SI1727786T1 - Kisle dodatne soli 5-aminolevulinske kisline ali njenih derivatov - Google Patents
Kisle dodatne soli 5-aminolevulinske kisline ali njenih derivatovInfo
- Publication number
- SI1727786T1 SI1727786T1 SI200531338T SI200531338T SI1727786T1 SI 1727786 T1 SI1727786 T1 SI 1727786T1 SI 200531338 T SI200531338 T SI 200531338T SI 200531338 T SI200531338 T SI 200531338T SI 1727786 T1 SI1727786 T1 SI 1727786T1
- Authority
- SI
- Slovenia
- Prior art keywords
- acid
- derivatives
- ala
- aminolevulinic
- addition salts
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 5
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical class NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002749 aminolevulinic acid Drugs 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- -1 5-ALA ester Chemical class 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 239000003504 photosensitizing agent Substances 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0406917.5A GB0406917D0 (en) | 2004-03-26 | 2004-03-26 | Compounds |
| EP05732530A EP1727786B1 (en) | 2004-03-26 | 2005-03-29 | Acid addition salts of 5-aminolevulinic acid or its derivatives |
| PCT/GB2005/001236 WO2005092838A1 (en) | 2004-03-26 | 2005-03-29 | Acid addition salts of 5-aminolevulinic acid or its derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1727786T1 true SI1727786T1 (sl) | 2011-09-30 |
Family
ID=32188818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200531338T SI1727786T1 (sl) | 2004-03-26 | 2005-03-29 | Kisle dodatne soli 5-aminolevulinske kisline ali njenih derivatov |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7888526B2 (https=) |
| EP (2) | EP1727786B1 (https=) |
| JP (1) | JP5164565B2 (https=) |
| CN (1) | CN1938264B (https=) |
| AT (1) | ATE514672T1 (https=) |
| AU (1) | AU2005225616B2 (https=) |
| CA (1) | CA2561050C (https=) |
| DK (1) | DK1727786T3 (https=) |
| ES (2) | ES2367789T3 (https=) |
| GB (1) | GB0406917D0 (https=) |
| PL (1) | PL1727786T3 (https=) |
| PT (1) | PT1727786E (https=) |
| RU (1) | RU2392266C2 (https=) |
| SI (1) | SI1727786T1 (https=) |
| WO (1) | WO2005092838A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005025614D1 (de) * | 2004-03-30 | 2011-02-10 | Cosmo Oil Co Ltd | 5-aminolevulinsäure-phosphatsalz, verfahren zu dessen herstellung und dessen verwendung |
| JP4719483B2 (ja) * | 2004-03-30 | 2011-07-06 | コスモ石油株式会社 | 5−アミノレブリン酸スルホン酸塩の製造方法 |
| GB0424833D0 (en) | 2004-11-10 | 2004-12-15 | Photocure Asa | Method |
| JP4934292B2 (ja) * | 2005-07-05 | 2012-05-16 | コスモ石油株式会社 | 5−アミノレブリン酸エステルリン酸類塩、その製造方法及びその用途 |
| JP4934293B2 (ja) * | 2005-07-05 | 2012-05-16 | コスモ石油株式会社 | 植物活力剤組成物 |
| US20070225518A1 (en) * | 2006-03-22 | 2007-09-27 | Zvi Malik | 5-Aminolevulinic acid salts and their use |
| KR100796450B1 (ko) * | 2006-06-29 | 2008-01-22 | 전남대학교산학협력단 | 5-아미노레불린산의 불포화 알킬 에스터 및 약학적으로허용되는 그의 염, 이의 제조방법 및 이의 용도 |
| JP4989153B2 (ja) | 2006-08-15 | 2012-08-01 | コスモ石油株式会社 | 5−アミノレブリン酸リン酸塩の新規結晶及びその製造方法 |
| GB0700580D0 (en) * | 2007-01-11 | 2007-02-21 | Photocure Asa | Use |
| WO2008106966A1 (en) * | 2007-03-06 | 2008-09-12 | Christiansen Kaare | A method for non-therapeutic or therapeutic photodynamic skin treatment |
| CN103626639B (zh) * | 2008-10-30 | 2016-12-07 | 阿彻丹尼尔斯米德兰德公司 | 用金属催化剂还原hmf醚 |
| GB0823472D0 (en) | 2008-12-23 | 2009-01-28 | Photocure Asa | Product |
| GB0900461D0 (en) * | 2009-01-12 | 2009-02-11 | Photocure Asa | Photodynamic therapy device |
| RU2526803C2 (ru) | 2009-06-11 | 2014-08-27 | ФотоКьюэр АСА | Полутвердые композиции и фармацевтические продукты |
| CA2790827A1 (en) | 2010-03-01 | 2011-09-09 | Photocure Asa | Cosmetic compositions |
| EP2394642A1 (en) | 2010-06-10 | 2011-12-14 | Universite De Geneve | 5-ALA ester formulations and use thereof |
| EP2585111A1 (en) | 2010-06-23 | 2013-05-01 | Photocure ASA | Hyperosmotic preparations comprising 5 -amino levulinic acid or derivative as photosensitizing agent |
| JP5991970B2 (ja) | 2010-07-09 | 2016-09-14 | フォトキュア エイエスエイ | 光力学的治療または光力学的診断で使用する乾燥組成物および当該乾燥組成物を含む装置 |
| WO2012086802A1 (ja) | 2010-12-24 | 2012-06-28 | アークレイ株式会社 | 癌細胞の検出方法 |
| US20140316534A1 (en) | 2011-10-14 | 2014-10-23 | Photocure Asa | Stent |
| EP2766049A1 (en) | 2011-10-14 | 2014-08-20 | Photocure ASA | Photodynamic diagnosis of abnormalities of the epithelial lining of the oesophagus with the means of a 5-ala ester |
| RU2615870C2 (ru) | 2011-12-19 | 2017-04-11 | ФотоКьюэр АСА | Устройство облучения |
| CA2880422C (en) | 2012-08-03 | 2021-02-09 | Photocure Asa | Derivatives of 5-aminolevulinic acid |
| WO2014026077A1 (en) | 2012-08-10 | 2014-02-13 | Dusa Pharmaceuticals, Inc. | Method for the treatment of acne |
| US20140067024A1 (en) | 2012-08-30 | 2014-03-06 | Photocure Asa | Dual panel photodynamic therapy lamp |
| GB201221123D0 (en) | 2012-11-23 | 2013-01-09 | Photocure As | Device for photodynamic treatment |
| GB201306369D0 (en) | 2013-04-09 | 2013-05-22 | Photocure As | Irradiation device |
| JP6595484B2 (ja) | 2013-12-20 | 2019-10-23 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 光損傷皮膚のパルス光力学的処置 |
| EP3095464A1 (en) | 2015-05-19 | 2016-11-23 | Universite De Geneve | 5-ala derivatives and use thereof |
| GB201522309D0 (en) | 2015-12-17 | 2016-02-03 | Photocure Asa | Use |
| GB201522311D0 (en) | 2015-12-17 | 2016-02-03 | Photocure Asa | Use |
| BR112018011965A2 (pt) | 2015-12-17 | 2018-12-04 | Photocure Asa | método de terapia fotodinâmica (pdt) para câncer de bexiga |
| GB201522398D0 (en) | 2015-12-18 | 2016-02-03 | Photocure As | Device for photodynamic therapy |
| CN106187793A (zh) * | 2016-01-26 | 2016-12-07 | 赵鸣 | 5‑氨基酮戊酸及其衍生物的盐化合物和应用 |
| RU2611441C2 (ru) * | 2016-04-28 | 2017-02-22 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский радиологический центр" Министерства здравоохранения Российской Федерации (ФГБУ "НМИРЦ" Минздрава России) | Способ получения гидрохлорида метилового эфира 5-аминолевулиновой кислоты |
| KR20190112096A (ko) | 2017-02-06 | 2019-10-02 | 쓰리스킨 에이에스 | 자외선 차단제 조성물 |
| CN108088838A (zh) * | 2017-12-13 | 2018-05-29 | 西南大学 | 双[2,4,6-三氯苯基]草酸酯在测定链格孢霉毒素中的应用及方法 |
| CN108440319B (zh) * | 2018-04-26 | 2021-05-18 | 爱斯特(成都)生物制药股份有限公司 | 一种制备盐酸氨基乙酰丙酸的方法 |
| EP3868372A1 (en) | 2020-02-19 | 2021-08-25 | JLP Health GmbH | A pharmaceutical combination of an artemisinin compound and a heme synthesis modulator for treating cancer |
| CN115671059B (zh) * | 2022-11-17 | 2024-06-11 | 兆科药业(合肥)有限公司 | 一种盐酸氨酮戊酸冻干制剂及制备方法 |
| CN116162038A (zh) * | 2023-01-06 | 2023-05-26 | 河南省精细化工研究院有限公司 | 一种5-氨基乙酰丙酸盐酸盐的环保型生产工艺 |
| CN120957714A (zh) | 2023-03-07 | 2025-11-14 | 光治疗Asa公司 | 膀胱癌疗法 |
| WO2026052815A1 (en) | 2024-09-05 | 2026-03-12 | Photocure Asa | Use of hal in a method for predicting bladder cancer immunotherapy response |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5079262A (en) | 1989-07-28 | 1992-01-07 | Queen's University At Kingston | Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid |
| JP2767318B2 (ja) * | 1990-04-11 | 1998-06-18 | 株式会社コスモ総合研究所 | 5―アミノレブリン酸アルキルエステル又はその塩及びその製造方法並びにこれを有効成分とする除草剤 |
| EP0483714B1 (en) * | 1990-10-29 | 1995-05-03 | Japan Tobacco Inc. | A method of preparing an acid additional salt of delta-aminolevulinic acid |
| US5284973A (en) * | 1990-10-29 | 1994-02-08 | Japan Tobacco Inc. | Method of preparing an acid additional salt of delta-aminolevulinic acid |
| JP2613136B2 (ja) * | 1991-05-14 | 1997-05-21 | 株式会社コスモ総合研究所 | 植物成長促進剤 |
| JP2997979B2 (ja) | 1993-01-20 | 2000-01-11 | 株式会社コスモ総合研究所 | 5−アミノレブリン酸の製造方法 |
| JP2887554B2 (ja) * | 1993-08-19 | 1999-04-26 | 株式会社コスモ総合研究所 | 植物の蓚酸含量低減剤 |
| US5489572A (en) | 1993-08-19 | 1996-02-06 | Cosmo Research Institue | Methods for reducing nitrate nitrogen and oxalic acids contents nin plants |
| GB9318841D0 (en) | 1993-09-10 | 1993-10-27 | Res Foundation Of The Norwegia | Composition |
| JPH07238063A (ja) | 1994-02-25 | 1995-09-12 | Cosmo Sogo Kenkyusho:Kk | 5−アミノレブリン酸の回収精製法 |
| JP2896963B2 (ja) | 1994-11-28 | 1999-05-31 | 株式会社コスモ総合研究所 | 植物の耐塩性向上剤 |
| GB9504948D0 (en) * | 1995-03-10 | 1995-04-26 | Norwegian Radium Hospital Rese | Compounds |
| ATE202076T1 (de) | 1995-03-10 | 2001-06-15 | Photocure Asa | Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie |
| US6992107B1 (en) * | 1995-03-10 | 2006-01-31 | Photocure Asa | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy |
| JPH1112197A (ja) | 1997-06-18 | 1999-01-19 | Cosmo Sogo Kenkyusho:Kk | 悪性腫瘍診断剤及び治療剤 |
| DE69826487T2 (de) | 1997-07-30 | 2005-12-01 | Wyeth | Trizyclische vasopressin-agonisten |
| US5907058A (en) * | 1998-07-29 | 1999-05-25 | Midwest Research Institute | Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters |
| GB0018527D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Composition |
| GB0018528D0 (en) * | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| GB0118251D0 (en) | 2001-07-26 | 2001-09-19 | Photocure Asa | Method |
| DE602005025614D1 (de) * | 2004-03-30 | 2011-02-10 | Cosmo Oil Co Ltd | 5-aminolevulinsäure-phosphatsalz, verfahren zu dessen herstellung und dessen verwendung |
-
2004
- 2004-03-26 GB GBGB0406917.5A patent/GB0406917D0/en not_active Ceased
-
2005
- 2005-03-29 JP JP2007504487A patent/JP5164565B2/ja not_active Expired - Lifetime
- 2005-03-29 EP EP05732530A patent/EP1727786B1/en not_active Expired - Lifetime
- 2005-03-29 CN CN2005800098456A patent/CN1938264B/zh not_active Expired - Fee Related
- 2005-03-29 WO PCT/GB2005/001236 patent/WO2005092838A1/en not_active Ceased
- 2005-03-29 PT PT05732530T patent/PT1727786E/pt unknown
- 2005-03-29 US US10/594,361 patent/US7888526B2/en not_active Expired - Lifetime
- 2005-03-29 PL PL05732530T patent/PL1727786T3/pl unknown
- 2005-03-29 DK DK05732530.0T patent/DK1727786T3/da active
- 2005-03-29 ES ES05732530T patent/ES2367789T3/es not_active Expired - Lifetime
- 2005-03-29 RU RU2006135487/04A patent/RU2392266C2/ru not_active IP Right Cessation
- 2005-03-29 ES ES10011759.7T patent/ES2639021T3/es not_active Expired - Lifetime
- 2005-03-29 SI SI200531338T patent/SI1727786T1/sl unknown
- 2005-03-29 AT AT05732530T patent/ATE514672T1/de active
- 2005-03-29 AU AU2005225616A patent/AU2005225616B2/en not_active Ceased
- 2005-03-29 CA CA2561050A patent/CA2561050C/en not_active Expired - Fee Related
- 2005-03-29 EP EP10011759.7A patent/EP2308830B1/en not_active Expired - Lifetime
-
2010
- 2010-10-29 US US12/916,326 patent/US8692014B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005225616B2 (en) | 2011-08-18 |
| CA2561050A1 (en) | 2005-10-06 |
| DK1727786T3 (da) | 2011-08-29 |
| CN1938264A (zh) | 2007-03-28 |
| JP2007530523A (ja) | 2007-11-01 |
| US20080064752A1 (en) | 2008-03-13 |
| ES2639021T3 (es) | 2017-10-25 |
| AU2005225616A1 (en) | 2005-10-06 |
| CN1938264B (zh) | 2012-05-23 |
| US20110125012A1 (en) | 2011-05-26 |
| EP1727786B1 (en) | 2011-06-29 |
| RU2392266C2 (ru) | 2010-06-20 |
| GB0406917D0 (en) | 2004-04-28 |
| ATE514672T1 (de) | 2011-07-15 |
| US7888526B2 (en) | 2011-02-15 |
| CA2561050C (en) | 2012-05-08 |
| PT1727786E (pt) | 2011-07-08 |
| EP2308830B1 (en) | 2017-06-14 |
| PL1727786T3 (pl) | 2011-11-30 |
| ES2367789T3 (es) | 2011-11-08 |
| WO2005092838A1 (en) | 2005-10-06 |
| EP2308830A1 (en) | 2011-04-13 |
| EP1727786A1 (en) | 2006-12-06 |
| US8692014B2 (en) | 2014-04-08 |
| RU2006135487A (ru) | 2008-05-10 |
| JP5164565B2 (ja) | 2013-03-21 |
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