SI2009000T1 - Selektivni serotoninski 2A/2C receptorski inverzni agonisti kot terapevtiki za nevrodegenerativne bolezni - Google Patents
Selektivni serotoninski 2A/2C receptorski inverzni agonisti kot terapevtiki za nevrodegenerativne bolezniInfo
- Publication number
- SI2009000T1 SI2009000T1 SI200431728T SI200431728T SI2009000T1 SI 2009000 T1 SI2009000 T1 SI 2009000T1 SI 200431728 T SI200431728 T SI 200431728T SI 200431728 T SI200431728 T SI 200431728T SI 2009000 T1 SI2009000 T1 SI 2009000T1
- Authority
- SI
- Slovenia
- Prior art keywords
- receptor inverse
- compound
- neurodegenerative diseases
- therapeutics
- efficacy
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 230000004770 neurodegeneration Effects 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 239000002469 receptor inverse agonist Substances 0.000 title abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
- 229940076279 serotonin Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000012661 Dyskinesia Diseases 0.000 abstract 2
- 208000028017 Psychotic disease Diseases 0.000 abstract 2
- 230000000561 anti-psychotic effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- PLRACCBDVIHHLZ-UHFFFAOYSA-N 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Chemical compound C1N(C)CCC(C=2C=CC=CC=2)=C1 PLRACCBDVIHHLZ-UHFFFAOYSA-N 0.000 abstract 1
- 101001135571 Mus musculus Tyrosine-protein phosphatase non-receptor type 2 Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000008484 agonism Effects 0.000 abstract 1
- 239000000002 anti-dyskinesia agent Substances 0.000 abstract 1
- 230000003374 anti-dyskinetic effect Effects 0.000 abstract 1
- 230000006399 behavior Effects 0.000 abstract 1
- 230000003542 behavioural effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000003137 locomotive effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000011809 primate model Methods 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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- C—CHEMISTRY; METALLURGY
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
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- Cardiology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44140603P | 2003-01-16 | 2003-01-16 | |
US47934603P | 2003-06-17 | 2003-06-17 | |
EP08015449A EP2009000B1 (en) | 2003-01-16 | 2004-01-15 | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2009000T1 true SI2009000T1 (sl) | 2011-09-30 |
Family
ID=32776052
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200431728T SI2009000T1 (sl) | 2003-01-16 | 2004-01-15 | Selektivni serotoninski 2A/2C receptorski inverzni agonisti kot terapevtiki za nevrodegenerativne bolezni |
SI200430956T SI1587789T1 (sl) | 2003-01-16 | 2004-01-15 | Selektivni inverzni agonisti serotoninskega 2A/2Creceptorja kot terapevtiki za nevrodegenerativne bolezni |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200430956T SI1587789T1 (sl) | 2003-01-16 | 2004-01-15 | Selektivni inverzni agonisti serotoninskega 2A/2Creceptorja kot terapevtiki za nevrodegenerativne bolezni |
Country Status (22)
Country | Link |
---|---|
US (17) | US7601740B2 (sl) |
EP (2) | EP1587789B1 (sl) |
JP (2) | JP5184777B2 (sl) |
KR (1) | KR101095939B1 (sl) |
CN (3) | CN101780080B (sl) |
AT (2) | ATE407117T1 (sl) |
AU (1) | AU2004206886B2 (sl) |
BR (1) | BRPI0406591B8 (sl) |
CA (1) | CA2512639C (sl) |
CY (1) | CY1108642T1 (sl) |
DE (1) | DE602004016288D1 (sl) |
DK (2) | DK1587789T3 (sl) |
ES (2) | ES2367135T3 (sl) |
HK (2) | HK1083759A1 (sl) |
MX (1) | MXPA05007568A (sl) |
NZ (1) | NZ541146A (sl) |
PT (1) | PT1587789E (sl) |
RU (2) | RU2332401C2 (sl) |
SG (1) | SG170617A1 (sl) |
SI (2) | SI2009000T1 (sl) |
WO (1) | WO2004064738A2 (sl) |
ZA (1) | ZA200505680B (sl) |
Families Citing this family (89)
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WO2001066521A1 (en) * | 2000-03-06 | 2001-09-13 | Acadia Pharmaceuticals, Inc. | Azacyclic compounds for use in the treatment of serotonin related diseases |
DE10043321B4 (de) * | 2000-08-24 | 2005-07-28 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung |
WO2003057698A2 (en) * | 2001-12-28 | 2003-07-17 | Acadia Pharmaceuticals, Inc. | Spiroazacyclic compounds as monoamine receptor modulators |
US7538222B2 (en) * | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
IL165907A0 (en) | 2002-06-24 | 2006-01-15 | Acadia Pharm Inc | N-substituted piperidine derivatives as serotonin receptor agents |
US7253186B2 (en) | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
MY139563A (en) * | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
PT1587789E (pt) | 2003-01-16 | 2008-12-16 | Acadia Pharm Inc | Agonistas inversos selectivos para receptores 2a/2c da serotonina como agentes terapêuticos para doenças neurodegenerativas |
NZ541014A (en) * | 2003-01-23 | 2008-05-30 | Acadia Pharm Inc | Use of N-desmethylclozapine to treat schizophrenia while increasing the level of activity of a muscarinic receptor |
US20040253274A1 (en) * | 2003-06-11 | 2004-12-16 | Allergan, Inc. | Use of a clostridial toxin to reduce appetite |
NZ527142A (en) * | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
US7855195B2 (en) * | 2003-12-02 | 2010-12-21 | Pharmaneuroboost N.V. | Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
US7884096B2 (en) * | 2003-12-02 | 2011-02-08 | Pharmaneuroboost N.V. | Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
US20050119249A1 (en) * | 2003-12-02 | 2005-06-02 | Erik Buntinx | Method of treating neurodegenerative diseases using D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
US20050203130A1 (en) * | 2003-12-02 | 2005-09-15 | Erik Buntinx | Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
EP1708790B1 (en) * | 2003-12-02 | 2010-04-21 | PharmaNeuroBoost N.V. | Use of pipamperone and a d2-receptor antagonist or a serotonin/dopamin antagonist for the treatment of psychotic disorders |
US20050261278A1 (en) * | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
US7820695B2 (en) * | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
CN101035759B (zh) | 2004-09-27 | 2011-06-15 | 阿卡蒂亚药品公司 | N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐的合成和晶形 |
US7790899B2 (en) * | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
KR20060030175A (ko) * | 2004-10-05 | 2006-04-10 | 경북대학교 산학협력단 | 무정위성 운동 치료용 약학조성물 |
MX2008012093A (es) * | 2006-03-24 | 2008-10-03 | Wyeth Corp | Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de trastornos psicoticos. |
US20080051429A1 (en) * | 2006-04-19 | 2008-02-28 | Van Kammen Daniel | Use of 4-amino-piperidines for treating sleep disorders |
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US20080254118A1 (en) * | 2007-04-11 | 2008-10-16 | Hans-Werner Wernersbach | Process for preparing pramipexole dihydrochloride tablets |
WO2008090632A1 (en) * | 2007-01-26 | 2008-07-31 | Otsuka Pharmaceutical Co., Ltd. | Marker for detecting the proposed efficacy of treatment |
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EP2150239A1 (en) * | 2007-04-24 | 2010-02-10 | Boehringer Ingelheim International GmbH | Combination with an extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof |
US20110111014A1 (en) * | 2007-06-26 | 2011-05-12 | Parkinson's Institute | Methods and compositions for treatment of neurological disorders |
US20090082342A1 (en) * | 2007-09-21 | 2009-03-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
AU2008302079A1 (en) * | 2007-09-21 | 2009-03-26 | Acadia Pharmaceuticals, Inc. | Co-administration of pimavanserin with other agents |
WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
ES2666324T3 (es) | 2008-10-28 | 2018-05-04 | Arena Pharmaceuticals, Inc. | Composiciones de un modulador del receptor de serotonina 5-HT2A útiles para el tratamiento de trastornos relacionados con el mismo |
US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
US9428506B2 (en) | 2012-04-14 | 2016-08-30 | Intra-Cellular Therapies, Inc. | Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders |
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IL305990A (en) | 2013-12-03 | 2023-11-01 | Intra Cellular Therapies Inc | Compressed gamma-carboline heterocyclic compounds are modified for use in the treatment of type I and/or type II bipolar disorders |
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- 2006-05-03 US US11/416,594 patent/US7713995B2/en active Active
- 2006-05-03 US US11/416,527 patent/US7732462B2/en active Active
- 2006-05-03 US US11/416,855 patent/US7659285B2/en active Active
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2008
- 2008-04-16 RU RU2008115009/04A patent/RU2465267C2/ru active
- 2008-12-03 CY CY20081101402T patent/CY1108642T1/el unknown
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2010
- 2010-03-10 JP JP2010053450A patent/JP2010174026A/ja active Pending
- 2010-04-13 US US12/759,662 patent/US7994193B2/en not_active Expired - Lifetime
- 2010-04-13 US US12/759,664 patent/US8008323B2/en not_active Expired - Lifetime
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2011
- 2011-06-27 US US13/169,893 patent/US8227487B2/en not_active Expired - Lifetime
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2012
- 2012-06-29 US US13/539,011 patent/US8377959B2/en not_active Expired - Lifetime
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2013
- 2013-01-25 US US13/750,778 patent/US8618130B2/en not_active Expired - Lifetime
- 2013-11-21 US US14/086,838 patent/US8921393B2/en not_active Expired - Lifetime
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2014
- 2014-11-10 US US14/537,793 patent/US9211289B2/en not_active Expired - Lifetime
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2015
- 2015-11-06 US US14/935,246 patent/US9566271B2/en not_active Expired - Lifetime
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2017
- 2017-01-03 US US15/397,582 patent/US10028944B2/en not_active Expired - Lifetime
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2018
- 2018-06-26 US US16/019,485 patent/US10525046B2/en not_active Expired - Lifetime
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2019
- 2019-11-18 US US16/687,467 patent/US20200323836A1/en not_active Abandoned
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2021
- 2021-01-29 US US17/162,476 patent/US20240091212A1/en active Pending
- 2021-09-14 US US17/474,816 patent/US20220241265A1/en active Pending
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