SI21187A - Postopek za pripravo 4-oksitetrahidropiran-2-onov - Google Patents

Postopek za pripravo 4-oksitetrahidropiran-2-onov Download PDF

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Publication number
SI21187A
SI21187A SI200200086A SI200200086A SI21187A SI 21187 A SI21187 A SI 21187A SI 200200086 A SI200200086 A SI 200200086A SI 200200086 A SI200200086 A SI 200200086A SI 21187 A SI21187 A SI 21187A
Authority
SI
Slovenia
Prior art keywords
simvastatin
process according
organic solvent
formula
acetate
Prior art date
Application number
SI200200086A
Other languages
English (en)
Slovenian (sl)
Inventor
Silvo ZUPAN�I�
Du�an KRA�OVEC
Pavel Zupet
Original Assignee
Krka, Tovarna Zdravil D.D., Novo Mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka, Tovarna Zdravil D.D., Novo Mesto filed Critical Krka, Tovarna Zdravil D.D., Novo Mesto
Priority to SI200200086A priority Critical patent/SI21187A/sl
Priority to DE60301267T priority patent/DE60301267T2/de
Priority to AU2003214791A priority patent/AU2003214791A1/en
Priority to KR10-2004-7015123A priority patent/KR20040106306A/ko
Priority to PL372360A priority patent/PL208279B1/pl
Priority to PCT/SI2003/000009 priority patent/WO2003080591A1/en
Priority to CNB038089475A priority patent/CN1281596C/zh
Priority to US10/509,611 priority patent/US7094912B2/en
Priority to AT03710622T priority patent/ATE301648T1/de
Priority to EP03710622A priority patent/EP1487814B1/de
Priority to JP2003578346A priority patent/JP2005523303A/ja
Priority to EA200401253A priority patent/EA007012B1/ru
Publication of SI21187A publication Critical patent/SI21187A/sl
Priority to HRP20040885AA priority patent/HRP20040885B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI200200086A 2002-03-26 2002-03-26 Postopek za pripravo 4-oksitetrahidropiran-2-onov SI21187A (sl)

Priority Applications (13)

Application Number Priority Date Filing Date Title
SI200200086A SI21187A (sl) 2002-03-26 2002-03-26 Postopek za pripravo 4-oksitetrahidropiran-2-onov
PCT/SI2003/000009 WO2003080591A1 (en) 2002-03-26 2003-03-17 Process for the preparation of 4-oxytetrahydropyran-2-ones
AU2003214791A AU2003214791A1 (en) 2002-03-26 2003-03-17 Process for the preparation of 4-oxytetrahydropyran-2-ones
KR10-2004-7015123A KR20040106306A (ko) 2002-03-26 2003-03-17 4-옥시테트라하이드로피란-2-온의 제조 방법
PL372360A PL208279B1 (pl) 2002-03-26 2003-03-17 Sposób wytwarzania 4-oksytetrahydropiran-2-onów
DE60301267T DE60301267T2 (de) 2002-03-26 2003-03-17 Verfahren zur herstellung von 4-oxytetrahydropyran-2-onen
CNB038089475A CN1281596C (zh) 2002-03-26 2003-03-17 制备4－氧代四氢吡喃－2－酮的方法
US10/509,611 US7094912B2 (en) 2002-03-26 2003-03-17 Process for the preparation of 4-oxytetrahydropyran-2-ones
AT03710622T ATE301648T1 (de) 2002-03-26 2003-03-17 Verfahren zur herstellung von 4- oxytetrahydropyran-2-onen
EP03710622A EP1487814B1 (de) 2002-03-26 2003-03-17 Verfahren zur herstellung von 4-oxytetrahydropyran-2-onen
JP2003578346A JP2005523303A (ja) 2002-03-26 2003-03-17 ４−オキシテトラヒドロピラン−２−オンの製造方法
EA200401253A EA007012B1 (ru) 2002-03-26 2003-03-17 Способ получения 4-окситетрагидропиран-2-онов
HRP20040885AA HRP20040885B1 (en) 2002-03-26 2004-09-24 Process for the preparation of 4-oxytetrahydropyran-2-ones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI200200086A SI21187A (sl) 2002-03-26 2002-03-26 Postopek za pripravo 4-oksitetrahidropiran-2-onov

Publications (1)

Publication Number Publication Date
SI21187A true SI21187A (sl) 2003-10-31

Family

ID=28450345

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200200086A SI21187A (sl) 2002-03-26 2002-03-26 Postopek za pripravo 4-oksitetrahidropiran-2-onov

Country Status (13)

Country Link
US (1) US7094912B2 (de)
EP (1) EP1487814B1 (de)
JP (1) JP2005523303A (de)
KR (1) KR20040106306A (de)
CN (1) CN1281596C (de)
AT (1) ATE301648T1 (de)
AU (1) AU2003214791A1 (de)
DE (1) DE60301267T2 (de)
EA (1) EA007012B1 (de)
HR (1) HRP20040885B1 (de)
PL (1) PL208279B1 (de)
SI (1) SI21187A (de)
WO (1) WO2003080591A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2239543B1 (es) * 2004-03-15 2006-08-01 Ercros Industrial, S.A. Procedimiento para la obtencion de simvastatina.
WO2007096753A2 (en) * 2006-02-21 2007-08-30 Cadila Healthcare Limited Process for preparing highly pure simvastatin

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU548996B2 (en) 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
DE3480923D1 (de) 1983-10-11 1990-02-08 Merck & Co Inc Verfahren zur c-methylierung von 2-methylbutyraten.
US4820850A (en) 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4894466A (en) 1988-02-29 1990-01-16 Merck & Co., Inc. Intermediates and processes for β-6-hydroxymethyl HMG-CoA reductable inhibitors
FI893004A (fi) 1988-06-29 1989-12-30 Merck & Co Inc 5-oxygenerade hmg-coa-reduktas -inhibitorer.
CA2036962C (en) 1990-02-26 1998-09-15 Ann E. Decamp Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
US5763653A (en) 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Key intermediates in the manufacture of simvastatin
US5763646A (en) 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Process for manufacturing simvastatin from lovastatin or mevinolinic acid
DE69813538T2 (de) 1997-01-28 2004-04-01 Plus Chemicals B.V. Verfahren zur herstellung von halbsynthetischen statinen vianeue zwischenprodukte
SI20159A (sl) 1999-02-04 2000-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nov postopek za odstranitev sililoksi zaščitne skupine iz 4-sililoksi tetrahidro-piran-2-on-ov
MXPA02008693A (es) 2000-03-30 2004-09-06 Cheil Jedang Corp Procedimiento para producir simvastatina.
WO2001045484A2 (en) 2001-02-27 2001-06-28 Chong Kun Dang Pharmaceutical Corp. An improved process for preparing simvastatin

Also Published As

Publication number Publication date
WO2003080591A1 (en) 2003-10-02
CN1281596C (zh) 2006-10-25
EA200401253A1 (ru) 2005-04-28
ATE301648T1 (de) 2005-08-15
PL372360A1 (en) 2005-07-25
HRP20040885B1 (en) 2012-09-30
HRP20040885A2 (en) 2005-04-30
DE60301267T2 (de) 2006-06-01
US7094912B2 (en) 2006-08-22
EP1487814B1 (de) 2005-08-10
EA007012B1 (ru) 2006-06-30
DE60301267D1 (de) 2005-09-15
AU2003214791A1 (en) 2003-10-08
EP1487814A1 (de) 2004-12-22
CN1646517A (zh) 2005-07-27
PL208279B1 (pl) 2011-04-29
JP2005523303A (ja) 2005-08-04
US20050182263A1 (en) 2005-08-18
KR20040106306A (ko) 2004-12-17

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Effective date: 20051230