SI1101765T1 - Camptothecin analogues, process for their preparation and pharmaceutical compositions containing them - Google Patents

Camptothecin analogues, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
SI1101765T1
SI1101765T1 SI200030016T SI200030016T SI1101765T1 SI 1101765 T1 SI1101765 T1 SI 1101765T1 SI 200030016 T SI200030016 T SI 200030016T SI 200030016 T SI200030016 T SI 200030016T SI 1101765 T1 SI1101765 T1 SI 1101765T1
Authority
SI
Slovenia
Prior art keywords
alkyl
aryl
groups
cycloalkyl
optionally substituted
Prior art date
Application number
SI200030016T
Other languages
English (en)
Slovenian (sl)
Inventor
Gilbert Lavielle
Patrick Hautefaye
Alain Pierre
Ghanem Atassi
John Hickman
Bernard Cimetiere
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SI1101765T1 publication Critical patent/SI1101765T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI200030016T 1999-11-18 2000-11-09 Camptothecin analogues, process for their preparation and pharmaceutical compositions containing them SI1101765T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9914499A FR2801309B1 (fr) 1999-11-18 1999-11-18 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP00403108A EP1101765B1 (fr) 1999-11-18 2000-11-09 Nouveaux composés analogues de la camptothécine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
SI1101765T1 true SI1101765T1 (en) 2002-12-31

Family

ID=9552253

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030016T SI1101765T1 (en) 1999-11-18 2000-11-09 Camptothecin analogues, process for their preparation and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (1) US6509345B2 (hu)
EP (1) EP1101765B1 (hu)
JP (1) JP3545332B2 (hu)
KR (1) KR100460785B1 (hu)
CN (2) CN1304395C (hu)
AT (1) ATE222253T1 (hu)
AU (1) AU772609B2 (hu)
BR (1) BR0005486A (hu)
CA (1) CA2325776C (hu)
DE (1) DE60000328T2 (hu)
DK (1) DK1101765T3 (hu)
EA (1) EA003206B1 (hu)
ES (1) ES2180501T3 (hu)
FR (1) FR2801309B1 (hu)
HK (2) HK1036803A1 (hu)
HU (1) HUP0004573A3 (hu)
MX (1) MXPA00011238A (hu)
NO (1) NO318464B1 (hu)
NZ (1) NZ508248A (hu)
PL (1) PL202231B1 (hu)
PT (1) PT1101765E (hu)
SI (1) SI1101765T1 (hu)
ZA (1) ZA200006730B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4369229B2 (ja) * 2001-10-05 2009-11-18 エフ．ホフマン−ラ ロシュ アーゲー 抗腫瘍活性を有する多環式化合物
US7071204B2 (en) * 2003-06-30 2006-07-04 Research Triangle Institute Camptothecin analogs having an E-ring ketone
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2889527A1 (fr) * 2005-08-05 2007-02-09 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2892418B1 (fr) * 2005-10-24 2010-10-22 Servier Lab Nouveaux composes aminoesterifies a cycle e hydrocarbone a six chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2892417B1 (fr) * 2005-10-24 2010-10-22 Servier Lab Nouveaux composes aminoesterifies a cycle e hydrocarbone a sept chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2007113687A2 (en) 2006-03-30 2007-10-11 Diatos S.A. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
CN103288842B (zh) * 2012-02-24 2016-01-13 中国人民解放军第二军医大学 氟取代e环喜树碱类似物及其作为药物的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829793B2 (ja) * 1975-02-07 1983-06-24 日本ケミフア （株） ７−アルコキシカルボニル−８−メチルインドリジノ〔１，２−ｂ〕キノリン−９（１１Ｈ）−オンの製法
JPS58435B2 (ja) * 1975-12-23 1983-01-06 カメタニ テツジ ルテカルピンノセイホウ
GB8513460D0 (en) * 1985-05-29 1985-07-03 Glaxo Group Ltd Chemical compounds
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH06509175A (ja) * 1991-07-22 1994-10-13 アボツト・ラボラトリーズ 医療用自動分析装置用試薬処理システム
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
JP3576171B2 (ja) * 1995-06-21 2004-10-13 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・（エス．セー．エール．アー．エス） カンプトテシンの新規な同族体、その製造方法、その医薬としての用途及びこれを含有する医薬組成物
UA57757C2 (uk) * 1996-12-20 2003-07-15 Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
DE19815812A1 (de) * 1998-04-08 1999-10-14 Bayer Ag Modifizierte Cytostatika
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds

Also Published As

Publication number Publication date
HK1071892A1 (en) 2005-08-05
ZA200006730B (en) 2001-05-31
AU7168300A (en) 2001-05-24
DE60000328T2 (de) 2003-04-17
BR0005486A (pt) 2001-08-07
US20020077325A1 (en) 2002-06-20
CN1552712A (zh) 2004-12-08
HUP0004573A3 (en) 2002-06-28
CN1301701A (zh) 2001-07-04
CA2325776C (fr) 2007-02-20
PL343949A1 (en) 2001-05-21
CN1304395C (zh) 2007-03-14
JP3545332B2 (ja) 2004-07-21
AU772609B2 (en) 2004-05-06
KR100460785B1 (ko) 2004-12-09
NO20005807D0 (no) 2000-11-17
HUP0004573A2 (hu) 2001-09-28
EP1101765B1 (fr) 2002-08-14
DK1101765T3 (da) 2002-12-16
HK1036803A1 (en) 2002-01-18
CN1158282C (zh) 2004-07-21
EP1101765A3 (fr) 2001-10-04
KR20010051779A (ko) 2001-06-25
DE60000328D1 (de) 2002-09-19
FR2801309B1 (fr) 2002-01-04
CA2325776A1 (fr) 2001-05-18
HU0004573D0 (hu) 2001-02-28
EA003206B1 (ru) 2003-02-27
NO318464B1 (no) 2005-03-21
EP1101765A2 (fr) 2001-05-23
FR2801309A1 (fr) 2001-05-25
MXPA00011238A (es) 2002-05-23
NZ508248A (en) 2001-08-31
ES2180501T3 (es) 2003-02-16
JP2001151776A (ja) 2001-06-05
PL202231B1 (pl) 2009-06-30
NO20005807L (no) 2001-05-21
PT1101765E (pt) 2002-11-29
ATE222253T1 (de) 2002-08-15
EA200001084A1 (ru) 2001-06-25
US6509345B2 (en) 2003-01-21

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