CY1122385T1 - Επιλεκτικα σε ογκο μεταλλαγματα αδενοϊου ε1α και ε1β - Google Patents
Επιλεκτικα σε ογκο μεταλλαγματα αδενοϊου ε1α και ε1βInfo
- Publication number
- CY1122385T1 CY1122385T1 CY20191101067T CY191101067T CY1122385T1 CY 1122385 T1 CY1122385 T1 CY 1122385T1 CY 20191101067 T CY20191101067 T CY 20191101067T CY 191101067 T CY191101067 T CY 191101067T CY 1122385 T1 CY1122385 T1 CY 1122385T1
- Authority
- CY
- Cyprus
- Prior art keywords
- tumor
- selective
- modified
- adeno
- mutants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15682209P | 2009-03-02 | 2009-03-02 | |
| PCT/US2010/025926 WO2010101921A2 (en) | 2009-03-02 | 2010-03-02 | Tumor-selective e1a and e1b mutants |
| EP10749205.0A EP2403951B1 (en) | 2009-03-02 | 2010-03-02 | Tumor-selective adenovirus e1a and e1b mutants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1122385T1 true CY1122385T1 (el) | 2021-01-27 |
Family
ID=42710189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191101067T CY1122385T1 (el) | 2009-03-02 | 2019-10-10 | Επιλεκτικα σε ογκο μεταλλαγματα αδενοϊου ε1α και ε1β |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US9073980B2 (OSRAM) |
| EP (4) | EP3029144B1 (OSRAM) |
| JP (5) | JP6072414B2 (OSRAM) |
| KR (4) | KR102150027B1 (OSRAM) |
| CY (1) | CY1122385T1 (OSRAM) |
| DK (2) | DK3029144T3 (OSRAM) |
| ES (2) | ES2750305T3 (OSRAM) |
| HR (2) | HRP20151396T1 (OSRAM) |
| HU (2) | HUE026386T2 (OSRAM) |
| LT (1) | LT3029144T (OSRAM) |
| PL (2) | PL2403951T3 (OSRAM) |
| PT (2) | PT3029144T (OSRAM) |
| SI (2) | SI2403951T1 (OSRAM) |
| SM (2) | SMT201900565T1 (OSRAM) |
| WO (1) | WO2010101921A2 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2403951T1 (sl) | 2009-03-02 | 2016-04-29 | The Regents Of The University Of California | Tumorsko selektivni mutanti adenovirusa e1a in e1b |
| CA2903582C (en) | 2013-03-14 | 2021-06-08 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
| CN106062207B (zh) | 2013-07-19 | 2020-07-03 | 路德维格癌症研究有限公司 | 全基因组且靶向的单体型重构 |
| WO2017147265A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
| JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
| CA3038526A1 (en) * | 2016-09-27 | 2018-04-05 | Epicentrx, Inc. | Immunomodulatory fusion proteins |
| CA3045892A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
| US10232053B2 (en) * | 2016-12-30 | 2019-03-19 | Trieza Therapeutics, Inc. | Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer |
| KR20190128634A (ko) * | 2017-01-30 | 2019-11-18 | 에피센트알엑스, 인코포레이티드 | 다중 트랜스진 재조합 아데노바이러스 |
| CN110741081B (zh) | 2017-01-30 | 2024-07-23 | 埃皮辛特瑞柯斯公司 | 肿瘤选择性tata盒和caat盒突变体 |
| KR102643016B1 (ko) * | 2017-04-10 | 2024-02-29 | 에피센트알엑스, 인코포레이티드 | 재조합 바이러스의 제조 방법 |
| EA201990822A1 (ru) * | 2017-04-12 | 2020-01-09 | Эписентарикс, Инк. | Иммуномодулирующие слитые белки |
| WO2018218083A1 (en) * | 2017-05-24 | 2018-11-29 | Epicentrx, Inc. | Anti-angiogenic adenovirus |
| NZ759833A (en) * | 2017-05-26 | 2023-01-27 | Epicentrx Inc | Recombinant adenoviruses carrying transgenes |
| CA3077223A1 (en) | 2017-09-27 | 2019-04-04 | Epicentrx, Inc. | Immunomodulatory fusion proteins |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| US12454561B2 (en) | 2018-03-19 | 2025-10-28 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer |
| WO2019191494A1 (en) * | 2018-03-28 | 2019-10-03 | Epicentrx, Inc. | Personalized cancer vaccines |
| AU2019251356B2 (en) | 2018-04-09 | 2025-06-12 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions with enhanced replication properties |
| CN113015806A (zh) * | 2018-08-31 | 2021-06-22 | 奥尔卡治疗有限公司 | 包含糖原合酶激酶-3(gsk3)编码区的重组的具有复制能力的病毒和杀伤异常细胞的方法 |
| CN114761546A (zh) | 2019-10-08 | 2022-07-15 | 波士顿学院董事会 | 含有多个不同非天然氨基酸的蛋白质以及制备和使用此类蛋白质的方法 |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| EP4114449A2 (en) | 2020-03-05 | 2023-01-11 | Neotx Therapeutics Ltd. | Methods and compositions for treating cancer with immune cells |
| CN114262691A (zh) * | 2020-09-16 | 2022-04-01 | 杭州康万达医药科技有限公司 | 分离的能够用于表达外源基因的溶瘤腺病毒、载体、治疗剂及其用途 |
| WO2024015876A1 (en) | 2022-07-13 | 2024-01-18 | Epicentrx, Inc. | Adenoviral vectors encapsulated in cationic liposomes, and preparation and use thereof |
| CN118931897A (zh) * | 2024-06-27 | 2024-11-12 | 中山大学 | 一种识别肿瘤细胞并诱导其焦亡的基因、重组载体和重组病毒及其应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643567A (en) * | 1990-12-04 | 1997-07-01 | Board Of Regents, The University Of Texas System | Methods for the suppression of neu mediated tumors by adenoviral E1A and SV40 large T antigen |
| US5352775A (en) | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
| JPH06509578A (ja) | 1991-07-26 | 1994-10-27 | ユニバーシティ・オブ・ロチェスター | 悪性細胞利用による癌治療法 |
| US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| EP0716148B1 (en) * | 1993-09-15 | 2004-01-02 | Chiron Corporation | Recombinant alphavirus vectors |
| AUPN477695A0 (en) | 1995-08-14 | 1995-09-07 | Commonwealth Scientific And Industrial Research Organisation | Gene therapy |
| US5902925A (en) | 1996-07-01 | 1999-05-11 | Integrated Sensor Solutions | System and method for high accuracy calibration of a sensor for offset and sensitivity variation with temperature |
| GB9626029D0 (en) | 1996-12-14 | 1997-01-29 | Univ Leeds | EVH-1 vectors |
| US20050287120A1 (en) | 1997-03-21 | 2005-12-29 | Fisher Paul B | Cancer - targeted viral vectors |
| DK1135514T3 (da) * | 1999-01-28 | 2009-09-07 | Onyx Pharma Inc | E1b-deleteret adenovirale shuttle-vektorer |
| US6764674B1 (en) * | 1999-01-28 | 2004-07-20 | Onyx Pharmaceuticals Inc. | Adenovirus E1B shuttle vectors |
| US7125705B2 (en) * | 2000-04-28 | 2006-10-24 | Genzyme Corporation | Polynucleotides for use in recombinant adeno-associated virus virion production |
| WO2002018550A1 (en) * | 2000-08-25 | 2002-03-07 | The General Hospital Corporation | Selective precipitation of viruses |
| CN1183250C (zh) | 2000-12-01 | 2005-01-05 | 卫健生物科技有限公司 | 高效表达肿瘤血管生成抑制因子的肿瘤细胞内特异性增殖的病毒及其构建方法 |
| GB0117198D0 (en) | 2001-07-13 | 2001-09-05 | Btg Int Ltd | Anti-neoplastic viral agents |
| JP2005532829A (ja) * | 2002-07-18 | 2005-11-04 | インヴィトロジェン コーポレーション | 組換え部位を含むウイルスベクター |
| WO2004020971A2 (en) * | 2002-08-28 | 2004-03-11 | Introgen Therapeutics Inc. | Chromatographic methods for adenovirus purification |
| CA2590257A1 (en) * | 2003-11-14 | 2005-06-09 | Per Sonne Holm | Novel adenoviruses, nucleic acids that code for the same and the use of said viruses |
| WO2006070024A2 (de) * | 2004-12-31 | 2006-07-06 | Per Sonne Holm | E1 -minus adenoviren und deren verwendung |
| KR101252065B1 (ko) * | 2007-04-20 | 2013-04-12 | 다카라 바이오 가부시키가이샤 | 유전자 치료를 위한 벡터 |
| SI2403951T1 (sl) | 2009-03-02 | 2016-04-29 | The Regents Of The University Of California | Tumorsko selektivni mutanti adenovirusa e1a in e1b |
-
2010
- 2010-03-02 SI SI201031077T patent/SI2403951T1/sl unknown
- 2010-03-02 EP EP15182086.7A patent/EP3029144B1/en active Active
- 2010-03-02 KR KR1020197025813A patent/KR102150027B1/ko active Active
- 2010-03-02 WO PCT/US2010/025926 patent/WO2010101921A2/en not_active Ceased
- 2010-03-02 JP JP2011553041A patent/JP6072414B2/ja active Active
- 2010-03-02 SI SI201031944T patent/SI3029144T1/sl unknown
- 2010-03-02 HU HUE10749205A patent/HUE026386T2/en unknown
- 2010-03-02 ES ES15182086T patent/ES2750305T3/es active Active
- 2010-03-02 DK DK15182086.7T patent/DK3029144T3/da active
- 2010-03-02 PT PT151820867T patent/PT3029144T/pt unknown
- 2010-03-02 SM SM20190565T patent/SMT201900565T1/it unknown
- 2010-03-02 EP EP19171420.3A patent/EP3591059B1/en active Active
- 2010-03-02 HR HRP20151396T patent/HRP20151396T1/hr unknown
- 2010-03-02 PT PT107492050T patent/PT2403951E/pt unknown
- 2010-03-02 ES ES10749205.0T patent/ES2557812T3/es active Active
- 2010-03-02 LT LT15182086T patent/LT3029144T/lt unknown
- 2010-03-02 PL PL10749205T patent/PL2403951T3/pl unknown
- 2010-03-02 EP EP10749205.0A patent/EP2403951B1/en active Active
- 2010-03-02 KR KR1020177017391A patent/KR101922539B1/ko active Active
- 2010-03-02 PL PL15182086T patent/PL3029144T3/pl unknown
- 2010-03-02 DK DK10749205.0T patent/DK2403951T3/en active
- 2010-03-02 HU HUE15182086A patent/HUE046565T2/hu unknown
- 2010-03-02 US US13/254,825 patent/US9073980B2/en active Active
- 2010-03-02 EP EP22178897.9A patent/EP4123030A1/en active Pending
- 2010-03-02 KR KR1020187012031A patent/KR102020018B1/ko active Active
- 2010-03-02 KR KR1020117022884A patent/KR101752910B1/ko active Active
-
2015
- 2015-05-26 US US14/722,021 patent/US20160017294A1/en not_active Abandoned
- 2015-08-12 JP JP2015159434A patent/JP6375273B2/ja active Active
- 2015-12-31 SM SM201500329T patent/SMT201500329B/it unknown
-
2018
- 2018-02-28 JP JP2018035231A patent/JP6817979B2/ja active Active
- 2018-08-08 US US16/058,886 patent/US10876097B2/en active Active
-
2019
- 2019-10-03 HR HRP20191808TT patent/HRP20191808T1/hr unknown
- 2019-10-10 CY CY20191101067T patent/CY1122385T1/el unknown
-
2020
- 2020-02-07 JP JP2020019294A patent/JP2020078326A/ja active Pending
- 2020-11-20 US US17/100,671 patent/US11618888B2/en active Active
-
2021
- 2021-09-29 JP JP2021158698A patent/JP7326396B2/ja active Active
-
2022
- 2022-11-23 US US17/993,182 patent/US12195766B2/en active Active
-
2024
- 2024-12-05 US US18/969,407 patent/US20250327037A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1122385T1 (el) | Επιλεκτικα σε ογκο μεταλλαγματα αδενοϊου ε1α και ε1β | |
| CY1125475T1 (el) | Χρηση οξυγονωμενης θειικης χοληστερολης (ocs) για την αντιμετωπιση της νεφρικης δυσλειτουργιας | |
| EP3890499A4 (en) | Use of lactase to provide high gos fiber level and low lactose level | |
| BRPI0510475B8 (pt) | adenovírus quimérico recombinante, uso do mesmo no tratamento de câncer e métodos de inibição de crescimento de uma célula de câncer, de fornecimento de uma proteína terapêutica a uma célula e para o isolamento do adenovírus | |
| EA201170242A1 (ru) | Модифицированные бычьи полипептиды g-csf и их применение | |
| CL2016001507A1 (es) | Compuestos para tratar pacientes con células cancerosas mutantes ros1 | |
| CY1120337T1 (el) | Θειοοξικες ενωσεις, συνθεσεις και μεθοδοι χρησης | |
| BRPI0809663A2 (pt) | Composição de vírus vivo atenuado, método de diminuição da inativação de composição de vírus vivo atenuado e kit respectivo | |
| BR112019024813A2 (pt) | adenovírus recombinantes portando transgenes | |
| EP2139423A4 (en) | SURGICAL PACKAGE AND BOWL | |
| EP2558478A4 (en) | AT 5 POSITIONS MODIFIED PYRIMIDINES AND THEIR USE | |
| MA32190B1 (fr) | Anticorps dirigés contre l'angiopoïétine 1 et l'angiopoïétine 2 et leur utilisation | |
| SA520412637B1 (ar) | B7 الفيروس الغدي الحال للورم المشفِّر لبروتين | |
| GB2475799A (en) | Hypoxia inducing factor (hif) stabilising glasses | |
| EP2118123A4 (en) | STABILIZED P53 PEPTIDES AND ITS USES | |
| CY1110002T1 (el) | Τροποποιημενη πρωτεϊνη ηεχον αδενοϊου και χρησεις αυτης | |
| MX354450B (es) | Anticuerpos anti proteína accesoria del receptor de interleucina-1 y su uso para tratamiento en humanos. | |
| BR112015032690A8 (pt) | uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir crescimento tumoral e metástases | |
| MX388981B (es) | Inhibidores de enzima 1 dependiente de inositol (ire-1alfa). | |
| NZ600974A (en) | Binding members for human cytomegalovirus | |
| BR112012001043A2 (pt) | tinturas fluorescentes e uso das mesmas | |
| WO2017062511A8 (en) | Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration | |
| CY1123144T1 (el) | Επαγωγη καρδιακης αναγεννησης μe microrna | |
| EP2170373A4 (en) | THERMOSTABILIZATION OF PROTEINS | |
| EA201290541A1 (ru) | Модифицированные бычьи соматотропиновые полипептиды и их применение |