SG49772A1 - Thrombin receptor antagonists - Google Patents
Thrombin receptor antagonistsInfo
- Publication number
- SG49772A1 SG49772A1 SG1996005407A SG1996005407A SG49772A1 SG 49772 A1 SG49772 A1 SG 49772A1 SG 1996005407 A SG1996005407 A SG 1996005407A SG 1996005407 A SG1996005407 A SG 1996005407A SG 49772 A1 SG49772 A1 SG 49772A1
- Authority
- SG
- Singapore
- Prior art keywords
- thrombin receptor
- receptor antagonists
- hydrophobic radical
- linkages
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92234092A | 1992-07-30 | 1992-07-30 | |
US8078893A | 1993-06-28 | 1993-06-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG49772A1 true SG49772A1 (en) | 1998-06-15 |
Family
ID=26763931
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1996005407A SG49772A1 (en) | 1992-07-30 | 1993-07-08 | Thrombin receptor antagonists |
Country Status (10)
Country | Link |
---|---|
US (1) | US5866681A (fr) |
EP (1) | EP0656008B1 (fr) |
JP (1) | JP2675438B2 (fr) |
AT (1) | ATE190625T1 (fr) |
AU (1) | AU669922B2 (fr) |
CA (1) | CA2140543C (fr) |
DE (1) | DE69328104T2 (fr) |
IL (1) | IL106197A (fr) |
SG (1) | SG49772A1 (fr) |
WO (1) | WO1994003479A1 (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6063847A (en) | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
EP1036072B1 (fr) * | 1997-11-25 | 2004-05-06 | Schering Corporation | Antagonistes de recepteur de thrombine |
DK1054892T3 (da) * | 1998-02-19 | 2003-01-20 | Ortho Mcneil Pharm Inc | Azolpeptidmimetiske forbindelser som thrombinreceptorantagonister |
US6017890A (en) * | 1998-02-19 | 2000-01-25 | Ortho-Mcneil Pharmaceutical, Inc. | Azole peptidomimetics as thrombin receptor antagonists |
GB2356198A (en) | 1999-10-29 | 2001-05-16 | Merck & Co Inc | Isoxazole thrombin receptor antagonists |
US6515023B2 (en) | 2000-01-31 | 2003-02-04 | Merck & Co., Inc. | Thrombin receptor antagonists |
US6403612B2 (en) | 2000-01-31 | 2002-06-11 | Merck & Co., Inc. | Thrombin receptor antagonists |
PE20020235A1 (es) | 2000-06-15 | 2002-04-02 | Schering Corp | Derivados de nor-seco himbacina como antagonistas de los receptores de trombina |
US7235567B2 (en) | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
JP2005506949A (ja) | 2000-12-20 | 2005-03-10 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | ケモカイン受容体の調節剤としてのジアミン |
CA2432369A1 (fr) | 2000-12-20 | 2002-08-08 | Bristol-Myers Squibb Pharma Company | Derives cycliques en tant que modulateurs de l'activite des recepteurs de chimiokines |
US20040096443A1 (en) * | 2002-03-08 | 2004-05-20 | Traynelis Stephen Francis | Treatment of neurodegenerative diseases and conditions using par1 antagonists |
HUP0500443A3 (en) | 2001-10-18 | 2009-12-28 | Schering Corp | Himbacine analogues as thrombin receptor antagonists and pharmaceutical compositions containing them |
IL164376A0 (en) * | 2002-04-03 | 2005-12-18 | Applied Research Systems | Ox4or binding agents, their preparation and pharmaceutical compositions containing them |
SI2065384T1 (sl) | 2002-04-16 | 2011-05-31 | Schering Corp | Tricikliäśni trombin receptor antagonist |
US7074765B2 (en) | 2003-05-01 | 2006-07-11 | The Regents Of The University Of Michigan | Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4 |
JP4558788B2 (ja) * | 2004-05-28 | 2010-10-06 | シェーリング コーポレイション | トロンビンレセプターアンタゴニストとしての条件付きヒンバシンアナログ |
MX2007004197A (es) | 2004-10-08 | 2007-06-15 | Schering Corp | Antagonistas del receptor de trombina. |
AU2006230292A1 (en) | 2005-03-31 | 2006-10-05 | Schering Corporation | Spirocyclic thrombin receptor antagonists |
WO2007126771A2 (fr) | 2006-03-29 | 2007-11-08 | Schering Corporation | Dérivés d'himbacine monocycliques et bicycli ques utiles en tant qu'antagonistes du récepteur de la thrombine |
AU2007238756A1 (en) | 2006-04-13 | 2007-10-25 | Schering Corporation | Fused ring thrombin receptor antagonists |
US8022088B2 (en) | 2006-06-29 | 2011-09-20 | Schering Corporation | Substituted bicyclic and tricyclic thrombin receptor antagonists |
AU2007305269A1 (en) | 2006-10-04 | 2008-04-10 | Schering Corporation | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
BRPI0809095A2 (pt) * | 2007-03-23 | 2014-09-09 | Schering Corp | Redução de eventos adversos após intervenção percutânea através de uso de um antagonista de receptor de trombina |
WO2008128038A2 (fr) * | 2007-04-13 | 2008-10-23 | The Scripps Research Institute | Procédés et compositions permettant de traiter les dysfonctionnements cardiaques |
WO2009143039A2 (fr) | 2008-05-19 | 2009-11-26 | Schering Corporation | Composés hétérocycliques en tant qu'inhibiteurs du facteur ixa |
TWI393716B (zh) | 2009-08-04 | 2013-04-21 | Merck Sharp & Dohme | 作為ixa因子抑制劑之雜環化合物 |
EP2335717A1 (fr) | 2009-11-16 | 2011-06-22 | Institut National De La Recherche Agronomique | Antagonistes PAR-1 pour une utilisation dans le traitement ou la prévention d'infections par le virus de la grippe de type A |
EP2822557B1 (fr) | 2012-03-06 | 2017-08-23 | Merck Sharp & Dohme Corp. | Préparation et utilisation de dérivés bicycliques d'himbacine en tant qu'antagonistes du récepteur de par |
EP3035929B1 (fr) | 2013-08-22 | 2024-07-03 | Merck Sharp & Dohme LLC | Dérivés bicycliques de 7a-amide substitué-6,6-difluoro himbacine |
US9808473B2 (en) | 2013-08-22 | 2017-11-07 | Merck Sharp & Dohme Corp. | Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists |
WO2015026685A1 (fr) | 2013-08-22 | 2015-02-26 | Merck Sharp & Dohme Corp. | Dérivés bicycliques de 7a-hétérocycle substitué-6,6-difluoro himbacine |
US9969724B2 (en) | 2014-04-16 | 2018-05-15 | Merck Sharp & Dohme Corp. | Factor IXa inhibitors |
WO2022018156A1 (fr) | 2020-07-22 | 2022-01-27 | Janssen Pharmaceutica Nv | Composés utiles en tant qu'inhibiteurs du facteur xia |
US11814364B2 (en) | 2021-03-18 | 2023-11-14 | Janssen Pharmaceutica Nv | Pyridine N-oxide derivatives useful as factor XIa inhibitors |
US11845748B2 (en) | 2021-03-18 | 2023-12-19 | Janssen Pharmaceutica Nv | Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors |
US11919881B2 (en) | 2021-03-18 | 2024-03-05 | Janssen Pharmaceutica Nv | Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors |
US11897880B2 (en) | 2021-04-30 | 2024-02-13 | Janssen Pharmaceutica Nv | 7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors |
US11958856B2 (en) | 2021-07-22 | 2024-04-16 | Janssen Pharmaceutica Nv | Substituted 1,2,3,8,9,9a-hexahydro-5H-pyrrolo[1,2-a]azepin-5-ones as factor XIa inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2589720A1 (fr) * | 1985-11-14 | 1987-05-15 | Aubaniac Jean | Ensemble prothetique pour l'articulation du genou |
US4859609A (en) * | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
US5352664A (en) * | 1986-10-31 | 1994-10-04 | Board Of Regents, The University Of Texas System | Thrombin derived polypeptides; compositions and methods for use |
AU618029B2 (en) * | 1987-11-02 | 1991-12-12 | Imperial Chemical Industries Plc | Polypeptide compounds |
US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
US5688768A (en) * | 1991-02-19 | 1997-11-18 | Cor Therapeutics, Inc. | Recombinant thrombin receptor and related pharmaceuticals |
US5256766A (en) * | 1991-02-19 | 1993-10-26 | The Regents Of The University Of California | Recombinant thrombin receptor and related pharmaceuticals |
WO1993018141A1 (fr) * | 1992-03-02 | 1993-09-16 | Biogen, Inc. | Antagonistes de recepteur de thrombine |
-
1993
- 1993-06-30 IL IL10619793A patent/IL106197A/en not_active IP Right Cessation
- 1993-07-08 DE DE69328104T patent/DE69328104T2/de not_active Expired - Fee Related
- 1993-07-08 AU AU46685/93A patent/AU669922B2/en not_active Ceased
- 1993-07-08 JP JP6505310A patent/JP2675438B2/ja not_active Expired - Fee Related
- 1993-07-08 SG SG1996005407A patent/SG49772A1/en unknown
- 1993-07-08 AT AT93917028T patent/ATE190625T1/de not_active IP Right Cessation
- 1993-07-08 EP EP93917028A patent/EP0656008B1/fr not_active Expired - Lifetime
- 1993-07-08 CA CA002140543A patent/CA2140543C/fr not_active Expired - Fee Related
- 1993-07-08 WO PCT/US1993/006428 patent/WO1994003479A1/fr active IP Right Grant
-
1995
- 1995-03-20 US US08/407,468 patent/US5866681A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2675438B2 (ja) | 1997-11-12 |
IL106197A0 (en) | 1994-05-30 |
CA2140543C (fr) | 2001-04-10 |
CA2140543A1 (fr) | 1994-02-17 |
AU669922B2 (en) | 1996-06-27 |
WO1994003479A1 (fr) | 1994-02-17 |
ATE190625T1 (de) | 2000-04-15 |
JPH07506115A (ja) | 1995-07-06 |
IL106197A (en) | 1999-11-30 |
DE69328104D1 (de) | 2000-04-20 |
EP0656008B1 (fr) | 2000-03-15 |
DE69328104T2 (de) | 2000-12-21 |
EP0656008A1 (fr) | 1995-06-07 |
US5866681A (en) | 1999-02-02 |
AU4668593A (en) | 1994-03-03 |
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