SG63555A1 - Biosynthesis of rebeccamycin analogs by triptophan analogs feeding - Google Patents

Biosynthesis of rebeccamycin analogs by triptophan analogs feeding

Info

Publication number
SG63555A1
SG63555A1 SG1996002071A SG1996002071A SG63555A1 SG 63555 A1 SG63555 A1 SG 63555A1 SG 1996002071 A SG1996002071 A SG 1996002071A SG 1996002071 A SG1996002071 A SG 1996002071A SG 63555 A1 SG63555 A1 SG 63555A1
Authority
SG
Singapore
Prior art keywords
analogs
rebeccamycin
triptophan
biosynthesis
feeding
Prior art date
Application number
SG1996002071A
Other languages
English (en)
Inventor
Kim Sing Lam
Daniel R Schroeder
Jacqueline Mattei
Salvatore Forenza
James A Matson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG63555A1 publication Critical patent/SG63555A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Ceramic Products (AREA)
SG1996002071A 1990-03-06 1991-03-05 Biosynthesis of rebeccamycin analogs by triptophan analogs feeding SG63555A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48943090A 1990-03-06 1990-03-06
US64875191A 1991-02-05 1991-02-05

Publications (1)

Publication Number Publication Date
SG63555A1 true SG63555A1 (en) 1999-03-30

Family

ID=27049711

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996002071A SG63555A1 (en) 1990-03-06 1991-03-05 Biosynthesis of rebeccamycin analogs by triptophan analogs feeding

Country Status (22)

Country Link
US (1) US5468849A (he)
EP (1) EP0450327B1 (he)
JP (1) JPH0780899B2 (he)
KR (1) KR940005657B1 (he)
AT (1) ATE138926T1 (he)
AU (1) AU623050B2 (he)
CY (1) CY1941A (he)
CZ (1) CZ279307B6 (he)
DE (1) DE69119964T2 (he)
DK (1) DK0450327T3 (he)
ES (1) ES2088439T3 (he)
FI (1) FI102376B1 (he)
GR (1) GR3020163T3 (he)
HK (1) HK181496A (he)
HU (1) HU211055B (he)
IE (1) IE910737A1 (he)
IL (1) IL97233A (he)
NO (1) NO179555C (he)
PT (1) PT96943B (he)
SG (1) SG63555A1 (he)
TW (1) TW232698B (he)
YU (1) YU39391A (he)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5437996A (en) * 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
WO1993018766A1 (en) * 1992-03-20 1993-09-30 The Wellcome Foundation Limited Further indole derivatives with antiviral activity
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
WO1995034663A1 (fr) * 1994-06-13 1995-12-21 Banyu Pharmaceutical Co., Ltd. Gene codant la glycosyl-transferase et utilisation de ce gene
IL127918A0 (en) * 1996-08-22 1999-11-30 Bristol Myers Squibb Co Novel amino sugar and related sugar derivatives of indolylopyrrolocarbazoles their use as antitumor agents and pharmaceutical formulations
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6855698B2 (en) * 2001-03-22 2005-02-15 Bristol-Myers Squibb Company Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552842A (en) * 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
US4487925A (en) * 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4567143A (en) * 1984-09-04 1986-01-28 Bristol-Myers Company Process for preparing 4'-deschlororebeccamycin
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
US4808613A (en) * 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs

Also Published As

Publication number Publication date
HU211055B (en) 1995-10-30
CZ279307B6 (cs) 1995-04-12
NO910855D0 (no) 1991-03-05
IL97233A0 (en) 1992-05-25
HK181496A (en) 1996-10-04
CY1941A (en) 1997-05-16
AU623050B2 (en) 1992-04-30
ATE138926T1 (de) 1996-06-15
FI102376B (fi) 1998-11-30
HUT61601A (en) 1993-01-28
JPH0780899B2 (ja) 1995-08-30
FI911047A (fi) 1991-09-07
NO910855L (no) 1991-09-09
EP0450327A1 (en) 1991-10-09
DK0450327T3 (da) 1996-06-24
FI102376B1 (fi) 1998-11-30
DE69119964T2 (de) 1997-02-06
JPH0789981A (ja) 1995-04-04
KR910016934A (ko) 1991-11-05
YU39391A (sh) 1994-01-20
GR3020163T3 (en) 1996-09-30
EP0450327B1 (en) 1996-06-05
AU7261691A (en) 1991-09-12
FI911047A0 (fi) 1991-03-01
KR940005657B1 (ko) 1994-06-22
ES2088439T3 (es) 1996-08-16
HU910716D0 (en) 1991-09-30
NO179555B (no) 1996-07-22
IL97233A (he) 1995-03-30
PT96943B (pt) 1998-07-31
TW232698B (he) 1994-10-21
IE910737A1 (en) 1991-09-11
CS9100586A2 (en) 1991-10-15
US5468849A (en) 1995-11-21
NO179555C (no) 1996-10-30
PT96943A (pt) 1991-10-31
DE69119964D1 (de) 1996-07-11

Similar Documents

Publication Publication Date Title
TW254946B (he)
KR101311571B1 (ko) 시티딘이인산 콜린의 정제 방법
SG63555A1 (en) Biosynthesis of rebeccamycin analogs by triptophan analogs feeding
IL101931A0 (en) Processes for the diastereoselective synthesis of nucleosides,and hydrofuran derivatives for use therein
TW291480B (he)
JPS5444096A (en) Preparation of l-arginine by fermentation
CA2037596A1 (en) Rebeccamycin analog by bromide precursor feeding
CA2037783A1 (en) Rebeccamycin analogs by tryptophan analogs feeding
HUT50513A (en) Process for production of antitumour 4'-dezoxi-13/s/-dihydro-4'-iodine-doxorubicine hydrocl by means of stereoselective microbiological reduction of the 4'-dezoxi-4'-iodine-dexorubicine
AU5497396A (en) Process for the synthesis of nucleoside analogues
DE3760262D1 (en) New biosynthetic anthracyclines related to daunorubicin
ES8401527A1 (es) Un metodo de producir inosina y-o guanosina.