PT1805192E - Sais de mostarda de isofosforamida e análogos da mesma como agentes antitumorais - Google Patents
Sais de mostarda de isofosforamida e análogos da mesma como agentes antitumoraisInfo
- Publication number
- PT1805192E PT1805192E PT58211251T PT05821125T PT1805192E PT 1805192 E PT1805192 E PT 1805192E PT 58211251 T PT58211251 T PT 58211251T PT 05821125 T PT05821125 T PT 05821125T PT 1805192 E PT1805192 E PT 1805192E
- Authority
- PT
- Portugal
- Prior art keywords
- analogs
- salts
- tumor agents
- isophosphoramide mustard
- isophosphoramide
- Prior art date
Links
- BKCJZNIZRWYHBN-UHFFFAOYSA-N Isophosphamide mustard Chemical class ClCCNP(=O)(O)NCCCl BKCJZNIZRWYHBN-UHFFFAOYSA-N 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/222—Amides of phosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62208704P | 2004-10-25 | 2004-10-25 | |
| US67270705P | 2005-04-18 | 2005-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1805192E true PT1805192E (pt) | 2013-01-23 |
Family
ID=35788704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT58211251T PT1805192E (pt) | 2004-10-25 | 2005-10-25 | Sais de mostarda de isofosforamida e análogos da mesma como agentes antitumorais |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US7678778B2 (https=) |
| EP (3) | EP2336140B1 (https=) |
| JP (1) | JP5336082B2 (https=) |
| KR (2) | KR101292026B1 (https=) |
| CN (3) | CN101087800B (https=) |
| AU (1) | AU2005299385B2 (https=) |
| CA (1) | CA2585125C (https=) |
| DK (2) | DK1805192T3 (https=) |
| ES (2) | ES2397165T3 (https=) |
| HK (1) | HK1209752A1 (https=) |
| IL (3) | IL182752A (https=) |
| NO (1) | NO20072478L (https=) |
| NZ (2) | NZ555323A (https=) |
| PL (1) | PL1805192T3 (https=) |
| PT (1) | PT1805192E (https=) |
| SI (1) | SI1805192T1 (https=) |
| WO (1) | WO2006047575A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2336140B1 (en) | 2004-10-25 | 2016-01-27 | Dekk-Tec, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| US7964583B2 (en) | 2006-02-17 | 2011-06-21 | Ziopharm Oncology, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| MX2009010820A (es) * | 2007-04-06 | 2010-03-18 | Ziopharm Oncology Inc | Sales de mostaza isofosforamida y analogos de la misma. |
| NZ601139A (en) * | 2008-07-31 | 2014-02-28 | Ziopharm Oncology Inc | Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof |
| AU2010218109B2 (en) | 2009-02-24 | 2015-04-09 | Dekk-Tec, Inc. | Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents |
| CN102659841B (zh) * | 2012-04-24 | 2015-03-25 | 石家庄学院 | 多元酚磷酰胺衍生物及其制备方法与应用 |
| AU2014209141B2 (en) | 2013-01-24 | 2018-05-10 | Palvella Therapeutics, Inc. | Compositions for transdermal delivery of mTOR inhibitors |
| WO2017044453A1 (en) | 2015-09-10 | 2017-03-16 | Becton, Dickinson And Company | Cyclophosphamide analogs for use as immunogens and assay conjugates for an immunoassay of cyclophosphamide and ifosfamide |
| EP3565520B1 (en) | 2017-01-06 | 2026-02-25 | Palvella Therapeutics, Inc. | Anhydrous compositions of mtor inhibitors and methods of use |
| EP3684944B1 (en) | 2017-09-21 | 2025-01-01 | Becton, Dickinson and Company | Hazardous contaminant collection kit and rapid testing |
| CN209400423U (zh) | 2017-09-21 | 2019-09-17 | 贝克顿·迪金森公司 | 横向流测定物、测定物读取器装置和包括其的系统 |
| CN111107939B (zh) | 2017-09-21 | 2022-04-12 | 贝克顿·迪金森公司 | 引导有害污染物样品的收集的系统和模板及使用其的方法 |
| USD859683S1 (en) | 2017-09-21 | 2019-09-10 | Becton, Dickinson And Company | Collection device |
| US11000513B2 (en) | 2018-07-02 | 2021-05-11 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
| EP3856754A1 (en) * | 2018-09-25 | 2021-08-04 | The United States of America, as represented by the Secretary, Department of Health and Human Services | 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof |
| CN113383222A (zh) | 2019-01-28 | 2021-09-10 | 贝克顿·迪金森公司 | 具有集成的拭子和测试装置的有害污染物收集装置 |
| CN111973583A (zh) * | 2020-07-29 | 2020-11-24 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 芹菜素在制备促进缺血超长随意皮瓣存活药物的作用 |
| CN111943979B (zh) | 2020-10-19 | 2020-12-22 | 南京卓康医药科技有限公司 | 一种异环磷酰胺中间体及其制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU427945A1 (ru) | 1972-07-24 | 1974-05-15 | Институт элементоорганических соединений | СПОСОБ ПОЛУЧЕНИЯа ПОЛИФТОРАЛКИЛЗАМЕЩЕННЫХБЕНЗИЛДИХЛОРФОСФАТОВ |
| JPS5159886A (https=) | 1974-11-20 | 1976-05-25 | Shionogi Seiyaku Kk | |
| ZA851062B (en) * | 1984-03-01 | 1985-11-27 | Asta Werke Ag Chem Fab | Salts of oxazaphosphorine derivatives and process for their production |
| ZA871260B (en) * | 1986-02-22 | 1987-09-30 | Asta Werke Ag Chem Fab | Novel heterocyclic compounds having a 2-(2-(n,n-bis-(2-chloroethyl)-diamidophosphoryloxy)ethyl)radical |
| US4841085A (en) * | 1986-06-30 | 1989-06-20 | Board Of Regents, University Of Texas System | Aldophosphamides |
| US5055459A (en) * | 1986-06-30 | 1991-10-08 | Board Of Regents, The University Of Texas | Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates |
| CA2130578A1 (en) | 1992-04-17 | 1993-10-28 | Geewananda P. Gunawardana | Taxol derivatives |
| US5468499A (en) * | 1993-11-15 | 1995-11-21 | Ohio State University | Liposomes containing the salt of phosphoramide mustard and related compounds |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| DE60007120T2 (de) | 1999-05-24 | 2004-09-16 | Southern Research Institute, Birmingham | Isophosphoramide-senfgasanalogen und deren verwendung |
| CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| GB2378948B (en) | 2000-04-13 | 2004-11-10 | Hsc Res Dev Lp | Novel compounds for modulating cell proliferation |
| DE10064312C2 (de) * | 2000-12-22 | 2003-05-22 | Degussa | Cholinpyruvat-Hydrat, Verfahren zu dessen Herstellung, Cholinpyruvat-Hydrat enthaltende Formulierung sowie deren Verwendung |
| EP2186811A1 (en) | 2002-08-23 | 2010-05-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| EP2336140B1 (en) * | 2004-10-25 | 2016-01-27 | Dekk-Tec, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| MX2009010820A (es) | 2007-04-06 | 2010-03-18 | Ziopharm Oncology Inc | Sales de mostaza isofosforamida y analogos de la misma. |
| NZ601139A (en) * | 2008-07-31 | 2014-02-28 | Ziopharm Oncology Inc | Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof |
-
2005
- 2005-10-25 EP EP10178422.1A patent/EP2336140B1/en not_active Expired - Lifetime
- 2005-10-25 NZ NZ555323A patent/NZ555323A/en not_active IP Right Cessation
- 2005-10-25 EP EP10178414A patent/EP2336139A3/en not_active Withdrawn
- 2005-10-25 US US11/257,766 patent/US7678778B2/en not_active Expired - Fee Related
- 2005-10-25 AU AU2005299385A patent/AU2005299385B2/en not_active Ceased
- 2005-10-25 JP JP2007538185A patent/JP5336082B2/ja not_active Expired - Fee Related
- 2005-10-25 PT PT58211251T patent/PT1805192E/pt unknown
- 2005-10-25 KR KR1020077011864A patent/KR101292026B1/ko not_active Expired - Fee Related
- 2005-10-25 ES ES05821125T patent/ES2397165T3/es not_active Expired - Lifetime
- 2005-10-25 EP EP05821125A patent/EP1805192B1/en not_active Expired - Lifetime
- 2005-10-25 ES ES10178422.1T patent/ES2565929T3/es not_active Expired - Lifetime
- 2005-10-25 CN CN200580044803.6A patent/CN101087800B/zh not_active Expired - Fee Related
- 2005-10-25 CN CN2013100286502A patent/CN103172662A/zh active Pending
- 2005-10-25 DK DK05821125.1T patent/DK1805192T3/da active
- 2005-10-25 US US11/666,215 patent/US8232262B2/en not_active Expired - Fee Related
- 2005-10-25 WO PCT/US2005/038523 patent/WO2006047575A2/en not_active Ceased
- 2005-10-25 SI SI200531655T patent/SI1805192T1/sl unknown
- 2005-10-25 CN CN201410730089.7A patent/CN104558023A/zh active Pending
- 2005-10-25 KR KR1020137008506A patent/KR20130041384A/ko not_active Withdrawn
- 2005-10-25 CA CA2585125A patent/CA2585125C/en not_active Expired - Fee Related
- 2005-10-25 PL PL05821125T patent/PL1805192T3/pl unknown
- 2005-10-25 NZ NZ589418A patent/NZ589418A/en not_active IP Right Cessation
- 2005-10-25 DK DK10178422.1T patent/DK2336140T3/en active
-
2007
- 2007-04-23 IL IL182752A patent/IL182752A/en not_active IP Right Cessation
- 2007-05-16 NO NO20072478A patent/NO20072478L/no not_active Application Discontinuation
-
2011
- 2011-03-24 IL IL211935A patent/IL211935A0/en unknown
- 2011-03-24 IL IL211936A patent/IL211936A/en not_active IP Right Cessation
-
2012
- 2012-07-03 US US13/541,522 patent/US8795659B2/en not_active Expired - Fee Related
-
2014
- 2014-07-10 US US14/328,125 patent/US9346836B2/en not_active Expired - Fee Related
-
2015
- 2015-10-22 HK HK15110402.4A patent/HK1209752A1/xx unknown
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