HK1209752A1 - Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents - Google Patents

Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents Download PDF

Info

Publication number
HK1209752A1
HK1209752A1 HK15110402.4A HK15110402A HK1209752A1 HK 1209752 A1 HK1209752 A1 HK 1209752A1 HK 15110402 A HK15110402 A HK 15110402A HK 1209752 A1 HK1209752 A1 HK 1209752A1
Authority
HK
Hong Kong
Prior art keywords
ipm
compound
dose
isophosphoramide mustard
day
Prior art date
Application number
HK15110402.4A
Other languages
English (en)
Chinese (zh)
Inventor
‧摩根
L‧摩根
Original Assignee
德克技术公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 德克技术公司 filed Critical 德克技术公司
Publication of HK1209752A1 publication Critical patent/HK1209752A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/222—Amides of phosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15110402.4A 2004-10-25 2015-10-22 Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents HK1209752A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62208704P 2004-10-25 2004-10-25
US60/622,087 2004-10-25
US67270705P 2005-04-18 2005-04-18
US60/672,707 2005-04-18

Publications (1)

Publication Number Publication Date
HK1209752A1 true HK1209752A1 (en) 2016-04-08

Family

ID=35788704

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15110402.4A HK1209752A1 (en) 2004-10-25 2015-10-22 Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents

Country Status (17)

Country Link
US (4) US8232262B2 (https=)
EP (3) EP1805192B1 (https=)
JP (1) JP5336082B2 (https=)
KR (2) KR20130041384A (https=)
CN (3) CN101087800B (https=)
AU (1) AU2005299385B2 (https=)
CA (1) CA2585125C (https=)
DK (2) DK2336140T3 (https=)
ES (2) ES2565929T3 (https=)
HK (1) HK1209752A1 (https=)
IL (3) IL182752A (https=)
NO (1) NO20072478L (https=)
NZ (2) NZ589418A (https=)
PL (1) PL1805192T3 (https=)
PT (1) PT1805192E (https=)
SI (1) SI1805192T1 (https=)
WO (1) WO2006047575A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2565929T3 (es) 2004-10-25 2016-04-07 Dekk-Tec, Inc. Sales de mostaza de isofosforamida y análogos de las mismas como agentes antitumorales
US7964583B2 (en) 2006-02-17 2011-06-21 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
ES2547302T3 (es) 2007-04-06 2015-10-05 Ziopharm Oncology, Inc. Sales de mostaza de isofosforamida y análogos de las mismas
CA2732290A1 (en) * 2008-07-31 2010-02-04 Ziopharm Oncology, Inc. Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
JP5779106B2 (ja) * 2009-02-24 2015-09-16 デック−テック， インコーポレイテッド 抗腫瘍剤としての４−ヒドロペルオキシイホスファミドの錯体
CN102659841B (zh) * 2012-04-24 2015-03-25 石家庄学院 多元酚磷酰胺衍生物及其制备方法与应用
WO2014117035A1 (en) 2013-01-24 2014-07-31 Transderm, Inc. COMPOSITIONS FOR TRANSDERMAL DELIVERY OF mTOR INHIBITORS
AU2016318613A1 (en) 2015-09-10 2018-03-22 Becton, Dickinson And Company Cyclophosphamide analogs for use as immunogens and assay conjugates for an immunoassay of cyclophosphamide and ifosfamide
JP7108631B2 (ja) 2017-01-06 2022-07-28 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物およびその使用方法
USD859683S1 (en) 2017-09-21 2019-09-10 Becton, Dickinson And Company Collection device
US11002642B2 (en) 2017-09-21 2021-05-11 Becton, Dickinson And Company Demarcation template for hazardous contaminant testing
WO2019060269A1 (en) 2017-09-21 2019-03-28 Becton, Dickinson And Company KIT FOR COLLECTING HAZARDOUS CONTAMINANTS AND RAPID ANALYSIS
US11391748B2 (en) 2017-09-21 2022-07-19 Becton, Dickinson And Company High dynamic range assays in hazardous contaminant testing
US11000513B2 (en) 2018-07-02 2021-05-11 Palvella Therapeutics, Inc. Anhydrous compositions of mTOR inhibitors and methods of use
JP7520822B2 (ja) * 2018-09-25 2024-07-23 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ２’－ハロゲン化－４’－チオ－２’－デオキシ－５－アザシチジンアナログおよびその使用
CA3125355A1 (en) 2019-01-28 2020-08-06 Becton, Dickinson And Company Hazardous contaminant collection device with integrated swab and test device
CN111973583A (zh) * 2020-07-29 2020-11-24 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 芹菜素在制备促进缺血超长随意皮瓣存活药物的作用
CN111943979B (zh) * 2020-10-19 2020-12-22 南京卓康医药科技有限公司 一种异环磷酰胺中间体及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU427945A1 (ru) 1972-07-24 1974-05-15 Институт элементоорганических соединений СПОСОБ ПОЛУЧЕНИЯа ПОЛИФТОРАЛКИЛЗАМЕЩЕННЫХБЕНЗИЛДИХЛОРФОСФАТОВ
JPS5159886A (https=) 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
DD260279A5 (de) * 1986-02-22 1988-09-21 Asta-Werke Ag Chemische Fabrik,De Verfahren zur herstellung heterocyclischer verbindungen mit einem 2-(2-[n,n-bis-12)2-chlorethyl)-diamido-phosphoryloxy]ethyl)-rest
US4841085A (en) * 1986-06-30 1989-06-20 Board Of Regents, University Of Texas System Aldophosphamides
US5055459A (en) * 1986-06-30 1991-10-08 Board Of Regents, The University Of Texas Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates
JPH07505887A (ja) 1992-04-17 1995-06-29 アボツト・ラボラトリーズ タキソール誘導体
US5468499A (en) * 1993-11-15 1995-11-21 Ohio State University Liposomes containing the salt of phosphoramide mustard and related compounds
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
EP1185276B1 (en) 1999-05-24 2003-12-10 Southern Research Institute Isophosphoramide mustard analogs and use thereof
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
WO2001079158A2 (en) 2000-04-13 2001-10-25 Hsc Research And Development Limited Partnership Compounds for modulating cell proliferation
DE10064312C2 (de) * 2000-12-22 2003-05-22 Degussa Cholinpyruvat-Hydrat, Verfahren zu dessen Herstellung, Cholinpyruvat-Hydrat enthaltende Formulierung sowie deren Verwendung
DE60330407D1 (de) 2002-08-23 2010-01-14 Sloan Kettering Inst Cancer Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung
ES2565929T3 (es) 2004-10-25 2016-04-07 Dekk-Tec, Inc. Sales de mostaza de isofosforamida y análogos de las mismas como agentes antitumorales
ES2547302T3 (es) * 2007-04-06 2015-10-05 Ziopharm Oncology, Inc. Sales de mostaza de isofosforamida y análogos de las mismas
CA2732290A1 (en) * 2008-07-31 2010-02-04 Ziopharm Oncology, Inc. Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof

Also Published As

Publication number Publication date
US7678778B2 (en) 2010-03-16
US20150152125A1 (en) 2015-06-04
DK2336140T3 (en) 2016-03-21
EP1805192A2 (en) 2007-07-11
CA2585125A1 (en) 2006-05-04
EP2336140A2 (en) 2011-06-22
ES2397165T3 (es) 2013-03-05
AU2005299385A1 (en) 2006-05-04
EP2336139A2 (en) 2011-06-22
NO20072478L (no) 2007-06-25
NZ589418A (en) 2012-03-30
KR101292026B1 (ko) 2013-08-01
EP2336139A3 (en) 2012-01-04
IL211935A0 (en) 2011-05-31
AU2005299385B2 (en) 2011-06-16
EP1805192B1 (en) 2012-10-17
EP2336140B1 (en) 2016-01-27
NZ555323A (en) 2010-12-24
IL182752A (en) 2012-09-24
ES2565929T3 (es) 2016-04-07
DK1805192T3 (da) 2013-02-04
SI1805192T1 (sl) 2013-02-28
PL1805192T3 (pl) 2013-03-29
HK1100945A1 (en) 2007-11-16
US8232262B2 (en) 2012-07-31
KR20130041384A (ko) 2013-04-24
KR20070121632A (ko) 2007-12-27
CA2585125C (en) 2014-04-22
WO2006047575A2 (en) 2006-05-04
US20060089333A1 (en) 2006-04-27
EP2336140A3 (en) 2012-01-11
IL182752A0 (en) 2007-07-24
US20080267945A1 (en) 2008-10-30
WO2006047575A3 (en) 2006-08-10
JP5336082B2 (ja) 2013-11-06
PT1805192E (pt) 2013-01-23
US8795659B2 (en) 2014-08-05
CN103172662A (zh) 2013-06-26
JP2008517949A (ja) 2008-05-29
CN104558023A (zh) 2015-04-29
IL211936A0 (en) 2011-05-31
US20130149296A1 (en) 2013-06-13
CN101087800A (zh) 2007-12-12
US9346836B2 (en) 2016-05-24
IL211936A (en) 2012-12-31
CN101087800B (zh) 2015-01-07

Similar Documents

Publication Publication Date Title
HK1209752A1 (en) Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
US20140194377A1 (en) Salts of Isophosphoramide Mustard and Analogs Thereof
US9254298B2 (en) Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
HK1185884A (en) Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
AU2011221388B2 (en) Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
US7964583B2 (en) Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
HK1100945B (en) Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents