SG55038A1 - Asymmetrically substituted xanthines with adenosine-antagonistic properties - Google Patents

Asymmetrically substituted xanthines with adenosine-antagonistic properties

Info

Publication number
SG55038A1
SG55038A1 SG1996003249A SG1996003249A SG55038A1 SG 55038 A1 SG55038 A1 SG 55038A1 SG 1996003249 A SG1996003249 A SG 1996003249A SG 1996003249 A SG1996003249 A SG 1996003249A SG 55038 A1 SG55038 A1 SG 55038A1
Authority
SG
Singapore
Prior art keywords
adenosine
asymmetrically substituted
antagonistic properties
substituted xanthines
xanthines
Prior art date
Application number
SG1996003249A
Other languages
English (en)
Inventor
Ulrike Kufner-Muhl
Helmut Ensinger
Joachim Mierau
Franz Josef Kuhn
Erich Lehr
Enzio Muller
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of SG55038A1 publication Critical patent/SG55038A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG1996003249A 1992-08-10 1993-08-05 Asymmetrically substituted xanthines with adenosine-antagonistic properties SG55038A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4226371 1992-08-10
DE4238423 1992-11-13

Publications (1)

Publication Number Publication Date
SG55038A1 true SG55038A1 (en) 1998-12-21

Family

ID=25917371

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996003249A SG55038A1 (en) 1992-08-10 1993-08-05 Asymmetrically substituted xanthines with adenosine-antagonistic properties

Country Status (21)

Country Link
US (1) US5719279A (he)
EP (1) EP0654033A1 (he)
JP (1) JPH08500344A (he)
KR (1) KR950702988A (he)
CN (1) CN1043348C (he)
AU (1) AU681348B2 (he)
BG (1) BG62618B1 (he)
CA (1) CA2140883A1 (he)
CZ (1) CZ286459B6 (he)
FI (1) FI950542A (he)
HU (1) HUT65734A (he)
IL (1) IL106624A (he)
MX (1) MX9304819A (he)
NZ (1) NZ254804A (he)
PL (1) PL176389B1 (he)
RU (1) RU2138500C1 (he)
SG (1) SG55038A1 (he)
SK (1) SK18595A3 (he)
TW (1) TW252044B (he)
UA (1) UA46697C2 (he)
WO (1) WO1994003456A1 (he)

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US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7569574B2 (en) 2002-08-22 2009-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Purine derivatives, the preparation thereof and their use as pharmaceutical compositions
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US7482337B2 (en) 2002-11-08 2009-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
DE10254304A1 (de) 2002-11-21 2004-06-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
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US7439370B2 (en) 2004-05-10 2008-10-21 Boehringer Ingelheim International Gmbh Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides
DE102004030502A1 (de) 2004-06-24 2006-01-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel
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US8071583B2 (en) * 2006-08-08 2011-12-06 Boehringer Ingelheim International Gmbh Pyrrolo[3,2-D] pyrimidines as DPP-IV inhibitors for the treatment of diabetes mellitus
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US7928259B2 (en) * 2008-02-12 2011-04-19 Frx Polymers, Inc. Diaryl alkylphosphonates and methods for preparing same
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
AU2009281122C1 (en) * 2008-08-15 2016-04-21 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
AU2009290911A1 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
JP5334511B2 (ja) * 2008-09-22 2013-11-06 日本精化株式会社 化粧料
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
AU2009331471B2 (en) 2008-12-23 2015-09-03 Boehringer Ingelheim International Gmbh Salt forms of organic compound
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
BRPI1013561A8 (pt) * 2009-03-26 2015-09-22 Mapi Pharma Ltd processo para a preparação de alogliptina
KR102668834B1 (ko) 2009-11-27 2024-05-24 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
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US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
WO2013171167A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
EP4233840A3 (en) 2016-06-10 2023-10-18 Boehringer Ingelheim International GmbH Combinations of linagliptin and metformin
RU2643336C1 (ru) * 2016-10-03 2018-01-31 Общество с Ограниченной Ответственностью "Компания "ЭЛТА" СРЕДСТВО, ПРОЯВЛЯЮЩЕЕ АНТИТРОМБОТИЧЕСКИЙ ЭФФЕКТ ПОСРЕДСТВОМ БЛОКИРОВАНИЯ РЕЦЕПТОРОВ ТРОМБОЦИТОВ ГП IIb-IIIa (ВАРИАНТЫ)
CN109796453A (zh) * 2019-02-12 2019-05-24 南京纽邦生物科技有限公司 一种1,7-二甲基黄嘌呤的制备方法
EP4229059A1 (en) 2020-10-15 2023-08-23 Rheinische Friedrich-Wilhelms-Universität Bonn 3-substituted xanthine derivatives as mrgprx4 receptor modulators

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Also Published As

Publication number Publication date
RU2138500C1 (ru) 1999-09-27
NZ254804A (en) 1997-01-29
IL106624A0 (en) 1993-12-08
CZ286459B6 (en) 2000-04-12
RU95109100A (ru) 1996-12-27
BG62618B1 (bg) 2000-03-31
FI950542A0 (fi) 1995-02-08
BG99489A (bg) 1996-01-31
IL106624A (he) 1999-01-26
WO1994003456A1 (de) 1994-02-17
HUT65734A (en) 1994-07-28
JPH08500344A (ja) 1996-01-16
SK18595A3 (en) 1995-07-11
US5719279A (en) 1998-02-17
AU4707193A (en) 1994-03-03
AU681348B2 (en) 1997-08-28
CN1043348C (zh) 1999-05-12
CN1086818A (zh) 1994-05-18
MX9304819A (es) 1994-02-28
HU9302302D0 (en) 1993-10-28
PL176389B1 (pl) 1999-05-31
CZ34895A3 (en) 1995-10-18
PL307397A1 (en) 1995-05-15
KR950702988A (ko) 1995-08-23
UA46697C2 (uk) 2002-06-17
CA2140883A1 (en) 1994-02-17
FI950542A (fi) 1995-02-08
TW252044B (he) 1995-07-21
EP0654033A1 (de) 1995-05-24

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