CA2037783A1 - Rebeccamycin analogs by tryptophan analogs feeding - Google Patents
Rebeccamycin analogs by tryptophan analogs feedingInfo
- Publication number
- CA2037783A1 CA2037783A1 CA2037783A CA2037783A CA2037783A1 CA 2037783 A1 CA2037783 A1 CA 2037783A1 CA 2037783 A CA2037783 A CA 2037783A CA 2037783 A CA2037783 A CA 2037783A CA 2037783 A1 CA2037783 A1 CA 2037783A1
- Authority
- CA
- Canada
- Prior art keywords
- analogs
- rebeccamycin
- feeding
- tryptophan
- results
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- INSACQSBHKIWNS-QZQSLCQPSA-N rebeccamycin Chemical class O[C@@H]1[C@@H](O)[C@H](OC)[C@@H](CO)O[C@H]1N1C2=C3N=C4[C](Cl)C=CC=C4C3=C3C(=O)NC(=O)C3=C2C2=CC=CC(Cl)=C21 INSACQSBHKIWNS-QZQSLCQPSA-N 0.000 title abstract 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical class C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title abstract 2
- ZGCSNRKSJLVANE-UHFFFAOYSA-N Aglycone-Rebeccamycin Natural products N1C2=C3NC4=C(Cl)C=CC=C4C3=C(C(=O)NC3=O)C3=C2C2=C1C(Cl)=CC=C2 ZGCSNRKSJLVANE-UHFFFAOYSA-N 0.000 abstract 1
- 241000970318 Lechevalieria aerocolonigenes Species 0.000 abstract 1
- QEHOIJJIZXRMAN-UHFFFAOYSA-N Rebeccamycin Natural products OC1C(O)C(OC)C(CO)OC1N1C2=C3NC4=C(Cl)C=CC=C4C3=C3C(=O)NC(=O)C3=C2C2=CC=CC(Cl)=C21 QEHOIJJIZXRMAN-UHFFFAOYSA-N 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960005567 rebeccamycin Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin analogs having advantageous antitumor properties.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48943090A | 1990-03-06 | 1990-03-06 | |
| US489,430 | 1995-06-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2037783A1 true CA2037783A1 (en) | 1991-09-07 |
| CA2037783C CA2037783C (en) | 1995-10-17 |
Family
ID=23943825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002037783A Expired - Fee Related CA2037783C (en) | 1990-03-06 | 1991-03-05 | Rebeccamycin analogs by tryptophan analogs feeding |
Country Status (3)
| Country | Link |
|---|---|
| CA (1) | CA2037783C (en) |
| SK (1) | SK278338B6 (en) |
| ZA (1) | ZA911613B (en) |
-
1991
- 1991-03-05 ZA ZA911613A patent/ZA911613B/en unknown
- 1991-03-05 CA CA002037783A patent/CA2037783C/en not_active Expired - Fee Related
- 1991-03-06 SK SK58691A patent/SK278338B6/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA911613B (en) | 1991-11-27 |
| SK278338B6 (en) | 1996-12-04 |
| CA2037783C (en) | 1995-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |