SI1805192T1 - Soli izofosforamidne gorčice in njeni analogi kot protitumorska sredstva - Google Patents
Soli izofosforamidne gorčice in njeni analogi kot protitumorska sredstvaInfo
- Publication number
- SI1805192T1 SI1805192T1 SI200531655T SI200531655T SI1805192T1 SI 1805192 T1 SI1805192 T1 SI 1805192T1 SI 200531655 T SI200531655 T SI 200531655T SI 200531655 T SI200531655 T SI 200531655T SI 1805192 T1 SI1805192 T1 SI 1805192T1
- Authority
- SI
- Slovenia
- Prior art keywords
- analogs
- salts
- tumor agents
- isophosphoramide mustard
- isophosphoramide
- Prior art date
Links
- BKCJZNIZRWYHBN-UHFFFAOYSA-N Isophosphamide mustard Chemical class ClCCNP(=O)(O)NCCCl BKCJZNIZRWYHBN-UHFFFAOYSA-N 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/222—Amides of phosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62208704P | 2004-10-25 | 2004-10-25 | |
| US67270705P | 2005-04-18 | 2005-04-18 | |
| PCT/US2005/038523 WO2006047575A2 (en) | 2004-10-25 | 2005-10-25 | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| EP05821125A EP1805192B1 (en) | 2004-10-25 | 2005-10-25 | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1805192T1 true SI1805192T1 (sl) | 2013-02-28 |
Family
ID=35788704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200531655T SI1805192T1 (sl) | 2004-10-25 | 2005-10-25 | Soli izofosforamidne gorčice in njeni analogi kot protitumorska sredstva |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US8232262B2 (https=) |
| EP (3) | EP1805192B1 (https=) |
| JP (1) | JP5336082B2 (https=) |
| KR (2) | KR20130041384A (https=) |
| CN (3) | CN101087800B (https=) |
| AU (1) | AU2005299385B2 (https=) |
| CA (1) | CA2585125C (https=) |
| DK (2) | DK2336140T3 (https=) |
| ES (2) | ES2565929T3 (https=) |
| HK (1) | HK1209752A1 (https=) |
| IL (3) | IL182752A (https=) |
| NO (1) | NO20072478L (https=) |
| NZ (2) | NZ589418A (https=) |
| PL (1) | PL1805192T3 (https=) |
| PT (1) | PT1805192E (https=) |
| SI (1) | SI1805192T1 (https=) |
| WO (1) | WO2006047575A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2565929T3 (es) | 2004-10-25 | 2016-04-07 | Dekk-Tec, Inc. | Sales de mostaza de isofosforamida y análogos de las mismas como agentes antitumorales |
| US7964583B2 (en) | 2006-02-17 | 2011-06-21 | Ziopharm Oncology, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| ES2547302T3 (es) | 2007-04-06 | 2015-10-05 | Ziopharm Oncology, Inc. | Sales de mostaza de isofosforamida y análogos de las mismas |
| CA2732290A1 (en) * | 2008-07-31 | 2010-02-04 | Ziopharm Oncology, Inc. | Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof |
| JP5779106B2 (ja) * | 2009-02-24 | 2015-09-16 | デック−テック， インコーポレイテッド | 抗腫瘍剤としての４−ヒドロペルオキシイホスファミドの錯体 |
| CN102659841B (zh) * | 2012-04-24 | 2015-03-25 | 石家庄学院 | 多元酚磷酰胺衍生物及其制备方法与应用 |
| WO2014117035A1 (en) | 2013-01-24 | 2014-07-31 | Transderm, Inc. | COMPOSITIONS FOR TRANSDERMAL DELIVERY OF mTOR INHIBITORS |
| AU2016318613A1 (en) | 2015-09-10 | 2018-03-22 | Becton, Dickinson And Company | Cyclophosphamide analogs for use as immunogens and assay conjugates for an immunoassay of cyclophosphamide and ifosfamide |
| JP7108631B2 (ja) | 2017-01-06 | 2022-07-28 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物およびその使用方法 |
| USD859683S1 (en) | 2017-09-21 | 2019-09-10 | Becton, Dickinson And Company | Collection device |
| US11002642B2 (en) | 2017-09-21 | 2021-05-11 | Becton, Dickinson And Company | Demarcation template for hazardous contaminant testing |
| WO2019060269A1 (en) | 2017-09-21 | 2019-03-28 | Becton, Dickinson And Company | KIT FOR COLLECTING HAZARDOUS CONTAMINANTS AND RAPID ANALYSIS |
| US11391748B2 (en) | 2017-09-21 | 2022-07-19 | Becton, Dickinson And Company | High dynamic range assays in hazardous contaminant testing |
| US11000513B2 (en) | 2018-07-02 | 2021-05-11 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
| JP7520822B2 (ja) * | 2018-09-25 | 2024-07-23 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | ２’－ハロゲン化－４’－チオ－２’－デオキシ－５－アザシチジンアナログおよびその使用 |
| CA3125355A1 (en) | 2019-01-28 | 2020-08-06 | Becton, Dickinson And Company | Hazardous contaminant collection device with integrated swab and test device |
| CN111973583A (zh) * | 2020-07-29 | 2020-11-24 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 芹菜素在制备促进缺血超长随意皮瓣存活药物的作用 |
| CN111943979B (zh) * | 2020-10-19 | 2020-12-22 | 南京卓康医药科技有限公司 | 一种异环磷酰胺中间体及其制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU427945A1 (ru) | 1972-07-24 | 1974-05-15 | Институт элементоорганических соединений | СПОСОБ ПОЛУЧЕНИЯа ПОЛИФТОРАЛКИЛЗАМЕЩЕННЫХБЕНЗИЛДИХЛОРФОСФАТОВ |
| JPS5159886A (https=) | 1974-11-20 | 1976-05-25 | Shionogi Seiyaku Kk | |
| ZA851062B (en) * | 1984-03-01 | 1985-11-27 | Asta Werke Ag Chem Fab | Salts of oxazaphosphorine derivatives and process for their production |
| DD260279A5 (de) * | 1986-02-22 | 1988-09-21 | Asta-Werke Ag Chemische Fabrik,De | Verfahren zur herstellung heterocyclischer verbindungen mit einem 2-(2-[n,n-bis-12)2-chlorethyl)-diamido-phosphoryloxy]ethyl)-rest |
| US4841085A (en) * | 1986-06-30 | 1989-06-20 | Board Of Regents, University Of Texas System | Aldophosphamides |
| US5055459A (en) * | 1986-06-30 | 1991-10-08 | Board Of Regents, The University Of Texas | Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates |
| JPH07505887A (ja) | 1992-04-17 | 1995-06-29 | アボツト・ラボラトリーズ | タキソール誘導体 |
| US5468499A (en) * | 1993-11-15 | 1995-11-21 | Ohio State University | Liposomes containing the salt of phosphoramide mustard and related compounds |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| EP1185276B1 (en) | 1999-05-24 | 2003-12-10 | Southern Research Institute | Isophosphoramide mustard analogs and use thereof |
| CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| WO2001079158A2 (en) | 2000-04-13 | 2001-10-25 | Hsc Research And Development Limited Partnership | Compounds for modulating cell proliferation |
| DE10064312C2 (de) * | 2000-12-22 | 2003-05-22 | Degussa | Cholinpyruvat-Hydrat, Verfahren zu dessen Herstellung, Cholinpyruvat-Hydrat enthaltende Formulierung sowie deren Verwendung |
| DE60330407D1 (de) | 2002-08-23 | 2010-01-14 | Sloan Kettering Inst Cancer | Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung |
| ES2565929T3 (es) | 2004-10-25 | 2016-04-07 | Dekk-Tec, Inc. | Sales de mostaza de isofosforamida y análogos de las mismas como agentes antitumorales |
| ES2547302T3 (es) * | 2007-04-06 | 2015-10-05 | Ziopharm Oncology, Inc. | Sales de mostaza de isofosforamida y análogos de las mismas |
| CA2732290A1 (en) * | 2008-07-31 | 2010-02-04 | Ziopharm Oncology, Inc. | Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof |
-
2005
- 2005-10-25 ES ES10178422.1T patent/ES2565929T3/es not_active Expired - Lifetime
- 2005-10-25 US US11/666,215 patent/US8232262B2/en not_active Expired - Fee Related
- 2005-10-25 WO PCT/US2005/038523 patent/WO2006047575A2/en not_active Ceased
- 2005-10-25 NZ NZ589418A patent/NZ589418A/en not_active IP Right Cessation
- 2005-10-25 SI SI200531655T patent/SI1805192T1/sl unknown
- 2005-10-25 CN CN200580044803.6A patent/CN101087800B/zh not_active Expired - Fee Related
- 2005-10-25 PL PL05821125T patent/PL1805192T3/pl unknown
- 2005-10-25 CN CN201410730089.7A patent/CN104558023A/zh active Pending
- 2005-10-25 PT PT58211251T patent/PT1805192E/pt unknown
- 2005-10-25 US US11/257,766 patent/US7678778B2/en not_active Expired - Fee Related
- 2005-10-25 DK DK10178422.1T patent/DK2336140T3/en active
- 2005-10-25 KR KR1020137008506A patent/KR20130041384A/ko not_active Withdrawn
- 2005-10-25 CN CN2013100286502A patent/CN103172662A/zh active Pending
- 2005-10-25 CA CA2585125A patent/CA2585125C/en not_active Expired - Fee Related
- 2005-10-25 DK DK05821125.1T patent/DK1805192T3/da active
- 2005-10-25 NZ NZ555323A patent/NZ555323A/en not_active IP Right Cessation
- 2005-10-25 AU AU2005299385A patent/AU2005299385B2/en not_active Ceased
- 2005-10-25 ES ES05821125T patent/ES2397165T3/es not_active Expired - Lifetime
- 2005-10-25 EP EP05821125A patent/EP1805192B1/en not_active Expired - Lifetime
- 2005-10-25 EP EP10178422.1A patent/EP2336140B1/en not_active Expired - Lifetime
- 2005-10-25 EP EP10178414A patent/EP2336139A3/en not_active Withdrawn
- 2005-10-25 JP JP2007538185A patent/JP5336082B2/ja not_active Expired - Fee Related
- 2005-10-25 KR KR1020077011864A patent/KR101292026B1/ko not_active Expired - Fee Related
-
2007
- 2007-04-23 IL IL182752A patent/IL182752A/en not_active IP Right Cessation
- 2007-05-16 NO NO20072478A patent/NO20072478L/no not_active Application Discontinuation
-
2011
- 2011-03-24 IL IL211936A patent/IL211936A/en not_active IP Right Cessation
- 2011-03-24 IL IL211935A patent/IL211935A0/en unknown
-
2012
- 2012-07-03 US US13/541,522 patent/US8795659B2/en not_active Expired - Fee Related
-
2014
- 2014-07-10 US US14/328,125 patent/US9346836B2/en not_active Expired - Fee Related
-
2015
- 2015-10-22 HK HK15110402.4A patent/HK1209752A1/xx unknown
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