CY1116176T1 - 2-αρυλο-προπιονικα οξεα και παραγωγα και φαρμακευτικες συνθεσεις οι οποιες τα περιεχουν - Google Patents

2-αρυλο-προπιονικα οξεα και παραγωγα και φαρμακευτικες συνθεσεις οι οποιες τα περιεχουν

Info

Publication number
CY1116176T1
CY1116176T1 CY20151100336T CY151100336T CY1116176T1 CY 1116176 T1 CY1116176 T1 CY 1116176T1 CY 20151100336 T CY20151100336 T CY 20151100336T CY 151100336 T CY151100336 T CY 151100336T CY 1116176 T1 CY1116176 T1 CY 1116176T1
Authority
CY
Cyprus
Prior art keywords
aryl
derivatives
pharmaceutical compositions
compositions containing
propionic acids
Prior art date
Application number
CY20151100336T
Other languages
English (en)
Inventor
Marcello Allegretti
Andrea Aramini
Gianluca Bianchini
Maria Candida Cesta
Original Assignee
Dompé Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompé Farmaceutici S.P.A. filed Critical Dompé Farmaceutici S.P.A.
Publication of CY1116176T1 publication Critical patent/CY1116176T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με (R,S) 2-αρυλο-προπιονικά οξέα και παράγωγα, το μεμονωμένο εναντιομερές τους (S) και με φαρμακευτικές συνθέσεις οι οποίες τα περιέχουν, οι οποίες χρησιμοποιούνται στην πρόληψη και αντιμετώπιση ιστικής βλάβης εξαιτίας της επιδεινωμένης επιστράτευσης πολυμορφοπύρηνων ουδετερόφιλων (ΡΜΝ λευκοκυττάρων) σε θέσεις φλεγμονής. Η παρούσα εφεύρεση παρέχει ενώσεις για χρήση στην αντιμετώπιση παροδικής εγκεφαλικής ισχαιμίας, πομφολυγώδους πεμφιγοειδούς, ρευματοειδούς αρθρίτιδας, ιδιοπαθούς ίνωσης, σπειραματονεφρίτιδας και βλαβών οι οποίες προκαλούνται από ισχαιμία και επαναιμάτωση.
CY20151100336T 2008-09-18 2015-04-08 2-αρυλο-προπιονικα οξεα και παραγωγα και φαρμακευτικες συνθεσεις οι οποιες τα περιεχουν CY1116176T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08164605A EP2166006A1 (en) 2008-09-18 2008-09-18 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
EP09783167.1A EP2346841B1 (en) 2008-09-18 2009-09-18 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
CY1116176T1 true CY1116176T1 (el) 2017-02-08

Family

ID=40291117

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100336T CY1116176T1 (el) 2008-09-18 2015-04-08 2-αρυλο-προπιονικα οξεα και παραγωγα και φαρμακευτικες συνθεσεις οι οποιες τα περιεχουν

Country Status (18)

Country Link
US (1) US8624036B2 (el)
EP (2) EP2166006A1 (el)
JP (1) JP5571669B2 (el)
CN (1) CN102159558B (el)
AU (1) AU2009294558B2 (el)
BR (1) BRPI0918759A2 (el)
CA (1) CA2737099C (el)
CY (1) CY1116176T1 (el)
DK (1) DK2346841T3 (el)
ES (1) ES2534634T3 (el)
HR (1) HRP20150395T1 (el)
IL (1) IL211683A (el)
PL (1) PL2346841T3 (el)
PT (1) PT2346841E (el)
RU (1) RU2520212C2 (el)
SI (1) SI2346841T1 (el)
SM (1) SMT201500098B (el)
WO (1) WO2010031835A2 (el)

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US20130231340A1 (en) 2012-03-02 2013-09-05 Sareum Limited Pharmaceutical compounds
US10561676B2 (en) * 2013-08-02 2020-02-18 Syntrix Biosystems Inc. Method for treating cancer using dual antagonists of CXCR1 and CXCR2
US10046002B2 (en) 2013-08-02 2018-08-14 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
MX369974B (es) * 2013-09-03 2019-11-27 Sareum Ltd Compuestos farmaceuticos.
AR103399A1 (es) * 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
EP3117835A1 (en) * 2015-07-14 2017-01-18 Dompé farmaceutici s.p.a. Il-8 inhibitors for use in the treatment of certain urological disorders
EP3192504A1 (en) 2016-01-15 2017-07-19 Dompé farmaceutici S.p.A. Il-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy
AU2017207850B2 (en) * 2016-01-15 2022-06-30 Dompe' Farmaceutici S.P.A. IL-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy
CN117503933A (zh) 2016-10-03 2024-02-06 儿童医疗中心公司 糖尿病肾病的预防和治疗
GB201617871D0 (en) 2016-10-21 2016-12-07 Sareum Limited Pharmaceutical compounds
US10660909B2 (en) 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
EP3342407A1 (en) 2017-01-03 2018-07-04 Dompé farmaceutici S.p.A. Il-8 inihibitors for use in the treatment of some urological disorders
EP3409277A1 (en) * 2017-05-30 2018-12-05 Dompé farmaceutici s.p.a. Il-8 inhibitors for use in the treatment and/or prevention of bacterial secondary infections
EP3476390A1 (en) 2017-10-24 2019-05-01 Dompé farmaceutici S.p.A. Il-8 inhibitors for use in the treatment of sarcomas
WO2019165315A1 (en) 2018-02-23 2019-08-29 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists alone or in combination
EP3868369A1 (en) 2020-02-21 2021-08-25 Dompe' Farmaceutici S.P.A. Cxcl8 inhibitor and pharmaceutical composition thereof for use in the treatment of cancer-related fatigue
EP3868368A1 (en) 2020-02-21 2021-08-25 Dompe' Farmaceutici S.P.A. Cxcl8 (interleukin-8) activity inhibitor and corticosteroid combination and pharmaceutical composition and use thereof
EP4008325A1 (en) 2020-12-02 2022-06-08 Dompe' Farmaceutici S.P.A. Cxcl8 inhibitors for use in the treatment of covid-19
WO2021191305A1 (en) 2020-03-26 2021-09-30 Dompe' Farmaceutici Spa Cxcl8 inhibitors for use in the treatment of covid-19
EP3884932A1 (en) 2020-03-26 2021-09-29 Dompe' Farmaceutici S.P.A. Cxcl8 inhibitors for use in the treatment of covid-19
EP3907214A1 (en) * 2020-05-04 2021-11-10 Dompe' Farmaceutici S.P.A. Co-crystal of ketoprofen, lysine and gabapentin, pharmaceutical compositions and their medical use
CA3196979A1 (en) 2020-11-05 2022-05-12 Icahn School Of Medicine At Mount Sinai Cxcr1/cxcr2 inhibitors for use in treating myelofibrosis
EP4052702A1 (en) 2021-03-04 2022-09-07 Dompé farmaceutici S.p.a. Cxcl8 inhibitor and pharmaceutical composition thereof for use in the treatment of seizures
EP4397305A1 (en) 2023-01-05 2024-07-10 Dompe' Farmaceutici S.P.A. Cxcl8 inhibitors for use in the treatment of ocular mucous membrane pemphigoid and/or oral mucous membrane pemphigoid
EP4406942A1 (en) * 2023-01-26 2024-07-31 Dompe' Farmaceutici S.P.A. Stable monohydrate of df2755a and process for its preparation

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JPS5537556B2 (el) * 1973-12-27 1980-09-29
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JPS62142168A (ja) * 1985-10-16 1987-06-25 Mitsubishi Chem Ind Ltd チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤
IT1298214B1 (it) 1998-01-28 1999-12-20 Dompe Spa Sali dell'acido (r) 2-(3-benzoilfenil) propionico e loro composizioni farmaceutiche.
IT1303249B1 (it) 1998-10-23 2000-11-06 Dompe Spa Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono.
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Also Published As

Publication number Publication date
RU2011114992A (ru) 2012-10-27
PL2346841T3 (pl) 2015-07-31
RU2520212C2 (ru) 2014-06-20
SMT201500098B (it) 2015-07-09
EP2166006A1 (en) 2010-03-24
US8624036B2 (en) 2014-01-07
HRP20150395T1 (hr) 2015-06-19
EP2346841A2 (en) 2011-07-27
US20110207785A1 (en) 2011-08-25
CN102159558B (zh) 2015-01-07
WO2010031835A2 (en) 2010-03-25
CN102159558A (zh) 2011-08-17
SI2346841T1 (sl) 2015-07-31
EP2346841B1 (en) 2015-01-14
CA2737099C (en) 2016-07-05
DK2346841T3 (en) 2015-04-20
AU2009294558A1 (en) 2010-03-25
JP2012502957A (ja) 2012-02-02
CA2737099A1 (en) 2010-03-25
WO2010031835A3 (en) 2010-06-24
IL211683A0 (en) 2011-06-30
JP5571669B2 (ja) 2014-08-13
ES2534634T3 (es) 2015-04-27
PT2346841E (pt) 2015-05-07
IL211683A (en) 2014-01-30
AU2009294558B2 (en) 2014-12-18
BRPI0918759A2 (pt) 2015-12-29

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