CY1111803T1 - Μεθοδος επιλογης μιας υποψηφιας ενωσης φαρμακο - Google Patents
Μεθοδος επιλογης μιας υποψηφιας ενωσης φαρμακοInfo
- Publication number
- CY1111803T1 CY1111803T1 CY20111100870T CY111100870T CY1111803T1 CY 1111803 T1 CY1111803 T1 CY 1111803T1 CY 20111100870 T CY20111100870 T CY 20111100870T CY 111100870 T CY111100870 T CY 111100870T CY 1111803 T1 CY1111803 T1 CY 1111803T1
- Authority
- CY
- Cyprus
- Prior art keywords
- selecting
- drug
- molecule
- protein
- relates
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medical Treatment And Welfare Office Work (AREA)
Abstract
Η εφεύρεση αφορά το πεδίο εξέτασης υποψήφιου φαρμάκου και ανάπτυξης φαρμάκου. Παρέχεται μέθοδος για παροχή μιας ένωσης που αποτελείται από τουλάχιστον ένα μόριο συνδεδεμένο μέσω τουλάχιστον δύο διασυνδέσεων προς ένα μοριακό ικρίωμα, η εν λόγω δε μέθοδος περιλαμβάνει παροχή ενός ικριώματος που περιλαμβάνει τουλάχιστον μια πρώτη και μια δεύτερη αντιδρώσα ομάδα, παροχή τουλάχιστον ενός μορίου ικανού αντίδρασης με την εν λόγω πρώτη και δεύτερη αντιδρώσα ομάδα, επαφή του εν λόγω ικριώματος με το εν λόγω τουλάχιστον ένα μόριο για να σχηματίσει τουλάχιστον δύο διασυνδέσεις μεταξύ του εν λόγω ικριώματος και του εν λόγω τουλάχιστον ενός μορίου σε μια αντίδραση σύζευξης, με την οποία ο σχηματισμός μιας διασύνδεσης επιταχύνει το σχηματισμό μιας διαδοχικής διασύνδεσης, κατά προτίμηση όπου η εν λόγω αντίδραση σύζευξης διεξάγεται σε διάλυμα, πιο προτιμότερα σε υδατικό διάλυμα. Περαιτέρω, παρέχεται μέθοδος για επιλογή μιας υποψήφιας ένωσης φάρμακο, που περιλαμβάνει παροχή μιας συλλογής ενώσεων σύμφωνα με την εφεύρεση και προσδιορισμό της σύνδεσης ενός μορίου στόχου προς τις εν λόγω ενώσεις.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03075597A EP1452868A2 (en) | 2003-02-27 | 2003-02-27 | Method for selecting a candidate drug compound |
EP04714981A EP1597585B1 (en) | 2003-02-27 | 2004-02-26 | Method for selecting a candidate drug compound |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111803T1 true CY1111803T1 (el) | 2015-10-07 |
Family
ID=32748903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100870T CY1111803T1 (el) | 2003-02-27 | 2011-09-09 | Μεθοδος επιλογης μιας υποψηφιας ενωσης φαρμακο |
Country Status (12)
Country | Link |
---|---|
US (4) | US8748105B2 (el) |
EP (2) | EP1452868A2 (el) |
AT (1) | ATE513218T1 (el) |
AU (1) | AU2004215030B2 (el) |
CA (1) | CA2517834C (el) |
CY (1) | CY1111803T1 (el) |
DK (1) | DK1597585T3 (el) |
ES (1) | ES2367991T3 (el) |
NZ (1) | NZ542043A (el) |
PT (1) | PT1597585E (el) |
SI (1) | SI1597585T1 (el) |
WO (1) | WO2004077062A2 (el) |
Families Citing this family (142)
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- 2004-02-26 SI SI200431730T patent/SI1597585T1/sl unknown
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- 2004-02-26 ES ES04714981T patent/ES2367991T3/es not_active Expired - Lifetime
- 2004-02-26 AT AT04714981T patent/ATE513218T1/de active
- 2004-02-26 DK DK04714981.0T patent/DK1597585T3/da active
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2014
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DK1597585T3 (da) | 2011-09-19 |
SI1597585T1 (sl) | 2011-10-28 |
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AU2004215030A1 (en) | 2004-09-10 |
ATE513218T1 (de) | 2011-07-15 |
US8748105B2 (en) | 2014-06-10 |
US9176127B2 (en) | 2015-11-03 |
US20140308303A1 (en) | 2014-10-16 |
US20140296478A1 (en) | 2014-10-02 |
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