SI0882021T1 - New phenanthridines - Google Patents

New phenanthridines

Info

Publication number
SI0882021T1
SI0882021T1 SI9730530T SI9730530T SI0882021T1 SI 0882021 T1 SI0882021 T1 SI 0882021T1 SI 9730530 T SI9730530 T SI 9730530T SI 9730530 T SI9730530 T SI 9730530T SI 0882021 T1 SI0882021 T1 SI 0882021T1
Authority
SI
Slovenia
Prior art keywords
new
phenanthridines
compounds
formula
description
Prior art date
Application number
SI9730530T
Other languages
English (en)
Slovenian (sl)
Inventor
Hermann Amschler
Dieter Flockerzi
Wolf-R�diger ULRICH
Thomas Br
Thomas Martin
Christian Schudt
Armin Hatzelmann
Rolf Beume
Dietrich H�FNER
Hildegard Boss
Hans-Peter Kley
Karl-Josef Goebel
Beate Schmidt
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19603321A external-priority patent/DE19603321A1/de
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of SI0882021T1 publication Critical patent/SI0882021T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
SI9730530T 1996-01-31 1997-01-30 New phenanthridines SI0882021T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19603321A DE19603321A1 (de) 1996-01-31 1996-01-31 Neue Phenanthridine
EP96101791 1996-02-08
PCT/EP1997/000402 WO1997028131A1 (de) 1996-01-31 1997-01-30 Neue phenanthridine
EP97904354A EP0882021B1 (de) 1996-01-31 1997-01-30 Neue phenanthridine

Publications (1)

Publication Number Publication Date
SI0882021T1 true SI0882021T1 (en) 2003-10-31

Family

ID=26022482

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9730530T SI0882021T1 (en) 1996-01-31 1997-01-30 New phenanthridines

Country Status (19)

Country Link
US (1) US6191138B1 (cs)
EP (1) EP0882021B1 (cs)
JP (1) JP4138003B2 (cs)
KR (1) KR100454781B1 (cs)
AT (1) ATE233735T1 (cs)
BR (1) BR9707233A (cs)
CA (1) CA2245142C (cs)
CY (1) CY2473B1 (cs)
CZ (1) CZ289340B6 (cs)
DE (1) DE59709437D1 (cs)
DK (1) DK0882021T3 (cs)
EA (1) EA001205B1 (cs)
EE (1) EE03523B1 (cs)
ES (1) ES2194180T3 (cs)
HU (1) HU221380B1 (cs)
PT (1) PT882021E (cs)
SI (1) SI0882021T1 (cs)
UA (1) UA48216C2 (cs)
WO (1) WO1997028131A1 (cs)

Families Citing this family (54)

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EE03523B1 (et) * 1996-01-31 2001-10-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine
ES2217575T3 (es) * 1997-07-25 2004-11-01 Altana Pharma Ag Nuevos derivados de tetrazol.
ES2189235T3 (es) * 1997-07-25 2003-07-01 Altana Pharma Ag 6-fenilfenantridinas sustituidas.
GB9828340D0 (en) * 1998-12-22 1999-02-17 Novartis Ag Organic compounds
DE60033918D1 (de) 1999-01-15 2007-04-26 Altana Pharma Ag Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung
US6534519B1 (en) 1999-01-15 2003-03-18 Altana Pharma Ag Phenanthridine-N-oxides with PDE-IV inhibiting activity
DK1147087T3 (da) * 1999-01-15 2005-09-05 Altana Pharma Ag Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet
PT1147088E (pt) 1999-01-15 2006-05-31 Altana Pharma Ag 6-arilfenantridinas com actividade inibitoria da pde-iv
HK1040997B (en) * 1999-01-15 2006-07-14 奥坦纳医药公司 Phenylphenanthridines with pde-iv inhibiting activity
IL147688A0 (en) 1999-08-21 2002-08-14 Byk Gulden Lomberg Chem Fab Synergistic combination
DE60133879D1 (de) * 2000-01-11 2008-06-19 Nycomed Gmbh Phenanthridin -n- oxide
AU2001281965A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Novel 6-phenylphenanthridines
WO2002006239A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Phenanthridine n-oxides
WO2002006238A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines
EP1303506B1 (en) * 2000-07-14 2005-02-02 ALTANA Pharma AG 6-heteroarylphenanthridines
CN1264574C (zh) * 2000-09-06 2006-07-19 田边制药株式会社 口服制剂
WO2002064119A1 (en) * 2001-02-15 2002-08-22 Tanabe Seiyaku Co., Ltd. Tablets quickly disintegrated in oral cavity
US20060116518A1 (en) * 2002-08-17 2006-06-01 Altana Pharma Ag Novel phenanthridines
US7423046B2 (en) 2002-08-29 2008-09-09 Nycomed Gmbh 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
CA2495827C (en) 2002-08-29 2012-05-08 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
WO2004087211A2 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
US20060189645A1 (en) * 2003-07-31 2006-08-24 Altana Pharma Ag Novel 6-phenylphenantridines
US20060189641A1 (en) * 2003-07-31 2006-08-24 Beate Schmidt Novel 6-phenlyphenanthridines
JP2007504201A (ja) * 2003-09-05 2007-03-01 アルタナ　ファルマ　アクチエンゲゼルシャフト 真性糖尿病の治療のためのｐｄｅ４阻害剤の使用
ES2400823T3 (es) 2004-02-18 2013-04-12 Takeda Gmbh Nuevas hidroxi-6-fenilfenantridinas sustituidas con guanidinilo como inhibidores eficaces de fosfodiesterasa (PDE) 4
KR101152488B1 (ko) 2004-03-03 2012-07-02 니코메드 게엠베하 신규 히드록시-6-헤테로아릴페난트리딘 및 ｐｄｅ4 억제제로서의 이의 용도
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
EP1745025A2 (en) * 2004-03-09 2007-01-24 Altana Pharma AG Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
JP2007527901A (ja) * 2004-03-10 2007-10-04 アルタナ　ファルマ　アクチエンゲゼルシャフト アミド置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用
EP1725532A1 (en) * 2004-03-10 2006-11-29 Altana Pharma AG Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
KR20060124783A (ko) * 2004-03-10 2006-12-05 알타나 파마 아게 신규 티오-함유 히드록시-6-페닐페난트리딘 및 ｐｄｅ４억제제로서의 이의 용도
JP5009799B2 (ja) 2004-09-08 2012-08-22 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の３−オキサ−１０−アザ−フェナントレン
EP1791847A2 (en) 2004-09-08 2007-06-06 Altana Pharma AG Novel 3-thia-10-aza-phenanthrene derivatives
US7411093B2 (en) * 2004-12-20 2008-08-12 Hoffman-La Roche Inc. Aminocycloalkanes as DPP-IV inhibitors
WO2006092422A1 (en) * 2005-03-02 2006-09-08 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
EP1874308A1 (en) * 2005-03-08 2008-01-09 Nycomed GmbH Roflumilast for the treatment of diabetes mellitus
JP2008532980A (ja) * 2005-03-09 2008-08-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング アミド置換された６−フェニルフェナントリジン
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP1991212A1 (en) * 2006-03-08 2008-11-19 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
BRPI0716604A2 (pt) * 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
US20080103165A1 (en) * 2006-09-19 2008-05-01 Braincells, Inc. Ppar mediated modulation of neurogenesis
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MX2009012685A (es) 2007-05-31 2009-12-14 Sepracor Inc Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina.
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
KR101067069B1 (ko) * 2009-03-09 2011-09-22 부경대학교 산학협력단 트리플루오로아세트산을 이용한 페난트리딘 유도체의 제조방법
CN102179655B (zh) * 2011-06-01 2013-09-04 柳州市久日工程机械有限公司 履带梁拼搭气动工装
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

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BE786031A (fr) * 1971-07-08 1973-01-08 Rhone Poulenc Sa Nouveaux derives de la phenanthridine, leur preparation et les compositions medicinales qui les contiennent
US4309545A (en) * 1980-07-28 1982-01-05 Pfizer Inc. Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof
EE03523B1 (et) * 1996-01-31 2001-10-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine

Also Published As

Publication number Publication date
EP0882021A1 (de) 1998-12-09
JP2000503996A (ja) 2000-04-04
PT882021E (pt) 2003-07-31
CZ241498A3 (cs) 1998-12-16
HUP9900666A2 (hu) 1999-06-28
HUP9900666A3 (en) 2000-04-28
JP4138003B2 (ja) 2008-08-20
KR100454781B1 (ko) 2005-04-08
ATE233735T1 (de) 2003-03-15
BR9707233A (pt) 1999-07-20
DE59709437D1 (de) 2003-04-10
CZ289340B6 (cs) 2002-01-16
EE9800223A (et) 1998-12-15
EE03523B1 (et) 2001-10-15
UA48216C2 (uk) 2002-08-15
WO1997028131A1 (de) 1997-08-07
EA001205B1 (ru) 2000-12-25
KR19990082143A (ko) 1999-11-15
EA199800667A1 (ru) 1999-02-25
US6191138B1 (en) 2001-02-20
EP0882021B1 (de) 2003-03-05
HU221380B1 (en) 2002-09-28
CA2245142A1 (en) 1997-08-07
ES2194180T3 (es) 2003-11-16
CA2245142C (en) 2004-11-30
DK0882021T3 (da) 2003-06-23
CY2473B1 (en) 2005-06-03

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