SI21102A - Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika - Google Patents

Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika Download PDF

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Publication number
SI21102A
SI21102A SI200100322A SI200100322A SI21102A SI 21102 A SI21102 A SI 21102A SI 200100322 A SI200100322 A SI 200100322A SI 200100322 A SI200100322 A SI 200100322A SI 21102 A SI21102 A SI 21102A
Authority
SI
Slovenia
Prior art keywords
csf
biologically active
imac
buffer
elution
Prior art date
Application number
SI200100322A
Other languages
English (en)
Slovenian (sl)
Inventor
Porekar Vladka Gaberc
Viktor Menart
Original Assignee
LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. filed Critical LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.
Priority to SI200100322A priority Critical patent/SI21102A/sl
Priority to SI200230822T priority patent/SI1458757T1/sl
Priority to HU0402547A priority patent/HUP0402547A3/hu
Priority to KR10-2004-7009409A priority patent/KR20040071212A/ko
Priority to NZ533305A priority patent/NZ533305A/en
Priority to EP09152902A priority patent/EP2053061A1/en
Priority to DE60231243T priority patent/DE60231243D1/de
Priority to JP2003552802A priority patent/JP4454311B2/ja
Priority to RU2004121982/13A priority patent/RU2358980C2/ru
Priority to MXPA04006076A priority patent/MXPA04006076A/es
Priority to PL369669A priority patent/PL207775B1/pl
Priority to PCT/EP2002/013810 priority patent/WO2003051922A1/en
Priority to IL16244802A priority patent/IL162448A0/xx
Priority to BR0215191-0A priority patent/BR0215191A/pt
Priority to AU2002366275A priority patent/AU2002366275B2/en
Priority to CNA028254651A priority patent/CN1606568A/zh
Priority to US10/499,315 priority patent/US20050159589A1/en
Priority to AT02804876T priority patent/ATE423136T1/de
Priority to CA2469984A priority patent/CA2469984C/en
Priority to EP02804876A priority patent/EP1458757B1/en
Publication of SI21102A publication Critical patent/SI21102A/sl
Priority to ZA200404291A priority patent/ZA200404291B/en
Priority to IL162448A priority patent/IL162448A/en
Priority to HR20040572A priority patent/HRP20040572A2/xx
Priority to NO20042967A priority patent/NO20042967L/no
Priority to HK04107314.0A priority patent/HK1064681A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
SI200100322A 2001-12-19 2001-12-19 Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika SI21102A (sl)

Priority Applications (25)

Application Number Priority Date Filing Date Title
SI200100322A SI21102A (sl) 2001-12-19 2001-12-19 Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika
PCT/EP2002/013810 WO2003051922A1 (en) 2001-12-19 2002-12-05 Process for the purification and/or isolation of biologically active granulocyte colony stimulating factor
AU2002366275A AU2002366275B2 (en) 2001-12-19 2002-12-05 Process for the purification and/or isolation of biologically active granulocyte colony stimulating factor
BR0215191-0A BR0215191A (pt) 2001-12-19 2002-12-05 Processo para a purificação e/ou isolamento de fator de estimulação de colÈnia de granulócito biologicamente ativo
NZ533305A NZ533305A (en) 2001-12-19 2002-12-05 Process for the purification and/or isolation of biologically active granulocyte colony stimulating factor
HU0402547A HUP0402547A3 (en) 2001-12-19 2002-12-05 Process for the purification and/or isolation of biologically active granulocyte colony stimulating factor
DE60231243T DE60231243D1 (de) 2001-12-19 2002-12-05 Prozess für die aufreinigung und isolierung von biologisch-aktivem granulozyten-koloniestimulierungsfaktor
JP2003552802A JP4454311B2 (ja) 2001-12-19 2002-12-05 生物学的に活性な顆粒球コロニー刺激因子の精製および／または単離方法
CNA028254651A CN1606568A (zh) 2001-12-19 2002-12-05 生物活性粒细胞集落刺激因子的纯化和/或分离方法
MXPA04006076A MXPA04006076A (es) 2001-12-19 2002-12-05 Proceso para la purificacion y/o aislamiento del factor estimulante de colonias de granulocitos biologicamente activos.
PL369669A PL207775B1 (pl) 2001-12-19 2002-12-05 Sposób izolowania biologicznie czynnego poprawnie zwiniętego czynnika stymulującego kolonie granulocytów (G-CSF)
SI200230822T SI1458757T1 (sl) 2001-12-19 2002-12-05 Postopek za äśiĺ äśenje in/ali izolacijo bioloĺ ko aktivnega rastnega dejavnika za granulocite (g-csf)
IL16244802A IL162448A0 (en) 2001-12-19 2002-12-05 Process for the purification and/orisolation of biologically active granulocyte colony stimulating factor
KR10-2004-7009409A KR20040071212A (ko) 2001-12-19 2002-12-05 생물학적 활성 과립구 콜로니 자극 인자의 정제 및(또는)단리 방법
EP09152902A EP2053061A1 (en) 2001-12-19 2002-12-05 Process for the purification and/or isolation of biologically active granulocyte colony stimulating factor
RU2004121982/13A RU2358980C2 (ru) 2001-12-19 2002-12-05 Способ очистки и/или выделения биологически активного гранулоцитарного колониестимулирующего фактора
US10/499,315 US20050159589A1 (en) 2001-12-19 2002-12-05 Process for the purification and/or isolation of biologically active granulocyte colony stimulating factor
AT02804876T ATE423136T1 (de) 2001-12-19 2002-12-05 Prozess für die aufreinigung und isolierung von biologisch-aktivem granulozyten- koloniestimulierungsfaktor
CA2469984A CA2469984C (en) 2001-12-19 2002-12-05 Process for the purification and/or isolation of biologically active granulocyte colony stimulating factor
EP02804876A EP1458757B1 (en) 2001-12-19 2002-12-05 Process for the purification and/or isolation of biologically active granulocyte colony stimulating factor
ZA200404291A ZA200404291B (en) 2001-12-19 2004-06-01 Process for the purification and/or isolation of biologically active granulocyte colony stimulating factor.
IL162448A IL162448A (en) 2001-12-19 2004-06-10 Process for the purification and isolation of biologically active granulocyte colony stimulating factor
HR20040572A HRP20040572A2 (en) 2001-12-19 2004-06-18 Process for the purification and/or isolation of biologically active granulocyte colony stimulating factor
NO20042967A NO20042967L (no) 2001-12-19 2004-07-14 Fremgangsmate for rensing og/eller isolasjon av biologisk aktiv granulocyt-koloni-stimulerende-faktor
HK04107314.0A HK1064681A1 (en) 2001-12-19 2004-09-23 Process for the purification and/or isolation of biologically active granulocyte colony stimulating factor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI200100322A SI21102A (sl) 2001-12-19 2001-12-19 Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika

Publications (1)

Publication Number Publication Date
SI21102A true SI21102A (sl) 2003-06-30

Family

ID=20433022

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200100322A SI21102A (sl) 2001-12-19 2001-12-19 Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika
SI200230822T SI1458757T1 (sl) 2001-12-19 2002-12-05 Postopek za äśiĺ äśenje in/ali izolacijo bioloĺ ko aktivnega rastnega dejavnika za granulocite (g-csf)

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200230822T SI1458757T1 (sl) 2001-12-19 2002-12-05 Postopek za äśiĺ äśenje in/ali izolacijo bioloĺ ko aktivnega rastnega dejavnika za granulocite (g-csf)

Country Status (22)

Country Link
US (1) US20050159589A1 (pl)
EP (2) EP1458757B1 (pl)
JP (1) JP4454311B2 (pl)
KR (1) KR20040071212A (pl)
CN (1) CN1606568A (pl)
AT (1) ATE423136T1 (pl)
AU (1) AU2002366275B2 (pl)
BR (1) BR0215191A (pl)
CA (1) CA2469984C (pl)
DE (1) DE60231243D1 (pl)
HK (1) HK1064681A1 (pl)
HR (1) HRP20040572A2 (pl)
HU (1) HUP0402547A3 (pl)
IL (2) IL162448A0 (pl)
MX (1) MXPA04006076A (pl)
NO (1) NO20042967L (pl)
NZ (1) NZ533305A (pl)
PL (1) PL207775B1 (pl)
RU (1) RU2358980C2 (pl)
SI (2) SI21102A (pl)
WO (1) WO2003051922A1 (pl)
ZA (1) ZA200404291B (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI21273A (sl) * 2002-07-31 2004-02-29 LEK farmacevtska dru�ba d.d. Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina
DE60304435T2 (de) * 2004-01-19 2006-08-24 Ares Trading S.A. Verfahren zur Reinigung von in Bakterien exprimierten Proteinen
EP1803464A4 (en) * 2004-09-17 2009-09-09 Cellgentech Inc TOPICAL PREPARATION FOR THE TREATMENT OF SKIN DISEASES
CA2597795A1 (en) * 2005-02-15 2006-08-24 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US20080171857A1 (en) * 2005-03-17 2008-07-17 Uma Devi Komath Process for the Purification of Recombinant Granulocyte-Colony Stimulating Factor
DE102005033250A1 (de) * 2005-07-15 2007-01-18 Bioceuticals Arzneimittel Ag Verfahren zur Reinigung von G-CSF
DE202006020194U1 (de) 2006-03-01 2007-12-06 Bioceuticals Arzneimittel Ag G-CSF-Flüssigformulierung
EP1878739A1 (en) 2006-07-14 2008-01-16 LEK Pharmaceuticals D.D. One step IMAC (MCAC) purification of proteins
WO2008096370A2 (en) * 2007-02-05 2008-08-14 Natco Pharma Limited An efficient and novel purification method of recombinant hg-csf
RS53404B (en) 2007-08-27 2014-10-31 Ratiopharm Gmbh LIQUID FORMULATION OF G-CSF CONJUGATES
JP2009073819A (ja) * 2007-08-29 2009-04-09 Fujifilm Corp 生理活性物質の精製方法
US20120093765A1 (en) * 2009-06-16 2012-04-19 Lupin Limited Process for purification of recombinant human granulocyte colony stimulating factor
EP2445924B2 (en) 2009-06-25 2023-12-13 Amgen Inc. Capture purification processes for proteins expressed in a non-mammalian system
AU2011234532B2 (en) * 2010-03-30 2015-04-09 Octapharma Ag Process for the purification of a Growth Factor Protein
ES2784628T3 (es) 2011-03-29 2020-09-29 Glaxosmithkline Llc Sistema de tampón para purificación de proteína
CN103215340A (zh) * 2012-01-19 2013-07-24 江苏粒福特生物科技有限公司 一种新颖的粒细胞制备及其抗癌活性检测方法
HUP1200171A1 (hu) 2012-03-19 2013-09-30 Richter Gedeon Nyrt Módszerek polipeptidek elõállítására
HUP1200172A2 (en) 2012-03-19 2013-10-28 Richter Gedeon Nyrt Methods for refolding g-csf from inclusion bodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61227526A (ja) 1984-07-25 1986-10-09 Chugai Pharmaceut Co Ltd 新規なコロニー刺激因子
EP0215126B1 (en) 1985-02-08 1991-07-31 Chugai Seiyaku Kabushiki Kaisha Human granulocyte colony stimulating factor
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
DK203187A (da) 1986-04-22 1987-10-23 Immunex Corp Human g-csf proteinekspression
US5055555A (en) 1989-01-05 1991-10-08 Helmut Sassenfeld Purification of G-CSF
US5169936A (en) 1989-04-14 1992-12-08 Biogen, Inc. Protein purification on immobilized metal affinity resins effected by elution using a weak ligand
US5932102A (en) 1998-01-12 1999-08-03 Schering Corporation Immobilized metal, affinity chromatography
FR2796071B1 (fr) * 1999-07-08 2001-09-07 Hoechst Marion Roussel Inc Procede de purification de facteur de stimulation de colonies de granulocytes

Also Published As

Publication number Publication date
PL207775B1 (pl) 2011-01-31
HUP0402547A2 (hu) 2005-03-29
ZA200404291B (en) 2005-08-05
HUP0402547A3 (en) 2010-01-28
NZ533305A (en) 2005-11-25
EP1458757B1 (en) 2009-02-18
EP2053061A1 (en) 2009-04-29
HK1064681A1 (en) 2005-02-04
BR0215191A (pt) 2004-11-16
KR20040071212A (ko) 2004-08-11
RU2004121982A (ru) 2005-04-20
IL162448A (en) 2010-12-30
US20050159589A1 (en) 2005-07-21
PL369669A1 (pl) 2005-05-02
WO2003051922A1 (en) 2003-06-26
JP4454311B2 (ja) 2010-04-21
DE60231243D1 (de) 2009-04-02
MXPA04006076A (es) 2005-02-24
RU2358980C2 (ru) 2009-06-20
AU2002366275B2 (en) 2009-04-02
CN1606568A (zh) 2005-04-13
ATE423136T1 (de) 2009-03-15
HRP20040572A2 (en) 2005-06-30
IL162448A0 (en) 2005-11-20
AU2002366275A1 (en) 2003-06-30
CA2469984C (en) 2014-05-20
SI1458757T1 (sl) 2009-10-31
EP1458757A1 (en) 2004-09-22
CA2469984A1 (en) 2003-06-26
JP2005525304A (ja) 2005-08-25
NO20042967L (no) 2004-09-07

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