CN101087800B - 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐 - Google Patents

作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐 Download PDF

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Publication number
CN101087800B
CN101087800B CN200580044803.6A CN200580044803A CN101087800B CN 101087800 B CN101087800 B CN 101087800B CN 200580044803 A CN200580044803 A CN 200580044803A CN 101087800 B CN101087800 B CN 101087800B
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China
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compound
ipm
amine
cancer
pharmaceutical composition
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Expired - Fee Related
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CN200580044803.6A
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English (en)
Chinese (zh)
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CN101087800A (zh
Inventor
L·摩根
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Dekk Tek Inc
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Dekk Tek Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/222—Amides of phosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200580044803.6A 2004-10-25 2005-10-25 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐 Expired - Fee Related CN101087800B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62208704P 2004-10-25 2004-10-25
US60/622,087 2004-10-25
US67270705P 2005-04-18 2005-04-18
US60/672,707 2005-04-18
PCT/US2005/038523 WO2006047575A2 (en) 2004-10-25 2005-10-25 Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201410730089.7A Division CN104558023A (zh) 2004-10-25 2005-10-25 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐
CN2013100286502A Division CN103172662A (zh) 2004-10-25 2005-10-25 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐

Publications (2)

Publication Number Publication Date
CN101087800A CN101087800A (zh) 2007-12-12
CN101087800B true CN101087800B (zh) 2015-01-07

Family

ID=35788704

Family Applications (3)

Application Number Title Priority Date Filing Date
CN200580044803.6A Expired - Fee Related CN101087800B (zh) 2004-10-25 2005-10-25 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐
CN201410730089.7A Pending CN104558023A (zh) 2004-10-25 2005-10-25 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐
CN2013100286502A Pending CN103172662A (zh) 2004-10-25 2005-10-25 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201410730089.7A Pending CN104558023A (zh) 2004-10-25 2005-10-25 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐
CN2013100286502A Pending CN103172662A (zh) 2004-10-25 2005-10-25 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐

Country Status (17)

Country Link
US (4) US8232262B2 (https=)
EP (3) EP1805192B1 (https=)
JP (1) JP5336082B2 (https=)
KR (2) KR20130041384A (https=)
CN (3) CN101087800B (https=)
AU (1) AU2005299385B2 (https=)
CA (1) CA2585125C (https=)
DK (2) DK2336140T3 (https=)
ES (2) ES2565929T3 (https=)
HK (1) HK1209752A1 (https=)
IL (3) IL182752A (https=)
NO (1) NO20072478L (https=)
NZ (2) NZ589418A (https=)
PL (1) PL1805192T3 (https=)
PT (1) PT1805192E (https=)
SI (1) SI1805192T1 (https=)
WO (1) WO2006047575A2 (https=)

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ES2565929T3 (es) 2004-10-25 2016-04-07 Dekk-Tec, Inc. Sales de mostaza de isofosforamida y análogos de las mismas como agentes antitumorales
US7964583B2 (en) 2006-02-17 2011-06-21 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
ES2547302T3 (es) 2007-04-06 2015-10-05 Ziopharm Oncology, Inc. Sales de mostaza de isofosforamida y análogos de las mismas
CA2732290A1 (en) * 2008-07-31 2010-02-04 Ziopharm Oncology, Inc. Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
JP5779106B2 (ja) * 2009-02-24 2015-09-16 デック−テック， インコーポレイテッド 抗腫瘍剤としての４−ヒドロペルオキシイホスファミドの錯体
CN102659841B (zh) * 2012-04-24 2015-03-25 石家庄学院 多元酚磷酰胺衍生物及其制备方法与应用
WO2014117035A1 (en) 2013-01-24 2014-07-31 Transderm, Inc. COMPOSITIONS FOR TRANSDERMAL DELIVERY OF mTOR INHIBITORS
AU2016318613A1 (en) 2015-09-10 2018-03-22 Becton, Dickinson And Company Cyclophosphamide analogs for use as immunogens and assay conjugates for an immunoassay of cyclophosphamide and ifosfamide
JP7108631B2 (ja) 2017-01-06 2022-07-28 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物およびその使用方法
USD859683S1 (en) 2017-09-21 2019-09-10 Becton, Dickinson And Company Collection device
US11002642B2 (en) 2017-09-21 2021-05-11 Becton, Dickinson And Company Demarcation template for hazardous contaminant testing
WO2019060269A1 (en) 2017-09-21 2019-03-28 Becton, Dickinson And Company KIT FOR COLLECTING HAZARDOUS CONTAMINANTS AND RAPID ANALYSIS
US11391748B2 (en) 2017-09-21 2022-07-19 Becton, Dickinson And Company High dynamic range assays in hazardous contaminant testing
US11000513B2 (en) 2018-07-02 2021-05-11 Palvella Therapeutics, Inc. Anhydrous compositions of mTOR inhibitors and methods of use
JP7520822B2 (ja) * 2018-09-25 2024-07-23 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ２’－ハロゲン化－４’－チオ－２’－デオキシ－５－アザシチジンアナログおよびその使用
CA3125355A1 (en) 2019-01-28 2020-08-06 Becton, Dickinson And Company Hazardous contaminant collection device with integrated swab and test device
CN111973583A (zh) * 2020-07-29 2020-11-24 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 芹菜素在制备促进缺血超长随意皮瓣存活药物的作用
CN111943979B (zh) * 2020-10-19 2020-12-22 南京卓康医药科技有限公司 一种异环磷酰胺中间体及其制备方法和应用

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WO2000071134A1 (en) * 1999-05-24 2000-11-30 Southern Research Institute Isophosphoramide mustard analogs and use thereof

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JPS5159886A (https=) 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
DD260279A5 (de) * 1986-02-22 1988-09-21 Asta-Werke Ag Chemische Fabrik,De Verfahren zur herstellung heterocyclischer verbindungen mit einem 2-(2-[n,n-bis-12)2-chlorethyl)-diamido-phosphoryloxy]ethyl)-rest
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ES2565929T3 (es) 2004-10-25 2016-04-07 Dekk-Tec, Inc. Sales de mostaza de isofosforamida y análogos de las mismas como agentes antitumorales
ES2547302T3 (es) * 2007-04-06 2015-10-05 Ziopharm Oncology, Inc. Sales de mostaza de isofosforamida y análogos de las mismas
CA2732290A1 (en) * 2008-07-31 2010-02-04 Ziopharm Oncology, Inc. Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof

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Also Published As

Publication number Publication date
US7678778B2 (en) 2010-03-16
US20150152125A1 (en) 2015-06-04
DK2336140T3 (en) 2016-03-21
EP1805192A2 (en) 2007-07-11
CA2585125A1 (en) 2006-05-04
EP2336140A2 (en) 2011-06-22
ES2397165T3 (es) 2013-03-05
AU2005299385A1 (en) 2006-05-04
EP2336139A2 (en) 2011-06-22
NO20072478L (no) 2007-06-25
NZ589418A (en) 2012-03-30
KR101292026B1 (ko) 2013-08-01
EP2336139A3 (en) 2012-01-04
IL211935A0 (en) 2011-05-31
AU2005299385B2 (en) 2011-06-16
EP1805192B1 (en) 2012-10-17
EP2336140B1 (en) 2016-01-27
NZ555323A (en) 2010-12-24
IL182752A (en) 2012-09-24
ES2565929T3 (es) 2016-04-07
DK1805192T3 (da) 2013-02-04
SI1805192T1 (sl) 2013-02-28
PL1805192T3 (pl) 2013-03-29
HK1100945A1 (en) 2007-11-16
US8232262B2 (en) 2012-07-31
KR20130041384A (ko) 2013-04-24
KR20070121632A (ko) 2007-12-27
CA2585125C (en) 2014-04-22
WO2006047575A2 (en) 2006-05-04
US20060089333A1 (en) 2006-04-27
EP2336140A3 (en) 2012-01-11
IL182752A0 (en) 2007-07-24
US20080267945A1 (en) 2008-10-30
WO2006047575A3 (en) 2006-08-10
JP5336082B2 (ja) 2013-11-06
PT1805192E (pt) 2013-01-23
US8795659B2 (en) 2014-08-05
CN103172662A (zh) 2013-06-26
JP2008517949A (ja) 2008-05-29
CN104558023A (zh) 2015-04-29
IL211936A0 (en) 2011-05-31
US20130149296A1 (en) 2013-06-13
CN101087800A (zh) 2007-12-12
US9346836B2 (en) 2016-05-24
IL211936A (en) 2012-12-31
HK1209752A1 (en) 2016-04-08

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Granted publication date: 20150107

Termination date: 20161025