SI2403951T1 - Tumorsko selektivni mutanti adenovirusa e1a in e1b - Google Patents

Tumorsko selektivni mutanti adenovirusa e1a in e1b

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Publication number
SI2403951T1
SI2403951T1 SI201031077T SI201031077T SI2403951T1 SI 2403951 T1 SI2403951 T1 SI 2403951T1 SI 201031077 T SI201031077 T SI 201031077T SI 201031077 T SI201031077 T SI 201031077T SI 2403951 T1 SI2403951 T1 SI 2403951T1
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SI
Slovenia
Prior art keywords
mutants
tumor
selective adenovirus
adenovirus
selective
Prior art date
Application number
SI201031077T
Other languages
English (en)
Slovenian (sl)
Inventor
Tony Reid
Farah Hedjran
Shantanu Kumar
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Publication of SI2403951T1 publication Critical patent/SI2403951T1/sl

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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SI201031077T 2009-03-02 2010-03-02 Tumorsko selektivni mutanti adenovirusa e1a in e1b SI2403951T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15682209P 2009-03-02 2009-03-02
PCT/US2010/025926 WO2010101921A2 (en) 2009-03-02 2010-03-02 Tumor-selective e1a and e1b mutants
EP10749205.0A EP2403951B1 (en) 2009-03-02 2010-03-02 Tumor-selective adenovirus e1a and e1b mutants

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Publication Number Publication Date
SI2403951T1 true SI2403951T1 (sl) 2016-04-29

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SI201031077T SI2403951T1 (sl) 2009-03-02 2010-03-02 Tumorsko selektivni mutanti adenovirusa e1a in e1b
SI201031944T SI3029144T1 (sl) 2009-03-02 2010-03-02 Tumorsko-selektivni adenovirus E1A in E1B mutanti

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SI201031944T SI3029144T1 (sl) 2009-03-02 2010-03-02 Tumorsko-selektivni adenovirus E1A in E1B mutanti

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US (6) US9073980B2 (OSRAM)
EP (4) EP3029144B1 (OSRAM)
JP (5) JP6072414B2 (OSRAM)
KR (4) KR102150027B1 (OSRAM)
CY (1) CY1122385T1 (OSRAM)
DK (2) DK3029144T3 (OSRAM)
ES (2) ES2750305T3 (OSRAM)
HR (2) HRP20151396T1 (OSRAM)
HU (2) HUE026386T2 (OSRAM)
LT (1) LT3029144T (OSRAM)
PL (2) PL2403951T3 (OSRAM)
PT (2) PT3029144T (OSRAM)
SI (2) SI2403951T1 (OSRAM)
SM (2) SMT201900565T1 (OSRAM)
WO (1) WO2010101921A2 (OSRAM)

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SI2403951T1 (sl) 2009-03-02 2016-04-29 The Regents Of The University Of California Tumorsko selektivni mutanti adenovirusa e1a in e1b
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CN113015806A (zh) * 2018-08-31 2021-06-22 奥尔卡治疗有限公司 包含糖原合酶激酶-3(gsk3)编码区的重组的具有复制能力的病毒和杀伤异常细胞的方法
CN114761546A (zh) 2019-10-08 2022-07-15 波士顿学院董事会 含有多个不同非天然氨基酸的蛋白质以及制备和使用此类蛋白质的方法
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EP4114449A2 (en) 2020-03-05 2023-01-11 Neotx Therapeutics Ltd. Methods and compositions for treating cancer with immune cells
CN114262691A (zh) * 2020-09-16 2022-04-01 杭州康万达医药科技有限公司 分离的能够用于表达外源基因的溶瘤腺病毒、载体、治疗剂及其用途
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SI2403951T1 (sl) 2009-03-02 2016-04-29 The Regents Of The University Of California Tumorsko selektivni mutanti adenovirusa e1a in e1b

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US20190136204A1 (en) 2019-05-09
JP2016028035A (ja) 2016-02-25
EP4123030A1 (en) 2023-01-25
KR20110122866A (ko) 2011-11-11
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US11618888B2 (en) 2023-04-04
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EP2403951A4 (en) 2012-08-22
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KR20190104643A (ko) 2019-09-10
SMT201500329B (it) 2016-02-25
US20230272349A1 (en) 2023-08-31
PL2403951T3 (pl) 2016-04-29
PT3029144T (pt) 2019-10-28
DK2403951T3 (en) 2016-01-11
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EP3591059B1 (en) 2022-07-20
HRP20151396T1 (hr) 2016-03-25
HUE046565T2 (hu) 2020-03-30
KR20180049188A (ko) 2018-05-10
JP2018113971A (ja) 2018-07-26
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ES2750305T3 (es) 2020-03-25
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SI3029144T1 (sl) 2019-11-29
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US20250327037A1 (en) 2025-10-23
LT3029144T (lt) 2019-10-25
SMT201900565T1 (it) 2019-11-13
HUE026386T2 (en) 2016-06-28
HRP20191808T1 (hr) 2019-12-27
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WO2010101921A2 (en) 2010-09-10
JP6072414B2 (ja) 2017-02-01
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US20110318311A1 (en) 2011-12-29
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EP2403951B1 (en) 2015-09-30

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