PT3029144T - Mutantes e1a e e1b de adenovírus seletivos de tumor - Google Patents

Mutantes e1a e e1b de adenovírus seletivos de tumor

Info

Publication number
PT3029144T
PT3029144T PT151820867T PT15182086T PT3029144T PT 3029144 T PT3029144 T PT 3029144T PT 151820867 T PT151820867 T PT 151820867T PT 15182086 T PT15182086 T PT 15182086T PT 3029144 T PT3029144 T PT 3029144T
Authority
PT
Portugal
Prior art keywords
mutants
tumor selective
adenoviruses
selective adenoviruses
tumor
Prior art date
Application number
PT151820867T
Other languages
English (en)
Portuguese (pt)
Inventor
Hedjran Farah
Reid Tony
Kumar Shantanu
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of PT3029144T publication Critical patent/PT3029144T/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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PT151820867T 2009-03-02 2010-03-02 Mutantes e1a e e1b de adenovírus seletivos de tumor PT3029144T (pt)

Applications Claiming Priority (1)

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US15682209P 2009-03-02 2009-03-02

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PT3029144T true PT3029144T (pt) 2019-10-28

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PT151820867T PT3029144T (pt) 2009-03-02 2010-03-02 Mutantes e1a e e1b de adenovírus seletivos de tumor
PT107492050T PT2403951E (pt) 2009-03-02 2010-03-02 Mutantes de adenovírus e1a e e1b de tumores

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US (6) US9073980B2 (OSRAM)
EP (4) EP3029144B1 (OSRAM)
JP (5) JP6072414B2 (OSRAM)
KR (4) KR102150027B1 (OSRAM)
CY (1) CY1122385T1 (OSRAM)
DK (2) DK3029144T3 (OSRAM)
ES (2) ES2750305T3 (OSRAM)
HR (2) HRP20151396T1 (OSRAM)
HU (2) HUE026386T2 (OSRAM)
LT (1) LT3029144T (OSRAM)
PL (2) PL2403951T3 (OSRAM)
PT (2) PT3029144T (OSRAM)
SI (2) SI2403951T1 (OSRAM)
SM (2) SMT201900565T1 (OSRAM)
WO (1) WO2010101921A2 (OSRAM)

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EP4114449A2 (en) 2020-03-05 2023-01-11 Neotx Therapeutics Ltd. Methods and compositions for treating cancer with immune cells
CN114262691A (zh) * 2020-09-16 2022-04-01 杭州康万达医药科技有限公司 分离的能够用于表达外源基因的溶瘤腺病毒、载体、治疗剂及其用途
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US20210171917A1 (en) 2021-06-10
SI2403951T1 (sl) 2016-04-29
US20190136204A1 (en) 2019-05-09
JP2016028035A (ja) 2016-02-25
EP4123030A1 (en) 2023-01-25
KR20110122866A (ko) 2011-11-11
EP3029144B1 (en) 2019-07-10
KR102020018B1 (ko) 2019-09-09
US11618888B2 (en) 2023-04-04
JP6375273B2 (ja) 2018-08-15
WO2010101921A3 (en) 2011-01-06
EP2403951A4 (en) 2012-08-22
JP2020078326A (ja) 2020-05-28
KR20190104643A (ko) 2019-09-10
SMT201500329B (it) 2016-02-25
US20230272349A1 (en) 2023-08-31
PL2403951T3 (pl) 2016-04-29
DK2403951T3 (en) 2016-01-11
KR20170077278A (ko) 2017-07-05
EP3591059B1 (en) 2022-07-20
HRP20151396T1 (hr) 2016-03-25
HUE046565T2 (hu) 2020-03-30
KR20180049188A (ko) 2018-05-10
JP2018113971A (ja) 2018-07-26
EP3591059A1 (en) 2020-01-08
KR101752910B1 (ko) 2017-06-30
ES2750305T3 (es) 2020-03-25
JP2012519014A (ja) 2012-08-23
PT2403951E (pt) 2016-01-29
ES2557812T3 (es) 2016-01-28
SI3029144T1 (sl) 2019-11-29
US20160017294A1 (en) 2016-01-21
JP6817979B2 (ja) 2021-01-20
EP3029144A1 (en) 2016-06-08
EP2403951A2 (en) 2012-01-11
US20250327037A1 (en) 2025-10-23
LT3029144T (lt) 2019-10-25
SMT201900565T1 (it) 2019-11-13
HUE026386T2 (en) 2016-06-28
HRP20191808T1 (hr) 2019-12-27
CY1122385T1 (el) 2021-01-27
WO2010101921A2 (en) 2010-09-10
JP6072414B2 (ja) 2017-02-01
KR102150027B1 (ko) 2020-10-26
US20110318311A1 (en) 2011-12-29
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DK3029144T3 (da) 2019-10-21
US9073980B2 (en) 2015-07-07
JP7326396B2 (ja) 2023-08-15
US10876097B2 (en) 2020-12-29
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PL3029144T3 (pl) 2020-06-01
EP2403951B1 (en) 2015-09-30

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