SI1268398T1 - Novel method for synthesis of n- (s)-1-carboxybutyl)-(s)-alanine esters and use in synthesis of perindopril - Google Patents

Novel method for synthesis of n- (s)-1-carboxybutyl)-(s)-alanine esters and use in synthesis of perindopril

Info

Publication number
SI1268398T1
SI1268398T1 SI200130380T SI200130380T SI1268398T1 SI 1268398 T1 SI1268398 T1 SI 1268398T1 SI 200130380 T SI200130380 T SI 200130380T SI 200130380 T SI200130380 T SI 200130380T SI 1268398 T1 SI1268398 T1 SI 1268398T1
Authority
SI
Slovenia
Prior art keywords
synthesis
carboxybutyl
perindopril
novel method
alanine esters
Prior art date
Application number
SI200130380T
Other languages
English (en)
Slovenian (sl)
Inventor
Jean-Claude Souvie
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SI1268398T1 publication Critical patent/SI1268398T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200130380T 2000-03-31 2001-03-30 Novel method for synthesis of n- (s)-1-carboxybutyl)-(s)-alanine esters and use in synthesis of perindopril SI1268398T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0004112A FR2807037B1 (fr) 2000-03-31 2000-03-31 NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
PCT/FR2001/000959 WO2001056353A2 (fr) 2000-03-31 2001-03-30 Nouveau procede de synthese de esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril
EP20010921440 EP1268398B1 (fr) 2000-03-31 2001-03-30 Nouveau procede de synthese des esters de la n- (s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (1)

Publication Number Publication Date
SI1268398T1 true SI1268398T1 (en) 2005-10-31

Family

ID=8848711

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130380T SI1268398T1 (en) 2000-03-31 2001-03-30 Novel method for synthesis of n- (s)-1-carboxybutyl)-(s)-alanine esters and use in synthesis of perindopril

Country Status (36)

Country Link
US (1) US6818788B2 (pt)
EP (1) EP1268398B1 (pt)
JP (1) JP3930322B2 (pt)
KR (1) KR100498869B1 (pt)
CN (1) CN1171855C (pt)
AP (1) AP1483A (pt)
AR (1) AR027754A1 (pt)
AT (1) ATE297377T1 (pt)
AU (2) AU4843301A (pt)
BG (1) BG65832B1 (pt)
BR (1) BRPI0109609B1 (pt)
CA (1) CA2404700C (pt)
CZ (1) CZ302840B6 (pt)
DE (1) DE60111364T2 (pt)
DK (1) DK1268398T3 (pt)
EA (1) EA004314B1 (pt)
EE (1) EE05079B1 (pt)
ES (1) ES2242743T3 (pt)
FR (1) FR2807037B1 (pt)
GE (1) GEP20063796B (pt)
HK (1) HK1053301A1 (pt)
HR (1) HRP20020860B1 (pt)
HU (1) HU229188B1 (pt)
ME (1) ME00437B (pt)
MX (1) MXPA02009378A (pt)
NO (1) NO328064B1 (pt)
NZ (1) NZ521324A (pt)
OA (1) OA12324A (pt)
PL (1) PL199714B1 (pt)
PT (1) PT1268398E (pt)
RS (1) RS50239B (pt)
SI (1) SI1268398T1 (pt)
SK (1) SK286851B6 (pt)
UA (1) UA73562C2 (pt)
WO (1) WO2001056353A2 (pt)
ZA (1) ZA200207150B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827860B1 (fr) 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
CA2517205C (en) 2003-02-28 2010-08-24 Lupin Limited Process for preparation of perindopril and salts thereof
PT1362845E (pt) * 2003-09-01 2009-11-05 Servier Lab Novo processo de síntese dos ésteres da n-((s)-1- carboxibutil)-(s)-alanina e aplicação à síntese do perindopril
EP1400531B1 (fr) * 2003-09-30 2006-01-04 Les Laboratoires Servier Procédé de synthèse de la N-[(S)-1-carbéthoxybutyl]-(S)-alanine et application à la synthèse du perindopril
DE60300806T2 (de) * 2003-09-30 2006-03-23 Les Laboratoires Servier Verfahren zur Herstellung von N-((S)-1-(Ethoxycarbonyl)butyl)-(S)-alanin und Verwendung in der Synthese von Perindopril
JP4948392B2 (ja) * 2004-03-29 2012-06-06 レ ラボラトア セルビエ 固形薬学的組成物を調製するためのプロセス
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
WO2006006183A2 (en) * 2004-07-12 2006-01-19 Matrix Laboratories Ltd An improved process for the preparation of n-[(s)-ethoxycarbonyl-l-butyl]-(s)-alanine
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247716A (en) * 1977-09-02 1981-01-27 Mitsui Toatsu Chemicals, Inc. Process for producing pyruvic acid
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
US6818788B2 (en) 2004-11-16
JP3930322B2 (ja) 2007-06-13
AR027754A1 (es) 2003-04-09
NO20024616L (no) 2002-09-26
CA2404700C (fr) 2007-02-20
WO2001056353A2 (fr) 2001-08-09
HUP0101335A2 (hu) 2001-11-28
AP2002002628A0 (en) 2002-09-30
DE60111364T2 (de) 2006-03-16
KR20030017484A (ko) 2003-03-03
HK1053301A1 (en) 2003-10-17
NO20024616D0 (no) 2002-09-26
HU229188B1 (hu) 2013-09-30
FR2807037A1 (fr) 2001-10-05
OA12324A (en) 2006-05-12
UA73562C2 (uk) 2005-08-15
EA004314B1 (ru) 2004-02-26
PT1268398E (pt) 2005-09-30
KR100498869B1 (ko) 2005-07-04
PL199714B1 (pl) 2008-10-31
CZ302840B6 (cs) 2011-12-07
SK286851B6 (sk) 2009-06-05
SK14052002A3 (sk) 2003-02-04
GEP20063796B (en) 2006-04-25
YU73202A (sh) 2006-03-03
BG65832B1 (bg) 2010-02-26
EP1268398A2 (fr) 2003-01-02
CA2404700A1 (fr) 2001-08-09
ZA200207150B (en) 2003-09-05
HU0101335D0 (en) 2001-06-28
ES2242743T3 (es) 2005-11-16
HUP0101335A3 (en) 2002-11-28
NO328064B1 (no) 2009-11-16
EA200201027A1 (ru) 2003-02-27
HRP20020860A2 (en) 2004-02-29
CN1420862A (zh) 2003-05-28
EP1268398B1 (fr) 2005-06-08
BG107234A (bg) 2003-07-31
AU4843301A (en) 2001-08-14
AP1483A (en) 2005-10-31
US20030045744A1 (en) 2003-03-06
DE60111364D1 (de) 2005-07-14
ATE297377T1 (de) 2005-06-15
EE05079B1 (et) 2008-10-15
MXPA02009378A (es) 2003-02-12
CN1171855C (zh) 2004-10-20
FR2807037B1 (fr) 2002-05-10
NZ521324A (en) 2004-03-26
HRP20020860B1 (en) 2011-02-28
AU2001248433B2 (en) 2004-10-28
JP2003534241A (ja) 2003-11-18
DK1268398T3 (da) 2005-10-03
RS50239B (sr) 2009-07-15
BR0109609A (pt) 2004-01-13
PL346554A1 (en) 2001-09-10
EE200200553A (et) 2004-04-15
WO2001056353A3 (fr) 2002-04-18
ME00437B (me) 2011-10-10
BRPI0109609B1 (pt) 2015-04-14

Similar Documents

Publication Publication Date Title
AP2002002630A0 (en) Method for synthesis of perindopril and its pharmaceutically acceptable salts
ATE288278T1 (de) Verfahren und zusammensetzungen zur peptidsynthese
AU5046701A (en) Method for synthesis of N-((S)-1-carboxybutyl)-(S)-alanine esters and use in synthesis of perindopril
EG24152A (en) Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in synthesis of perindopril
SI1268398T1 (en) Novel method for synthesis of n- (s)-1-carboxybutyl)-(s)-alanine esters and use in synthesis of perindopril
AU2001248433A1 (en) Novel method for synthesis of N-((S)-1-carboxybutyl)-(S)-alanine esters and use in synthesis of perindopril
AU2001250467A1 (en) Method for synthesis of N-[(S)-1-carboxybutyl]-(S)-alanine esters and use in synthesis of perindopril
HK1096378A1 (en) Novel method for synthesizing esters of n-[(s)-1-carboxybutyl]-(s)-alanine and use thereof for synthesizing perindopril
SI1272454T1 (sl) Postopek za sintezo estrov n-((s)-karboksibutil)-(s)-alanina in uporaba pri sintezi perindoprila
PL339360A1 (en) Method of crystallising n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-l-proline maleate
SI1403278T1 (en) Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril
SI1354874T1 (en) Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril
SI1354875T1 (en) Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril
SI1268424T1 (sl) Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli