SI1607090T1 - Asimadolin za zdravljenje sindroma razdraĹľljivega ÄŤrevesa - Google Patents
Asimadolin za zdravljenje sindroma razdraĹľljivega ÄŤrevesaInfo
- Publication number
- SI1607090T1 SI1607090T1 SI9931065T SI9931065T SI1607090T1 SI 1607090 T1 SI1607090 T1 SI 1607090T1 SI 9931065 T SI9931065 T SI 9931065T SI 9931065 T SI9931065 T SI 9931065T SI 1607090 T1 SI1607090 T1 SI 1607090T1
- Authority
- SI
- Slovenia
- Prior art keywords
- asimadoline
- treatment
- bowel syndrome
- irritable bowel
- irritable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B35/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving a change in the type of bonding between two carbon atoms already directly linked
- C07B35/02—Reduction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19817393 | 1998-04-20 | ||
DE19827633A DE19827633A1 (de) | 1998-04-20 | 1998-06-20 | Verfahren zur Herstellung von enantiomerenreinem N-Methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamid |
EP05016750A EP1607090B1 (de) | 1998-04-20 | 1999-04-16 | Asimadolin für die Behandlung des Irritable Bowel Syndroms |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1607090T1 true SI1607090T1 (sl) | 2012-01-31 |
Family
ID=7865063
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9931065T SI1607090T1 (sl) | 1998-04-20 | 1999-04-16 | Asimadolin za zdravljenje sindroma razdraĹľljivega ÄŤrevesa |
SI9930848T SI1073634T1 (sl) | 1998-04-20 | 1999-04-16 | Postopek za izdelavo enantiomerno cistega n-metil-n-(1s)-1-fenil-2-((3s)-3-hidroksipirolidin-1-il)etil)-2,2-difen= ilacetamida |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9930848T SI1073634T1 (sl) | 1998-04-20 | 1999-04-16 | Postopek za izdelavo enantiomerno cistega n-metil-n-(1s)-1-fenil-2-((3s)-3-hidroksipirolidin-1-il)etil)-2,2-difen= ilacetamida |
Country Status (28)
Country | Link |
---|---|
US (1) | US6344566B1 (sl) |
EP (2) | EP1073634B1 (sl) |
JP (1) | JP4688292B2 (sl) |
KR (1) | KR100649175B1 (sl) |
CN (2) | CN1846696A (sl) |
AR (2) | AR019080A1 (sl) |
AT (2) | ATE527999T1 (sl) |
AU (2) | AU761721B2 (sl) |
BR (1) | BR9909731A (sl) |
CA (1) | CA2329210C (sl) |
CY (1) | CY1112314T1 (sl) |
CZ (1) | CZ301121B6 (sl) |
DE (2) | DE19827633A1 (sl) |
DK (2) | DK1073634T3 (sl) |
ES (2) | ES2375384T3 (sl) |
HK (1) | HK1039111A1 (sl) |
HU (1) | HUP0101600A3 (sl) |
MY (1) | MY120471A (sl) |
NO (1) | NO317984B1 (sl) |
PL (1) | PL206969B1 (sl) |
PT (1) | PT1607090E (sl) |
RU (1) | RU2298549C2 (sl) |
SI (2) | SI1607090T1 (sl) |
SK (2) | SK286442B6 (sl) |
TW (1) | TWI249524B (sl) |
UA (1) | UA73472C2 (sl) |
WO (1) | WO1999054298A1 (sl) |
ZA (1) | ZA200006689B (sl) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10259245A1 (de) * | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | Derivate des Asimadolins mit kovalent gebundenen Säuren |
CA2544245A1 (en) * | 2003-10-30 | 2005-05-26 | Tioga Pharmaceuticals, Inc. | Use of selective opiate receptor modulators in the treatment of neuropathy |
US20070160559A1 (en) * | 2006-01-12 | 2007-07-12 | Roszell James A | Skin disinfectant composition and methods for using |
CN101677997B (zh) | 2007-03-30 | 2012-05-09 | 泰奥加制药公司 | 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂 |
CN103664727A (zh) * | 2013-12-19 | 2014-03-26 | 无锡万全医药技术有限公司 | 一种一锅法制备1-[(3s)-3-羟基吡咯烷-1-基]-(2s)-2-甲氨基-2-苯基乙烷的工艺 |
CN103772257A (zh) * | 2013-12-31 | 2014-05-07 | 无锡万全医药技术有限公司 | 一种制备2-((3s)-3-羟基吡咯烷-1-基)-(1s)-1-苯乙基氨基甲酸酯的方法 |
EP3277274A4 (en) | 2015-04-01 | 2018-12-05 | Cedars-Sinai Medical Center | Anti-methanogenic lovastatin analogs or derivatives and uses thereof |
CN112574068A (zh) * | 2020-11-17 | 2021-03-30 | 万华化学(宁波)有限公司 | 一种低色号高稳定性碳化二亚胺改性异氰酸酯的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4034785A1 (de) * | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | 1-(2-arylethyl)-pyrrolidine |
US5232978A (en) * | 1988-12-23 | 1993-08-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1-(2-arylethyl)-pyrrolidines |
DE4215213A1 (de) * | 1992-05-09 | 1993-11-11 | Merck Patent Gmbh | Arylacetamide |
DE4425071C2 (de) * | 1994-07-15 | 1996-08-29 | Degussa | Verfahren zur Herstellung optisch aktiver Pyrrolidine mit hoher Enantiomerenreinheit |
DE19523502A1 (de) * | 1995-06-28 | 1997-01-02 | Merck Patent Gmbh | Kappa-Opiatagonisten für entzündliche Darmerkrankungen |
DE19531464A1 (de) * | 1995-08-26 | 1997-02-27 | Merck Patent Gmbh | N-Methyl-N-[(1S-)-1-phenyl-2-((3S)-3-hydroxypyrrolidin 1-yl-)-ethyl]-2,2-diphenyl-acetamid |
WO1998003491A1 (en) * | 1996-07-24 | 1998-01-29 | Warner-Lambert Company | Diphenyl-cyclopropenes as selective k-agonists |
DE19647538A1 (de) * | 1996-11-16 | 1998-05-20 | Merck Patent Gmbh | Verfahren zur Herstellung von enantiomerenreinem N-Methyl-N-[1-phenyl-2-(-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamid |
-
1998
- 1998-06-20 DE DE19827633A patent/DE19827633A1/de not_active Withdrawn
-
1999
- 1999-04-16 AU AU40311/99A patent/AU761721B2/en not_active Ceased
- 1999-04-16 PT PT05016750T patent/PT1607090E/pt unknown
- 1999-04-16 EP EP99923421A patent/EP1073634B1/de not_active Expired - Lifetime
- 1999-04-16 SK SK1557-2000A patent/SK286442B6/sk not_active IP Right Cessation
- 1999-04-16 AT AT05016750T patent/ATE527999T1/de active
- 1999-04-16 DK DK99923421T patent/DK1073634T3/da active
- 1999-04-16 PL PL343556A patent/PL206969B1/pl unknown
- 1999-04-16 WO PCT/EP1999/002574 patent/WO1999054298A1/de active Application Filing
- 1999-04-16 DK DK05016750.1T patent/DK1607090T3/da active
- 1999-04-16 ES ES05016750T patent/ES2375384T3/es not_active Expired - Lifetime
- 1999-04-16 KR KR1020007011480A patent/KR100649175B1/ko not_active IP Right Cessation
- 1999-04-16 UA UA2000116543A patent/UA73472C2/uk unknown
- 1999-04-16 HU HU0101600A patent/HUP0101600A3/hu unknown
- 1999-04-16 CN CNA2006100710951A patent/CN1846696A/zh active Pending
- 1999-04-16 CZ CZ20003860A patent/CZ301121B6/cs not_active IP Right Cessation
- 1999-04-16 AT AT99923421T patent/ATE303361T1/de active
- 1999-04-16 SI SI9931065T patent/SI1607090T1/sl unknown
- 1999-04-16 RU RU2000128663/04A patent/RU2298549C2/ru not_active IP Right Cessation
- 1999-04-16 EP EP05016750A patent/EP1607090B1/de not_active Expired - Lifetime
- 1999-04-16 CA CA002329210A patent/CA2329210C/en not_active Expired - Fee Related
- 1999-04-16 AR ARP990101758A patent/AR019080A1/es active IP Right Grant
- 1999-04-16 SK SK5006-2008A patent/SK288016B6/sk not_active IP Right Cessation
- 1999-04-16 CN CNB998052469A patent/CN1310884C/zh not_active Expired - Fee Related
- 1999-04-16 BR BR9909731-1A patent/BR9909731A/pt not_active Application Discontinuation
- 1999-04-16 ES ES99923421T patent/ES2251194T3/es not_active Expired - Lifetime
- 1999-04-16 JP JP2000544639A patent/JP4688292B2/ja not_active Expired - Fee Related
- 1999-04-16 DE DE59912502T patent/DE59912502D1/de not_active Expired - Lifetime
- 1999-04-16 SI SI9930848T patent/SI1073634T1/sl unknown
- 1999-04-19 MY MYPI99001517A patent/MY120471A/en unknown
- 1999-04-20 TW TW088106298A patent/TWI249524B/zh not_active IP Right Cessation
-
2000
- 2000-10-19 NO NO20005259A patent/NO317984B1/no not_active IP Right Cessation
- 2000-11-16 ZA ZA200006689A patent/ZA200006689B/en unknown
-
2001
- 2001-01-26 US US09/647,813 patent/US6344566B1/en not_active Expired - Lifetime
- 2001-11-12 HK HK01107952A patent/HK1039111A1/ not_active IP Right Cessation
-
2003
- 2003-09-29 AU AU2003248428A patent/AU2003248428B2/en not_active Ceased
-
2008
- 2008-05-06 AR ARP080101910A patent/AR066455A2/es unknown
-
2012
- 2012-01-05 CY CY20121100015T patent/CY1112314T1/el unknown
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