HRP20040885B1 - Process for the preparation of 4-oxytetrahydropyran-2-ones - Google Patents
Process for the preparation of 4-oxytetrahydropyran-2-onesInfo
- Publication number
- HRP20040885B1 HRP20040885B1 HRP20040885AA HRP20040885A HRP20040885B1 HR P20040885 B1 HRP20040885 B1 HR P20040885B1 HR P20040885A A HRP20040885A A HR P20040885AA HR P20040885 A HRP20040885 A HR P20040885A HR P20040885 B1 HRP20040885 B1 HR P20040885B1
- Authority
- HR
- Croatia
- Prior art keywords
- ones
- preparation
- oxytetrahydropyran
- reaction
- reagent
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- PARWIGJQSWCJKP-UHFFFAOYSA-N 4-silyloxyoxan-2-one Chemical class [SiH3]OC1CCOC(=O)C1 PARWIGJQSWCJKP-UHFFFAOYSA-N 0.000 abstract 1
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 abstract 1
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 abstract 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000005828 desilylation reaction Methods 0.000 abstract 1
- IKGLACJFEHSFNN-UHFFFAOYSA-N hydron;triethylazanium;trifluoride Chemical compound F.F.F.CCN(CC)CC IKGLACJFEHSFNN-UHFFFAOYSA-N 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 1
- 229960002855 simvastatin Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200200086A SI21187A (sl) | 2002-03-26 | 2002-03-26 | Postopek za pripravo 4-oksitetrahidropiran-2-onov |
| PCT/SI2003/000009 WO2003080591A1 (en) | 2002-03-26 | 2003-03-17 | Process for the preparation of 4-oxytetrahydropyran-2-ones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20040885A2 HRP20040885A2 (en) | 2005-04-30 |
| HRP20040885B1 true HRP20040885B1 (en) | 2012-09-30 |
Family
ID=28450345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20040885AA HRP20040885B1 (en) | 2002-03-26 | 2004-09-24 | Process for the preparation of 4-oxytetrahydropyran-2-ones |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7094912B2 (xx) |
| EP (1) | EP1487814B1 (xx) |
| JP (1) | JP2005523303A (xx) |
| KR (1) | KR20040106306A (xx) |
| CN (1) | CN1281596C (xx) |
| AT (1) | ATE301648T1 (xx) |
| AU (1) | AU2003214791A1 (xx) |
| DE (1) | DE60301267T2 (xx) |
| EA (1) | EA007012B1 (xx) |
| HR (1) | HRP20040885B1 (xx) |
| PL (1) | PL208279B1 (xx) |
| SI (1) | SI21187A (xx) |
| WO (1) | WO2003080591A1 (xx) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2239543B1 (es) * | 2004-03-15 | 2006-08-01 | Ercros Industrial, S.A. | Procedimiento para la obtencion de simvastatina. |
| WO2007096753A2 (en) * | 2006-02-21 | 2007-08-30 | Cadila Healthcare Limited | Process for preparing highly pure simvastatin |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0331240A2 (en) * | 1988-02-29 | 1989-09-06 | Merck & Co. Inc. | Intermediates and processes for beta 6-hydroxymethyl HMG-COA |
| EP0349063A2 (en) * | 1988-06-29 | 1990-01-03 | Merck & Co. Inc. | 5-oxygenated HMG-COA reductase inhibitors |
| WO2000046217A1 (en) * | 1999-02-04 | 2000-08-10 | Lek Pharmaceuticals And Chemical Company D.D. | Novel process for the removal of a silyloxy protecting group from 4-silyloxy-tetrahydro-pyran-2-ones |
| WO2001045484A2 (en) * | 2001-02-27 | 2001-06-28 | Chong Kun Dang Pharmaceutical Corp. | An improved process for preparing simvastatin |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU548996B2 (en) | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
| DE3480923D1 (de) | 1983-10-11 | 1990-02-08 | Merck & Co Inc | Verfahren zur c-methylierung von 2-methylbutyraten. |
| US4820850A (en) | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
| CA2036962C (en) | 1990-02-26 | 1998-09-15 | Ann E. Decamp | Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one |
| US5393893A (en) * | 1993-11-08 | 1995-02-28 | Apotex, Inc. | Process for producing simvastatin and analogs thereof |
| US5763653A (en) | 1997-03-13 | 1998-06-09 | Ranbaxy Laboratories, Ltd. | Key intermediates in the manufacture of simvastatin |
| US5763646A (en) | 1997-03-13 | 1998-06-09 | Ranbaxy Laboratories, Ltd. | Process for manufacturing simvastatin from lovastatin or mevinolinic acid |
| DE69813538T2 (de) | 1997-01-28 | 2004-04-01 | Plus Chemicals B.V. | Verfahren zur herstellung von halbsynthetischen statinen vianeue zwischenprodukte |
| MXPA02008693A (es) | 2000-03-30 | 2004-09-06 | Cheil Jedang Corp | Procedimiento para producir simvastatina. |
-
2002
- 2002-03-26 SI SI200200086A patent/SI21187A/sl not_active IP Right Cessation
-
2003
- 2003-03-17 EP EP03710622A patent/EP1487814B1/en not_active Expired - Lifetime
- 2003-03-17 AT AT03710622T patent/ATE301648T1/de not_active IP Right Cessation
- 2003-03-17 US US10/509,611 patent/US7094912B2/en not_active Expired - Fee Related
- 2003-03-17 DE DE60301267T patent/DE60301267T2/de not_active Expired - Lifetime
- 2003-03-17 WO PCT/SI2003/000009 patent/WO2003080591A1/en active IP Right Grant
- 2003-03-17 CN CNB038089475A patent/CN1281596C/zh not_active Expired - Fee Related
- 2003-03-17 KR KR10-2004-7015123A patent/KR20040106306A/ko not_active Application Discontinuation
- 2003-03-17 PL PL372360A patent/PL208279B1/pl unknown
- 2003-03-17 EA EA200401253A patent/EA007012B1/ru not_active IP Right Cessation
- 2003-03-17 JP JP2003578346A patent/JP2005523303A/ja active Pending
- 2003-03-17 AU AU2003214791A patent/AU2003214791A1/en not_active Abandoned
-
2004
- 2004-09-24 HR HRP20040885AA patent/HRP20040885B1/xx not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0331240A2 (en) * | 1988-02-29 | 1989-09-06 | Merck & Co. Inc. | Intermediates and processes for beta 6-hydroxymethyl HMG-COA |
| EP0349063A2 (en) * | 1988-06-29 | 1990-01-03 | Merck & Co. Inc. | 5-oxygenated HMG-COA reductase inhibitors |
| WO2000046217A1 (en) * | 1999-02-04 | 2000-08-10 | Lek Pharmaceuticals And Chemical Company D.D. | Novel process for the removal of a silyloxy protecting group from 4-silyloxy-tetrahydro-pyran-2-ones |
| WO2001045484A2 (en) * | 2001-02-27 | 2001-06-28 | Chong Kun Dang Pharmaceutical Corp. | An improved process for preparing simvastatin |
Also Published As
| Publication number | Publication date |
|---|---|
| SI21187A (sl) | 2003-10-31 |
| WO2003080591A1 (en) | 2003-10-02 |
| CN1281596C (zh) | 2006-10-25 |
| EA200401253A1 (ru) | 2005-04-28 |
| ATE301648T1 (de) | 2005-08-15 |
| PL372360A1 (en) | 2005-07-25 |
| HRP20040885A2 (en) | 2005-04-30 |
| DE60301267T2 (de) | 2006-06-01 |
| US7094912B2 (en) | 2006-08-22 |
| EP1487814B1 (en) | 2005-08-10 |
| EA007012B1 (ru) | 2006-06-30 |
| DE60301267D1 (de) | 2005-09-15 |
| AU2003214791A1 (en) | 2003-10-08 |
| EP1487814A1 (en) | 2004-12-22 |
| CN1646517A (zh) | 2005-07-27 |
| PL208279B1 (pl) | 2011-04-29 |
| JP2005523303A (ja) | 2005-08-04 |
| US20050182263A1 (en) | 2005-08-18 |
| KR20040106306A (ko) | 2004-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| B1PR | Patent granted | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20130213 Year of fee payment: 11 |
|
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20140317 |