DK1255716T3 - Segmentsyntese - Google Patents

Segmentsyntese

Info

Publication number
DK1255716T3
DK1255716T3 DK01908463T DK01908463T DK1255716T3 DK 1255716 T3 DK1255716 T3 DK 1255716T3 DK 01908463 T DK01908463 T DK 01908463T DK 01908463 T DK01908463 T DK 01908463T DK 1255716 T3 DK1255716 T3 DK 1255716T3
Authority
DK
Denmark
Prior art keywords
segment
nucleic acid
protein
discontinuous
molecule
Prior art date
Application number
DK01908463T
Other languages
English (en)
Inventor
Wouter Cornelis Puijk
Jelle Wouter Slootstra
Dijk Evert Van
Original Assignee
Pepscan Systems Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pepscan Systems Bv filed Critical Pepscan Systems Bv
Application granted granted Critical
Publication of DK1255716T3 publication Critical patent/DK1255716T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Structural Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Prostheses (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
DK01908463T 2000-02-16 2001-02-16 Segmentsyntese DK1255716T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00200536A EP1125905A1 (en) 2000-02-16 2000-02-16 Segment synthesis
PCT/NL2001/000131 WO2001060769A1 (en) 2000-02-16 2001-02-16 Segment synthesis

Publications (1)

Publication Number Publication Date
DK1255716T3 true DK1255716T3 (da) 2009-04-20

Family

ID=8171031

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01908463T DK1255716T3 (da) 2000-02-16 2001-02-16 Segmentsyntese

Country Status (14)

Country Link
US (2) US20040110224A1 (da)
EP (2) EP1125905A1 (da)
JP (1) JP2003522961A (da)
AT (1) ATE420226T1 (da)
AU (2) AU3620501A (da)
CA (1) CA2400338C (da)
CY (1) CY1108962T1 (da)
DE (1) DE60137311D1 (da)
DK (1) DK1255716T3 (da)
ES (1) ES2321477T3 (da)
IL (2) IL151184A0 (da)
NZ (1) NZ520698A (da)
PT (1) PT1255716E (da)
WO (1) WO2001060769A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR038568A1 (es) 2002-02-20 2005-01-19 Hoffmann La Roche Anticuerpos anti-a beta y su uso
PL218660B1 (pl) 2002-10-17 2015-01-30 Genmab As Izolowane ludzkie przeciwciało monoklonalne wiążące ludzki CD20, związane z tym przeciwciałem transfektoma, komórka gospodarza, transgeniczne zwierzę lub roślina, kompozycja, immunokoniugat, cząsteczka bispecyficzna, wektor ekspresyjny, kompozycja farmaceutyczna, zastosowanie medyczne, zestaw oraz przeciwciało antyidiotypowe i jego zastosowanie
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
ATE517923T1 (de) 2005-12-12 2011-08-15 Hoffmann La Roche Antikörper gegen amyloid beta mit glykosilierung in der variablen region
EP2393832B1 (en) 2009-02-06 2015-07-08 Pepscan Systems BV Truncated cystine-knot proteins
JP6294076B2 (ja) 2011-01-06 2018-03-14 ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ 多量体ペプチド
NZ737205A (en) 2015-06-24 2024-07-26 F Hoffmann La Roche Ag Anti-transferrin receptor antibodies with tailored affinity
PE20181322A1 (es) 2015-09-01 2018-08-14 Agenus Inc Anticuerpo anti-pd1 y sus metodos de uso
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
MY192668A (en) 2015-10-02 2022-08-30 Hoffmann La Roche Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use
NZ749355A (en) 2016-05-27 2023-04-28 Agenus Inc Anti-tim-3 antibodies and methods of use thereof
CA3037380A1 (en) 2016-10-11 2018-04-19 Agenus Inc. Anti-lag-3 antibodies and methods of use thereof
SI3551660T1 (sl) 2016-12-07 2024-02-29 Agenus Inc. Protitelesa proti antictla-4 in načini njihove uporabe
WO2018157048A1 (en) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy
WO2018157074A1 (en) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Methods for diagnosing neoplastic lesions
KR102629972B1 (ko) 2017-04-13 2024-01-29 아게누스 인코포레이티드 항-cd137 항체 및 이의 사용 방법
US11021537B2 (en) 2017-05-01 2021-06-01 Agenus Inc. Anti-TIGIT antibodies and methods of use thereof
US11873374B2 (en) 2018-02-06 2024-01-16 Massachusetts Institute Of Technology Swellable and structurally homogenous hydrogels and methods of use thereof
WO2021042019A1 (en) 2019-08-30 2021-03-04 Agenus Inc. Anti-cd96 antibodies and methods of use thereof
US11802822B2 (en) 2019-12-05 2023-10-31 Massachusetts Institute Of Technology Multiplexed expansion (MultiExM) pathology
EP4387979A1 (en) * 2021-09-22 2024-06-26 Massachusetts Institute of Technology Single-molecule protein and peptide sequencing

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923772A (en) * 1970-03-16 1975-12-02 Shionogi & Co (1-{60 -aminoisobutyric acid)-corticotropin peptides
NZ207394A (en) * 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4931223A (en) * 1986-07-24 1990-06-05 Tropix, Inc. Methods of using chemiluminescent 1,2-dioxetanes
US6291158B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US5368712A (en) * 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
US6040423A (en) * 1990-08-31 2000-03-21 Gsellschaft Fur Biotechnologische Forschung Mbh (Gbf) Process for synthesis of peptides
IE68675B1 (en) * 1990-11-01 1996-07-10 Takeda Chemical Industries Ltd Aminocoumaran derivatives their production and use
WO1992008808A1 (en) * 1990-11-14 1992-05-29 Siska Diagnostics, Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
US5208148A (en) * 1990-12-07 1993-05-04 Molecular Probes, Inc. Lipophilic fluorescent glycosidase substrates
WO1993004204A1 (en) * 1991-08-23 1993-03-04 Isis Pharmaceuticals, Inc. Synthetic unrandomization of oligomer fragments
US6310180B1 (en) * 1993-06-21 2001-10-30 Vanderbilt University Method for synthesis of proteins
US5824483A (en) * 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
DE69526665T2 (de) * 1994-09-21 2002-11-21 Cytogen Corp., Princeton Antigen bindende peptide (abtides) aus peptidbibliotheken
US5885577A (en) * 1994-09-21 1999-03-23 Cytogen Corporation Antigen binding peptides (abtides) from peptide libraries
US5629179A (en) * 1995-03-17 1997-05-13 Novagen, Inc. Method and kit for making CDNA library
JP2947729B2 (ja) * 1995-07-06 1999-09-13 科学技術振興事業団 脂質単分子膜によるペプチド認識方法
EP0937253A1 (en) * 1996-10-31 1999-08-25 Novalon Pharmaceutical Corporation Identification of drugs using complementary combinatorial libraries
DE19703801A1 (de) * 1997-02-01 1998-08-06 Boehringer Ingelheim Kg Neue Dipeptidtemplate, Verfahren zu deren Herstellung und deren Verwendung zum Einbau in Peptidsequenzen, unter anderem auf Gebiet der kombinatorischen Chemie
US20020068301A1 (en) * 1997-05-28 2002-06-06 Hung-Sen Lai Cyclic peptide libraries and methods of use thereof to identify binding motifs
US6844161B2 (en) * 1997-09-04 2005-01-18 Gryphon Therapeutics, Inc. Modular protein libraries and methods of preparation
DE19741716A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Adressierbares modulares Erkennungssystem, seine Herstellung und Verwendung
US6461812B2 (en) * 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
US6852696B2 (en) * 1999-03-26 2005-02-08 The University Of Texas System Inhibitors of glycosaminoglycans
JP2009544697A (ja) * 2006-07-26 2009-12-17 ペプスキャン システムズ ベー．フェー． 免疫原性化合物及びタンパク質擬態物

Also Published As

Publication number Publication date
EP1255716B1 (en) 2009-01-07
AU3620501A (en) 2001-08-27
NZ520698A (en) 2004-03-26
AU2001236205B2 (en) 2006-08-24
PT1255716E (pt) 2009-04-03
CA2400338C (en) 2011-11-01
IL151184A (en) 2010-11-30
DE60137311D1 (en) 2009-02-26
US20080139407A1 (en) 2008-06-12
US20040110224A1 (en) 2004-06-10
ATE420226T1 (de) 2009-01-15
EP1255716A1 (en) 2002-11-13
IL151184A0 (en) 2003-04-10
ES2321477T3 (es) 2009-06-08
EP1125905A1 (en) 2001-08-22
WO2001060769A1 (en) 2001-08-23
CA2400338A1 (en) 2001-08-23
CY1108962T1 (el) 2014-07-02
JP2003522961A (ja) 2003-07-29

Similar Documents

Publication Publication Date Title
CY1108962T1 (el) Συνθεση μεταμεριδιου
DK1325340T3 (da) Identifikation af proteinbindingssteder
ATE513218T1 (de) Verfahren zur auswahl von kandidat- drogenverbindungen
ATE423140T1 (de) Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften
DE60010080D1 (de) Tragbares informationsgerät für fahrer
NO20025976D0 (no) Fremgangsmåte for bestemmelse av molekyl¶re egenskaper til hydrokarbondblandinger fra NMR-data
DE60035434D1 (de) Auswahl von epitop-bindungsfähigen verbindungen aus bibliotheken
DE60301245D1 (de) System zum Lesen von Informationen über den Unfall eines Fahrzeuges mittels Telematiksystems
ATE446511T1 (de) Neue fusionsproteine und molekulare bindungsassays
DE69628194D1 (de) Verfahren zum nachweis von verbindungen die bestimmte zielmoleküle binden
DE602004005083D1 (de) Eine Banknotendetektionseinheit für ein Banknotenerkennungsgerät
WO2003002724A3 (en) Proteins, druggable regions of proteins and target analysis for chemistry of therapeutics
DE60332249D1 (de) Treiberkonstruktion für einen stapler
DE60229788D1 (de) Verfahren und system zum erstellen von optimalen modellen für dreidimensionale, molekulare strukturen
DE60038677D1 (de) Verfahren zum nachweis von proteinen, die miteinander interagieren
DE602004022472D1 (de) Vorrichtung für Erkennung von Änderungsinformation
WO2003010536A3 (en) Tnf-alpha mimics and lead optimisation
DE50214438D1 (de) Bedienteil für eine Fahrerinformationsvorrichtung
DE50201535D1 (de) Betätigungsvorrichtung für Entriegelungseinrichtungen von Fahrzeugen, vorzugsweise von Kraftfahrzeugen
ATE434792T1 (de) Verfahren zur konformationsanalyse von aminosäuresequenzen
DE60315760D1 (de) Heftvorrichtung für eine Zusammentragmaschine
DE69405989D1 (de) Hippurikasegen
DE602004031736D1 (de) Verbessertes verfahren für festphasensynthese
DE10117857B4 (de) Verfahren zum Nachweis von molekularen Wechselwirkungen auf Sonden-Arrays
DE50312988D1 (de) Tastatur, vorzugsweise für Datenkassen