SI2346841T1 - 2-aril-propionske kisline in derivati in farmacevtski sestavki, ki jih vsebujejo - Google Patents

2-aril-propionske kisline in derivati in farmacevtski sestavki, ki jih vsebujejo

Info

Publication number
SI2346841T1
SI2346841T1 SI200931170T SI200931170T SI2346841T1 SI 2346841 T1 SI2346841 T1 SI 2346841T1 SI 200931170 T SI200931170 T SI 200931170T SI 200931170 T SI200931170 T SI 200931170T SI 2346841 T1 SI2346841 T1 SI 2346841T1
Authority
SI
Slovenia
Prior art keywords
aryl
derivatives
pharmaceutical compositions
compositions containing
propionic acids
Prior art date
Application number
SI200931170T
Other languages
English (en)
Slovenian (sl)
Inventor
Marcello Allegretti
Andrea Aramini
Gianluca Bianchini
Maria Candida Cesta
Original Assignee
Dompe Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Farmaceutici S.P.A. filed Critical Dompe Farmaceutici S.P.A.
Publication of SI2346841T1 publication Critical patent/SI2346841T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48Nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/42Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI200931170T 2008-09-18 2009-09-18 2-aril-propionske kisline in derivati in farmacevtski sestavki, ki jih vsebujejo SI2346841T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08164605A EP2166006A1 (en) 2008-09-18 2008-09-18 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
EP09783167.1A EP2346841B1 (en) 2008-09-18 2009-09-18 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
PCT/EP2009/062109 WO2010031835A2 (en) 2008-09-18 2009-09-18 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
SI2346841T1 true SI2346841T1 (sl) 2015-07-31

Family

ID=40291117

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200931170T SI2346841T1 (sl) 2008-09-18 2009-09-18 2-aril-propionske kisline in derivati in farmacevtski sestavki, ki jih vsebujejo

Country Status (17)

Country Link
US (1) US8624036B2 (enExample)
EP (2) EP2166006A1 (enExample)
JP (1) JP5571669B2 (enExample)
CN (1) CN102159558B (enExample)
AU (1) AU2009294558B2 (enExample)
CA (1) CA2737099C (enExample)
CY (1) CY1116176T1 (enExample)
DK (1) DK2346841T3 (enExample)
ES (1) ES2534634T3 (enExample)
HR (1) HRP20150395T1 (enExample)
IL (1) IL211683A (enExample)
PL (1) PL2346841T3 (enExample)
PT (1) PT2346841E (enExample)
RU (1) RU2520212C2 (enExample)
SI (1) SI2346841T1 (enExample)
SM (1) SMT201500098B (enExample)
WO (1) WO2010031835A2 (enExample)

Families Citing this family (27)

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DK3040336T3 (da) 2012-03-02 2020-06-22 Sareum Ltd Forbindelser til brug i behandling af TYK2 Kinase-medierede tilstande
US10046002B2 (en) 2013-08-02 2018-08-14 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
US10561676B2 (en) * 2013-08-02 2020-02-18 Syntrix Biosystems Inc. Method for treating cancer using dual antagonists of CXCR1 and CXCR2
RU2652795C2 (ru) * 2013-09-03 2018-05-03 Сареум Лимитед Производные 2-фенил-оксазол-4-карбоксамида, модулирующие активность jak и tyk2 киназ
AR103399A1 (es) * 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
EP3117835A1 (en) * 2015-07-14 2017-01-18 Dompé farmaceutici s.p.a. Il-8 inhibitors for use in the treatment of certain urological disorders
EP3192504A1 (en) 2016-01-15 2017-07-19 Dompé farmaceutici S.p.A. Il-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy
ES2893701T3 (es) 2016-01-15 2022-02-09 Dompe Farm Spa Inhibidores de IL-8 para su uso en el tratamiento de neuropatía periférica inducida por quimioterapia
CN117503933A (zh) 2016-10-03 2024-02-06 儿童医疗中心公司 糖尿病肾病的预防和治疗
GB201617871D0 (en) 2016-10-21 2016-12-07 Sareum Limited Pharmaceutical compounds
US10660909B2 (en) 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
EP3342407A1 (en) 2017-01-03 2018-07-04 Dompé farmaceutici S.p.A. Il-8 inihibitors for use in the treatment of some urological disorders
EP3409277A1 (en) * 2017-05-30 2018-12-05 Dompé farmaceutici s.p.a. Il-8 inhibitors for use in the treatment and/or prevention of bacterial secondary infections
EP3476390A1 (en) * 2017-10-24 2019-05-01 Dompé farmaceutici S.p.A. Il-8 inhibitors for use in the treatment of sarcomas
WO2019165315A1 (en) 2018-02-23 2019-08-29 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists alone or in combination
GB201816369D0 (en) 2018-10-08 2018-11-28 Sareum Ltd Pharmaceutical compounds
EP3868368A1 (en) 2020-02-21 2021-08-25 Dompe' Farmaceutici S.P.A. Cxcl8 (interleukin-8) activity inhibitor and corticosteroid combination and pharmaceutical composition and use thereof
EP3868369A1 (en) 2020-02-21 2021-08-25 Dompe' Farmaceutici S.P.A. Cxcl8 inhibitor and pharmaceutical composition thereof for use in the treatment of cancer-related fatigue
EP3884932A1 (en) 2020-03-26 2021-09-29 Dompe' Farmaceutici S.P.A. Cxcl8 inhibitors for use in the treatment of covid-19
EP4008325A1 (en) 2020-12-02 2022-06-08 Dompe' Farmaceutici S.P.A. Cxcl8 inhibitors for use in the treatment of covid-19
EP4125848A1 (en) 2020-03-26 2023-02-08 Dompe' Farmaceutici SpA Cxcl8 inhibitors for use in the treatment of covid-19
EP3907214A1 (en) * 2020-05-04 2021-11-10 Dompe' Farmaceutici S.P.A. Co-crystal of ketoprofen, lysine and gabapentin, pharmaceutical compositions and their medical use
WO2022098822A1 (en) 2020-11-05 2022-05-12 Icahn School Of Medicine At Mount Sinai Cxcr1/cxcr2 inhibitors for use in treating myelofibrosis
EP4052702A1 (en) 2021-03-04 2022-09-07 Dompé farmaceutici S.p.a. Cxcl8 inhibitor and pharmaceutical composition thereof for use in the treatment of seizures
EP4397305A1 (en) 2023-01-05 2024-07-10 Dompe' Farmaceutici S.P.A. Cxcl8 inhibitors for use in the treatment of ocular mucous membrane pemphigoid and/or oral mucous membrane pemphigoid
EP4406942A1 (en) * 2023-01-26 2024-07-31 Dompe' Farmaceutici S.P.A. Stable monohydrate of df2755a and process for its preparation
EP4563594A1 (en) 2023-11-28 2025-06-04 Dompe' Farmaceutici SpA Cxcl8 inhibitors for use in the treatment of tumors with low stromal cav1 levels

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4025528A (en) * 1973-10-24 1977-05-24 Shionogi & Co., Ltd. Thiazole derivatives of benzoic and phenylalkanoic acids
JPS5537556B2 (enExample) * 1973-12-27 1980-09-29
CA1051906A (en) * 1973-10-24 1979-04-03 Shionogi And Co. Thiazole derivatives and production thereof
JPS565747B2 (enExample) * 1973-10-24 1981-02-06
JPS5629871B2 (enExample) * 1974-05-22 1981-07-10
JPS62142168A (ja) * 1985-10-16 1987-06-25 Mitsubishi Chem Ind Ltd チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤
IT1298214B1 (it) 1998-01-28 1999-12-20 Dompe Spa Sali dell'acido (r) 2-(3-benzoilfenil) propionico e loro composizioni farmaceutiche.
IT1303249B1 (it) * 1998-10-23 2000-11-06 Dompe Spa Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono.
IT1317826B1 (it) 2000-02-11 2003-07-15 Dompe Spa Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.
ITMI20012434A1 (it) 2001-11-20 2003-05-20 Dompe Spa Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono
EP1467981A1 (en) * 2002-01-25 2004-10-20 Kylix Pharmaceuticals B.V. 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2
PL1776336T3 (pl) * 2004-03-23 2010-06-30 Dompe Farm Spa Pochodne kwasu 2-fenylopropionowego i zawierające je kompozycje farmaceutyczne
RU2458051C2 (ru) * 2005-11-24 2012-08-10 ДОМПЕ ФА.Р.МА С.п.А. (r)-арилалкиламинопроизводные и содержащие их фармацевтические композиции
HRP20130989T1 (hr) * 2006-05-18 2013-12-06 Dompe` S.P.A. (2r) -2-[(4-sulfonil)aminofenil] propanamidi i farmaceutski sastavi koji ih sadrže
PT2094638E (pt) * 2006-12-19 2012-11-20 Dompe Spa Ácidos 2-aril-fluoropropanóicos e derivados e composições farmacêuticas que os contêm
HRP20110406T1 (hr) * 2007-10-18 2011-06-30 Domp S.P.A. Derivati (r)-4-(heteroaril)feniletila i farmaceutski sastavi koji ih sadrže

Also Published As

Publication number Publication date
RU2520212C2 (ru) 2014-06-20
CA2737099A1 (en) 2010-03-25
EP2166006A1 (en) 2010-03-24
CY1116176T1 (el) 2017-02-08
CN102159558B (zh) 2015-01-07
AU2009294558A1 (en) 2010-03-25
US8624036B2 (en) 2014-01-07
WO2010031835A2 (en) 2010-03-25
AU2009294558B2 (en) 2014-12-18
PL2346841T3 (pl) 2015-07-31
HRP20150395T1 (hr) 2015-06-19
US20110207785A1 (en) 2011-08-25
EP2346841A2 (en) 2011-07-27
JP5571669B2 (ja) 2014-08-13
DK2346841T3 (en) 2015-04-20
RU2011114992A (ru) 2012-10-27
EP2346841B1 (en) 2015-01-14
BRPI0918759A2 (pt) 2015-12-29
PT2346841E (pt) 2015-05-07
JP2012502957A (ja) 2012-02-02
ES2534634T3 (es) 2015-04-27
IL211683A0 (en) 2011-06-30
CA2737099C (en) 2016-07-05
CN102159558A (zh) 2011-08-17
IL211683A (en) 2014-01-30
WO2010031835A3 (en) 2010-06-24
SMT201500098B (it) 2015-07-09

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