CY1108962T1 - Συνθεση μεταμεριδιου - Google Patents
Συνθεση μεταμεριδιουInfo
- Publication number
- CY1108962T1 CY1108962T1 CY20091100390T CY091100390T CY1108962T1 CY 1108962 T1 CY1108962 T1 CY 1108962T1 CY 20091100390 T CY20091100390 T CY 20091100390T CY 091100390 T CY091100390 T CY 091100390T CY 1108962 T1 CY1108962 T1 CY 1108962T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nucleic acid
- protein
- discontinuous
- segment
- molecule
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Structural Engineering (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Prostheses (AREA)
- Carbon And Carbon Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
Abstract
Η ευρεσιτεχνία σχετίζεται με το πεδίον της μοριακής αναγνώρισης ή ανίχνευσης των ασυνεχών περιοχών πρόσδεσης ή επιτόπων ή των περιοχών πρόσδεσης ή επιτόπων διαμόρφωσης, που αντιστοιχούν σε ένα μόριο πρόσδεσης, ιδιαίτερα σε σχέση με τις αλληλεπιδράσεις πρωτεΐνη-πρωτεΐνη πρωτεΐνη-νουκλεϊκό οξύ, νουκλεϊκό οξύ-νουκλεϊκό οξύ ή βιομόριο-προσδέτης. Η ευρεσιτεχνία παρέχει μία συνθετική μοριακή βιβλιοθήκη επιτρέποντας την δοκιμασία για ταυτοποίηση, χαρακτηρισμό ή ανίχνευση μίας ασυνεχούς περιοχής πρόσδεσης ικανής να αλληλεπιδρά με ένα μόριο πρόσδεσης, η εν λόγω βιβλιοθήκη έχει παρασχεθεί με ένα πλήθος μορίων, έκαστο μόριο των εν λόγω μορίων περιλαμβάνει τουλάχιστον ένα πρώτο μεταμερίδιο, το οποίο συνδέεται με ένα δεύτερο μεταμερίδιο, έκαστο μεταμερίδιο που έχει την ικανότητα να είναι ένα δυνητικό μονό τμήμα μίας ασυνεχούς περιοχής πρόσδεσης.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00200536A EP1125905A1 (en) | 2000-02-16 | 2000-02-16 | Segment synthesis |
| EP01908463A EP1255716B1 (en) | 2000-02-16 | 2001-02-16 | Segment synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1108962T1 true CY1108962T1 (el) | 2014-07-02 |
Family
ID=8171031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100390T CY1108962T1 (el) | 2000-02-16 | 2009-04-02 | Συνθεση μεταμεριδιου |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20040110224A1 (el) |
| EP (2) | EP1125905A1 (el) |
| JP (1) | JP2003522961A (el) |
| AT (1) | ATE420226T1 (el) |
| AU (2) | AU3620501A (el) |
| CA (1) | CA2400338C (el) |
| CY (1) | CY1108962T1 (el) |
| DE (1) | DE60137311D1 (el) |
| DK (1) | DK1255716T3 (el) |
| ES (1) | ES2321477T3 (el) |
| IL (2) | IL151184A0 (el) |
| NZ (1) | NZ520698A (el) |
| PT (1) | PT1255716E (el) |
| WO (1) | WO2001060769A1 (el) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR038568A1 (es) | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| ES2744275T3 (es) | 2002-10-17 | 2020-02-24 | Genmab As | Anticuerpos monoclonales humanos contra CD20 para su uso en el tratamiento de esclerosis múltiple |
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| KR101401159B1 (ko) | 2005-12-12 | 2014-05-29 | 에프. 호프만-라 로슈 아게 | 가변 부위에 글리코실화를 가지는 아밀로이드 베타에 대한 항체 |
| US8772236B2 (en) | 2009-02-06 | 2014-07-08 | Pepscan Systems B.V. | Truncated cystine-knot proteins |
| MX346475B (es) | 2011-01-06 | 2017-03-22 | Bionor Immuno As | Peptidos inmunogenicos monomericos y multimericos. |
| BR112017024610A2 (pt) | 2015-06-24 | 2018-07-31 | F. Hoffmann-La Roche Ag | anticorpos para receptor antitransferrina com afinidade especificada |
| KR20220131277A (ko) | 2015-09-01 | 2022-09-27 | 아게누스 인코포레이티드 | 항-pd-1 항체 및 이를 이용하는 방법 |
| RU2753390C1 (ru) | 2015-10-02 | 2021-08-13 | Ф. Хоффманн-Ля Рош Аг | Биспецифические антитела к человеческому cd20/человеческому рецептору трансферрина и способы их применения |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| MA45123A (fr) | 2016-05-27 | 2019-04-10 | Agenus Inc | Anticorps anti-tim-3 et leurs méthodes d'utilisation |
| CN110023337B (zh) | 2016-10-11 | 2024-01-05 | 艾吉纳斯公司 | 抗lag-3抗体及其使用方法 |
| AU2017373944B2 (en) | 2016-12-07 | 2022-02-03 | Agenus Inc. | Anti-CTLA-4 antibodies and methods of use thereof |
| WO2018157048A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy |
| BR112019017241A2 (pt) | 2017-04-13 | 2020-04-14 | Agenus Inc | anticorpos anti-cd137 e métodos de uso dos mesmos |
| EP3618863B1 (en) | 2017-05-01 | 2023-07-26 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
| WO2019156957A1 (en) | 2018-02-06 | 2019-08-15 | Massachusetts Institute Of Technology | Swellable and structurally homogenous hydrogels and methods of use thereof |
| WO2021042019A1 (en) | 2019-08-30 | 2021-03-04 | Agenus Inc. | Anti-cd96 antibodies and methods of use thereof |
| WO2021113505A1 (en) | 2019-12-05 | 2021-06-10 | Massachusetts Institute Of Technology | Method for preparing a specimen for expansion microscopy |
| CN117980319A (zh) * | 2021-09-22 | 2024-05-03 | 麻省理工学院 | 单分子蛋白质和肽测序 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3923772A (en) * | 1970-03-16 | 1975-12-02 | Shionogi & Co | (1-{60 -aminoisobutyric acid)-corticotropin peptides |
| NZ207394A (en) * | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| US4931223A (en) * | 1986-07-24 | 1990-06-05 | Tropix, Inc. | Methods of using chemiluminescent 1,2-dioxetanes |
| US6291158B1 (en) * | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US5368712A (en) * | 1989-11-02 | 1994-11-29 | Synporin Technologies, Inc. | Biologically mimetic synthetic ion channel transducers |
| DE4027675C2 (de) * | 1990-08-31 | 1997-05-07 | Biotechnolog Forschung Gmbh | Verfahren zur parallelen Herstellung von trägergebundenen oder freien Peptiden, trägergebundene Peptide und ihre Verwendung |
| IE68675B1 (en) * | 1990-11-01 | 1996-07-10 | Takeda Chemical Industries Ltd | Aminocoumaran derivatives their production and use |
| EP0557456A4 (en) * | 1990-11-14 | 1995-11-15 | Siska Diagnostics Inc | Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor |
| US5208148A (en) * | 1990-12-07 | 1993-05-04 | Molecular Probes, Inc. | Lipophilic fluorescent glycosidase substrates |
| JPH07501929A (ja) * | 1991-08-23 | 1995-03-02 | アイシス・ファーマシューティカルス・インコーポレーテッド | オリゴマーフラグメントの合成非ランダム化 |
| US6310180B1 (en) * | 1993-06-21 | 2001-10-30 | Vanderbilt University | Method for synthesis of proteins |
| US5824483A (en) * | 1994-05-18 | 1998-10-20 | Pence Inc. | Conformationally-restricted combinatiorial library composition and method |
| AU3719395A (en) * | 1994-09-21 | 1996-04-09 | Cytogen Corporation | Antigen binding peptides (abtides) from peptide libraries |
| US5885577A (en) * | 1994-09-21 | 1999-03-23 | Cytogen Corporation | Antigen binding peptides (abtides) from peptide libraries |
| US5629179A (en) * | 1995-03-17 | 1997-05-13 | Novagen, Inc. | Method and kit for making CDNA library |
| JP2947729B2 (ja) * | 1995-07-06 | 1999-09-13 | 科学技術振興事業団 | 脂質単分子膜によるペプチド認識方法 |
| CA2270394A1 (en) * | 1996-10-31 | 1998-05-07 | Novalon Pharmaceutical Corporation | Identification of drugs using complementary combinatorial libraries |
| DE19703801A1 (de) * | 1997-02-01 | 1998-08-06 | Boehringer Ingelheim Kg | Neue Dipeptidtemplate, Verfahren zu deren Herstellung und deren Verwendung zum Einbau in Peptidsequenzen, unter anderem auf Gebiet der kombinatorischen Chemie |
| US20020068301A1 (en) * | 1997-05-28 | 2002-06-06 | Hung-Sen Lai | Cyclic peptide libraries and methods of use thereof to identify binding motifs |
| CA2301846A1 (en) * | 1997-09-04 | 1999-03-11 | Gryphon Sciences | Modular protein libraries and methods of preparation |
| DE19741716A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Adressierbares modulares Erkennungssystem, seine Herstellung und Verwendung |
| US6461812B2 (en) * | 1998-09-09 | 2002-10-08 | Agilent Technologies, Inc. | Method and multiple reservoir apparatus for fabrication of biomolecular arrays |
| US6852696B2 (en) * | 1999-03-26 | 2005-02-08 | The University Of Texas System | Inhibitors of glycosaminoglycans |
| WO2008013454A2 (en) * | 2006-07-26 | 2008-01-31 | Pepscan Systems B.V. | Immunogenic compounds and protein mimics |
-
2000
- 2000-02-16 EP EP00200536A patent/EP1125905A1/en not_active Withdrawn
-
2001
- 2001-02-16 DK DK01908463T patent/DK1255716T3/da active
- 2001-02-16 JP JP2001559824A patent/JP2003522961A/ja active Pending
- 2001-02-16 ES ES01908463T patent/ES2321477T3/es not_active Expired - Lifetime
- 2001-02-16 CA CA2400338A patent/CA2400338C/en not_active Expired - Fee Related
- 2001-02-16 IL IL15118401A patent/IL151184A0/xx unknown
- 2001-02-16 NZ NZ520698A patent/NZ520698A/en not_active IP Right Cessation
- 2001-02-16 AT AT01908463T patent/ATE420226T1/de active
- 2001-02-16 WO PCT/NL2001/000131 patent/WO2001060769A1/en active IP Right Grant
- 2001-02-16 DE DE60137311T patent/DE60137311D1/de not_active Expired - Lifetime
- 2001-02-16 US US10/203,969 patent/US20040110224A1/en not_active Abandoned
- 2001-02-16 AU AU3620501A patent/AU3620501A/xx active Pending
- 2001-02-16 EP EP01908463A patent/EP1255716B1/en not_active Expired - Lifetime
- 2001-02-16 PT PT01908463T patent/PT1255716E/pt unknown
- 2001-02-16 AU AU2001236205A patent/AU2001236205B2/en not_active Ceased
-
2002
- 2002-08-11 IL IL151184A patent/IL151184A/en not_active IP Right Cessation
-
2007
- 2007-04-23 US US11/785,975 patent/US20080139407A1/en not_active Abandoned
-
2009
- 2009-04-02 CY CY20091100390T patent/CY1108962T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001060769A1 (en) | 2001-08-23 |
| IL151184A0 (en) | 2003-04-10 |
| PT1255716E (pt) | 2009-04-03 |
| US20080139407A1 (en) | 2008-06-12 |
| ATE420226T1 (de) | 2009-01-15 |
| JP2003522961A (ja) | 2003-07-29 |
| EP1125905A1 (en) | 2001-08-22 |
| EP1255716A1 (en) | 2002-11-13 |
| EP1255716B1 (en) | 2009-01-07 |
| CA2400338A1 (en) | 2001-08-23 |
| AU3620501A (en) | 2001-08-27 |
| AU2001236205B2 (en) | 2006-08-24 |
| DK1255716T3 (da) | 2009-04-20 |
| DE60137311D1 (en) | 2009-02-26 |
| NZ520698A (en) | 2004-03-26 |
| CA2400338C (en) | 2011-11-01 |
| IL151184A (en) | 2010-11-30 |
| US20040110224A1 (en) | 2004-06-10 |
| ES2321477T3 (es) | 2009-06-08 |
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