SI0810206T1 - Substituted 2-naphthoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them - Google Patents

Substituted 2-naphthoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them

Info

Publication number
SI0810206T1
SI0810206T1 SI9730102T SI9730102T SI0810206T1 SI 0810206 T1 SI0810206 T1 SI 0810206T1 SI 9730102 T SI9730102 T SI 9730102T SI 9730102 T SI9730102 T SI 9730102T SI 0810206 T1 SI0810206 T1 SI 0810206T1
Authority
SI
Slovenia
Prior art keywords
medicament
naphthoylguanidines
substituted
preparation
diagnostic agent
Prior art date
Application number
SI9730102T
Other languages
English (en)
Inventor
Joachim Dr Brendel
Heinz-Werner Dr Kleemann
Heinrich Christian Dr Englert
Hans Jochen Dr Lang
Jan-Robert Dr Schwark
Andreas Dr Weichert
Bansi Dr Lal
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of SI0810206T1 publication Critical patent/SI0810206T1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40Acylated substituent nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Surgery (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
SI9730102T 1996-05-29 1997-05-16 Substituted 2-naphthoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them SI0810206T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19621483A DE19621483A1 (de) 1996-05-29 1996-05-29 Substituierte 2-Naphthoylguanidine, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP97108013A EP0810206B1 (de) 1996-05-29 1997-05-16 Substituierte 2-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
SI0810206T1 true SI0810206T1 (en) 2001-04-30

Family

ID=7795549

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9730102T SI0810206T1 (en) 1996-05-29 1997-05-16 Substituted 2-naphthoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them

Country Status (29)

Country Link
US (1) US6087304A (el)
EP (1) EP0810206B1 (el)
JP (1) JP4039588B2 (el)
KR (1) KR970074776A (el)
CN (1) CN1167759A (el)
AR (1) AR008373A1 (el)
AT (1) ATE198320T1 (el)
AU (1) AU710065B2 (el)
BR (1) BR9703338A (el)
CA (1) CA2206366C (el)
CZ (1) CZ163097A3 (el)
DE (2) DE19621483A1 (el)
DK (1) DK0810206T3 (el)
ES (1) ES2154002T3 (el)
GR (1) GR3035126T3 (el)
HR (1) HRP970292B1 (el)
HU (1) HUP9700955A3 (el)
ID (1) ID16989A (el)
IL (1) IL120924A (el)
NO (1) NO308527B1 (el)
NZ (1) NZ314915A (el)
PL (1) PL185754B1 (el)
PT (1) PT810206E (el)
RU (1) RU2190600C2 (el)
SI (1) SI0810206T1 (el)
SK (1) SK282020B6 (el)
TR (1) TR199700428A2 (el)
TW (1) TW416944B (el)
ZA (1) ZA974665B (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19621482A1 (de) 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6395897B1 (en) 1999-03-02 2002-05-28 Boehringer Ingelheim Pharmaceuticals, Inc. Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
PE20040167A1 (es) * 2002-03-28 2004-05-26 Novartis Ag Amidas del acido sulfamico
PL1755593T3 (pl) * 2004-06-02 2008-06-30 Hoffmann La Roche Pochodne naftalenu przydatne jako ligandy 3-receptora histaminowego
TW200614995A (en) * 2004-11-10 2006-05-16 Nicholas Piramal India Ltd Tricyclic guanidine derivatives as sodium-proton exchange inhibitors
AU2013205388B2 (en) * 2005-06-24 2016-05-05 Biotron Limited Antiviral compounds and methods
PL2826770T3 (pl) 2005-06-24 2019-02-28 Biotron Limited Przeciwwirusowe związki acyloguanidynowe
DE602007008742D1 (de) * 2006-09-15 2010-10-07 Pfizer Substituierte pyridylmethylbicyclocarboxyamidverbindungen
JPWO2010090304A1 (ja) * 2009-02-09 2012-08-09 アステラス製薬株式会社 アシルグアニジン誘導体
JPWO2010090305A1 (ja) * 2009-02-09 2012-08-09 アステラス製薬株式会社 置換アシルグアニジン誘導体
TW201116281A (en) * 2009-08-06 2011-05-16 Astellas Pharma Inc N atom containing ring acylguanidine derivatives
KR20140003484A (ko) 2011-02-02 2014-01-09 아스테라스 세이야쿠 가부시키가이샤 테트라히드로이소퀴놀린 유도체

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251545A (en) * 1979-09-19 1981-02-17 Gaf Corporation Fungicidal process using 1-(alkoxyaroyl)guanidines
IT1238227B (it) * 1989-12-01 1993-07-12 Modulo di smistamento per impianti di convogliamento a nastro e simili
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4415873A1 (de) * 1994-05-05 1995-11-09 Hoechst Ag Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
JPH08225513A (ja) * 1994-12-21 1996-09-03 Kanebo Ltd ナフトイルグアニジン誘導体
DE19621482A1 (de) * 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
PL185754B1 (pl) 2003-07-31
BR9703338A (pt) 1998-08-18
DE19621483A1 (de) 1997-12-04
ATE198320T1 (de) 2001-01-15
US6087304A (en) 2000-07-11
NO972433D0 (no) 1997-05-28
ZA974665B (en) 1997-12-01
DE59702802D1 (de) 2001-02-01
HUP9700955A3 (en) 1998-04-28
PT810206E (pt) 2001-06-29
TW416944B (en) 2001-01-01
NO308527B1 (no) 2000-09-25
HUP9700955A2 (hu) 1998-03-02
HU9700955D0 (en) 1997-07-28
SK282020B6 (sk) 2001-10-08
AU710065B2 (en) 1999-09-16
JP4039588B2 (ja) 2008-01-30
CA2206366A1 (en) 1997-11-29
AR008373A1 (es) 2000-01-19
ES2154002T3 (es) 2001-03-16
AU2364597A (en) 1997-12-04
JPH1081664A (ja) 1998-03-31
GR3035126T3 (en) 2001-03-30
ID16989A (id) 1997-11-27
HRP970292A2 (en) 1998-04-30
RU2190600C2 (ru) 2002-10-10
KR970074776A (ko) 1997-12-10
EP0810206B1 (de) 2000-12-27
PL318723A1 (en) 1997-12-08
NO972433L (no) 1997-12-01
SK67097A3 (en) 1997-12-10
NZ314915A (en) 1998-02-26
IL120924A0 (en) 1997-09-30
HRP970292B1 (en) 2001-08-31
MX9703922A (es) 1997-11-29
DK0810206T3 (da) 2001-02-26
IL120924A (en) 2002-03-10
CZ163097A3 (cs) 1998-06-17
CN1167759A (zh) 1997-12-17
CA2206366C (en) 2008-02-19
TR199700428A2 (xx) 1997-12-21
EP0810206A1 (de) 1997-12-03

Similar Documents

Publication Publication Date Title
HRP970450B1 (en) Phenyl-substituted alkenoylguanidides, process for their preparation, their use as drugs or diagnostic agents and drugs containing them
SI0771788T1 (en) Substituted sulphonimidamides, method for their preparation, their use as medicament or diagnostic and medicament containing them
HK1040980A1 (zh) 聯苯磺酰基氨基氰、其製備方法及其作為藥物的用途
GR3035126T3 (en) Substituted 2-naphtoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them
AU3892593A (en) Composition for therapeutic or diagnostic use, process for its preparation and its use
ZA963893B (en) Substituted benzyloxycarbonylguanidines, process for their preparation, their use as a medicament of diagnostic, and medicament containing them.
ZA968091B (en) Substituted benzolyguanidines a process for their preparation their use as a medicament or diagnostic agent and medicament comprising them
CY2220B1 (en) Substituted benzenesulfonylureas and -thioureas process for their preparation their use as medicament or diagnostic agent as well as medicaments containing them
AU2330095A (en) Ortho-amino-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them
HUP9600665A2 (en) Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
HRP970424B1 (en) Substituted indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
HRP970304B1 (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicaments containing them
PL346165A1 (en) Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them
HRP970294A2 (en) Substituted 1-naphtoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicaments containing them
SI0790245T1 (en) Substituted Thiophenylalkenylcarbonylguanidide, method for their preparation, their use as medicinal or diagnostic agent as well as medicament containing them
HRP970293A2 (en) Bis-ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicaments containing them
GR3032293T3 (en) Ortho-substituted benzylguanidines, process for their preparation and their use as medicament or diagnostic agent as well as medicament containing them
IL120093A0 (en) Substituted diaryldicarboxylic acid diguanidides processes for their preparation their use as a medicament or diagnostic and medicament containing them
ZA96644B (en) Basically-substituted benzolyguanidines a process for preparing them their use as a medicament or diagnostic agent and medicament containing them