SG11201805000RA - Method of photodynamic therapy (pdt) for bladder cancer - Google Patents
Method of photodynamic therapy (pdt) for bladder cancerInfo
- Publication number
- SG11201805000RA SG11201805000RA SG11201805000RA SG11201805000RA SG11201805000RA SG 11201805000R A SG11201805000R A SG 11201805000RA SG 11201805000R A SG11201805000R A SG 11201805000RA SG 11201805000R A SG11201805000R A SG 11201805000RA SG 11201805000R A SG11201805000R A SG 11201805000RA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- bladder cancer
- photodynamic therapy
- pdt
- oslo
- Prior art date
Links
- 206010005003 Bladder cancer Diseases 0.000 title abstract 5
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 title abstract 5
- 201000005112 urinary bladder cancer Diseases 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 238000002428 photodynamic therapy Methods 0.000 title abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- ILBBNQMSDGAAPF-UHFFFAOYSA-N 1-(6-hydroxy-6-methylcyclohexa-2,4-dien-1-yl)propan-1-one Chemical compound CCC(=O)C1C=CC=CC1(C)O ILBBNQMSDGAAPF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 238000009098 adjuvant therapy Methods 0.000 abstract 1
- -1 hexyl 5-ALA ester Chemical class 0.000 abstract 1
- 238000009099 neoadjuvant therapy Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/307—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/061—Bladder and/or urethra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
- A61N2005/0663—Coloured light
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Surgery (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Radiation-Therapy Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 June 2017 (22.06.2017) WIPO I PCT (10) International Publication Number WO 2017/103285 Al 1111111111111101110111111111110101111101110101111101110111H1111111111111110111111 (51) International Patent Classification: A61K 41/00 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/EP2016/081809 (22) International Filing Date: 19 December 2016 (19.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15200938.7 17 December 2015 (17.12.2015) EP (71) Applicant: PHOTOCURE ASA [NO/NO]; Hoffsveien 4, 0275 Oslo (NO). (72) Inventors: HESTDAL, Kjetil; Vwkeroasen 8b, 0282 Oslo (NO). GODAL, Aslak; Gaustadveien 77, 0372 Oslo (NO). (74) Agents: DEHNS et al.; St Bride's House, 10 Salisbury Square, London, Greater London EC4Y 8JD (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) W O 20 17 / 103 285 Al (54) Title: METHOD OF PHOTODYNAMIC THERAPY (PDT) FOR BLADDER CANCER (57) : This invention relates to a method of photodynamic therapy (PDT) for bladder cancer and its use as an adjuvant or neoadjuvant therapy in the treatment of bladder cancer. The invention provides a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a method of photodynamic therapy for bladder cancer, wherein said composi - tion is instilled into the bladder of a patient in need of such treatment and the inside of said bladder is exposed to blue light having a fluence rate of 1.5 to 12.5 mW/cm2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15200938 | 2015-12-17 | ||
| PCT/EP2016/081809 WO2017103285A1 (en) | 2015-12-17 | 2016-12-19 | Method of photodynamic therapy (pdt) for bladder cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201805000RA true SG11201805000RA (en) | 2018-07-30 |
Family
ID=55066354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201805000RA SG11201805000RA (en) | 2015-12-17 | 2016-12-19 | Method of photodynamic therapy (pdt) for bladder cancer |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11235168B2 (en) |
| EP (1) | EP3389716B1 (en) |
| JP (1) | JP6995755B2 (en) |
| KR (1) | KR20180094986A (en) |
| CN (1) | CN108697800A (en) |
| AU (1) | AU2016372575B2 (en) |
| BR (1) | BR112018011965A2 (en) |
| CA (1) | CA3008552C (en) |
| CL (1) | CL2018001612A1 (en) |
| DK (1) | DK3389716T3 (en) |
| ES (1) | ES2910034T3 (en) |
| IL (1) | IL259925B (en) |
| PL (1) | PL3389716T3 (en) |
| RU (1) | RU2745194C2 (en) |
| SG (1) | SG11201805000RA (en) |
| WO (1) | WO2017103285A1 (en) |
| ZA (1) | ZA201804530B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017103285A1 (en) * | 2015-12-17 | 2017-06-22 | Photocure Asa | Method of photodynamic therapy (pdt) for bladder cancer |
| CN110420326A (en) * | 2019-09-17 | 2019-11-08 | 上海复旦张江生物医药股份有限公司 | A kind of application mostly fragrant for pool |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ303251A (en) | 1995-03-10 | 2000-10-27 | Photocure Asa | Use of esters of 5-aminolevulinic acid as photosensitising agents in photochemotherapy |
| US7530461B2 (en) * | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US20050003154A1 (en) * | 2002-12-13 | 2005-01-06 | White Gary L. | Laminated building panels having preselected colors |
| GB0406917D0 (en) | 2004-03-26 | 2004-04-28 | Photocure Asa | Compounds |
| GB0700580D0 (en) | 2007-01-11 | 2007-02-21 | Photocure Asa | Use |
| GB0724279D0 (en) | 2007-12-12 | 2008-01-23 | Photocure Asa | Use |
| CN101891639A (en) | 2009-05-20 | 2010-11-24 | 上海先导化学有限公司 | Method for preparing 5-aminolevulinic acid hydrochloride |
| CN102802612A (en) | 2009-06-11 | 2012-11-28 | 光治疗Asa公司 | Solid compositions comprising 5-aminolevulinic acid |
| NZ596943A (en) | 2009-06-11 | 2013-09-27 | Photocure Asa | Semi-solid compositions and pharmaceutical products |
| RU2448745C2 (en) * | 2010-05-31 | 2012-04-27 | Олег Феликсович Каган | Method of treating superficial urinary bladder cancer |
| EP2793679B1 (en) | 2011-12-19 | 2017-05-17 | Technical University of Denmark | An illumination system for endoscopic applications |
| IN2015DN00837A (en) | 2012-08-03 | 2015-06-12 | Photocure Asa | |
| GB201221123D0 (en) * | 2012-11-23 | 2013-01-09 | Photocure As | Device for photodynamic treatment |
| WO2017103285A1 (en) * | 2015-12-17 | 2017-06-22 | Photocure Asa | Method of photodynamic therapy (pdt) for bladder cancer |
-
2016
- 2016-12-19 WO PCT/EP2016/081809 patent/WO2017103285A1/en active Application Filing
- 2016-12-19 SG SG11201805000RA patent/SG11201805000RA/en unknown
- 2016-12-19 KR KR1020187020005A patent/KR20180094986A/en not_active Application Discontinuation
- 2016-12-19 RU RU2018123834A patent/RU2745194C2/en active
- 2016-12-19 ES ES16810437T patent/ES2910034T3/en active Active
- 2016-12-19 CN CN201680079638.6A patent/CN108697800A/en active Pending
- 2016-12-19 BR BR112018011965A patent/BR112018011965A2/en not_active Application Discontinuation
- 2016-12-19 CA CA3008552A patent/CA3008552C/en active Active
- 2016-12-19 AU AU2016372575A patent/AU2016372575B2/en active Active
- 2016-12-19 EP EP16810437.0A patent/EP3389716B1/en active Active
- 2016-12-19 JP JP2018532037A patent/JP6995755B2/en active Active
- 2016-12-19 US US16/063,142 patent/US11235168B2/en active Active
- 2016-12-19 DK DK16810437.0T patent/DK3389716T3/en active
- 2016-12-19 PL PL16810437T patent/PL3389716T3/en unknown
-
2018
- 2018-06-10 IL IL259925A patent/IL259925B/en unknown
- 2018-06-14 CL CL2018001612A patent/CL2018001612A1/en unknown
- 2018-07-06 ZA ZA2018/04530A patent/ZA201804530B/en unknown
-
2022
- 2022-01-31 US US17/588,978 patent/US11980772B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2745194C2 (en) | 2021-03-22 |
| IL259925B (en) | 2022-04-01 |
| JP2019501161A (en) | 2019-01-17 |
| EP3389716B1 (en) | 2022-03-23 |
| EP3389716A1 (en) | 2018-10-24 |
| AU2016372575B2 (en) | 2022-12-08 |
| CA3008552A1 (en) | 2017-06-22 |
| IL259925A (en) | 2018-07-31 |
| DK3389716T3 (en) | 2022-04-11 |
| PL3389716T3 (en) | 2022-06-20 |
| US20190022404A1 (en) | 2019-01-24 |
| ES2910034T3 (en) | 2022-05-11 |
| BR112018011965A2 (en) | 2018-12-04 |
| KR20180094986A (en) | 2018-08-24 |
| AU2016372575A1 (en) | 2018-07-12 |
| US11980772B2 (en) | 2024-05-14 |
| US11235168B2 (en) | 2022-02-01 |
| CL2018001612A1 (en) | 2019-01-11 |
| US20220152411A1 (en) | 2022-05-19 |
| CN108697800A (en) | 2018-10-23 |
| ZA201804530B (en) | 2019-09-25 |
| RU2018123834A3 (en) | 2020-04-13 |
| RU2018123834A (en) | 2020-01-17 |
| CA3008552C (en) | 2024-01-02 |
| WO2017103285A1 (en) | 2017-06-22 |
| JP6995755B2 (en) | 2022-01-17 |
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