SI2631248T1 - Zdravljenje tumorjev z uporabo specifičnega protitelesa proti L1 - Google Patents
Zdravljenje tumorjev z uporabo specifičnega protitelesa proti L1 Download PDFInfo
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- SI2631248T1 SI2631248T1 SI200831916T SI200831916T SI2631248T1 SI 2631248 T1 SI2631248 T1 SI 2631248T1 SI 200831916 T SI200831916 T SI 200831916T SI 200831916 T SI200831916 T SI 200831916T SI 2631248 T1 SI2631248 T1 SI 2631248T1
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- 206010028980 Neoplasm Diseases 0.000 title claims abstract 6
- 239000002246 antineoplastic agent Substances 0.000 claims 9
- 238000001959 radiotherapy Methods 0.000 claims 9
- 229940127089 cytotoxic agent Drugs 0.000 claims 8
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- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 2
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- RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims 2
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- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
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- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
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- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims 1
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- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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Claims (16)
- Zdravljenje tumorjev z uporabo specifičnega protitelesa proti L1 PATENTNI ZAHTEVKI1. Vezavna molekula, ki je sposobna vezave L1, (a) izbrana iz skupine, ki jo sestavljajo eno verižna protitelesa, scFv, multimeri scFv podobna dvojna-protitelesa (ang.«diabodies«), triaprotitelesa ali tetraprotitelesa, fragmenti protiteles, Fab, tandabs, fleksibilna protitelesa (ang. »flexibodies«), bispecifična protitelesa in himema protitelesa, in/ali (b) , ki obsega vsaj eno domeno Ig, in kjer je vezavna molekula, sposobna vezave L1: (i) je označena s tem, da imajo njene komplementarnost določujoče regije (CDR) naslednje sekvence: LCDR1: RASQDISNYLN (SEQ ID No.: 24), LCDR2: YTSRLHS (SEQ ID No.: 25), LCDR3: QQGNTLPWT (SEQ ID No.: 26), HCDR1: RYWML (SEQ ID No.: 27), HCDR2: EINPRNDRTNYNEKFKT (SEQ ID No.: 28), in HCDR3: GGGYAMDY (SEQ ID No.: 29), in ki veže L1 z afiniteto (KD) najmanj 10'10 M, ali (ii) je označena s tem, da imajo njene komplementarnost določujoče regije (CDR) naslednje sekvence: LCDR1: QDISNY (SEQ ID No.: 30), LCDR2: YTS, LCDR3: QQGNTLPWT (SEQ ID No.: 31), HCDR1: GYTFTRYW (SEQ ID No.: 32), HCDR2: INPRNDRT (SEQ ID No.: 33), in HCDR3: ALGGGYAMDY (SEQ ID No.: 34), in ki veže L1 z afiniteto (KD) najmanj 10'10 M.
- 2. Vezavna molekula, ki je sposobna vezave L1 po zahtevku 1, kjer vezavna molekula veže L1 z afiniteto (KD) vsaj 10'11 M.
- 3. Vezavna molekula, ki je sposobna vezave L1 po zahtevku 1 ali 2, vezana na aktivno substanco, prednostno toksin, citokin, nanodelec ali radionuklid.
- 4. Vezavna molekula, ki je sposobna vezave L1 po katerem koli od zahtevkov 1 do 3, za uporabo pri metodi zdravljenja tumorogeni bolezni.
- 5. Vezavna molekula, ki je sposobna vezave L1 po katerem koli od zahtevkov 1 do 3, za uporabo pri metodi preobčutljivosti tumorskih celic pri pacientu za zdravljenje s kemoterapevtskim zdravilom ali radioterapijo.
- 6. Vezavna molekula, ki je sposobna vezave L1 za uporabo po zahtevku 5, kjer so celice vsaj delno odporne na zdravljenje z omenjenim kemoterapevtskim zdravilom ali radioterapijo.
- 7. Vezavna molekula, ki je sposobna vezave L1 za uporabo po zahtevku 5 ali 6, kjer po senzitizaciji z vezavno molekulo, pacienta nadalje zdravimo z omenjenim kemoterapevtskim zdravilom ali z radioterapijo.
- 8. Vezavna molekula, ki je sposobna vezave L1 za uporabo po zahtevku 4, pri pacientu, ki je bil prej tretiran s kemoterapevtskim zdravilom ali radioterapijo.
- 9. Vezavna molekula, ki je sposobna vezave L1 za uporabo po zahtevku 8, kjer je pacient vsaj delno odporen na zdravljenje z omenjenim kemoterapevtskim zdravilom ali z radioterapijo.
- 10. Vezavna molekula, ki je sposobna vezave L1, (i) za uporabo po zahtevku 4 pri pacientu, ki je vsaj delno odporen na zdravljenje z danim kemoterapevtskim zdravilom ali z radioterapijo, ali (ii) za uporabo po zahtevku 4, pri čemer se vezavna molekula daje v kombinaciji s kemoterapevtskim zdravilom ali z radioterapijo.
- 11. Vezavna molekula, ki je sposobna vezave L1 za uporabo po zahtevku 10, točka (ii), kjer se kemoterapevtsko zdravilo ali radioterapija daje pred vezavno molekulo.
- 12. Vezavna molekula, ki je sposobna vezave L1 za uporabo po katerem koli od zahtevkov 4 do 11, kjer so tumorske celice ali tumorogena bolezen tipa, izbranega iz skupine, ki jo sestavljajo astrocitom, oligodendrogliom, meningiom, nevrofibrom, glioblastom, ependimom, Schvvannom, nevrofibrosarkom, meduloblastom, melanom, rak pankreasa, karcinom prostate, rak glave in vratu, rak dojk, pljučni rak, ovarijski rak, rak endometrija, ledvični rak, nevroblastomi, skvamozni karcinomi, hepatom, rak kolona in mezoteliom ter epidermoidni karcinom ali, kjer so tumorske celice iz epitelijskega tumorja ali je tumorogena bolezen epitelijski tumor.
- 13. Vezavna molekula, ki je sposobna vezave L1 za uporabo po zahtevku 12, kjer je epitelijski tumor rak pankreasa, rak kolona, rak jajčnikov ali rak endometrija.
- 14. Vezavna molekula, ki je sposobna vezave L1 za uporabo po katerem koli zahtevku od 5 do 13, kjer je kemoterapevtsko zdravilo sredstvo škodljivo za DNA, prednostno izbrano iz skupine, ki jo sestavljajo aktinomicin-D, mitomicin C, cisplatin, doksorubicin, etopozid, verapamil, podofilotoksin, 5-FU, taksani, prednostno paklitaksel in karboplatin, ali, kjer je radioterapija izbrana iz skupine, ki jo sestavljajo rentgensko sevanje, UV-sevanje, γ-obsevanje, a- ali β-obsevanje in mikrovalovi.
- 15. Farmacevtski sestavek, ki obsega vezavno molekulo, ki je sposobna vezave L1 po katerem koli od zahtevkov 1 do 3.
- 16. Uporaba vezave molekule, ki je sposobna vezave L1 po katerem koli od zahtevkov 1 do 3, za določanje nivoja proteina L1 v telesnih tkivih ali tekočinah in vitro.
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EP13000027.6A EP2631248B9 (en) | 2007-06-15 | 2008-06-13 | Treatment of tumors using specific anti-L1 antibody |
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NO (1) | NO2631248T3 (sl) |
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WO2012058627A2 (en) * | 2010-10-29 | 2012-05-03 | Miqin Zhang | Pre-targeted nanoparticle system and method for labeling biological particles |
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WO2018026947A1 (en) | 2016-08-02 | 2018-02-08 | Memorial Sloan-Kettering Cancer Center | Treating metastatic cancer and model systems for metastatic disease |
CN113101364B (zh) * | 2018-05-29 | 2023-12-01 | 康诺亚生物医药科技(成都)有限公司 | 一种自免疫抑制剂的开发和应用 |
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