SI1597585T1 - Postopek za izbiro spojine, ki je kandidat za zdravilo - Google Patents

Postopek za izbiro spojine, ki je kandidat za zdravilo

Info

Publication number
SI1597585T1
SI1597585T1 SI200431730T SI200431730T SI1597585T1 SI 1597585 T1 SI1597585 T1 SI 1597585T1 SI 200431730 T SI200431730 T SI 200431730T SI 200431730 T SI200431730 T SI 200431730T SI 1597585 T1 SI1597585 T1 SI 1597585T1
Authority
SI
Slovenia
Prior art keywords
selecting
molecule
protein
candidate
relates
Prior art date
Application number
SI200431730T
Other languages
English (en)
Inventor
Peter Timmerman
Joris Beld
Robert Hans Meloen
Wouter Cornelis Puijk
Original Assignee
Pepscan Systems Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32748903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1597585(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pepscan Systems Bv filed Critical Pepscan Systems Bv
Publication of SI1597585T1 publication Critical patent/SI1597585T1/sl

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
SI200431730T 2003-02-27 2004-02-26 Postopek za izbiro spojine, ki je kandidat za zdravilo SI1597585T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03075597A EP1452868A2 (en) 2003-02-27 2003-02-27 Method for selecting a candidate drug compound
PCT/NL2004/000146 WO2004077062A2 (en) 2003-02-27 2004-02-26 Method for selecting a candidate drug compound
EP04714981A EP1597585B1 (en) 2003-02-27 2004-02-26 Method for selecting a candidate drug compound

Publications (1)

Publication Number Publication Date
SI1597585T1 true SI1597585T1 (sl) 2011-10-28

Family

ID=32748903

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200431730T SI1597585T1 (sl) 2003-02-27 2004-02-26 Postopek za izbiro spojine, ki je kandidat za zdravilo

Country Status (12)

Country Link
US (4) US8748105B2 (sl)
EP (2) EP1452868A2 (sl)
AT (1) ATE513218T1 (sl)
AU (1) AU2004215030B2 (sl)
CA (1) CA2517834C (sl)
CY (1) CY1111803T1 (sl)
DK (1) DK1597585T3 (sl)
ES (1) ES2367991T3 (sl)
NZ (1) NZ542043A (sl)
PT (1) PT1597585E (sl)
SI (1) SI1597585T1 (sl)
WO (1) WO2004077062A2 (sl)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
US7598356B2 (en) 2004-07-08 2009-10-06 Board of Regents of the University of Nebraska by and on behalf of the University of Nebraska Medical Center Method for purifying a protein of the cystine-knot superfamily
DK1844337T3 (da) * 2005-01-24 2013-09-30 Pepscan Systems Bv Bindingsforbindelser, immunogene forbindelser og peptidmimetika
WO2008013454A2 (en) * 2006-07-26 2008-01-31 Pepscan Systems B.V. Immunogenic compounds and protein mimics
AU2007333846B2 (en) 2006-12-14 2014-01-23 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US7981998B2 (en) * 2006-12-14 2011-07-19 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
ES2558928T3 (es) 2007-01-31 2016-02-09 Dana-Farber Cancer Institute, Inc. Péptidos p53 estabilizados y usos de los mismos
CN109627287A (zh) 2007-02-23 2019-04-16 爱勒让治疗公司 三唑大环系统
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
WO2008127136A1 (en) * 2007-04-12 2008-10-23 Dmitry Gennadievich Tovbin Method of determination of protein ligand binding and of the most probable ligand pose in protein binding site
AT506150B1 (de) 2007-12-12 2010-01-15 Apeptico Forschung Und Entwick Zyklisches und cystein-freies peptid
AT506151B1 (de) 2007-12-12 2010-01-15 Apeptico Forschung Und Entwick Fusionsprotein
EP2653545A1 (en) * 2008-02-05 2013-10-23 Bicycle Therapeutics Limited Methods and compositions
CA2744088A1 (en) 2009-01-14 2010-07-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
GB0913775D0 (en) * 2009-08-06 2009-09-16 Medical Res Council Multispecific peptides
EP2393832B1 (en) 2009-02-06 2015-07-08 Pepscan Systems BV Truncated cystine-knot proteins
GB0914110D0 (en) * 2009-08-12 2009-09-16 Medical Res Council Peptide libraries
US20130072439A1 (en) 2009-09-22 2013-03-21 Huw M. Nash Peptidomimetic macrocycles
GB201012410D0 (en) 2010-07-23 2010-09-08 Medical Res Council Intracellular immunity
JP2013535514A (ja) 2010-08-13 2013-09-12 エイルロン セラピューティクス，インコーポレイテッド ペプチド模倣大環状分子
GB201013980D0 (en) 2010-08-20 2010-10-06 Ecole Polytech Bicyclic uPA inhibitors
WO2012051405A1 (en) 2010-10-13 2012-04-19 Bristol-Myers Squibb Company Methods for preparing macrocycles and macrocycle stabilized peptides
WO2012057624A1 (en) 2010-10-25 2012-05-03 Pepscan Systems B.V. Novel bicyclic peptide mimetics
WO2012083078A2 (en) 2010-12-15 2012-06-21 The Research Foundation Of State University Of New York Croos-linked peptides and proteins, methods of making same, and uses thereof
CN102095874A (zh) * 2011-01-05 2011-06-15 盛世泰科生物医药技术(苏州)有限公司 一种生物素标记探针联合蛋白芯片寻找小分子化学药靶点的方法
CN102095875A (zh) * 2011-01-05 2011-06-15 盛世泰科生物医药技术(苏州)有限公司 一种点击化学技术与荧光染料探针联合蛋白芯片寻找小分子化学药靶点的方法
EP2726101B1 (en) 2011-06-30 2018-08-08 Genzyme Corporation Inhibitors of t-cell activation
LT3299377T (lt) 2011-10-07 2021-03-25 Bicyclerd Limited Struktūrizuoto polipeptido specifiškumo moduliavimas
GB201117428D0 (en) 2011-10-07 2011-11-23 Bicycle Therapeutics Ltd Structured polypeptides with sarcosine linkers
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
IN2014MN01384A (sl) 2011-12-19 2015-04-03 Janssen R & D Ireland
GB201202268D0 (en) 2012-02-09 2012-03-28 Medical Res Council Intracellular immunity
CN104159595A (zh) 2012-02-15 2014-11-19 爱勒让治疗公司 拟肽大环化合物
WO2013123267A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US9238676B2 (en) 2012-05-17 2016-01-19 Ra Pharmaceuticals, Inc. Peptide and peptidomimetic inhibitors
US9556229B2 (en) * 2012-05-18 2017-01-31 The Regents Of The University Of California Modification of peptides using a bis(thioether)arylbridge approach
MX2015005244A (es) 2012-11-01 2015-07-14 Aileron Therapeutics Inc Aminoacidos disustituidos y metodos de preparacion y el uso de los mismos.
US10267788B1 (en) * 2013-02-01 2019-04-23 National Technology & Engineering Solutions Of Sandia, Llc Linear peptides that mimic structural epitopes for antibody assays
GB201306623D0 (en) 2013-04-11 2013-05-29 Bicycle Therapeutics Ltd Modulation of structured polypeptide specificity
GB201313352D0 (en) 2013-07-26 2013-09-11 Isis Innovation Identification of peptide ligands
GB201318728D0 (en) 2013-10-23 2013-12-04 Mologic Ltd Detection of cleavage activity of an enzyme
WO2015063465A2 (en) 2013-10-28 2015-05-07 Bicycle Therapeutics Limited Novel polypeptides
AU2015320549A1 (en) 2014-09-24 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
JP6882978B2 (ja) 2014-10-29 2021-06-02 バイスクルアールディー・リミテッド Ｍｔ１−ｍｍｐに特異的な二環性ペプチドリガンド
BR112017019738A2 (pt) 2015-03-20 2018-05-29 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
ES2901273T3 (es) 2015-04-06 2022-03-21 Subdomain Llc Polipéptidos que contienen dominios de unión de novo y usos de los mismos
TWI751110B (zh) * 2015-06-24 2022-01-01 荷蘭商科林生物醫療有限責任公司 Ａｍｌ抗原及其用途
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
KR20180101483A (ko) 2016-01-08 2018-09-12 에임 쎄라퓨틱스 비.브이. 치료적 항-ｃｄ９ 항체
GB201600903D0 (en) 2016-01-18 2016-03-02 Bicycle Therapeutics Ltd Peptide derivaties
GB201600911D0 (en) 2016-01-18 2016-03-02 Bicycle Therapeutics Ltd Stabilized peptide derivatives
GB201607827D0 (en) 2016-05-04 2016-06-15 Bicycle Therapeutics Ltd Bicyclic peptide-toxin conjugates specific for MT1-MMP
US11566047B2 (en) 2016-08-10 2023-01-31 Tokyo University Of Pharmacy & Life Sciences Peptide or pharmaceutically acceptable salt thereof, or prodrug thereof
GB201618432D0 (en) * 2016-11-01 2016-12-14 Matn Scient Ltd Detection and treatment of demyelinating diseases
WO2018096365A1 (en) 2016-11-27 2018-05-31 Bicyclerd Limited Methods for treating cancer
AU2017371472A1 (en) * 2016-12-06 2019-06-27 Stichting Voor De Technische Wetenschappen Multicyclic peptides and methods for their preparation
CN110506049A (zh) 2016-12-23 2019-11-26 拜斯科技术开发有限公司 用于结合mt1-mmp的肽配体
US11730819B2 (en) 2016-12-23 2023-08-22 Bicycletx Limited Peptide derivatives having novel linkage structures
WO2018127699A1 (en) 2017-01-06 2018-07-12 Bicyclerd Limited Compounds for treating cancer
GB201706477D0 (en) 2017-04-24 2017-06-07 Bicycle Therapeutics Ltd Modification of polypeptides
WO2018197893A1 (en) 2017-04-27 2018-11-01 Bicycletx Limited Bicyclic peptide ligands and uses thereof
CA3064512A1 (en) 2017-06-09 2018-12-13 Vib Vzw Glutamine dehydrogenase inhibitors for use in muscle regeneration
JP7301757B2 (ja) 2017-06-26 2023-07-03 バイスクルアールディー・リミテッド 検出可能部分を持つ二環式ペプチドリガンドおよびその使用
WO2019016123A1 (en) 2017-07-17 2019-01-24 Vib Vzw TARGETING SYNAPTOGYRIN-3 IN THE TREATMENT OF TAUOPATHY
JP2020529427A (ja) 2017-08-04 2020-10-08 バイスクルテクス・リミテッド Ｃｄ１３７に対して特異的な二環式ペプチドリガンド
US20200283482A1 (en) 2017-08-14 2020-09-10 Bicyclerd Limited Bicyclic peptide ligand prr-a conjugates and uses thereof
US20200291096A1 (en) 2017-08-14 2020-09-17 Bicyclerd Limited Bicyclic peptide ligand sting conjugates and uses thereof
JP7317815B2 (ja) 2017-10-19 2023-07-31 シュレーディンガー インコーポレイテッド 代替コアを有する化合物の活性セットを予測する方法、およびそれを伴う創薬方法
WO2019081714A1 (en) 2017-10-26 2019-05-02 Vib Vzw POSITIVE MACROPHAGES TO PODOPLANIN
MX2020004935A (es) 2017-11-14 2020-09-25 Arcellx Inc Terapias con celulas inmunitarias multifuncionales.
US11377482B2 (en) 2017-11-14 2022-07-05 Arcellx, Inc. D-domain containing polypeptides and uses thereof
US11464803B2 (en) 2017-11-14 2022-10-11 Arcellx, Inc. D-domain containing polypeptides and uses thereof
TWI825046B (zh) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Epha2特用之雙環胜肽配位基
GB201721265D0 (en) 2017-12-19 2018-01-31 Bicyclerd Ltd Bicyclic peptide ligands specific for EphA2
WO2019158579A1 (en) 2018-02-13 2019-08-22 Vib Vzw Targeting minimal residual disease in cancer with rxr antagonists
CN111902429A (zh) * 2018-02-23 2020-11-06 拜斯科技术开发有限公司 多聚体双环肽配体
AU2019247795A1 (en) 2018-04-04 2020-11-12 Bicycletx Limited Heterotandem bicyclic peptide complexes
GB201808835D0 (en) 2018-05-30 2018-07-11 Bicyclerd Ltd Ligands and methods of selecting binding targets for such
GB201810320D0 (en) 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to CD38
GB201810329D0 (en) 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to integrin avB3
GB201810327D0 (en) 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to IL-17
GB201810316D0 (en) 2018-06-22 2018-08-08 Bicyclerd Ltd Peptide ligands for binding to EphA2
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
JP2022512779A (ja) 2018-10-23 2022-02-07 バイスクルテクス・リミテッド 二環式ペプチドリガンドおよびその使用
GB201819659D0 (en) 2018-12-03 2019-01-16 Vib Vzw Cancer regression by inducing a regeneration-like reponse
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
GB201820320D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for FAPalpha
SG11202106081YA (en) 2018-12-13 2021-07-29 Bicycletx Ltd Bicyclic peptide ligands specific for mt1-mmp
GB201820316D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for IL-17
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
US20220088207A1 (en) 2018-12-21 2022-03-24 Bicycletx Limited Bicyclic peptide ligands specific for pd-l1
GB201900530D0 (en) 2019-01-15 2019-03-06 Bicyclerd Ltd Bicyclic peptide ligands specific for CD38
GB201900526D0 (en) 2019-01-15 2019-03-06 Bicyclerd Ltd Bicyclic peptide ligands specific for caix
GB201900528D0 (en) 2019-01-15 2019-03-06 Bicyclerd Ltd Bicyclic peptide ligands specific for integrin AVB3
WO2020165600A1 (en) 2019-02-14 2020-08-20 Bicycletx Limited Bicyclic peptide ligand sting conjugates and uses thereof
GB201902458D0 (en) 2019-02-22 2019-04-10 Mologic Ltd Treatment stratification for an excerbation of inflamation
US20220135614A1 (en) 2019-03-04 2022-05-05 Bicyclerd Limited Synthesis of bicycle toxin conjugates, and intermediates thereof
GB2582571B (en) 2019-03-25 2024-02-28 Syntherix Ltd Peptides and use thereof
KR20220007098A (ko) 2019-05-09 2022-01-18 바이사이클티엑스 리미티드 Ox40에 특이적인 이환식 펩티드 리간드
EP3976067A1 (en) 2019-05-28 2022-04-06 Vib Vzw Cd8+ t-cells lacking plexins and their application in cancer treatment
WO2020239945A1 (en) 2019-05-28 2020-12-03 Vib Vzw Cancer treatment by targeting plexins in the immune compartment
US20220315554A1 (en) * 2019-07-08 2022-10-06 3B Pharmaceuticals Gmbh Compounds comprising a fibroblast activation protein ligand and use thereof
EP3763726A1 (en) * 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
MX2022000252A (es) * 2019-07-08 2022-02-21 3B Pharmaceuticals Gmbh Compuestos que comprenden un ligando de proteina de activacion de fibroblasto y uso del mismo.
TW202118770A (zh) 2019-07-30 2021-05-16 英商拜西可泰克斯有限公司 異質雙環肽複合物
US20220363713A1 (en) 2019-08-07 2022-11-17 Belyntic GmbH A method for modification of peptides immobilized on a solid support by traceless reductively cleavable linker molecules
CN114787197A (zh) 2019-08-13 2022-07-22 拜斯科技术开发有限公司 修饰的多聚双环肽配体
GB201912320D0 (en) 2019-08-28 2019-10-09 Bicycletx Ltd PBP Binding Bicyclic Peptide Ligands
GB201914233D0 (en) 2019-10-02 2019-11-13 Bicyclerd Ltd Phage cyclisation assay
JP2022551607A (ja) 2019-10-03 2022-12-12 バイスクルテクス・リミテッド ヘテロタンデム二環式ペプチド複合体
GB201914872D0 (en) 2019-10-15 2019-11-27 Bicycletx Ltd Bicyclic peptide ligand drug conjugates
WO2021123767A1 (en) 2019-12-16 2021-06-24 Bicycletx Limited Bicyclic peptide ligands specific for il-17
GB201918558D0 (en) 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
GB201918557D0 (en) 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
GB201918559D0 (en) 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
GB202002706D0 (en) 2020-02-26 2020-04-08 Bicycletx Ltd Pbp3 binding bicyclic peptide ligands
GB202002705D0 (en) 2020-02-26 2020-04-08 Bicycletx Ltd Anti-infective bicyclic peptide conjugates
JP2023520714A (ja) 2020-04-06 2023-05-18 バイスクルテクス・リミテッド Ｔｓｌｐに特異的な二環式ペプチドリガンド
WO2021220011A1 (en) 2020-05-01 2021-11-04 Bicycletx Limited Anti-infective bicyclic peptide conjugates
JP2023526067A (ja) 2020-05-15 2023-06-20 バイスクルテクス・リミテッド 抗感染性二環式ペプチドリガンド
WO2022063957A1 (en) 2020-09-24 2022-03-31 Vib Vzw Biomarker for anti-tumor therapy
EP4216943A1 (en) 2020-09-24 2023-08-02 Vib Vzw Combination of p2y6 inhibitors and immune checkpoint inhibitors
GB202016331D0 (en) 2020-10-15 2020-12-02 Bicyclerd Ltd Bicyclic peptide ligand drug conjugates
WO2022148971A1 (en) 2021-01-08 2022-07-14 Bicycletx Limited Anti-infective bicyclic peptide ligands
EP4274839A1 (en) 2021-01-08 2023-11-15 BicycleTx Limited Anti-infective bicyclic peptide ligands
CN117120459A (zh) 2021-01-08 2023-11-24 拜斯科技术开发有限公司 抗感染双环肽配体
JP2024504068A (ja) 2021-01-08 2024-01-30 バイスクルテクス・リミテッド 抗感染性二環式ペプチドリガンド
CA3206529A1 (en) 2021-01-08 2022-07-14 Bicycletx Limited Heterotandem bicyclic peptide complexes
US20240083944A1 (en) 2021-01-08 2024-03-14 Bicycle TX Limited Anti-infective bicyclic peptide ligands
AU2022206395A1 (en) 2021-01-11 2023-08-17 Bicycletx Limited Methods for treating cancer
AU2022209878A1 (en) * 2021-01-19 2023-09-07 The Council Of The Queensland Institute Of Medical Research Novel bicyclic peptides
CA3211257A1 (en) 2021-02-17 2022-08-25 Vib Vzw Inhibition of slc4a4 in the treatment of cancer
WO2022199804A1 (en) 2021-03-24 2022-09-29 Vib Vzw Nek6 inhibition to treat als and ftd
WO2023031623A2 (en) 2021-09-03 2023-03-09 Bicycletx Limited Synthesis of bicycle toxin conjugates, and intermediates thereof
GB202114282D0 (en) 2021-10-06 2021-11-17 Bicyclerd Ltd Bicyclic peptide ligand drug conjugates
GB202114279D0 (en) 2021-10-06 2021-11-17 Bicycletx Ltd Bicyclic peptide ligand drug conjugates
EP4170347A1 (en) * 2021-10-25 2023-04-26 3B Pharmaceuticals GmbH Gastric inhibitory peptide receptor ligands
GB202116266D0 (en) 2021-11-11 2021-12-29 Bicycletx Ltd Novel use
WO2023139292A1 (en) 2022-01-24 2023-07-27 Cambridge Enterprise Limited Tau therapy
WO2024009108A1 (en) 2022-07-07 2024-01-11 Bicycletx Limited Anti-infective bicyclic peptide ligands

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929758A (en) * 1974-09-12 1975-12-30 Armour Pharma Cyclization of cysteine-containing peptides
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4518711A (en) * 1983-05-16 1985-05-21 Gibson-Stephens Institute Conformationally constrained cyclic enkephalin analogs with delta receptor specificity
US5368712A (en) * 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
WO1991009051A1 (en) 1989-12-15 1991-06-27 G.D. Searle & Co. Substituted cyclic penicillanic acid tetrapeptides
WO1991008759A1 (en) 1989-12-15 1991-06-27 G.D. Searle & Co. Alkyl substituted cyclic penicillanic acid pentapaptides
US5216124A (en) * 1989-12-15 1993-06-01 G. D. Searle & Co. Substituted cyclic tetrapeptides
US5169833A (en) * 1989-12-15 1992-12-08 G. D. Searle & Co. Substituted cyclic pentapeptides
CA2047042A1 (en) 1990-07-19 1992-01-20 John Hannah Cyclic hiv principal neutralizing determinant peptides
DE4027675C2 (de) * 1990-08-31 1997-05-07 Biotechnolog Forschung Gmbh Verfahren zur parallelen Herstellung von trägergebundenen oder freien Peptiden, trägergebundene Peptide und ihre Verwendung
TW199152B (sl) * 1990-11-01 1993-02-01 Takeda Pharm Industry Co Ltd
EP0557456A4 (en) * 1990-11-14 1995-11-15 Siska Diagnostics Inc Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
JPH04204379A (ja) 1990-11-30 1992-07-24 Hitachi Ltd 生体成分分析法
NL9101953A (nl) 1991-11-21 1993-06-16 Seed Capital Investments Testinrichting omvattende een plaat met een veelvoud van putjes met een bijbehorende doseerinrichting, alsmede een kit die deze inrichtingen omvat en toepassing van de inrichtingen.
US5824483A (en) * 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
DE69526665T2 (de) * 1994-09-21 2002-11-21 Cytogen Corp Antigen bindende peptide (abtides) aus peptidbibliotheken
US5885577A (en) * 1994-09-21 1999-03-23 Cytogen Corporation Antigen binding peptides (abtides) from peptide libraries
US6169194B1 (en) * 1997-10-16 2001-01-02 Michael Thompson High surface density covalent immobilization of oligonucleotide monolayers using a 1-(thiotrifluoroacetato)-11-(trichlorososilyl)-undecane linker
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6461812B2 (en) * 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
US6911307B1 (en) * 1998-12-08 2005-06-28 Proteus S.A. Method of detection in vitro of a target substance in a sample comprising the labelling of said substance with a reporter gene and with the sequences necessary for the expression of said reporter gene in vitro
JP4024442B2 (ja) 1998-12-15 2007-12-19 富士フイルム株式会社 試験片と生体由来物質の定量方法及び装置
EP1125905A1 (en) 2000-02-16 2001-08-22 Pepscan Systems B.V. Segment synthesis
EP1197755A1 (en) 2000-10-11 2002-04-17 Pepscan Systems B.V. Identification of protein binding sites
WO2002062822A2 (en) * 2001-02-02 2002-08-15 University Of Rochester Methods of identifying regulator molecules
FR2839452A1 (fr) 2002-05-07 2003-11-14 Pf Medicament Utilisation de peptide derive de la sous-unite beta de l'hcg pour generer une reponse de type ctl antitumorale
GB0213878D0 (en) 2002-06-17 2002-07-31 Protherics Plc Use
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
WO2008004253A1 (en) 2006-07-03 2008-01-10 Valiani Srl System for the rapid change of head on operating machines
WO2008013454A2 (en) 2006-07-26 2008-01-31 Pepscan Systems B.V. Immunogenic compounds and protein mimics

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AU2004215030B2 (en) 2010-09-23
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EP1597585B1 (en) 2011-06-15
US20130158232A1 (en) 2013-06-20
US8742070B2 (en) 2014-06-03
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EP1597585A2 (en) 2005-11-23
WO2004077062B1 (en) 2005-02-24
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CA2517834A1 (en) 2004-09-10
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