EP1951914A4 - Diagnostic and therapeutic methods and agents - Google Patents

Diagnostic and therapeutic methods and agents

Info

Publication number
EP1951914A4
EP1951914A4 EP06837256A EP06837256A EP1951914A4 EP 1951914 A4 EP1951914 A4 EP 1951914A4 EP 06837256 A EP06837256 A EP 06837256A EP 06837256 A EP06837256 A EP 06837256A EP 1951914 A4 EP1951914 A4 EP 1951914A4
Authority
EP
European Patent Office
Prior art keywords
diagnostic
agents
therapeutic methods
therapeutic
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06837256A
Other languages
German (de)
French (fr)
Other versions
EP1951914A2 (en
Inventor
George Ka-Kit Lau
Chee-Kin Hui
Hai Ying Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHENG SI YUAN (CHINA-INTERNATIONAL) HEPATITIS RESEARCH FOUNDATION
CHENG SI YUAN CHINA INTERNATIO
LAU GEORGE KA KIT
Original Assignee
CHENG SI YUAN (CHINA-INTERNATIONAL) HEPATITIS RESEARCH FOUNDATION
CHENG SI YUAN CHINA INTERNATIO
LAU GEORGE KA KIT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHENG SI YUAN (CHINA-INTERNATIONAL) HEPATITIS RESEARCH FOUNDATION, CHENG SI YUAN CHINA INTERNATIO, LAU GEORGE KA KIT filed Critical CHENG SI YUAN (CHINA-INTERNATIONAL) HEPATITIS RESEARCH FOUNDATION
Publication of EP1951914A2 publication Critical patent/EP1951914A2/en
Publication of EP1951914A4 publication Critical patent/EP1951914A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
EP06837256A 2005-11-09 2006-11-09 Diagnostic and therapeutic methods and agents Withdrawn EP1951914A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73548005P 2005-11-09 2005-11-09
PCT/US2006/043665 WO2007056527A2 (en) 2005-11-09 2006-11-09 Diagnostic and therapeutic methods and agents

Publications (2)

Publication Number Publication Date
EP1951914A2 EP1951914A2 (en) 2008-08-06
EP1951914A4 true EP1951914A4 (en) 2009-11-04

Family

ID=38023993

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06837256A Withdrawn EP1951914A4 (en) 2005-11-09 2006-11-09 Diagnostic and therapeutic methods and agents

Country Status (3)

Country Link
EP (1) EP1951914A4 (en)
AU (1) AU2006311462A1 (en)
WO (1) WO2007056527A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101979557B (en) * 2010-10-28 2015-07-01 百奥迈科生物技术有限公司 SiRNA molecule and application thereof to antiviral medicaments
MY190603A (en) 2015-03-16 2022-04-27 Hoffmann La Roche Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
CN108802383B (en) * 2018-06-21 2021-05-11 首都医科大学附属北京地坛医院 Hepatitis B three-small positive low replication period pregnancy period reactivation monitoring equipment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003043572A2 (en) * 2001-11-16 2003-05-30 3M Innovative Properties Company Methods and compositions related to irm compounds and toll-like receptor pathways
WO2005020912A2 (en) * 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
WO2005025583A2 (en) * 2003-09-05 2005-03-24 Anadys Pharmaceuticals, Inc. Tlr7 ligands for the treatment of hepatitis c

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003043572A2 (en) * 2001-11-16 2003-05-30 3M Innovative Properties Company Methods and compositions related to irm compounds and toll-like receptor pathways
WO2005020912A2 (en) * 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
WO2005025583A2 (en) * 2003-09-05 2005-03-24 Anadys Pharmaceuticals, Inc. Tlr7 ligands for the treatment of hepatitis c

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DAVIES S L ET AL: "Isatoribine - Anti-hepatitis C virus drug TLR7 receptor agonist", DRUGS OF THE FUTURE, vol. 30, no. 9, September 2005 (2005-09-01), pages 886 - 891, XP002547239, ISSN: 0377-8282 *
HEMMI H ET AL: "SMALL ANTI-VIRAL COMPOUNDS ACTIVATE IMMUNE CELLLS VIA THE TLR7 MYD88-DEPENDENT SIGNALING PATHWAY", NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, GB, vol. 3, no. 2, 1 February 2002 (2002-02-01), pages 196 - 200, XP009000917, ISSN: 1529-2908 *
HORSMANS YVES ET AL: "Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection", HEPATOLOGY, vol. 42, no. 3, September 2005 (2005-09-01), pages 724 - 731, XP002547240, ISSN: 0270-9139 *
HUI CHEE-KIN ET AL: "Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection", HEPATOLOGY, vol. 42, no. 4, Suppl. 1, October 2005 (2005-10-01), 56TH ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-THE-STUDY-OF-LIVE R-DISEASES; SAN FRANCISCO, CA, USA; NOVEMBER 11 -15, 2005, pages 707A - 708A, XP002547237, ISSN: 0270-9139 *
ISOGAWA MASANORI ET AL: "Toll-like receptor signaling inhibits hepatitis B virus replication in vivo.", JOURNAL OF VIROLOGY JUN 2005, vol. 79, no. 11, June 2005 (2005-06-01), pages 7269 - 7272, XP002547238, ISSN: 0022-538X *
LEE ET AL: "Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 100, no. 11, 27 May 2003 (2003-05-27), pages 6646 - 6651, XP002307483, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2007056527A2 (en) 2007-05-18
EP1951914A2 (en) 2008-08-06
AU2006311462A1 (en) 2007-05-18
WO2007056527A3 (en) 2009-05-14

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20080605

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ZHANG, HAI YING,THE UNIVERSITY OF HONG KONG

Inventor name: HUI, CHEE-KIN,THE UNIVERSITY OF HONG KONG

Inventor name: LAU, GEORGE KA-KIT,THE UNIVERSITY OF HONG KONG

R17D Deferred search report published (corrected)

Effective date: 20090514

A4 Supplementary search report drawn up and despatched

Effective date: 20091005

RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/68 20060101ALI20090925BHEP

Ipc: C12Q 1/70 20060101AFI20070720BHEP

17Q First examination report despatched

Effective date: 20100120

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20100602