 포함하는 고체 형태, 그의 조성물 및 그의 용도 |
| CA2696807C (en) * | 2007-11-08 | 2017-11-28 | Ambit Biosciences Corp. | Methods of administering n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea to treat proliferative disease |
| JP5686736B2 (ja) * | 2008-11-06 | 2015-03-18 | アムビト ビオスシエンセス コルポラチオン | プロテインキナーゼモジュレーターとしてのイミダゾロチアゾール化合物 |
| MX2011009989A (es) * | 2009-03-23 | 2011-10-14 | Ambit Biosciences Corp | Metodos de tratamiento utilizando terapia de combinacion. |
| SMT202000092T1 (it) * | 2009-05-14 | 2020-05-08 | Ambit Biosciences Corp | Formulazione essiccata a spruzzo o liofilizzata di ac220 |
-
2012
- 2012-10-01 JP JP2012219334A patent/JP6116847B2/ja active Active
-
2013
- 2013-09-30 US US14/432,387 patent/US9675549B2/en active Active
- 2013-09-30 EP EP13776660.6A patent/EP2903593B1/en active Active
- 2013-09-30 ES ES13776660.6T patent/ES2665868T3/es active Active
- 2013-09-30 WO PCT/US2013/062577 patent/WO2014055397A1/en not_active Ceased
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